PMC:7594251 / 73594-74381 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T508","span":{"begin":55,"end":64},"obj":"Body_part"},{"id":"T64393","span":{"begin":85,"end":88},"obj":"Body_part"},{"id":"T14796","span":{"begin":440,"end":447},"obj":"Body_part"},{"id":"T31078","span":{"begin":469,"end":472},"obj":"Body_part"},{"id":"T2567","span":{"begin":518,"end":521},"obj":"Body_part"},{"id":"T82556","span":{"begin":698,"end":701},"obj":"Body_part"}],"attributes":[{"id":"A5227","pred":"fma_id","subj":"T508","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A31050","pred":"fma_id","subj":"T64393","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A27138","pred":"fma_id","subj":"T14796","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A84376","pred":"fma_id","subj":"T31078","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A98631","pred":"fma_id","subj":"T2567","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A46124","pred":"fma_id","subj":"T82556","obj":"http://purl.org/sig/ont/fma/fma74412"}],"text":"For example, Iwahara et al. (2003) demonstrated that a protein’s binding polarity to DNA can be determined by PRE, using EDTA-derivatized deoxythymidine (dT-EDTA) with a chelated metal ion (such as Cu2+ or Mn2+) as a probe. dT-EDTA with a chelated metal ion is a convenient choice, as it can be inserted into any position of a synthesized oligonucleotide. With data derived from the PRE effect, one can easily determine the polarity of the protein (or drug) binding to DNA [348]. Several researchers have investigated DNA as a drug target [349], and the study of Iwahara et al. clearly demonstrates, and even indicates, that PRE can potentially be used to study the interactions between a drug and DNA [348], provided that a paramagnetic center such as dT-EDTA or a metal ion is present."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T517","span":{"begin":53,"end":54},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T518","span":{"begin":168,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T519","span":{"begin":215,"end":216},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T520","span":{"begin":237,"end":238},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T521","span":{"begin":261,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T522","span":{"begin":325,"end":326},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T523","span":{"begin":525,"end":526},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T524","span":{"begin":687,"end":688},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T525","span":{"begin":723,"end":724},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T526","span":{"begin":764,"end":765},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"For example, Iwahara et al. (2003) demonstrated that a protein’s binding polarity to DNA can be determined by PRE, using EDTA-derivatized deoxythymidine (dT-EDTA) with a chelated metal ion (such as Cu2+ or Mn2+) as a probe. dT-EDTA with a chelated metal ion is a convenient choice, as it can be inserted into any position of a synthesized oligonucleotide. With data derived from the PRE effect, one can easily determine the polarity of the protein (or drug) binding to DNA [348]. Several researchers have investigated DNA as a drug target [349], and the study of Iwahara et al. clearly demonstrates, and even indicates, that PRE can potentially be used to study the interactions between a drug and DNA [348], provided that a paramagnetic center such as dT-EDTA or a metal ion is present."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T59910","span":{"begin":85,"end":88},"obj":"Chemical"},{"id":"T56479","span":{"begin":121,"end":125},"obj":"Chemical"},{"id":"T72961","span":{"begin":157,"end":161},"obj":"Chemical"},{"id":"T35743","span":{"begin":185,"end":188},"obj":"Chemical"},{"id":"T36080","span":{"begin":217,"end":222},"obj":"Chemical"},{"id":"T55724","span":{"begin":227,"end":231},"obj":"Chemical"},{"id":"T58023","span":{"begin":254,"end":257},"obj":"Chemical"},{"id":"T75367","span":{"begin":339,"end":354},"obj":"Chemical"},{"id":"T43428","span":{"begin":440,"end":447},"obj":"Chemical"},{"id":"T68600","span":{"begin":452,"end":456},"obj":"Chemical"},{"id":"T47732","span":{"begin":469,"end":472},"obj":"Chemical"},{"id":"T79371","span":{"begin":518,"end":521},"obj":"Chemical"},{"id":"T28586","span":{"begin":527,"end":531},"obj":"Chemical"},{"id":"T80769","span":{"begin":689,"end":693},"obj":"Chemical"},{"id":"T87406","span":{"begin":698,"end":701},"obj":"Chemical"},{"id":"T99086","span":{"begin":756,"end":760},"obj":"Chemical"},{"id":"T29834","span":{"begin":772,"end":775},"obj":"Chemical"}],"attributes":[{"id":"A57764","pred":"chebi_id","subj":"T59910","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A88423","pred":"chebi_id","subj":"T56479","obj":"http://purl.obolibrary.org/obo/CHEBI_42191"},{"id":"A78159","pred":"chebi_id","subj":"T56479","obj":"http://purl.obolibrary.org/obo/CHEBI_64755"},{"id":"A59544","pred":"chebi_id","subj":"T72961","obj":"http://purl.obolibrary.org/obo/CHEBI_42191"},{"id":"A16097","pred":"chebi_id","subj":"T72961","obj":"http://purl.obolibrary.org/obo/CHEBI_64755"},{"id":"A38244","pred":"chebi_id","subj":"T35743","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A77106","pred":"chebi_id","subj":