PMC:7594251 / 99307-99628 JSONTXT

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1462","span":{"begin":61,"end":68},"obj":"Chemical"},{"id":"T73744","span":{"begin":133,"end":151},"obj":"Chemical"},{"id":"T45570","span":{"begin":160,"end":166},"obj":"Chemical"},{"id":"T6158","span":{"begin":175,"end":187},"obj":"Chemical"},{"id":"T85158","span":{"begin":175,"end":181},"obj":"Chemical"},{"id":"T13480","span":{"begin":182,"end":187},"obj":"Chemical"},{"id":"T97666","span":{"begin":229,"end":234},"obj":"Chemical"},{"id":"T70994","span":{"begin":235,"end":240},"obj":"Chemical"},{"id":"T86094","span":{"begin":261,"end":269},"obj":"Chemical"}],"attributes":[{"id":"A82147","pred":"chebi_id","subj":"T1462","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A20329","pred":"chebi_id","subj":"T73744","obj":"http://purl.obolibrary.org/obo/CHEBI_48384"},{"id":"A28451","pred":"chebi_id","subj":"T45570","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A45459","pred":"chebi_id","subj":"T6158","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A21732","pred":"chebi_id","subj":"T85158","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A6036","pred":"chebi_id","subj":"T13480","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A53388","pred":"chebi_id","subj":"T97666","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A89430","pred":"chebi_id","subj":"T70994","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A12899","pred":"chebi_id","subj":"T86094","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"}],"text":"Finally, the results obtained from X-ray crystallography for ligands with such modifications allowed to find the binding mode of the triazolopyridazine ring of ligand 1 (with methyl group pointing internally) and the substituted amino group was found to create hydrogen bond to the side chain of Asn140 of Brd4-BD1 [402]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1061","span":{"begin":306,"end":310},"obj":"Gene"},{"id":"1062","span":{"begin":311,"end":314},"obj":"Gene"},{"id":"1069","span":{"begin":133,"end":151},"obj":"Chemical"},{"id":"1070","span":{"begin":261,"end":269},"obj":"Chemical"},{"id":"1071","span":{"begin":296,"end":302},"obj":"Chemical"}],"attributes":[{"id":"A1061","pred":"tao:has_database_id","subj":"1061","obj":"Gene:23476"},{"id":"A1062","pred":"tao:has_database_id","subj":"1062","obj":"Gene:1672"},{"id":"A1070","pred":"tao:has_database_id","subj":"1070","obj":"MESH:D006859"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Finally, the results obtained from X-ray crystallography for ligands with such modifications allowed to find the binding mode of the triazolopyridazine ring of ligand 1 (with methyl group pointing internally) and the substituted amino group was found to create hydrogen bond to the side chain of Asn140 of Brd4-BD1 [402]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T652","span":{"begin":0,"end":321},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Finally, the results obtained from X-ray crystallography for ligands with such modifications allowed to find the binding mode of the triazolopyridazine ring of ligand 1 (with methyl group pointing internally) and the substituted amino group was found to create hydrogen bond to the side chain of Asn140 of Brd4-BD1 [402]."}