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PMC:7594251 / 26944-28862 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T65570 1144-1149 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T64417 1253-1258 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30907 1472-1477 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T71500 1544-1549 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7498 1605-1610 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T49050 1688-1693 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T73203 1735-1740 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75762 1906-1911 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T16 1112-1129 Disease denotes ovarian carcinoma http://purl.obolibrary.org/obo/MONDO_0005140
T17 1120-1129 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T92227 766-773 http://purl.obolibrary.org/obo/OBI_0100026 denotes organic
T84020 766-773 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organic
T7565 1101-1111 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T25877 1137-1143 http://purl.obolibrary.org/obo/CLO_0009063 denotes Skov-3
T65918 1137-1143 http://purl.obolibrary.org/obo/CLO_0052004 denotes Skov-3
T15262 1137-1143 http://purl.obolibrary.org/obo/CLO_0052005 denotes Skov-3
T84733 1137-1143 http://purl.obolibrary.org/obo/CLO_0052006 denotes Skov-3
T563 1137-1143 http://purl.obolibrary.org/obo/CLO_0052007 denotes Skov-3
T68261 1144-1149 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18385 1246-1252 http://purl.obolibrary.org/obo/CLO_0009063 denotes Skov-3
T7784 1246-1252 http://purl.obolibrary.org/obo/CLO_0052004 denotes Skov-3
T18201 1246-1252 http://purl.obolibrary.org/obo/CLO_0052005 denotes Skov-3
T44166 1246-1252 http://purl.obolibrary.org/obo/CLO_0052006 denotes Skov-3
T15184 1246-1252 http://purl.obolibrary.org/obo/CLO_0052007 denotes Skov-3
T72019 1253-1258 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T67725 1409-1414 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T49059 1537-1543 http://purl.obolibrary.org/obo/CLO_0009063 denotes Skov-3
T24432 1537-1543 http://purl.obolibrary.org/obo/CLO_0052004 denotes Skov-3
T13031 1537-1543 http://purl.obolibrary.org/obo/CLO_0052005 denotes Skov-3
T58426 1537-1543 http://purl.obolibrary.org/obo/CLO_0052006 denotes Skov-3
T52203 1537-1543 http://purl.obolibrary.org/obo/CLO_0052007 denotes Skov-3
T21105 1544-1549 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T98431 1598-1604 http://purl.obolibrary.org/obo/CLO_0009063 denotes Skov-3
T53038 1598-1604 http://purl.obolibrary.org/obo/CLO_0052004 denotes Skov-3
T12991 1598-1604 http://purl.obolibrary.org/obo/CLO_0052005 denotes Skov-3
T66845 1598-1604 http://purl.obolibrary.org/obo/CLO_0052006 denotes Skov-3
T99568 1598-1604 http://purl.obolibrary.org/obo/CLO_0052007 denotes Skov-3
T50576 1605-1610 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T80995 1735-1740 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T54819 1817-1818 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69803 1899-1905 http://purl.obolibrary.org/obo/CLO_0009063 denotes Skov-3
T3282 1899-1905 http://purl.obolibrary.org/obo/CLO_0052004 denotes Skov-3
T25858 1899-1905 http://purl.obolibrary.org/obo/CLO_0052005 denotes Skov-3
T4936 1899-1905 http://purl.obolibrary.org/obo/CLO_0052006 denotes Skov-3
T20172 1899-1905 http://purl.obolibrary.org/obo/CLO_0052007 denotes Skov-3
T80018 1906-1911 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T247 10-12 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T248 312-318 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T249 332-334 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T250 342-344 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T251 420-426 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T252 475-479 Chemical denotes atom http://purl.obolibrary.org/obo/CHEBI_33250
T253 506-508 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T254 592-599 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T255 603-605 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T256 629-636 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T257 735-739 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T258 756-761 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T259 789-795 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T261 796-801 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T262 898-900 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T263 1081-1090 Chemical denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899
T264 1318-1320 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T265 1341-1343 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T266 1472-1477 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T267 1478-1489 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T268 1584-1592 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T269 1624-1633 Chemical denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899
T270 1688-1693 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T271 1694-1704 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T272 1784-1793 Chemical denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899
T273 1875-1884 Chemical denotes cisplatin http://purl.obolibrary.org/obo/CHEBI_27899

