PMC:7594251 / 99307-99628 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T1462	61-68	Chemical	denotes	ligands	http://purl.obolibrary.org/obo/CHEBI_52214
T73744	133-151	Chemical	denotes	triazolopyridazine	http://purl.obolibrary.org/obo/CHEBI_48384
T45570	160-166	Chemical	denotes	ligand	http://purl.obolibrary.org/obo/CHEBI_52214
T6158	175-187	Chemical	denotes	methyl group	http://purl.obolibrary.org/obo/CHEBI_32875
T85158	175-181	Chemical	denotes	methyl	http://purl.obolibrary.org/obo/CHEBI_29309
T13480	182-187	Chemical	denotes	group	http://purl.obolibrary.org/obo/CHEBI_24433
T97666	229-234	Chemical	denotes	amino	http://purl.obolibrary.org/obo/CHEBI_46882
T70994	235-240	Chemical	denotes	group	http://purl.obolibrary.org/obo/CHEBI_24433
T86094	261-269	Chemical	denotes	hydrogen	http://purl.obolibrary.org/obo/CHEBI_49637

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1061	306-310	Gene	denotes	Brd4	Gene:23476
1062	311-314	Gene	denotes	BD1	Gene:1672
1069	133-151	Chemical	denotes	triazolopyridazine
1070	261-269	Chemical	denotes	hydrogen	MESH:D006859
1071	296-302	Chemical	denotes	Asn140

Id	Subject	Object	Predicate	Lexical cue
T652	0-321	Sentence	denotes	Finally, the results obtained from X-ray crystallography for ligands with such modifications allowed to find the binding mode of the triazolopyridazine ring of ligand 1 (with methyl group pointing internally) and the substituted amino group was found to create hydrogen bond to the side chain of Asn140 of Brd4-BD1 [402].