PMC:7600245 / 68384-69158 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T301","span":{"begin":565,"end":569},"obj":"Body_part"},{"id":"T302","span":{"begin":588,"end":593},"obj":"Body_part"}],"attributes":[{"id":"A301","pred":"fma_id","subj":"T301","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A302","pred":"fma_id","subj":"T302","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T34","span":{"begin":565,"end":569},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T320","span":{"begin":123,"end":130},"obj":"Disease"},{"id":"T321","span":{"begin":203,"end":211},"obj":"Disease"},{"id":"T322","span":{"begin":523,"end":531},"obj":"Disease"},{"id":"T323","span":{"begin":538,"end":547},"obj":"Disease"},{"id":"T324","span":{"begin":693,"end":701},"obj":"Disease"}],"attributes":[{"id":"A320","pred":"mondo_id","subj":"T320","obj":"http://purl.obolibrary.org/obo/MONDO_0005136"},{"id":"A321","pred":"mondo_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A322","pred":"mondo_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A323","pred":"mondo_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A324","pred":"mondo_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T691","span":{"begin":23,"end":24},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T692","span":{"begin":336,"end":342},"obj":"http://purl.obolibrary.org/obo/CLO_0007926"},{"id":"T693","span":{"begin":506,"end":514},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T694","span":{"begin":548,"end":555},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T695","span":{"begin":559,"end":564},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T696","span":{"begin":565,"end":569},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T697","span":{"begin":565,"end":569},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T698","span":{"begin":570,"end":580},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T699","span":{"begin":581,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0051840"},{"id":"T700","span":{"begin":581,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0051841"},{"id":"T701","span":{"begin":581,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0051842"},{"id":"T702","span":{"begin":581,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0051843"},{"id":"T703","span":{"begin":581,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0051844"},{"id":"T704","span":{"begin":581,"end":587},"obj":"http://purl.obolibrary.org/obo/CLO_0002192"},{"id":"T705","span":{"begin":749,"end":750},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T224","span":{"begin":367,"end":379},"obj":"Chemical"},{"id":"T225","span":{"begin":389,"end":401},"obj":"Chemical"},{"id":"T17995","span":{"begin":402,"end":406},"obj":"Chemical"},{"id":"T47921","span":{"begin":496,"end":505},"obj":"Chemical"},{"id":"T5752","span":{"begin":607,"end":618},"obj":"Chemical"},{"id":"T229","span":{"begin":706,"end":716},"obj":"Chemical"},{"id":"T230","span":{"begin":717,"end":727},"obj":"Chemical"},{"id":"T79229","span":{"begin":738,"end":748},"obj":"Chemical"},{"id":"T6724","span":{"begin":755,"end":767},"obj":"Chemical"}],"attributes":[{"id":"A92713","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_135951"},{"id":"A61848","pred":"chebi_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/CHEBI_38068"},{"id":"A87053","pred":"chebi_id","subj":"T17995","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A18128","pred":"chebi_id","subj":"T47921","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A53321","pred":"chebi_id","subj":"T5752","obj":"http://purl.obolibrary.org/obo/CHEBI_223316"},{"id":"A51766","pred":"chebi_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/CHEBI_63609"},{"id":"A93632","pred":"chebi_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/CHEBI_63918"},{"id":"A87332","pred":"chebi_id","subj":"T79229","obj":"http://purl.obolibrary.org/obo/CHEBI_223316"},{"id":"A1241","pred":"chebi_id","subj":"T6724","obj":"http://purl.obolibrary.org/obo/CHEBI_156095"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T530","span":{"begin":0,"end":5},"obj":"Sentence"},{"id":"T531","span":{"begin":6,"end":16},"obj":"Sentence"},{"id":"T532","span":{"begin":17,"end":89},"obj":"Sentence"},{"id":"T533","span":{"begin":90,"end":131},"obj":"Sentence"},{"id":"T534","span":{"begin":132,"end":266},"obj":"Sentence"},{"id":"T535","span":{"begin":267,"end":454},"obj":"Sentence"},{"id":"T536","span":{"begin":455,"end":600},"obj":"Sentence"},{"id":"T537","span":{"begin":601,"end":774},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2113","span":{"begin":6,"end":16},"obj":"Chemical"},{"id":"2127","span":{"begin":203,"end":211},"obj":"Species"},{"id":"2128","span":{"begin":523,"end":533},"obj":"Species"},{"id":"2129","span":{"begin":538,"end":555},"obj":"Species"},{"id":"2130","span":{"begin":559,"end":564},"obj":"Species"},{"id":"2131","span":{"begin":57,"end":69},"obj":"Chemical"},{"id":"2132","span":{"begin":367,"end":379},"obj":"Chemical"},{"id":"2133","span":{"begin":607,"end":618},"obj":"Chemical"},{"id":"2134","span":{"begin":706,"end":727},"obj":"Chemical"},{"id":"2135","span":{"begin":738,"end":750},"obj":"Chemical"},{"id":"2136","span":{"begin":755,"end":767},"obj":"Chemical"},{"id":"2137","span":{"begin":123,"end":130},"obj":"Disease"},{"id":"2138","span":{"begin":693,"end":701},"obj":"Disease"},{"id":"2139","span":{"begin":581,"end":587},"obj":"CellLine"}],"attributes":[{"id":"A2113","pred":"tao:has_database_id","subj":"2113","obj":"MESH:D000077332"},{"id":"A2127","pred":"tao:has_database_id","subj":"2127","obj":"Tax:694009"},{"id":"A2128","pred":"tao:has_database_id","subj":"2128","obj":"Tax:2697049"},{"id":"A2129","pred":"tao:has_database_id","subj":"2129","obj":"Tax:11308"},{"id":"A2130","pred":"tao:has_database_id","subj":"2130","obj":"Tax:9606"},{"id":"A2132","pred":"tao:has_database_id","subj":"2132","obj":"MESH:C027871"},{"id":"A2133","pred":"tao:has_database_id","subj":"2133","obj":"MESH:C031327"},{"id":"A2135","pred":"tao:has_database_id","subj":"2135","obj":"MESH:C006634"},{"id":"A2136","pred":"tao:has_database_id","subj":"2136","obj":"MESH:D000078102"},{"id":"A2137","pred":"tao:has_database_id","subj":"2137","obj":"MESH:D008288"},{"id":"A2138","pred":"tao:has_database_id","subj":"2138","obj":"MESH:C000657245"},{"id":"A2139","pred":"tao:has_database_id","subj":"2139","obj":"CVCL:0609"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.16. Artesunate\nIt is a polycyclic natural product with endoperoxide moiety (Figure S6). It is parenterally used to treat malaria. Initially, there was not enough information about its efficacy against SARS-CoV, except the results of herbal extract screening [246]. It is now being evaluated in few clinical trials alone (NCT04387240; n = 22) or in combination with pyronaridine, another antimalarial drug (NCT04475107; n = 76 and NCT04532931; n = 250). In particular, the combination exhibited antiviral activity against SARS-CoV-2 and influenza viruses in human lung epithelial Calu-3 cells [247]. Other artemisinin-based combinations that appear to be on the rise for potentially treating COVID-19 are mefloquine-artesunate [248] and arteannuin B and lumefantrine [249]."}