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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T319","span":{"begin":1312,"end":1329},"obj":"Body_part"},{"id":"T320","span":{"begin":1930,"end":1935},"obj":"Body_part"},{"id":"T321","span":{"begin":2063,"end":2068},"obj":"Body_part"},{"id":"T322","span":{"begin":2518,"end":2541},"obj":"Body_part"}],"attributes":[{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma265130"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma45662"}],"text":"Table 3 Main studies on vitamin C supplementation against viral infections.\nStudy Author Study Population Micronutrient (Dosage) Results\nThe effect of vitamin C on upper respiratory infections in adolescents swimmers: a randomized trial. Constantini NV 2011 [68] Children (12–17 years)RCT Vitamin C (1 g/day for 3 months) In the male swimmers duration (p = 0.003) and severity (p = 0.003) of URTI episodes were decreased.\nVitamin C for preventing and treating the common cold. Hemilä H 2013 [67] Adults and children31 RCTs Vitamin C (\u003e0.2 g/day) Significant reduction in the duration of common cold episodes. Decreased cold severity in Vitamin C group.\nVitamin C for preventing and treating pneumonia. Hemilä H 2013 [65] Adults3 RCTs Vitamin C Significant reduction in pneumonia risk (\u003e80%). Lower mortality in the vitamin C group vs. placebo group.\nVitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Schumacher SS 2014 [66] AdultsRCT Vitamin C (1 g/day for 8 weeks) Reduced cold episodes in young men with low to average vitamin C status (p = 0.04). Cold duration was reduced 59% in the vitamin C vs. placebo groups (p = 0.06).\nProbiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Ďuračková Z 2015 [69] ChildrenRCT Vitamin C (50 mg/day for 6 months) Reduced incidence (p = 0.002) and duration (p = 0.006) of URTIs. No significant differences in the duration or incidence of LRTIs.\nExtra dose of vitamin C based on a daily supplementation shortens the common cold: a meta-analysis of 9 randomized controlled trials. Ran L 2018 [70] Adults and children9 RCTs Vitamin C (4–8 g/day)administrated at the onset of cold Reduced cold duration (MD = −0.56, p = 0.02). Relieved cold symptoms including chest pain (MD = −0.40, p = 0.03), fever (MD = −0.45, p = 0.009), and chills (MD = −0.36, p = 0.01).\nEffect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. Fowler AA 2019 [72] AdultsRCT Vitamin C (IV 50 mg/kg every 6 h for 96 h) Significant reduction in 28-day all-cause mortality (p = 0.03), and with significantly increased ICU-free days to day 28 (p = 0.03) and hospital-free days to day 60 (p = 0.04).\nICU, intensive care unit; LRTI, lower respiratory tract infection; MD, mean difference; RCT, randomized controlled trial; URTI, upper respiratory infection."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T125","span":{"begin":1312,"end":1329},"obj":"Body_part"},{"id":"T126","span":{"begin":1930,"end":1935},"obj":"Body_part"},{"id":"T127","span":{"begin":2063,"end":2068},"obj":"Body_part"},{"id":"T128","span":{"begin":2518,"end":2541},"obj":"Body_part"},{"id":"T129","span":{"begin":2524,"end":2541},"obj":"Body_part"}],"attributes":[{"id":"A125","pred":"uberon_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A126","pred":"uberon_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A127","pred":"uberon_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A128","pred":"uberon_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A129","pred":"uberon_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"Table 3 Main studies on vitamin C supplementation against viral infections.\nStudy Author Study Population Micronutrient (Dosage) Results\nThe effect of vitamin C on upper respiratory infections in adolescents swimmers: a randomized trial. Constantini NV 2011 [68] Children (12–17 years)RCT Vitamin C (1 g/day for 3 months) In the male swimmers duration (p = 0.003) and severity (p = 0.003) of URTI episodes were decreased.