> top > docs > PMC:7600245 > spans > 29542-30498 > annotations

PMC:7600245 / 29542-30498 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T122 147-152 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T123 760-767 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T124 822-825 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T125 899-902 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T110 119-127 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 400-408 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 668-676 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 947-955 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T271 102-110 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T272 130-135 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T273 139-152 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T274 192-197 http://purl.obolibrary.org/obo/CLO_0007488 denotes M [85
T275 324-330 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T276 383-391 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T277 473-479 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T278 745-749 http://purl.obolibrary.org/obo/CLO_0001649 denotes a C2

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T418 24-33 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T419 69-78 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T420 92-101 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T421 247-256 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T422 354-363 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T423 590-609 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T424 590-599 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T425 600-609 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T426 625-634 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T427 747-749 Chemical denotes C2 http://purl.obolibrary.org/obo/CHEBI_30083
T428 760-767 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T429 804-813 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T430 828-847 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T432 837-847 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T433 905-914 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T436 915-934 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T438 924-934 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T217 0-68 Sentence denotes The rationale for using lopinavir is attributed to multiple studies.
T218 69-199 Sentence denotes Lopinavir exhibited an antiviral activity against SARS-CoV-2 virus in Vero E6 cells with an estimated EC50 value of 26.63 μM [85].
T219 200-344 Sentence denotes Computational studies have also suggested that lopinavir may inhibit the viral main protease Mpro, perhaps by targeting its active site [86,87].
T220 345-435 Sentence denotes Earlier, lopinavir exhibited in vitro activity against SARS-CoV-1 and MERS-CoV [88,89,90].
T221 436-526 Sentence denotes It also showed beneficial effects in animal studies for the treatment of MERS-CoV [91,92].
T222 527-688 Sentence denotes Furthermore, there is an evidence of some clinical benefit for lopinavir/ritonavir when used with ribavirin and/or INFs against MERS-CoV and SARS-CoV [88,93,94].
T223 689-848 Sentence denotes Yet, coronavirus proteases, including Mpro, do not have a C2-symmetric protein architecture which is the target of lopinavir and all HIV-1 protease inhibitors.
T224 849-956 Sentence denotes This subsequently sheds doubts on the prospect of HIV-1 aspartate protease inhibitors in treating COVID-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
846 293-297 Gene denotes Mpro Gene:8673700
847 727-731 Gene denotes Mpro Gene:8673700
848 119-129 Species denotes SARS-CoV-2 Tax:2697049
849 400-408 Species denotes SARS-CoV Tax:694009
850 415-423 Species denotes MERS-CoV Tax:1335626
851 509-517 Species denotes MERS-CoV Tax:1335626
852 655-663 Species denotes MERS-CoV Tax:1335626
853 668-676 Species denotes SARS-CoV Tax:694009
854 694-705 Species denotes coronavirus Tax:11118
855 822-827 Species denotes HIV-1 Tax:11676
856 899-904 Species denotes HIV-1 Tax:11676
857 24-33 Chemical denotes lopinavir MESH:D061466
858 69-78 Chemical denotes Lopinavir MESH:D061466
859 247-256 Chemical denotes lopinavir MESH:D061466
860 354-363 Chemical denotes lopinavir MESH:D061466
861 590-609 Chemical denotes lopinavir/ritonavir MESH:C558899
862 625-634 Chemical denotes ribavirin MESH:D012254
863 804-813 Chemical denotes lopinavir MESH:D061466
864 947-955 Disease denotes COVID-19 MESH:C000657245
865 139-146 CellLine denotes Vero E6 CVCL:0574