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PMC:7594251 / 73594-74381 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T508 55-64 Body_part denotes protein’s http://purl.org/sig/ont/fma/fma67257
T64393 85-88 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T14796 440-447 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31078 469-472 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T2567 518-521 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T82556 698-701 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T517 53-54 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T518 168-169 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T519 215-216 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T520 237-238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T521 261-262 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T522 325-326 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T523 525-526 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T524 687-688 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T525 723-724 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T526 764-765 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T59910 85-88 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T56479 121-125 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T72961 157-161 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T35743 185-188 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T36080 217-222 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T55724 227-231 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T58023 254-257 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T75367 339-354 Chemical denotes oligonucleotide http://purl.obolibrary.org/obo/CHEBI_7754
T43428 440-447 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68600 452-456 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T47732 469-472 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T79371 518-521 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T28586 527-531 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T80769 689-693 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T87406 698-701 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T99086 756-760 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T29834 772-775 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
719 121-125 Chemical denotes EDTA MESH:D004492
720 138-152 Chemical denotes deoxythymidine MESH:D013936
721 154-161 Chemical denotes dT-EDTA
722 179-184 Chemical denotes metal MESH:D008670
723 198-202 Chemical denotes Cu2+
724 206-210 Chemical denotes Mn2+
725 224-231 Chemical denotes dT-EDTA
726 248-253 Chemical denotes metal MESH:D008670
727 339-354 Chemical denotes oligonucleotide MESH:D009841
728 753-760 Chemical denotes dT-EDTA
729 766-771 Chemical denotes metal MESH:D008670

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T491 0-355 Sentence denotes For example, Iwahara et al. (2003) demonstrated that a protein’s binding polarity to DNA can be determined by PRE, using EDTA-derivatized deoxythymidine (dT-EDTA) with a chelated metal ion (such as Cu2+ or Mn2+) as a probe. dT-EDTA with a chelated metal ion is a convenient choice, as it can be inserted into any position of a synthesized oligonucleotide.
T492 356-479 Sentence denotes With data derived from the PRE effect, one can easily determine the polarity of the protein (or drug) binding to DNA [348].
T493 480-787 Sentence denotes Several researchers have investigated DNA as a drug target [349], and the study of Iwahara et al. clearly demonstrates, and even indicates, that PRE can potentially be used to study the interactions between a drug and DNA [348], provided that a paramagnetic center such as dT-EDTA or a metal ion is present.