> top > docs > PMC:7594251 > spans > 98131-99628 > annotations

PMC:7594251 / 98131-99628 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T212 178-185 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T213 307-314 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T214 394-401 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T685 83-84 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T686 155-156 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T687 855-856 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T688 977-978 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T689 1108-1109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T23797 96-103 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T25837 178-185 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T75648 261-267 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T96730 307-314 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T53890 394-401 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32855 442-449 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T55729 491-498 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T47776 537-555 Chemical denotes triazolopyridazine http://purl.obolibrary.org/obo/CHEBI_48384
T84009 571-578 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T62193 689-695 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T44312 696-701 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T25777 707-713 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T26250 726-732 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T88957 738-744 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T85582 760-766 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T46490 772-778 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T38398 796-801 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T94756 905-910 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T55063 911-920 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T3389 965-971 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T5082 989-996 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T39367 1012-1030 Chemical denotes triazolopyridazine http://purl.obolibrary.org/obo/CHEBI_48384
T28009 1073-1078 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T17318 1148-1155 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T1462 1237-1244 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T73744 1309-1327 Chemical denotes triazolopyridazine http://purl.obolibrary.org/obo/CHEBI_48384
T45570 1336-1342 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T6158 1351-1363 Chemical denotes methyl group http://purl.obolibrary.org/obo/CHEBI_32875
T85158 1351-1357 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_29309
T13480 1358-1363 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T97666 1405-1410 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T70994 1411-1416 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86094 1437-1445 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1058 405-409 Gene denotes Brd4 Gene:23476
1059 467-471 Gene denotes Brd4 Gene:23476
1060 624-628 Gene denotes Brd4 Gene:23476
1061 1482-1486 Gene denotes Brd4 Gene:23476
1062 1487-1490 Gene denotes BD1 Gene:1672
1063 472-475 Gene denotes BD1 Gene:1672
1064 410-413 Gene denotes BD1 Gene:1672
1065 537-555 Chemical denotes triazolopyridazine
1066 796-801 Chemical denotes water MESH:D014867
1067 905-910 Chemical denotes water MESH:D014867
1068 1012-1030 Chemical denotes triazolopyridazine
1069 1309-1327 Chemical denotes triazolopyridazine
1070 1437-1445 Chemical denotes hydrogen MESH:D006859
1071 1472-1478 Chemical denotes Asn140

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T644 0-118 Sentence denotes Another variant of WaterLOGSY method called LOGSY utilizes the titration slopes as a measure of solvent accessibility.
T645 119-201 Sentence denotes The titration slopes are created by a constant increase of protein concentrations.
T646 202-346 Sentence denotes This method also provides more insight into the process of ligand solvation by checking the influence of protein concentration onto the process.
T647 347-508 Sentence denotes This approach was used on the bromodomain 1 of protein 4 (Brd4-BD1) by mapping epitopes of two ligands interacting with Brd4-BD1 and predicting ligands position.
T648 509-629 Sentence denotes The results showed that the triazolopyridazine moiety of both ligands was implanted into the binding pocket of the Brd4.
T649 630-806 Sentence denotes Additionally, the results from LOGSY titration showed that methyl-group 1 of ligand 1, aromatic proton 8 of ligand 2 and aromatic proton 8 of ligand 1 exhibit strong water NOE.
T650 807-1036 Sentence denotes This information enabled researchers to utilize a chemical replacement strategy (substitute bound water molecules by suitable functional groups) for aromatic proton 8 in a series of ligands containing the triazolopyridazine ring.
T651 1037-1175 Sentence denotes Those protons were replaced with an amino or aminomethyl groups and as a result, the binding affinity of those ligands increased 100-fold.
T652 1176-1497 Sentence denotes Finally, the results obtained from X-ray crystallography for ligands with such modifications allowed to find the binding mode of the triazolopyridazine ring of ligand 1 (with methyl group pointing internally) and the substituted amino group was found to create hydrogen bond to the side chain of Asn140 of Brd4-BD1 [402].