PMC:7589163 / 49017-50009 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T232","span":{"begin":8,"end":19},"obj":"Body_part"},{"id":"T233","span":{"begin":70,"end":80},"obj":"Body_part"},{"id":"T234","span":{"begin":109,"end":119},"obj":"Body_part"},{"id":"T235","span":{"begin":238,"end":255},"obj":"Body_part"},{"id":"T236","span":{"begin":282,"end":288},"obj":"Body_part"},{"id":"T237","span":{"begin":326,"end":332},"obj":"Body_part"},{"id":"T238","span":{"begin":404,"end":415},"obj":"Body_part"},{"id":"T239","span":{"begin":467,"end":472},"obj":"Body_part"},{"id":"T240","span":{"begin":485,"end":496},"obj":"Body_part"},{"id":"T241","span":{"begin":548,"end":568},"obj":"Body_part"},{"id":"T242","span":{"begin":563,"end":568},"obj":"Body_part"},{"id":"T243","span":{"begin":580,"end":591},"obj":"Body_part"},{"id":"T244","span":{"begin":643,"end":671},"obj":"Body_part"},{"id":"T245","span":{"begin":748,"end":756},"obj":"Body_part"},{"id":"T246","span":{"begin":884,"end":889},"obj":"Body_part"},{"id":"T247","span":{"begin":926,"end":935},"obj":"Body_part"}],"attributes":[{"id":"A232","pred":"fma_id","subj":"T232","obj":"http://purl.org/sig/ont/fma/fma82738"},{"id":"A233","pred":"fma_id","subj":"T233","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A234","pred":"fma_id","subj":"T234","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma0326465"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma62854"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T86","span":{"begin":238,"end":244},"obj":"Body_part"},{"id":"T87","span":{"begin":282,"end":288},"obj":"Body_part"},{"id":"T88","span":{"begin":326,"end":332},"obj":"Body_part"}],"attributes":[{"id":"A86","pred":"uberon_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A87","pred":"uberon_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A88","pred":"uberon_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T187","span":{"begin":70,"end":90},"obj":"Disease"},{"id":"T188","span":{"begin":133,"end":145},"obj":"Disease"},{"id":"T189","span":{"begin":347,"end":359},"obj":"Disease"},{"id":"T190","span":{"begin":973,"end":985},"obj":"Disease"}],"attributes":[{"id":"A187","pred":"mondo_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/MONDO_0008091"},{"id":"A188","pred":"mondo_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T491","span":{"begin":189,"end":190},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T492","span":{"begin":256,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T493","span":{"begin":467,"end":472},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T494","span":{"begin":548,"end":568},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T495","span":{"begin":769,"end":770},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T496","span":{"begin":872,"end":881},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T497","span":{"begin":882,"end":889},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T47450","span":{"begin":8,"end":19},"obj":"Chemical"},{"id":"T57233","span":{"begin":14,"end":19},"obj":"Chemical"},{"id":"T26611","span":{"begin":20,"end":31},"obj":"Chemical"},{"id":"T55451","span":{"begin":32,"end":41},"obj":"Chemical"},{"id":"T90199","span":{"begin":175,"end":179},"obj":"Chemical"},{"id":"T19336","span":{"begin":533,"end":537},"obj":"Chemical"},{"id":"T1204","span":{"begin":725,"end":729},"obj":"Chemical"}],"attributes":[{"id":"A40637","pred":"chebi_id","subj":"T47450","obj":"http://purl.obolibrary.org/obo/CHEBI_35366"},{"id":"A94633","pred":"chebi_id","subj":"T57233","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A43062","pred":"chebi_id","subj":"T26611","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A59234","pred":"chebi_id","subj":"T55451","obj":"http://purl.obolibrary.org/obo/CHEBI_132120"},{"id":"A8447","pred":"chebi_id","subj":"T90199","obj":"http://purl.obolibrary.org/obo/CHEBI_140399"},{"id":"A59018","pred":"chebi_id","subj":"T19336","obj":"http://purl.obolibrary.org/obo/CHEBI_140399"},{"id":"A25673","pred":"chebi_id","subj":"T1204","obj":"http://purl.obolibrary.org/obo/CHEBI_140399"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T122","span":{"begin":59,"end":90},"obj":"http://purl.obolibrary.org/obo/GO_1902623"},{"id":"T123","span":{"begin":70,"end":90},"obj":"http://purl.obolibrary.org/obo/GO_1990266"},{"id":"T124","span":{"begin":133,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T125","span":{"begin":245,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0042119"},{"id":"T126","span":{"begin":347,"end":359},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T127","span":{"begin":431,"end":453},"obj":"http://purl.obolibrary.org/obo/GO_0050766"},{"id":"T128","span":{"begin":441,"end":453},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T129","span":{"begin":592,"end":601},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T130","span":{"begin":592,"end":601},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T131","span":{"begin":683,"end":709},"obj":"http://purl.obolibrary.org/obo/GO_0050728"},{"id":"T132","span":{"begin":688,"end":709},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T133","span":{"begin":748,"end":767},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T134","span":{"begin":896,"end":908},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T135","span":{"begin":973,"end":985},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T296","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T297","span":{"begin":162,"end":306},"obj":"Sentence"},{"id":"T298","span":{"begin":307,"end":519},"obj":"Sentence"},{"id":"T299","span":{"begin":520,"end":678},"obj":"Sentence"},{"id":"T300","span":{"begin":679,"end":768},"obj":"Sentence"},{"id":"T301","span":{"begin":769,"end":992},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1247","span":{"begin":842,"end":846},"obj":"Gene"},{"id":"1248","span":{"begin":0,"end":19},"obj":"Chemical"},{"id":"1249","span":{"begin":133,"end":145},"obj":"Disease"},{"id":"1250","span":{"begin":347,"end":359},"obj":"Disease"},{"id":"1251","span":{"begin":973,"end":985},"obj":"Disease"}],"attributes":[{"id":"A1247","pred":"tao:has_database_id","subj":"1247","obj":"Gene:1234"},{"id":"A1248","pred":"tao:has_database_id","subj":"1248","obj":"MESH:D015525"},{"id":"A1249","pred":"tao:has_database_id","subj":"1249","obj":"MESH:D007249"},{"id":"A1250","pred":"tao:has_database_id","subj":"1250","obj":"MESH:D007249"},{"id":"A1251","pred":"tao:has_database_id","subj":"1251","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]."}