"T36080","obj":"http://purl.obolibrary.org/obo/CHEBI_50406"},{"id":"A41551","pred":"chebi_id","subj":"T55724","obj":"http://purl.obolibrary.org/obo/CHEBI_42191"},{"id":"A87031","pred":"chebi_id","subj":"T55724","obj":"http://purl.obolibrary.org/obo/CHEBI_64755"},{"id":"A41606","pred":"chebi_id","subj":"T58023","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A8911","pred":"chebi_id","subj":"T75367","obj":"http://purl.obolibrary.org/obo/CHEBI_7754"},{"id":"A57091","pred":"chebi_id","subj":"T43428","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A40920","pred":"chebi_id","subj":"T68600","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A18194","pred":"chebi_id","subj":"T47732","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A87291","pred":"chebi_id","subj":"T79371","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A96994","pred":"chebi_id","subj":"T28586","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A15604","pred":"chebi_id","subj":"T80769","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A49619","pred":"chebi_id","subj":"T87406","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A92302","pred":"chebi_id","subj":"T99086","obj":"http://purl.obolibrary.org/obo/CHEBI_42191"},{"id":"A82815","pred":"chebi_id","subj":"T99086","obj":"http://purl.obolibrary.org/obo/CHEBI_64755"},{"id":"A86857","pred":"chebi_id","subj":"T29834","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"}],"text":"For example, Iwahara et al. (2003) demonstrated that a protein’s binding polarity to DNA can be determined by PRE, using EDTA-derivatized deoxythymidine (dT-EDTA) with a chelated metal ion (such as Cu2+ or Mn2+) as a probe. dT-EDTA with a chelated metal ion is a convenient choice, as it can be inserted into any position of a synthesized oligonucleotide. With data derived from the PRE effect, one can easily determine the polarity of the protein (or drug) binding to DNA [348]. Several researchers have investigated DNA as a drug target [349], and the study of Iwahara et al. clearly demonstrates, and even indicates, that PRE can potentially be used to study the interactions between a drug and DNA [348], provided that a paramagnetic center such as dT-EDTA or a metal ion is present."}

{"project":"LitCovid-PubTator","denotations":[{"id":"719","span":{"begin":121,"end":125},"obj":"Chemical"},{"id":"720","span":{"begin":138,"end":152},"obj":"Chemical"},{"id":"721","span":{"begin":154,"end":161},"obj":"Chemical"},{"id":"722","span":{"begin":179,"end":184},"obj":"Chemical"},{"id":"723","span":{"begin":198,"end":202},"obj":"Chemical"},{"id":"724","span":{"begin":206,"end":210},"obj":"Chemical"},{"id":"725","span":{"begin":224,"end":231},"obj":"Chemical"},{"id":"726","span":{"begin":248,"end":253},"obj":"Chemical"},{"id":"727","span":{"begin":339,"end":354},"obj":"Chemical"},{"id":"728","span":{"begin":753,"end":760},"obj":"Chemical"},{"id":"729","span":{"begin":766,"end":771},"obj":"Chemical"}],"attributes":[{"id":"A719","pred":"tao:has_database_id","subj":"719","obj":"MESH:D004492"},{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"MESH:D013936"},{"id":"A722","pred":"tao:has_database_id","subj":"722","obj":"MESH:D008670"},{"id":"A726","pred":"tao:has_database_id","subj":"726","obj":"MESH:D008670"},{"id":"A727","pred":"tao:has_database_id","subj":"727","obj":"MESH:D009841"},{"id":"A729","pred":"tao:has_database_id","subj":"729","obj":"MESH:D008670"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"For example, Iwahara et al. (2003) demonstrated that a protein’s binding polarity to DNA can be determined by PRE, using EDTA-derivatized deoxythymidine (dT-EDTA) with a chelated metal ion (such as Cu2+ or Mn2+) as a probe. dT-EDTA with a chelated metal ion is a convenient choice, as it can be inserted into any position of a synthesized oligonucleotide. With data derived from the PRE effect, one can easily determine the polarity of the protein (or drug) binding to DNA [348]. Several researchers have investigated DNA as a drug target [349], and the study of Iwahara et al. clearly demonstrates, and even indicates, that PRE can potentially be used to study the interactions between a drug and DNA [348], provided that a paramagnetic center such as dT-EDTA or a metal ion is present."}

{"project":"LitCovid-sentences","denotations":[{"id":"T491","span":{"begin":0,"end":355},"obj":"Sentence"},{"id":"T492","span":{"begin":356,"end":479},"obj":"Sentence"},{"id":"T493","span":{"begin":480,"end":787},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"For example, Iwahara et al. (2003) demonstrated that a protein’s binding polarity to DNA can be determined by PRE, using EDTA-derivatized deoxythymidine (dT-EDTA) with a chelated metal ion (such as Cu2+ or Mn2+) as a probe. dT-EDTA with a chelated metal ion is a convenient choice, as it can be inserted into any position of a synthesized oligonucleotide. With data derived from the PRE effect, one can easily determine the polarity of the protein (or drug) binding to DNA [348]. Several researchers have investigated DNA as a drug target [349], and the study of Iwahara et al. clearly demonstrates, and even indicates, that PRE can potentially be used to study the interactions between a drug and DNA [348], provided that a paramagnetic center such as dT-EDTA or a metal ion is present."}