PMC:7600245 / 19544-19868 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T178","span":{"begin":0,"end":10},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T179","span":{"begin":177,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T180","span":{"begin":295,"end":301},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T181","span":{"begin":315,"end":317},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"}],"text":"Activation of the drug starts with the hydrolysis of the external esters followed by spontaneous release of carbon dioxide and formaldehyde to form the corresponding tenofovir, a nucleoside monophosphate, which subsequently undergoes two phosphorylation steps to form tenofovir diphosphate, the active drug (Figure S1) [64]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T240","span":{"begin":18,"end":22},"obj":"Chemical"},{"id":"T241","span":{"begin":66,"end":72},"obj":"Chemical"},{"id":"T242","span":{"begin":108,"end":122},"obj":"Chemical"},{"id":"T243","span":{"begin":108,"end":114},"obj":"Chemical"},{"id":"T245","span":{"begin":127,"end":139},"obj":"Chemical"},{"id":"T246","span":{"begin":166,"end":175},"obj":"Chemical"},{"id":"T249","span":{"begin":177,"end":189},"obj":"Chemical"},{"id":"T250","span":{"begin":268,"end":277},"obj":"Chemical"},{"id":"T253","span":{"begin":278,"end":289},"obj":"Chemical"},{"id":"T255","span":{"begin":302,"end":306},"obj":"Chemical"}],"attributes":[{"id":"A240","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A241","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_35701"},{"id":"A242","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_16526"},{"id":"A243","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A244","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A245","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_16842"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A247","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A248","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_33838"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A251","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A252","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_18361"},{"id":"A254","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_33019"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Activation of the drug starts with the hydrolysis of the external esters followed by spontaneous release of carbon dioxide and formaldehyde to form the corresponding tenofovir, a nucleoside monophosphate, which subsequently undergoes two phosphorylation steps to form tenofovir diphosphate, the active drug (Figure S1) [64]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T38","span":{"begin":238,"end":253},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Activation of the drug starts with the hydrolysis of the external esters followed by spontaneous release of carbon dioxide and formaldehyde to form the corresponding tenofovir, a nucleoside monophosphate, which subsequently undergoes two phosphorylation steps to form tenofovir diphosphate, the active drug (Figure S1) [64]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T146","span":{"begin":0,"end":324},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Activation of the drug starts with the hydrolysis of the external esters followed by spontaneous release of carbon dioxide and formaldehyde to form the corresponding tenofovir, a nucleoside monophosphate, which subsequently undergoes two phosphorylation steps to form tenofovir diphosphate, the active drug (Figure S1) [64]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"523","span":{"begin":66,"end":72},"obj":"Chemical"},{"id":"524","span":{"begin":108,"end":122},"obj":"Chemical"},{"id":"525","span":{"begin":127,"end":139},"obj":"Chemical"},{"id":"526","span":{"begin":166,"end":175},"obj":"Chemical"},{"id":"527","span":{"begin":179,"end":203},"obj":"Chemical"},{"id":"528","span":{"begin":268,"end":289},"obj":"Chemical"}],"attributes":[{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"MESH:D004952"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"MESH:D002245"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"MESH:D005557"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"MESH:D000068698"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"MESH:C583447"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Activation of the drug starts with the hydrolysis of the external esters followed by spontaneous release of carbon dioxide and formaldehyde to form the corresponding tenofovir, a nucleoside monophosphate, which subsequently undergoes two phosphorylation steps to form tenofovir diphosphate, the active drug (Figure S1) [64]."}