PMC:7600245 / 96917-97676 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7600245","sourcedb":"PMC","sourceid":"7600245","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7600245","text":"Table 3 Most frequently evaluated antithrombotics in clinical trials for COVID-19 a.\nTherapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3\na From clinicaltrials.gov, b No. is as of 25 July 2020.","divisions":[{"label":"label","span":{"begin":0,"end":7}},{"label":"caption","span":{"begin":9,"end":85}},{"label":"p","span":{"begin":9,"end":85}},{"label":"table","span":{"begin":86,"end":703}},{"label":"tr","span":{"begin":86,"end":151}},{"label":"th","span":{"begin":86,"end":93}},{"label":"th","span":{"begin":95,"end":99}},{"label":"th","span":{"begin":101,"end":110}},{"label":"th","span":{"begin":112,"end":151}},{"label":"tr","span":{"begin":152,"end":352}},{"label":"td","span":{"begin":152,"end":256}},{"label":"td","span":{"begin":258,"end":285}},{"label":"td","span":{"begin":287,"end":347}},{"label":"td","span":{"begin":349,"end":352}},{"label":"tr","span":{"begin":353,"end":430}},{"label":"td","span":{"begin":353,"end":383}},{"label":"td","span":{"begin":385,"end":399}},{"label":"td","span":{"begin":401,"end":426}},{"label":"td","span":{"begin":428,"end":430}},{"label":"tr","span":{"begin":431,"end":499}},{"label":"td","span":{"begin":431,"end":451}},{"label":"td","span":{"begin":453,"end":467}},{"label":"td","span":{"begin":469,"end":495}},{"label":"td","span":{"begin":497,"end":499}},{"label":"tr","span":{"begin":500,"end":610}},{"label":"td","span":{"begin":500,"end":522}},{"label":"td","span":{"begin":524,"end":538}},{"label":"td","span":{"begin":540,"end":606}},{"label":"td","span":{"begin":608,"end":610}},{"label":"tr","span":{"begin":611,"end":703}},{"label":"td","span":{"begin":611,"end":630}},{"label":"td","span":{"begin":632,"end":646}},{"label":"td","span":{"begin":648,"end":699}},{"label":"td","span":{"begin":701,"end":703}}],"tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":167,"end":174},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T2","span":{"begin":167,"end":174},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T3","span":{"begin":199,"end":207},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T4","span":{"begin":199,"end":207},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T2","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T3","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T4","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T449","span":{"begin":167,"end":174},"obj":"Body_part"},{"id":"T450","span":{"begin":199,"end":207},"obj":"Body_part"},{"id":"T451","span":{"begin":267,"end":285},"obj":"Body_part"}],"attributes":[{"id":"A449","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A450","pred":"fma_id","subj":"T450","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A451","pred":"fma_id","subj":"T451","obj":"http://purl.org/sig/ont/fma/fma63011"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T450","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T437","span":{"begin":74,"end":82},"obj":"Disease"}],"attributes":[{"id":"A437","pred":"mondo_id","subj":"T437","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T964","span":{"begin":83,"end":84},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T965","span":{"begin":150,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T966","span":{"begin":287,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T967","span":{"begin":575,"end":576},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T968","span":{"begin":704,"end":705},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T969","span":{"begin":731,"end":732},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T964","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T965","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T966","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T967","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T968","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T969","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T734","span":{"begin":167,"end":174},"obj":"Chemical"},{"id":"T735","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T736","span":{"begin":209,"end":219},"obj":"Chemical"},{"id":"T737","span":{"begin":258,"end":285},"obj":"Chemical"},{"id":"T738","span":{"begin":267,"end":285},"obj":"Chemical"},{"id":"T739","span":{"begin":353,"end":360},"obj":"Chemical"},{"id":"T740","span":{"begin":362,"end":382},"obj":"Chemical"},{"id":"T741","span":{"begin":378,"end":382},"obj":"Chemical"},{"id":"T742","span":{"begin":391,"end":399},"obj":"Chemical"},{"id":"T743","span":{"begin":417,"end":426},"obj":"Chemical"},{"id":"T744","span":{"begin":443,"end":450},"obj":"Chemical"},{"id":"T745","span":{"begin":459,"end":467},"obj":"Chemical"},{"id":"T746","span":{"begin":476,"end":495},"obj":"Chemical"},{"id":"T747","span":{"begin":486,"end":495},"obj":"Chemical"},{"id":"T748","span":{"begin":530,"end":538},"obj":"Chemical"},{"id":"T749","span":{"begin":540,"end":550},"obj":"Chemical"},{"id":"T750","span":{"begin":561,"end":570},"obj":"Chemical"},{"id":"T751","span":{"begin":597,"end":606},"obj":"Chemical"},{"id":"T90414","span":{"begin":623,"end":629},"obj":"Chemical"},{"id":"T753","span":{"begin":638,"end":646},"obj":"Chemical"},{"id":"T754","span":{"begin":661,"end":670},"obj":"Chemical"},{"id":"T755","span":{"begin":671,"end":682},"obj":"Chemical"}],"attributes":[{"id":"A734","pred":"chebi_id","subj":"T734","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A735","pred":"chebi_id","subj":"T735","obj":"http://purl.obolibrary.org/obo/CHEBI_24505"},{"id":"A736","pred":"chebi_id","subj":"T736","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A737","pred":"chebi_