PMC:7600245 / 50216-50408 JSONTXT

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{"project":"LitCovid-PD-CLO","denotations":[{"id":"T496","span":{"begin":161,"end":170},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T497","span":{"begin":171,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T498","span":{"begin":186,"end":191},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T4722","span":{"begin":20,"end":24},"obj":"Chemical"},{"id":"T60213","span":{"begin":46,"end":60},"obj":"Chemical"},{"id":"T49164","span":{"begin":128,"end":138},"obj":"Chemical"},{"id":"T10698","span":{"begin":145,"end":156},"obj":"Chemical"}],"attributes":[{"id":"A60971","pred":"chebi_id","subj":"T4722","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A77142","pred":"chebi_id","subj":"T60213","obj":"http://purl.obolibrary.org/obo/CHEBI_30867"},{"id":"A32140","pred":"chebi_id","subj":"T49164","obj":"http://purl.obolibrary.org/obo/CHEBI_16898"},{"id":"A73334","pred":"chebi_id","subj":"T10698","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"}],"text":"The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T84","span":{"begin":112,"end":124},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells."}

{"project":"LitCovid-sentences","denotations":[{"id":"T374","span":{"begin":0,"end":192},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1594","span":{"begin":46,"end":74},"obj":"Gene"},{"id":"1604","span":{"begin":128,"end":144},"obj":"Chemical"}],"attributes":[{"id":"A1594","pred":"tao:has_database_id","subj":"1594","obj":"Gene:1723"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells."}