PMC:7589163 / 69393-72035
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T319 | 1312-1329 | Body_part | denotes | respiratory tract | http://purl.org/sig/ont/fma/fma265130 |
| T320 | 1930-1935 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
| T321 | 2063-2068 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T322 | 2518-2541 | Body_part | denotes | lower respiratory tract | http://purl.org/sig/ont/fma/fma45662 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T125 | 1312-1329 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T126 | 1930-1935 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
| T127 | 2063-2068 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T128 | 2518-2541 | Body_part | denotes | lower respiratory tract | http://purl.obolibrary.org/obo/UBERON_0001558 |
| T129 | 2524-2541 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T264 | 59-75 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T265 | 169-197 | Disease | denotes | upper respiratory infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T266 | 473-484 | Disease | denotes | common cold | http://purl.obolibrary.org/obo/MONDO_0005709 |
| T267 | 600-611 | Disease | denotes | common cold | http://purl.obolibrary.org/obo/MONDO_0005709 |
| T268 | 704-713 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T269 | 786-795 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T270 | 1312-1343 | Disease | denotes | respiratory tract infections in | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T271 | 1685-1696 | Disease | denotes | common cold | http://purl.obolibrary.org/obo/MONDO_0005709 |
| T272 | 2095-2107 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T273 | 2121-2127 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T274 | 2163-2188 | Disease | denotes | acute respiratory failure | http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113 |
| T276 | 2524-2551 | Disease | denotes | respiratory tract infection | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T277 | 2542-2551 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T278 | 2614-2641 | Disease | denotes | upper respiratory infection | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T279 | 2632-2641 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T662 | 223-224 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T663 | 338-342 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
| T664 | 338-342 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
| T665 | 920-928 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T666 | 1002-1003 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T667 | 1374-1375 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T668 | 1648-1649 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T669 | 1698-1699 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T670 | 1756-1760 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T671 | 1805-1808 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 4–8 |
| T672 | 1874-1876 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T673 | 1930-1935 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T674 | 1942-1944 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T675 | 1972-1974 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T676 | 2008-2010 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T677 | 2063-2068 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T678 | 2240-2242 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | AA |
| T679 | 2518-2541 | http://purl.obolibrary.org/obo/UBERON_0001558 | denotes | lower respiratory tract |
| T680 | 2553-2555 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T45571 | 25-34 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T311 | 25-32 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T312 | 156-165 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T67174 | 156-163 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T30765 | 256-258 | Chemical | denotes | NV | http://purl.obolibrary.org/obo/CHEBI_73825 |
| T23073 | 297-306 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T50522 | 297-304 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T85412 | 338-342 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
| T19714 | 431-440 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T94163 | 431-438 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T98262 | 535-544 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T1277 | 535-542 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T96200 | 649-658 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T39699 | 649-656 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T42206 | 659-664 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T14276 | 666-675 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T23574 | 666-673 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T86089 | 750-759 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T27669 | 750-757 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T37739 | 832-841 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T42546 | 832-839 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T65313 | 842-847 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T41854 | 860-865 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T60069 | 867-876 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T42812 | 867-874 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T17766 | 984-993 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T14118 | 984-991 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T65677 | 1045-1047 | Chemical | denotes | SS | http://purl.obolibrary.org/obo/CHEBI_73653 |
