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PMC:7600245 / 9727-11362 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T59 65-70 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T60 283-298 Body_part denotes epithelial cell http://purl.org/sig/ont/fma/fma66768
T61 294-298 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 483-487 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T63 488-493 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T64 664-668 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T65 1364-1368 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T66 1369-1374 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67 1547-1551 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 483-487 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 664-668 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 1364-1368 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 1547-1551 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T33 85-93 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 200-208 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 569-577 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 1264-1273 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 1332-1340 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 1471-1479 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T66 40-48 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T67 57-70 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T68 183-191 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T69 270-275 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T70 276-282 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T71 283-293 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T72 294-298 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T73 397-400 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T74 407-410 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T75 446-451 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T76 477-482 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T77 483-487 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T78 483-487 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T79 488-493 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T80 505-506 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81 539-547 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T82 552-553 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 554-559 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T84 664-668 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T85 664-668 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T86 824-825 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T87 856-864 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T88 906-907 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T89 954-955 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T90 1130-1132 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T91 1231-1245 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes rhesus macaque
T92 1275-1277 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T93 1358-1363 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T94 1364-1368 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T95 1364-1368 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T96 1369-1374 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T97 1387-1392 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T98 1393-1399 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T99 1400-1410 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T100 1460-1461 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 1547-1551 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T102 1547-1551 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T103 1631-1633 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T88 625-635 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T89 791-801 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T90 807-817 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T91 819-822 Chemical denotes INF http://purl.obolibrary.org/obo/CHEBI_52999
T92 846-855 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T93 877-896 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T94 877-886 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T95 887-896 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T96 902-905 Chemical denotes INF http://purl.obolibrary.org/obo/CHEBI_52999
T97 930-949 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T98 930-939 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T99 940-949 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T100 950-953 Chemical denotes INF http://purl.obolibrary.org/obo/CHEBI_52999
T101 997-1007 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T102 1191-1201 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T103 1295-1305 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T104 1525-1535 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T75 0-147 Sentence denotes Remdesivir itself demonstrated in vitro activity against Vero E6 cells infected with SARS-CoV-2 with an EC50 value of 0.77 µM (CC50 > 100 µM) [33].
T76 148-345 Sentence denotes Remdesivir also exhibited in vitro activity against SARS-CoV and MERS-CoV in multiple in vitro systems, including primary human airway epithelial cell cultures with sub-micromolar IC50 values [28].
T77 346-548 Sentence denotes Remdesivir was also effective against pre-pandemic bat-CoVs, bat-CoVs, and contemporary circulating human coronaviruses in primary human lung cells suggesting a broad-spectrum anti-coronavirus activity.
T78 549-777 Sentence denotes In a mouse model of SARS-CoV, the prophylactic and early therapeutic use of remdesivir significantly decreased the lung viral load and improved the respiratory functions as well as the overall clinical signs of the disease [28].
T79 778-917 Sentence denotes Furthermore, remdesivir with interferon (INF)-b demonstrated better antiviral activity compared to lopinavir/ritonavir with INF-b in vitro.
T80 918-1134 Sentence denotes Compared to lopinavir/ritonavir/INF-b, the prophylactic and therapeutic use of remdesivir also more effectively diminished the pulmonary viral loads and improved the pulmonary function in mice model of MERS-CoV [34].
T81 1135-1279 Sentence denotes The efficacy of the prophylactic and therapeutic use of remdesivir was also demonstrated in the rhesus macaque model of MERS-CoV infection [35].
T82 1280-1437 Sentence denotes Very recently, remdesivir was also shown to inhibit SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures (EC50 = 0.01 μM).
T83 1438-1635 Sentence denotes In mice infected with a chimeric SARS-CoV encoding RdRp, therapeutic administration of remdesivir diminished lung viral load and improved pulmonary function compared with vehicle-treated mice [36].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
213 1489-1493 Gene denotes RdRp Gene:43740578
214 85-95 Species denotes SARS-CoV-2 Tax:2697049
215 200-208 Species denotes SARS-CoV Tax:694009
216 213-221 Species denotes MERS-CoV Tax:1335626
217 270-275 Species denotes human Tax:9606
218 401-405 Species denotes CoVs Tax:11118
219 411-415 Species denotes CoVs Tax:11118
220 446-451 Species denotes human Tax:9606
221 452-465 Species denotes coronaviruses Tax:11118
222 477-482 Species denotes human Tax:9606
223 554-559 Species denotes mouse Tax:10090
224 569-577 Species denotes SARS-CoV Tax:694009
225 1106-1110 Species denotes mice Tax:10090
226 1120-1128 Species denotes MERS-CoV Tax:1335626
227 1231-1245 Species denotes rhesus macaque Tax:9544
228 1332-1342 Species denotes SARS-CoV-2 Tax:2697049
229 1358-1363 Species denotes human Tax:9606
230 1387-1392 Species denotes human Tax:9606
231 1441-1445 Species denotes mice Tax:10090
232 1471-1479 Species denotes SARS-CoV Tax:694009
233 1625-1629 Species denotes mice Tax:10090
234 697-708 Species denotes respiratory Tax:12814
235 527-538 Species denotes coronavirus Tax:11118
236 0-10 Chemical denotes Remdesivir MESH:C000606551
237 148-158 Chemical denotes Remdesivir MESH:C000606551
238 346-356 Chemical denotes Remdesivir MESH:C000606551
239 625-635 Chemical denotes remdesivir MESH:C000606551
240 791-801 Chemical denotes remdesivir MESH:C000606551
241 877-896 Chemical denotes lopinavir/ritonavir MESH:C558899
242 930-949 Chemical denotes lopinavir/ritonavir MESH:C558899
243 953-955 Chemical denotes -b MESH:D001895
244 997-1007 Chemical denotes remdesivir MESH:C000606551
245 1191-1201 Chemical denotes remdesivir MESH:C000606551
246 1295-1305 Chemical denotes remdesivir MESH:C000606551
247 1525-1535 Chemical denotes remdesivir MESH:C000606551
248 71-79 Disease denotes infected MESH:D007239
249 1260-1273 Disease denotes CoV infection MESH:D018352
250 1446-1454 Disease denotes infected MESH:D007239
251 62-64 CellLine denotes E6 CVCL:4582