PMC:7600245 / 68384-69158
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T301 | 565-569 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T302 | 588-593 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T34 | 565-569 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T320 | 123-130 | Disease | denotes | malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
| T321 | 203-211 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T322 | 523-531 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T323 | 538-547 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T324 | 693-701 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T691 | 23-24 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T692 | 336-342 | http://purl.obolibrary.org/obo/CLO_0007926 | denotes | n = 22 |
| T693 | 506-514 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T694 | 548-555 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T695 | 559-564 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T696 | 565-569 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T697 | 565-569 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T698 | 570-580 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T699 | 581-593 | http://purl.obolibrary.org/obo/CLO_0051840 | denotes | Calu-3 cells |
| T700 | 581-593 | http://purl.obolibrary.org/obo/CLO_0051841 | denotes | Calu-3 cells |
| T701 | 581-593 | http://purl.obolibrary.org/obo/CLO_0051842 | denotes | Calu-3 cells |
| T702 | 581-593 | http://purl.obolibrary.org/obo/CLO_0051843 | denotes | Calu-3 cells |
| T703 | 581-593 | http://purl.obolibrary.org/obo/CLO_0051844 | denotes | Calu-3 cells |
| T704 | 581-587 | http://purl.obolibrary.org/obo/CLO_0002192 | denotes | Calu-3 |
| T705 | 749-750 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T224 | 367-379 | Chemical | denotes | pyronaridine | http://purl.obolibrary.org/obo/CHEBI_135951 |
| T225 | 389-401 | Chemical | denotes | antimalarial | http://purl.obolibrary.org/obo/CHEBI_38068 |
| T17995 | 402-406 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T47921 | 496-505 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T5752 | 607-618 | Chemical | denotes | artemisinin | http://purl.obolibrary.org/obo/CHEBI_223316 |
| T229 | 706-716 | Chemical | denotes | mefloquine | http://purl.obolibrary.org/obo/CHEBI_63609 |
| T230 | 717-727 | Chemical | denotes | artesunate | http://purl.obolibrary.org/obo/CHEBI_63918 |
| T79229 | 738-748 | Chemical | denotes | arteannuin | http://purl.obolibrary.org/obo/CHEBI_223316 |
| T6724 | 755-767 | Chemical | denotes | lumefantrine | http://purl.obolibrary.org/obo/CHEBI_156095 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T530 | 0-5 | Sentence | denotes | 4.16. |
| T531 | 6-16 | Sentence | denotes | Artesunate |
| T532 | 17-89 | Sentence | denotes | It is a polycyclic natural product with endoperoxide moiety (Figure S6). |
| T533 | 90-131 | Sentence | denotes | It is parenterally used to treat malaria. |
| T534 | 132-266 | Sentence | denotes | Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. |
| T535 | 267-454 | Sentence | denotes | It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). |
| T536 | 455-600 | Sentence | denotes | In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. |
| T537 | 601-774 | Sentence | denotes | Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2113 | 6-16 | Chemical | denotes | Artesunate | MESH:D000077332 |
| 2127 | 203-211 | Species | denotes | SARS-CoV | Tax:694009 |
| 2128 | 523-533 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2129 | 538-555 | Species | denotes | influenza viruses | Tax:11308 |
| 2130 | 559-564 | Species | denotes | human | Tax:9606 |
| 2131 | 57-69 | Chemical | denotes | endoperoxide | |
| 2132 | 367-379 | Chemical | denotes | pyronaridine | MESH:C027871 |
| 2133 | 607-618 | Chemical | denotes | artemisinin | MESH:C031327 |
| 2134 | 706-727 | Chemical | denotes | mefloquine-artesunate | |
| 2135 | 738-750 | Chemical | denotes | arteannuin B | MESH:C006634 |
| 2136 | 755-767 | Chemical | denotes | lumefantrine | MESH:D000078102 |
| 2137 | 123-130 | Disease | denotes | malaria | MESH:D008288 |
| 2138 | 693-701 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2139 | 581-587 | CellLine | denotes | Calu-3 | CVCL:0609 |