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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T43243","span":{"begin":193,"end":201},"obj":"Body_part"},{"id":"T42194","span":{"begin":397,"end":404},"obj":"Body_part"}],"attributes":[{"id":"A49478","pred":"fma_id","subj":"T43243","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A16049","pred":"fma_id","subj":"T42194","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"T2 measurements of ligands are also useful for determining the binding nature of a small molecule. The T2 values of small molecules are quite large compared to those of bigger molecules (i.e., proteins) mostly because macromolecules have more spin-spin diffusion [175]. Bound ligands will, therefore, display shorter T2 values than non-binding ligands because they interact with the target (i.e., protein), adopting similar vibrational and rotational energies to the target [176]. This interaction is represented by the resonance line broadening in the binding ligand’s spectrum when a receptor is introduced into the sample [156]. Given the sizable difference of T2 values of binding and non-binding ligands, one can utilize 1D relaxation-edited experiments to distinguish the binding ligands from the non-binding ligands efficiently and effectively based on the differences in the T2 values [167]. These and other related relaxation edited experiments prove useful in drug design."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T88676","span":{"begin":0,"end":2},"obj":"http://purl.obolibrary.org/obo/CLO_0050160"},{"id":"T90343","span":{"begin":81,"end":82},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T92264","span":{"begin":103,"end":105},"obj":"http://purl.obolibrary.org/obo/CLO_0050160"},{"id":"T51742","span":{"begin":317,"end":319},"obj":"http://purl.obolibrary.org/obo/CLO_0050160"},{"id":"T65081","span":{"begin":584,"end":585},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T76730","span":{"begin":664,"end":666},"obj":"http://purl.obolibrary.org/obo/CLO_0050160"},{"id":"T85793","span":{"begin":883,"end":885},"obj":"http://purl.obolibrary.org/obo/CLO_0050160"}],"text":"T2 measurements of ligands are also useful for determining the binding nature of a small molecule. The T2 values of small molecules are quite large compared to those of bigger molecules (i.e., proteins) mostly because macromolecules have more spin-spin diffusion [175]. Bound ligands will, therefore, display shorter T2 values than non-binding ligands because they interact with the target (i.e., protein), adopting similar vibrational and rotational energies to the target [176]. This interaction is represented by the resonance line broadening in the binding ligand’s spectrum when a receptor is introduced into the sample [156]. Given the sizable difference of T2 values of binding and non-binding ligands, one can utilize 1D relaxation-edited experiments to distinguish the binding ligands from the non-binding ligands efficiently and effectively based on the differences in the T2 values [167]. These and other related relaxation edited experiments prove useful in drug design."}

LitCovid-PD-CHEBI

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"514","span":{"begin":248,"end":252},"obj":"Gene"},{"id":"515","span":{"begin":243,"end":247},"obj":"Gene"}],"attributes":[{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"Gene:10927"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"Gene:10927"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"T2 measurements of ligands are also useful for determining the binding nature of a small molecule. The T2 values of small molecules are quite large compared to those of bigger molecules (i.e., proteins) mostly because macromolecules have more spin-spin diffusion [175]. Bound ligands will, therefore, display shorter T2 values than non-binding ligands because they interact with the target (i.e., protein), adopting similar vibrational and rotational energies to the target [176]. This interaction is represented by the resonance line broadening in the binding ligand’s spectrum when a receptor is introduced into the sample [156]. Given the sizable difference of T2 values of binding and non-binding ligands, one can utilize 1D relaxation-edited experiments to distinguish the binding ligands from the non-binding ligands efficiently and effectively based on the differences in the T2 values [167]. These and other related relaxation edited experiments prove useful in drug design."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T250","span":{"begin":0,"end":98},"obj":"Sentence"},{"id":"T251","span":{"begin":99,"end":269},"obj":"Sentence"},{"id":"T252","span":{"begin":270,"end":480},"obj":"Sentence"},{"id":"T253","span":{"begin":481,"end":631},"obj":"Sentence"},{"id":"T254","span":{"begin":632,"end":899},"obj":"Sentence"},{"id":"T255","span":{"begin":900,"end":982},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"T2 measurements of ligands are also useful for determining the binding nature of a small molecule. The T2 values of small molecules are quite large compared to those of bigger molecules (i.e., proteins) mostly because macromolecules have more spin-spin diffusion [175]. Bound ligands will, therefore, display shorter T2 values than non-binding ligands because they interact with the target (i.e., protein), adopting similar vibrational and rotational energies to the target [176]. This interaction is represented by the resonance line broadening in the binding ligand’s spectrum when a receptor is introduced into the sample [156]. Given the sizable difference of T2 values of binding and non-binding ligands, one can utilize 1D relaxation-edited experiments to distinguish the binding ligands from the non-binding ligands efficiently and effectively based on the differences in the T2 values [167]. These and other related relaxation edited experiments prove useful in drug design."}