| T39578 | 1070-1079 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T81461 | 1070-1077 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T7710 | 1158-1167 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T86599 | 1158-1165 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T65405 | 1224-1233 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T64661 | 1224-1231 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T49031 | 1280-1289 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T361 | 1280-1287 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T362 | 1448-1457 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T71202 | 1448-1455 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T47284 | 1629-1638 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T90948 | 1629-1636 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T4114 | 1794-1803 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T47261 | 1794-1801 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T68235 | 1874-1876 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T92109 | 1942-1944 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T91846 | 1972-1974 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T96893 | 2008-2010 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T44905 | 2041-2050 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T19600 | 2041-2048 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T94988 | 2240-2242 | Chemical | denotes | AA | http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816 |
| T46703 | 2265-2274 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T26709 | 2265-2272 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T3031 | 2276-2278 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T69115 | 2553-2555 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T164 | 59-75 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T165 | 2095-2107 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T135 | 175-197 | Phenotype | denotes | respiratory infections | http://purl.obolibrary.org/obo/HP_0011947 |
| T136 | 704-713 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T137 | 786-795 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T138 | 1312-1340 | Phenotype | denotes | respiratory tract infections | http://purl.obolibrary.org/obo/HP_0011947 |
| T139 | 1930-1940 | Phenotype | denotes | chest pain | http://purl.obolibrary.org/obo/HP_0100749 |
| T140 | 1965-1970 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T141 | 2000-2006 | Phenotype | denotes | chills | http://purl.obolibrary.org/obo/HP_0025143 |
| T142 | 2145-2151 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T143 | 2169-2188 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
| T144 | 2518-2551 | Phenotype | denotes | lower respiratory tract infection | http://purl.obolibrary.org/obo/HP_0002783 |
| T145 | 2620-2641 | Phenotype | denotes | respiratory infection | http://purl.obolibrary.org/obo/HP_0011947 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T434 | 0-76 | Sentence | denotes | Table 3 Main studies on vitamin C supplementation against viral infections. |
| T435 | 77-141 | Sentence | denotes | Study Author Study Population Micronutrient (Dosage) Results |
| T436 | 142-242 | Sentence | denotes | The effect of vitamin C on upper respiratory infections in adolescents swimmers: a randomized trial. |
| T437 | 244-430 | Sentence | denotes | Constantini NV 2011 [68] Children (12–17 years)RCT Vitamin C (1 g/day for 3 months) In the male swimmers duration (p = 0.003) and severity (p = 0.003) of URTI episodes were decreased. |
| T438 | 431-485 | Sentence | denotes | Vitamin C for preventing and treating the common cold. |
| T439 | 487-621 | Sentence | denotes | Hemilä H 2013 [67] Adults and children31 RCTs Vitamin C (>0.2 g/day) Significant reduction in the duration of common cold episodes. |
| T440 | 622-665 | Sentence | denotes | Decreased cold severity in Vitamin C group. |
| T441 | 666-714 | Sentence | denotes | Vitamin C for preventing and treating pneumonia. |
| T442 | 716-808 | Sentence | denotes | Hemilä H 2013 [65] Adults3 RCTs Vitamin C Significant reduction in pneumonia risk (>80%). |
| T443 | 809-866 | Sentence | denotes | Lower mortality in the vitamin C group vs. placebo group. |
| T444 | 867-1032 | Sentence | denotes | Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. |
| T445 | 1034-1186 | Sentence | denotes | Schumacher SS 2014 [66] AdultsRCT Vitamin C (1 g/day for 8 weeks) Reduced cold episodes in young men with low to average vitamin C status (p = 0.04). |
