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PMC:7600245 / 25077-26455 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T101 41-47 Body_part denotes purine http://purl.org/sig/ont/fma/fma82772
T102 48-58 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T103 159-162 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 589-598 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T105 605-615 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T106 624-631 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T107 807-814 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T97 1156-1165 Disease denotes cirrhosis http://purl.obolibrary.org/obo/MONDO_0005155
T98 1337-1345 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T229 33-39 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T230 86-89 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T231 110-118 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T232 163-170 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T233 182-187 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T234 231-232 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 395-405 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T236 458-463 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T237 507-508 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T238 948-954 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T239 1071-1079 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T240 1213-1214 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T338 41-58 Chemical denotes purine nucleotide http://purl.obolibrary.org/obo/CHEBI_26395
T339 41-47 Chemical denotes purine http://purl.obolibrary.org/obo/CHEBI_35584
T340 48-58 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T341 59-66 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T342 75-77 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T343 100-109 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T344 240-249 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T345 308-320 Chemical denotes sulfate salt http://purl.obolibrary.org/obo/CHEBI_35175
T346 308-315 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T347 316-320 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T349 326-330 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T350 531-539 Chemical denotes L-alanyl http://purl.obolibrary.org/obo/CHEBI_32433|http://purl.obolibrary.org/obo/CHEBI_46217
T352 533-539 Chemical denotes alanyl http://purl.obolibrary.org/obo/CHEBI_22280|http://purl.obolibrary.org/obo/CHEBI_32441
T354 589-598 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T355 605-615 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T356 624-631 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T357 708-718 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T358 762-771 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T359 782-791 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T360 807-814 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T361 886-908 Chemical denotes nucleoside diphosphate http://purl.obolibrary.org/obo/CHEBI_16862
T362 886-896 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T363 897-908 Chemical denotes diphosphate http://purl.obolibrary.org/obo/CHEBI_18361|http://purl.obolibrary.org/obo/CHEBI_33019
T365 970-981 Chemical denotes diphosphate http://purl.obolibrary.org/obo/CHEBI_18361|http://purl.obolibrary.org/obo/CHEBI_33019
T367 1017-1019 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T368 1061-1070 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T369 1176-1180 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T45 677-686 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 1156-1165 Phenotype denotes cirrhosis http://purl.obolibrary.org/obo/HP_0001394

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T183 0-224 Sentence denotes It is an investigational, orally active, purine nucleotide prodrug (Figure S3), which has exhibited antiviral activity against many single-stranded, enveloped RNA viruses, including human flaviviruses and coronaviruses [77].
T184 225-269 Sentence denotes It is a potent inhibitor of viral RdRp [78].
T185 270-412 Sentence denotes Following oral administration as hemi-sulfate salt, the drug gets converted to the monophosphate form via multiple metabolic activation steps.
T186 413-553 Sentence denotes The first step is catalyzed by the action of human carboxylesterase 1 (CES1) and/or cathepsin A (CatA) to produce the L-alanyl intermediate.
T187 554-719 Sentence denotes Spontaneous hydrolysis followed by histidine triad nucleotide-binding protein 1 (HINT1)-mediated hydrolysis results in the formation of the monophosphate metabolite.
T188 720-1026 Sentence denotes Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78].
T189 1027-1171 Sentence denotes The safety, pharmacokinetics, and antiviral activity of AT-527 was earlier established in HCV-infected subjects with and without cirrhosis [79].
T190 1172-1378 Sentence denotes The drug is currently being evaluated in a phase 2 double-blind, randomized, placebo-controlled study to determine its efficacy and safety in patients with moderate COVID-19 symptoms (NCT04396106; n = 190).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
707 259-263 Gene denotes RdRp Gene:43740578
708 464-482 Gene denotes carboxylesterase 1 Gene:1066
709 484-488 Gene denotes CES1 Gene:1066
710 497-508 Gene denotes cathepsin A Gene:5476
711 510-514 Gene denotes CatA Gene:5476
712 589-633 Gene denotes histidine triad nucleotide-binding protein 1 Gene:3094
713 635-640 Gene denotes HINT1 Gene:3094
714 856-874 Gene denotes guanylate kinase 1 Gene:2987
715 876-880 Gene denotes GUK1 Gene:2987
716 886-915 Gene denotes nucleoside diphosphate kinase Gene:129607
717 917-921 Gene denotes NDPK Gene:129607
718 182-187 Species denotes human Tax:9606
719 205-218 Species denotes coronaviruses Tax:11118
720 458-463 Species denotes human Tax:9606
721 1314-1322 Species denotes patients Tax:9606
722 41-58 Chemical denotes purine nucleotide MESH:D011685
723 303-320 Chemical denotes hemi-sulfate salt
724 353-366 Chemical denotes monophosphate
725 531-539 Chemical denotes L-alanyl
726 694-707 Chemical denotes monophosphate
727 730-743 Chemical denotes monophosphate
728 762-771 Chemical denotes guanosine MESH:D006151
729 782-791 Chemical denotes adenosine MESH:D000241
730 970-981 Chemical denotes diphosphate MESH:D011756
731 1117-1129 Disease denotes HCV-infected MESH:D006526
732 1156-1165 Disease denotes cirrhosis MESH:D005355
733 1337-1345 Disease denotes COVID-19 MESH:C000657245