PMC:7594251 / 70312-70729 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7594251","sourcedb":"PMC","sourceid":"7594251","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7594251","text":"For example, Li et al. [338] used virtual screening filtered by NMR to identify and characterize non-metal chelating metallo-β-lactamase (MBL) inhibitors, and in particular, Verona integron-encoded MBL (VIM)-2, when previously there were no clinically significant inhibitors of MBL, since MBL enzymes hydrolyse many, if not all, β-lactam antibacterials compounds specifically designed to inhibit their activity [339].","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T71124","span":{"begin":202,"end":209},"obj":"https://glytoucan.org/Structures/Glycans/G22418PV"},{"id":"T79079","span":{"begin":203,"end":206},"obj":"https://glytoucan.org/Structures/Glycans/G00065MO"}],"attributes":[{"subj":"T71124","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T79079","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T501","span":{"begin":13,"end":15},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T502","span":{"begin":13,"end":15},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T503","span":{"begin":203,"end":206},"obj":"http://purl.obolibrary.org/obo/PR_000017298"},{"id":"T504","span":{"begin":402,"end":410},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T501","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T502","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T503","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T504","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9030","span":{"begin":13,"end":15},"obj":"Chemical"},{"id":"T219","span":{"begin":97,"end":106},"obj":"Chemical"},{"id":"T26168","span":{"begin":143,"end":153},"obj":"Chemical"},{"id":"T34443","span":{"begin":264,"end":274},"obj":"Chemical"},{"id":"T42210","span":{"begin":331,"end":337},"obj":"Chemical"},{"id":"T5328","span":{"begin":338,"end":352},"obj":"Chemical"}],"attributes":[{"id":"A19322","pred":"chebi_id","subj":"T9030","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A25513","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_25585"},{"id":"A72749","pred":"chebi_id","subj":"T26168","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A22831","pred":"chebi_id","subj":"T34443","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A64322","pred":"chebi_id","subj":"T42210","obj":"http://purl.obolibrary.org/obo/CHEBI_24995"},{"id":"A24550","pred":"chebi_id","subj":"T5328","obj":"http://purl.obolibrary.org/obo/CHEBI_33282"},{"subj":"T9030","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26168","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34443","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42210","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5328","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"696","span":{"begin":174,"end":209},"obj":"Gene"},{"id":"697","span":{"begin":101,"end":106},"obj":"Chemical"},{"id":"698","span":{"begin":329,"end":337},"obj":"Chemical"},{"id":"699","span":{"begin":138,"end":141},"obj":"Disease"},{"id":"700","span":{"begin":278,"end":281},"obj":"Disease"},{"id":"701","span":{"begin":289,"end":292},"obj":"Disease"}],"attributes":[{"id":"A696","pred":"tao:has_database_id","subj":"696","obj":"Gene:100130535"},{"id":"A697","pred":"tao:has_database_id","subj":"697","obj":"MESH:D008670"},{"id":"A698","pred":"tao:has_database_id","subj":"698","obj":"MESH:D047090"},{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"MESH:C563602"},{"id":"A700","pred":"tao:has_database_id","subj":"700","obj":"MESH:C563602"},{"id":"A701","pred":"tao:has_database_id","subj":"701","obj":"MESH:C563602"},{"subj":"696","pred":"source","obj":"LitCovid-PubTator"},{"subj":"697","pred":"source","obj":"LitCovid-PubTator"},{"subj":"698","pred":"source","obj":"LitCovid-PubTator"},{"subj":"699","pred":"source","obj":"LitCovid-PubTator"},{"subj":"700","pred":"source","obj":"LitCovid-PubTator"},{"subj":"701","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T472","span":{"begin":0,"end":417},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T472","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#b8ec93","default":true},{"id":"LitCovid-PD-CLO","color":"#ec93d2"},{"id":"LitCovid-PD-CHEBI","color":"#93eceb"},{"id":"LitCovid-PubTator","color":"#ecd193"},{"id":"LitCovid-sentences","color":"#b793ec"}]}]}}