| T446 | 1187-1264 | Sentence | denotes | Cold duration was reduced 59% in the vitamin C vs. placebo groups (p = 0.06). |
| T447 | 1265-1548 | Sentence | denotes | Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Ďuračková Z 2015 [69] ChildrenRCT Vitamin C (50 mg/day for 6 months) Reduced incidence (p = 0.002) and duration (p = 0.006) of URTIs. |
| T448 | 1549-1614 | Sentence | denotes | No significant differences in the duration or incidence of LRTIs. |
| T449 | 1615-1748 | Sentence | denotes | Extra dose of vitamin C based on a daily supplementation shortens the common cold: a meta-analysis of 9 randomized controlled trials. |
| T450 | 1750-1896 | Sentence | denotes | Ran L 2018 [70] Adults and children9 RCTs Vitamin C (4–8 g/day)administrated at the onset of cold Reduced cold duration (MD = −0.56, p = 0.02). |
| T451 | 1897-2030 | Sentence | denotes | Relieved cold symptoms including chest pain (MD = −0.40, p = 0.03), fever (MD = −0.45, p = 0.009), and chills (MD = −0.36, p = 0.01). |
| T452 | 2031-2231 | Sentence | denotes | Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. |
| T453 | 2233-2485 | Sentence | denotes | Fowler AA 2019 [72] AdultsRCT Vitamin C (IV 50 mg/kg every 6 h for 96 h) Significant reduction in 28-day all-cause mortality (p = 0.03), and with significantly increased ICU-free days to day 28 (p = 0.03) and hospital-free days to day 60 (p = 0.04). |
| T454 | 2486-2642 | Sentence | denotes | ICU, intensive care unit; LRTI, lower respiratory tract infection; MD, mean difference; RCT, randomized controlled trial; URTI, upper respiratory infection. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2884 | 1750-1753 | Gene | denotes | Ran | Gene:5901 |
| 2885 | 270-278 | Species | denotes | Children | Tax:9606 |
| 2886 | 966-969 | Species | denotes | men | Tax:9606 |
| 2887 | 1134-1137 | Species | denotes | men | Tax:9606 |
| 2888 | 1344-1352 | Species | denotes | children | Tax:9606 |
| 2889 | 2131-2139 | Species | denotes | patients | Tax:9606 |
| 2890 | 518-526 | Species | denotes | children | Tax:9606 |
| 2891 | 1778-1786 | Species | denotes | children | Tax:9606 |
| 2892 | 1754-1755 | Gene | denotes | L | Gene:21832 |
| 2893 | 156-165 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2894 | 297-306 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2895 | 431-440 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2896 | 535-544 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2897 | 649-658 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2898 | 666-675 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2899 | 750-759 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2900 | 832-841 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2901 | 867-876 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2902 | 984-993 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2903 | 1070-1079 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2904 | 1158-1167 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2905 | 1224-1233 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2906 | 1280-1289 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2907 | 1448-1457 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2908 | 1629-1638 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2909 | 1794-1803 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2910 | 2041-2050 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2911 | 2194-2200 | Chemical | denotes | CITRIS | |
| 2912 | 2265-2274 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 2913 | 169-197 | Disease | denotes | upper respiratory infections | MESH:D012141 |
| 2914 | 622-636 | Disease | denotes | Decreased cold | MESH:D000067390 |
| 2915 | 704-713 | Disease | denotes | pneumonia | MESH:D011014 |
| 2916 | 773-795 | Disease | denotes | reduction in pneumonia | MESH:D007022 |
| 2917 | 815-824 | Disease | denotes | mortality | MESH:D003643 |
| 2918 | 1187-1191 | Disease | denotes | Cold | MESH:D000067390 |
| 2919 | 1312-1340 | Disease | denotes | respiratory tract infections | MESH:D012141 |
| 2920 | 1845-1863 | Disease | denotes | cold Reduced cold | MESH:D000067390 |
| 2921 | 1906-1919 | Disease | denotes | cold symptoms | MESH:D051271 |
| 2922 | 1930-1940 | Disease | denotes | chest pain | MESH:D002637 |
| 2923 | 1965-1970 | Disease | denotes | fever | MESH:D005334 |
| 2924 | 2063-2076 | Disease | denotes | organ failure | MESH:D009102 |
| 2925 | 2095-2107 | Disease | denotes | inflammation | MESH:D007249 |
| 2926 | 2112-2127 | Disease | denotes | vascular injury | MESH:D057772 |
| 2927 | 2145-2151 | Disease | denotes | sepsis | MESH:D018805 |
| 2928 | 2169-2188 | Disease | denotes | respiratory failure | MESH:D012131 |
| 2929 | 2351-2360 | Disease | denotes | mortality | MESH:D003643 |
| 2932 | 25-34 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2933 | 59-75 | Disease | denotes | viral infections | MESH:D001102 |
| 2936 | 2524-2551 | Disease | denotes | respiratory tract infection | MESH:D012141 |
| 2937 | 2614-2641 | Disease | denotes | upper respiratory infection | MESH:D012141 |