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
372 10-12 Chemical denotes 1H
373 13-16 Chemical denotes 13C MESH:C000615229
391 157-160 Chemical denotes 13C MESH:C000615229
392 225-228 Chemical denotes 13C MESH:C000615229
393 332-334 Chemical denotes 1H
394 335-338 Chemical denotes 13C MESH:C000615229
395 342-344 Chemical denotes 1H
396 345-348 Chemical denotes 15N
397 506-508 Chemical denotes 1H
398 509-512 Chemical denotes 13C MESH:C000615229
399 513-516 Chemical denotes 15N
400 603-605 Chemical denotes 1H
401 640-643 Chemical denotes 13C MESH:C000615229
402 644-647 Chemical denotes 15N
403 789-795 Chemical denotes carbon MESH:D002244
404 834-837 Chemical denotes 13C MESH:C000615229
405 898-900 Chemical denotes 1H
406 904-907 Chemical denotes 13C MESH:C000615229
407 971-974 Chemical denotes 13C MESH:C000615229
425 1409-1414 Species denotes Human Tax:9606
426 1081-1090 Chemical denotes cisplatin MESH:D002945
427 1285-1291 Chemical denotes Ptac2S
428 1318-1320 Chemical denotes 1H
429 1321-1324 Chemical denotes 13C MESH:C000615229
430 1341-1343 Chemical denotes 1H
431 1472-1477 Chemical denotes lipid MESH:D008055
432 1563-1569 Chemical denotes Ptac2S
433 1584-1592 Chemical denotes pyruvate MESH:D019289
434 1624-1633 Chemical denotes cisplatin MESH:D002945
435 1688-1693 Chemical denotes lipid MESH:D008055
436 1754-1760 Chemical denotes Ptac2S
437 1784-1793 Chemical denotes cisplatin MESH:D002945
438 1848-1854 Chemical denotes Ptac2S
439 1875-1884 Chemical denotes cisplatin MESH:D002945
440 1061-1073 Disease denotes cytotoxicity MESH:D064420
441 1101-1129 Disease denotes epithelial ovarian carcinoma MESH:D010051

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 1112-1129 Phenotype denotes ovarian carcinoma http://purl.obolibrary.org/obo/HP_0025318

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T188 0-6 Sentence denotes 2.2.3.
T189 7-21 Sentence denotes 2D 1H,13C-HSQC
T190 22-258 Sentence denotes 2D- Heteronuclear Single Quantum Coherence (HSQC) experiments are commonly used to help resolve spectral overlap [139] while providing 13C information without the inherent sensitivity losses involved in 13C direct detection (see below).
T191 259-355 Sentence denotes HSQC shows the correlations between directly coupled nuclei [140], e.g., 1H-13C or 1H-15N [140].
T192 356-502 Sentence denotes As such, an HSQC spectrum will show clean peaks for each unique proton directly connected to the heteronuclear nuclear atom of interest [140,141].
T193 503-674 Sentence denotes In 1H,13C/15N HSQC experiments, the magnetization is transferred from the more sensitive nucleus (I:1H) to the less sensitive nucleus (S:13C/15N) [142,143,144] (Figure 3).
T194 675-864 Sentence denotes This is especially useful when applying NMR spectroscopy to drug design, as most drugs are organic (i.e., contain carbon atoms), and the relative abundance of 13C (1.1%) is quite low [143].
T195 865-993 Sentence denotes By transferring sensitivity from 1H to 13C, one can circumvent the long experimental time required for 1D 13C experiments [143].
T196 994-1150 Sentence denotes For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells.
T197 1151-1292 Sentence denotes In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S.
T198 1293-1521 Sentence denotes In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples.
T199 1522-1634 Sentence denotes Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin.
T200 1635-1794 Sentence denotes The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin.
T201 1795-1918 Sentence denotes These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145].