> top > docs > PMC:7589163 > spans > 57597-59135 > annotations

PMC:7589163 / 57597-59135 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T293 21-34 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T294 285-294 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T295 445-454 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T296 463-467 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T297 613-631 Body_part denotes regulatory T cells http://purl.org/sig/ont/fma/fma84070
T298 626-631 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T299 779-789 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T300 790-799 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T301 1525-1529 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T110 21-34 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T111 790-799 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T222 1093-1099 Disease denotes Dengue http://purl.obolibrary.org/obo/MONDO_0005502
T223 1467-1483 Disease denotes SARS-coronavirus http://purl.obolibrary.org/obo/MONDO_0005091
T224 1485-1493 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T225 1506-1515 Disease denotes arteritis http://purl.obolibrary.org/obo/MONDO_0043494

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T561 21-34 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T562 115-116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T563 203-204 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T564 309-314 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T565 463-467 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T566 515-516 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T567 517-526 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T568 603-631 http://purl.obolibrary.org/obo/CL_0000902 denotes inducible regulatory T cells
T569 711-719 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T570 779-789 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T571 779-789 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T572 849-857 http://purl.obolibrary.org/obo/OBI_0100026 denotes organism
T573 849-857 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organism
T574 1053-1054 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T575 1100-1105 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T576 1174-1175 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T577 1253-1260 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T578 1280-1282 http://purl.obolibrary.org/obo/CLO_0009287 denotes Te
T579 1499-1505 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes equine
T580 1516-1521 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T581 1525-1529 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T86265 223-227 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T30821 333-337 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T50512 463-465 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T89729 469-471 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T73992 511-513 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T59906 684-688 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T18624 1062-1071 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T11522 1191-1202 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T45452 1208-1212 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T72024 1280-1282 Chemical denotes Te http://purl.obolibrary.org/obo/CHEBI_30452
T77663 1338-1341 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T43302 1347-1351 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T34893 1352-1362 Chemical denotes ionophores http://purl.obolibrary.org/obo/CHEBI_24869
T34838 1368-1378 Chemical denotes pyrithione http://purl.obolibrary.org/obo/CHEBI_36578
T47124 1410-1413 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T150 381-402 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T151 517-534 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T152 517-526 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T153 1352-1362 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophores

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T106 371-402 Phenotype denotes increased inflammatory response http://purl.obolibrary.org/obo/HP_0012649
T107 942-958 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T108 1506-1515 Phenotype denotes arteritis http://purl.obolibrary.org/obo/HP_0012089

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T351 0-202 Sentence denotes Zinc’s effect on the immune system is complex; it can both enhance and inhibit different immune functions to reach a correct balance between pro and anti-inflammatory effects through various mechanisms.
T352 203-569 Sentence denotes A correct intake of zinc is essential to limit the overproduction of inflammatory cytokines: in vitro and human studies show that zinc deficiency is associated with an increased inflammatory response and excessive release of pro inflammatory cytokines such as IL-2, IL-6, and TNF-alfa, regulated through the NF-κB signaling pathway [230,231,232,233,234,235,236,237].
T353 570-650 Sentence denotes Zinc also enhances the number of inducible regulatory T cells [238,239,240,241].
T354 651-888 Sentence denotes Another important role played by zinc is the maintenance of membrane barrier integrity, which is essential in the pulmonary and intestinal epithelia that constitute the first barrier to protect the organism from pathogens. [242,243,244].
T355 889-1137 Sentence denotes Zinc supplementation is also effective in decreasing oxidative stress [245,246], in shortening the duration of cold symptoms in adults [247], and was found to have a direct antiviral effect on RSV [248], Dengue virus [249], and coronaviruses [250].
T356 1138-1279 Sentence denotes Lastly, some authors suggested that a combination of chloroquine with zinc might enhance chloroquine’s toxicity on viruses [249,250,251,252].
T357 1280-1538 Sentence denotes Te Velthius et al. [249] reported that the combination of Zn2+ and zinc-ionophores like pyrithione can increase the intracellular Zn2+ concentration, and thus inhibits the replication of SARS-coronavirus (SARS-CoV) and equine arteritis virus in cell culture.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1470 463-467 Gene denotes IL-2 Gene:3558
1471 469-473 Gene denotes IL-6 Gene:3569
1472 511-516 Gene denotes NF-κB Gene:4790
1473 309-314 Species denotes human Tax:9606
1474 1093-1105 Species denotes Dengue virus Tax:12637
1475 1117-1130 Species denotes coronaviruses Tax:11118
1479 1191-1202 Chemical denotes chloroquine MESH:D002738
1480 1227-1238 Chemical denotes chloroquine MESH:D002738
1484 333-348 Disease denotes zinc deficiency MESH:C564286
1485 479-487 Disease denotes TNF-alfa MESH:C536657
1486 1000-1013 Disease denotes cold symptoms MESH:D051271
1487 1241-1249 Disease denotes toxicity MESH:D064420