id","subj":"T737","obj":"http://purl.obolibrary.org/obo/CHEBI_35722"},{"id":"A738","pred":"chebi_id","subj":"T738","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"},{"id":"A739","pred":"chebi_id","subj":"T739","obj":"http://purl.obolibrary.org/obo/CHEBI_15365"},{"id":"A740","pred":"chebi_id","subj":"T740","obj":"http://purl.obolibrary.org/obo/CHEBI_15365"},{"id":"A741","pred":"chebi_id","subj":"T741","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A742","pred":"chebi_id","subj":"T742","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A743","pred":"chebi_id","subj":"T743","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A744","pred":"chebi_id","subj":"T744","obj":"http://purl.obolibrary.org/obo/CHEBI_68579"},{"id":"A745","pred":"chebi_id","subj":"T745","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A746","pred":"chebi_id","subj":"T746","obj":"http://purl.obolibrary.org/obo/CHEBI_68581"},{"id":"A747","pred":"chebi_id","subj":"T747","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A748","pred":"chebi_id","subj":"T748","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A749","pred":"chebi_id","subj":"T749","obj":"http://purl.obolibrary.org/obo/CHEBI_33838"},{"id":"A750","pred":"chebi_id","subj":"T750","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A751","pred":"chebi_id","subj":"T751","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A752","pred":"chebi_id","subj":"T90414","obj":"http://purl.obolibrary.org/obo/CHEBI_3759"},{"id":"A753","pred":"chebi_id","subj":"T753","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A754","pred":"chebi_id","subj":"T754","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A755","pred":"chebi_id","subj":"T755","obj":"http://purl.obolibrary.org/obo/CHEBI_18361"},{"id":"A756","pred":"chebi_id","subj":"T755","obj":"http://purl.obolibrary.org/obo/CHEBI_33019"},{"subj":"T734","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T735","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T736","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T737","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T738","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T739","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T740","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T741","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T742","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T743","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T744","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T745","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T746","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T747","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T748","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T749","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T750","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T751","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T90414","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T753","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T754","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T755","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T194","span":{"begin":540,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0015858"},{"id":"T195","span":{"begin":551,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"attributes":[{"subj":"T194","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T804","span":{"begin":0,"end":85},"obj":"Sentence"},{"id":"T805","span":{"begin":86,"end":151},"obj":"Sentence"},{"id":"T806","span":{"begin":152,"end":352},"obj":"Sentence"},{"id":"T807","span":{"begin":353,"end":430},"obj":"Sentence"},{"id":"T808","span":{"begin":431,"end":499},"obj":"Sentence"},{"id":"T809","span":{"begin":500,"end":610},"obj":"Sentence"},{"id":"T810","span":{"begin":611,"end":703},"obj":"Sentence"},{"id":"T811","span":{"begin":704,"end":759},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T804","pred":"source","obj":"LitCovid-sentences"},{"subj":"T805","pred":"source","obj":"LitCovid-sentences"},{"subj":"T806","pred":"source","obj":"LitCovid-sentences"},{"subj":"T807","pred":"source","obj":"LitCovid-sentences"},{"subj":"T808","pred":"source","obj":"LitCovid-sentences"},{"subj":"T809","pred":"source","obj":"LitCovid-sentences"},{"subj":"T810","pred":"source","obj":"LitCovid-sentences"},{"subj":"T811","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"4100","span":{"begin":301,"end":313},"obj":"Gene"},{"id":"4101","span":{"begin":325,"end":333},"obj":"Gene"},{"id":"4102","span":{"begin":167,"end":174},"obj":"Chemical"},{"id":"4103","span":{"begin":661,"end":670},"obj":"Chemical"},{"id":"4105","span":{"begin":74,"end":82},"obj":"Disease"}],"attributes":[{"id":"A4100","pred":"tao:has_database_id","subj":"4100","obj":"Gene:462"},{"id":"A4101","pred":"tao:has_database_id","subj":"4101","obj":"Gene:2147"},{"id":"A4102","pred":"tao:has_database_id","subj":"4102","obj":"MESH:D006493"},{"id":"A4103","pred":"tao:has_database_id","subj":"4103","obj":"MESH:D000241"},{"id":"A4105","pred":"tao:has_database_id","subj":"4105","obj":"MESH:C000657245"},{"subj":"4100","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4101","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4102","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4103","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4105","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#d593ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecbb"},{"id":"LitCovid-PD-MONDO","color":"#eca193"},{"id":"LitCovid-PD-CLO","color":"#939fec"},{"id":"LitCovid-PD-CHEBI","color":"#b9ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93d3"},{"id":"LitCovid-sentences","color":"#93eceb"},{"id":"LitCovid-PubTator","color":"#ecd193"}]}]}}