PMC:7594251 / 79396-80403 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T151","span":{"begin":80,"end":88},"obj":"Body_part"},{"id":"T152","span":{"begin":768,"end":776},"obj":"Body_part"}],"attributes":[{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"As mentioned before, ssNMR can provide information about membranes and membrane proteins. For this reason, ssNMR can be used to detect interactions of ligands with receptors embedded to the membrane which enables the mapping of binding site of a receptor by utilizing CP-MAS (cross-polarization magic-angle spinning) NMR and site specific mutagenesis [355]. ssNMR can provide the conformation of ligands bound to the receptor which can then be used to optimize future drug in terms of better affinity and efficiency [355]. Since ssNMR is also applicable to amyloid research, it can be used for probing polypeptide structures of amyloid and intermolecular contacts between fibrils. The potential is for the design a drug that will inhibit the process of aggregation of proteins and peptides [355]. Lastly, since ssNMR gains insight into physical properties of a chemical compound it can be used for control of the process of formulation and processing of a drug to help assess the purity of a compound [358]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T74","span":{"begin":557,"end":564},"obj":"Disease"},{"id":"T75","span":{"begin":628,"end":635},"obj":"Disease"}],"attributes":[{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0019065"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0019065"}],"text":"As mentioned before, ssNMR can provide information about membranes and membrane proteins. For this reason, ssNMR can be used to detect interactions of ligands with receptors embedded to the membrane which enables the mapping of binding site of a receptor by utilizing CP-MAS (cross-polarization magic-angle spinning) NMR and site specific mutagenesis [355]. ssNMR can provide the conformation of ligands bound to the receptor which can then be used to optimize future drug in terms of better affinity and efficiency [355]. Since ssNMR is also applicable to amyloid research, it can be used for probing polypeptide structures of amyloid and intermolecular contacts between fibrils. The potential is for the design a drug that will inhibit the process of aggregation of proteins and peptides [355]. Lastly, since ssNMR gains insight into physical properties of a chemical compound it can be used for control of the process of formulation and processing of a drug to help assess the purity of a compound [358]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T559","span":{"begin":57,"end":66},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T560","span":{"begin":71,"end":79},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T561","span":{"begin":190,"end":198},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T562","span":{"begin":244,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T96610","span":{"begin":268,"end":270},"obj":"http://purl.obolibrary.org/obo/PR_000005794"},{"id":"T564","span":{"begin":713,"end":714},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T565","span":{"begin":781,"end":789},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T566","span":{"begin":859,"end":860},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T567","span":{"begin":954,"end":955},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T568","span":{"begin":990,"end":991},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"As mentioned before, ssNMR can provide information about membranes and membrane proteins. For this reason, ssNMR can be used to detect interactions of ligands with receptors embedded to the membrane which enables the mapping of binding site of a receptor by utilizing CP-MAS (cross-polarization magic-angle spinning) NMR and site specific mutagenesis [355]. ssNMR can provide the conformation of ligands bound to the receptor which can then be used to optimize future drug in terms of better affinity and efficiency [355]. Since ssNMR is also applicable to amyloid research, it can be used for probing polypeptide structures of amyloid and intermolecular contacts between fibrils. The potential is for the design a drug that will inhibit the process of aggregation of proteins and peptides [355]. Lastly, since ssNMR gains insight into physical properties of a chemical compound it can be used for control of the process of formulation and processing of a drug to help assess the purity of a compound [358]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6388","span":{"begin":80,"end":88},"obj":"Chemical"},{"id":"T89619","span":{"begin":151,"end":158},"obj":"Chemical"},{"id":"T8279","span":{"begin":268,"end":270},"obj":"Chemical"},{"id":"T37445","span":{"begin":396,"end":403},"obj":"Chemical"},{"id":"T13543","span":{"begin":468,"end":472},"obj":"Chemical"},{"id":"T67042","span":{"begin":602,"end":613},"obj":"Chemical"},{"id":"T90729","span":{"begin":715,"end":719},"obj":"Chemical"},{"id":"T47940","span":{"begin":768,"end":776},"obj":"Chemical"},{"id":"T337","span":{"begin":781,"end":789},"obj":"Chemical"},{"id":"T60143","span":{"begin":861,"end":878},"obj":"Chemical"},{"id":"T22513","span":{"begin":956,"end":960},"obj":"Chemical"}],"attributes":[{"id":"A44532","pred":"chebi_id","subj":"T6388","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A21342","pred":"chebi_id","subj":"T89619","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A64592","pred":"chebi_id","subj":"T8279","obj":"http://purl.obolibrary.org/obo/CHEBI_3380"},{"id":"A84483","pred":"chebi_id","subj":"T8279","obj":"http://purl.obolibrary.org/obo/CHEBI_73461"},{"id":"A51525","pred":"chebi_id","subj":"T37445","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A76057","pred":"chebi_id","subj":"T13543","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A17606","pred":"chebi_id","subj":"T67042","obj":"http://purl.obolibrary.org/obo/CHEBI_15841"},{"id":"A69718","pred":"chebi_id","subj":"T90729","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A68868","pred":"chebi_id","subj":"T47940","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A16072","pred":"chebi_id","subj":"T337","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A49737","pred":"chebi_id","subj":"T60143","obj":"http://purl.obolibrary.org/obo/CHEBI_37577"},{"id":"A99483","pred":"chebi_id","subj":"T22513","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"As mentioned before, ssNMR can provide information about membranes and membrane proteins. For this reason, ssNMR can be used to detect interactions of ligands with receptors embedded to the membrane which enables the mapping of binding site of a receptor by utilizing CP-MAS (cross-polarization magic-angle spinning) NMR and site specific mutagenesis [355]. ssNMR can provide the conformation of ligands bound to the receptor which can then be used to optimize future drug in terms of better affinity and efficiency [355]. Since ssNMR is also applicable to amyloid research, it can be used for probing polypeptide structures of amyloid and intermolecular contacts between fibrils. The potential is for the design a drug that will inhibit the process of aggregation of proteins and peptides [355]. Lastly, since ssNMR gains insight into physical properties of a chemical compound it can be used for control of the process of formulation and processing of a drug to help assess the purity of a compound [358]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T521","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"T522","span":{"begin":90,"end":522},"obj":"Sentence"},{"id":"T523","span":{"begin":523,"end":680},"obj":"Sentence"},{"id":"T524","span":{"begin":681,"end":796},"obj":"Sentence"},{"id":"T525","span":{"begin":797,"end":1007},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As mentioned before, ssNMR can provide information about membranes and membrane proteins. For this reason, ssNMR can be used to detect interactions of ligands with receptors embedded to the membrane which enables the mapping of binding site of a receptor by utilizing CP-MAS (cross-polarization magic-angle spinning) NMR and site specific mutagenesis [355]. ssNMR can provide the conformation of ligands bound to the receptor which can then be used to optimize future drug in terms of better affinity and efficiency [355]. Since ssNMR is also applicable to amyloid research, it can be used for probing polypeptide structures of amyloid and intermolecular contacts between fibrils. The potential is for the design a drug that will inhibit the process of aggregation of proteins and peptides [355]. Lastly, since ssNMR gains insight into physical properties of a chemical compound it can be used for control of the process of formulation and processing of a drug to help assess the purity of a compound [358]."}