PMC:7601109 / 16730-17778 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T46727","span":{"begin":48,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T23081","span":{"begin":66,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T78989","span":{"begin":93,"end":103},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T90348","span":{"begin":278,"end":279},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T23908","span":{"begin":538,"end":539},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T89614","span":{"begin":1029,"end":1039},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The attention of several drug targeting studies has recently been focused on the therapeutic activities of individual bioactive compounds in propolis [65,68]. Flavonoids comprise the majority of mostly studies bioactive substances in propolis. Chrysin (5,7-dihydroxyflavone) is a flavonoid that exists in certain mushrooms, flowers (e.g., blue passion flower), and in other bee products (e.g., honey). It expresses anti-inflammatory, antioxidant, anti-proliferative, and neuroprotective effects [72]. Caffeic acid phenethyl ester (CAPE), a derivative of hydroxycinnamic acid, expresses anti-oxidant, immunomodulatory, anti-inflammatory, antiviral, and ant-neoplastic properties [73,74,75]. Pinocembrin (5,7-dihydroxyflavanone) is the most copious flavonoid in propolis—1 g of balsam/an ethanolic extract from poplar propolis found in Spain contains up to 606–701 mg of pinocembrin [76]. It exists in numerous plants (e.g., Eucalyptus and Populus). It exhibits anti-inflammatory, antioxidant, antimicrobial, and antiproliferative activities [77,78]."}

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