\nVitamin C for preventing and treating the common cold. Hemilä H 2013 [67] Adults and children31 RCTs Vitamin C (\u003e0.2 g/day) Significant reduction in the duration of common cold episodes. Decreased cold severity in Vitamin C group.\nVitamin C for preventing and treating pneumonia. Hemilä H 2013 [65] Adults3 RCTs Vitamin C Significant reduction in pneumonia risk (\u003e80%). Lower mortality in the vitamin C group vs. placebo group.\nVitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Schumacher SS 2014 [66] AdultsRCT Vitamin C (1 g/day for 8 weeks) Reduced cold episodes in young men with low to average vitamin C status (p = 0.04). Cold duration was reduced 59% in the vitamin C vs. placebo groups (p = 0.06).\nProbiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Ďuračková Z 2015 [69] ChildrenRCT Vitamin C (50 mg/day for 6 months) Reduced incidence (p = 0.002) and duration (p = 0.006) of URTIs. No significant differences in the duration or incidence of LRTIs.\nExtra dose of vitamin C based on a daily supplementation shortens the common cold: a meta-analysis of 9 randomized controlled trials. Ran L 2018 [70] Adults and children9 RCTs Vitamin C (4–8 g/day)administrated at the onset of cold Reduced cold duration (MD = −0.56, p = 0.02). Relieved cold symptoms including chest pain (MD = −0.40, p = 0.03), fever (MD = −0.45, p = 0.009), and chills (MD = −0.36, p = 0.01).\nEffect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. Fowler AA 2019 [72] AdultsRCT Vitamin C (IV 50 mg/kg every 6 h for 96 h) Significant reduction in 28-day all-cause mortality (p = 0.03), and with significantly increased ICU-free days to day 28 (p = 0.03) and hospital-free days to day 60 (p = 0.04).\nICU, intensive care unit; LRTI, lower respiratory tract infection; MD, mean difference; RCT, randomized controlled trial; URTI, upper respiratory infection."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T164","span":{"begin":59,"end":75},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T165","span":{"begin":2095,"end":2107},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Table 3 Main studies on vitamin C supplementation against viral infections.\nStudy Author Study Population Micronutrient (Dosage) Results\nThe effect of vitamin C on upper respiratory infections in adolescents swimmers: a randomized trial. Constantini NV 2011 [68] Children (12–17 years)RCT Vitamin C (1 g/day for 3 months) In the male swimmers duration (p = 0.003) and severity (p = 0.003) of URTI episodes were decreased.\nVitamin C for preventing and treating the common cold. Hemilä H 2013 [67] Adults and children31 RCTs Vitamin C (\u003e0.2 g/day) Significant reduction in the duration of common cold episodes. Decreased cold severity in Vitamin C group.\nVitamin C for preventing and treating pneumonia. Hemilä H 2013 [65] Adults3 RCTs Vitamin C Significant reduction in pneumonia risk (\u003e80%). Lower mortality in the vitamin C group vs. placebo group.\nVitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Schumacher SS 2014 [66] AdultsRCT Vitamin C (1 g/day for 8 weeks) Reduced cold episodes in young men with low to average vitamin C status (p = 0.04). Cold duration was reduced 59% in the vitamin C vs. placebo groups (p = 0.06).\nProbiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Ďuračková Z 2015 [69] ChildrenRCT Vitamin C (50 mg/day for 6 months) Reduced incidence (p = 0.002) and duration (p = 0.006) of URTIs. No significant differences in the duration or incidence of LRTIs.\nExtra dose of vitamin C based on a daily supplementation shortens the common cold: a meta-analysis of 9 randomized controlled trials. Ran L 2018 [70] Adults and children9 RCTs Vitamin C (4–8 g/day)administrated at the onset of cold Reduced cold duration (MD = −0.56, p = 0.02). Relieved cold symptoms including chest pain (MD = −0.40, p = 0.03), fever (MD = −0.45, p = 0.009), and chills (MD = −0.36, p = 0.01).\nEffect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. Fowler AA 2019 [72] AdultsRCT Vitamin C (IV 50 mg/kg every 6 h for 96 h) Significant reduction in 28-day all-cause mortality (p = 0.03), and with significantly increased ICU-free days to day 28 (p = 0.03) and hospital-free days to day 60 (p = 0.04).\nICU, intensive care unit; LRTI, lower respiratory tract infection; MD, mean difference; RCT, randomized controlled trial; URTI, upper respiratory infection."}

LitCovid-PD-HP

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T434","span":{"begin":0,"end":76},"obj":"Sentence"},{"id":"T435","span":{"begin":77,"end":141},"obj":"Sentence"},{"id":"T436","span":{"begin":142,"end":242},"obj":"Sentence"},{"id":"T437","span":{"begin":244,"end":430},"obj":"Sentence"},{"id":"T438","span":{"begin":431,"end":485},"obj":"Sentence"},{"id":"T439","span":{"begin":487,"end":621},"obj":"Sentence"},{"id":"T440","span":{"begin":622,"end":665},"obj":"Sentence"},{"id":"T441","span":{"begin":666,"end":714},"obj":"Sentence"},{"id":"T442","span":{"begin":716,"end":808},"obj":"Sentence"},{"id":"T443","span":{"begin":809,"end":866},"obj":"Sentence"},{"id":"T444","span":{"begin":867,"end":1032},"obj":"Sentence"},{"id":"T445","span":{"begin":1034,"end":1186},"obj":"Sentence"},{"id":"T446","span":{"begin":1187,"end":1264},"obj":"Sentence"},{"id":"T447","span":{"begin":1265,"end":1548},"obj":"Sentence"},{"id":"T448","span":{"begin":1549,"end":1614},"obj":"Sentence"},{"id":"T449","span":{"begin":1615,"end":1748},"obj":"Sentence"},{"id":"T450","span":{"begin":1750,"end":1896},"obj":"Sentence"},{"id":"T451","span":{"begin":1897,"end":2030},"obj":"Sentence"},{"id":"T452","span":{"begin":2031,"end":2231},"obj":"Sentence"},{"id":"T453","span":{"begin":2233,"end":2485},"obj":"Sentence"},{"id":"T454","span":{"begin":2486,"end":2642},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 3 Main studies on vitamin C supplementation against viral infections.\nStudy Author Study Population Micronutrient (Dosage) Results\nThe effect of vitamin C on upper respiratory infections in adolescents swimmers: a randomized trial. Constantini NV 2011 [68] Children (12–17 years)RCT Vitamin C (1 g/day for 3 months) In the male swimmers duration (p = 0.003) and severity (p = 0.003) of URTI episodes were decreased.\nVitamin C for preventing and treating the common cold. Hemilä H 2013 [67] Adults and children31 RCTs Vitamin C (\u003e0.2 g/day) Significant reduction in the duration of common cold episodes. Decreased cold severity in Vitamin C group.\nVitamin C for preventing and treating pneumonia. Hemilä H 2013 [65] Adults3 RCTs Vitamin C Significant reduction in pneumonia risk (\u003e80%). Lower mortality in the vitamin C group vs. placebo group.\nVitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Schumacher SS 2014 [66] AdultsRCT Vitamin C (1 g/day for 8 weeks) Reduced cold episodes in young men with low to average vitamin C status (p = 0.04). Cold duration was reduced 59% in the vitamin C vs. placebo groups (p = 0.06).\nProbiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Ďuračková Z 2015 [69] ChildrenRCT Vitamin C (50 mg/day for 6 months) Reduced incidence (p = 0.002) and duration (p = 0.006) of URTIs. No significant differences in the duration or incidence of LRTIs.\nExtra dose of vitamin C based on a daily supplementation shortens the common cold: a meta-analysis of 9 randomized controlled trials. Ran L 2018 [70] Adults and children9 RCTs Vitamin C (4–8 g/day)administrated at the onset of cold Reduced cold duration (MD = −0.56, p = 0.02). Relieved cold symptoms including chest pain (MD = −0.40, p = 0.03), fever (MD = −0.45, p = 0.009), and chills (MD = −0.36, p = 0.01).\nEffect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. Fowler AA 2019 [72] AdultsRCT Vitamin C (IV 50 mg/kg every 6 h for 96 h) Significant reduction in 28-day all-cause mortality (p = 0.03), and with significantly increased ICU-free days to day 28 (p = 0.03) and hospital-free days to day 60 (p = 0.04).\nICU, intensive care unit; LRTI, lower respiratory tract infection; MD, mean difference; RCT, randomized controlled trial; URTI, upper respiratory infection."}

LitCovid-PubTator

PMC:7589163 / 69393-72035 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7589163 / 69393-72035 JSON TXT