PMC:7589163 / 46536-50009
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T216 | 38-49 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T217 | 82-93 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T218 | 198-208 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T219 | 278-288 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T220 | 433-444 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T221 | 873-884 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T222 | 1229-1240 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T223 | 1389-1400 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T224 | 1429-1433 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T225 | 1455-1468 | Body_part | denotes | phospholipids | http://purl.org/sig/ont/fma/fma82779 |
| T226 | 1497-1511 | Body_part | denotes | cell membranes | http://purl.org/sig/ont/fma/fma63841 |
| T227 | 1497-1501 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T228 | 1554-1558 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T229 | 1675-1692 | Body_part | denotes | endocrine systems | http://purl.org/sig/ont/fma/fma9668 |
| T230 | 2208-2218 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T231 | 2353-2357 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T232 | 2489-2500 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T233 | 2551-2561 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T234 | 2590-2600 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T235 | 2719-2736 | Body_part | denotes | tissue neutrophil | http://purl.org/sig/ont/fma/fma0326465 |
| T236 | 2763-2769 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T237 | 2807-2813 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T238 | 2885-2896 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T239 | 2948-2953 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T240 | 2966-2977 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T241 | 3029-3049 | Body_part | denotes | natural killer cells | http://purl.org/sig/ont/fma/fma63147 |
| T242 | 3044-3049 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T243 | 3061-3072 | Body_part | denotes | granulocyte | http://purl.org/sig/ont/fma/fma62854 |
| T244 | 3124-3152 | Body_part | denotes | polymorphonuclear leukocytes | http://purl.org/sig/ont/fma/fma62860 |
| T245 | 3229-3237 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T246 | 3365-3370 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T247 | 3407-3416 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T85 | 1675-1692 | Body_part | denotes | endocrine systems | http://purl.obolibrary.org/obo/UBERON_0000949 |
| T86 | 2719-2725 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T87 | 2763-2769 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T88 | 2807-2813 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T185 | 1917-1929 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T186 | 2461-2473 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T187 | 2551-2571 | Disease | denotes | neutrophil migration | http://purl.obolibrary.org/obo/MONDO_0008091 |
| T188 | 2614-2626 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T189 | 2828-2840 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T190 | 3454-3466 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T469 | 54-55 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T470 | 135-136 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T471 | 230-232 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T472 | 304-306 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T473 | 379-381 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T474 | 410-412 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T475 | 588-593 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T476 | 594-602 | http://purl.obolibrary.org/obo/OBI_0100026 | denotes | organism |
| T477 | 594-602 | http://purl.obolibrary.org/obo/UBERON_0000468 | denotes | organism |
| T478 | 619-626 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T479 | 779-781 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T480 | 1002-1003 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T481 | 1088-1091 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T482 | 1166-1172 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T483 | 1348-1352 | http://purl.obolibrary.org/obo/NCBITaxon_117565 | denotes | fish |
| T484 | 1354-1358 | http://purl.obolibrary.org/obo/NCBITaxon_117565 | denotes | fish |
| T485 | 1497-1501 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T486 | 1502-1511 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T487 | 1675-1692 | http://purl.obolibrary.org/obo/UBERON_0000949 | denotes | endocrine systems |
| T488 | 1675-1692 | http://www.ebi.ac.uk/efo/EFO_0002969 | denotes | endocrine systems |
| T489 | 2353-2357 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T490 | 2415-2416 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T491 | 2670-2671 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T492 | 2737-2747 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T493 | 2948-2953 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T494 | 3029-3049 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | natural killer cells |
| T495 | 3250-3251 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T496 | 3353-3362 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T497 | 3363-3370 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T648 | 38-49 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T649 | 44-49 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T650 | 66-93 | Chemical | denotes | polyunsaturated fatty acids | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T651 | 82-93 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T652 | 88-93 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T653 | 95-100 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T654 | 164-175 | Chemical | denotes | carbon atom | http://purl.obolibrary.org/obo/CHEBI_27594 |
| T655 | 164-170 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_33415 |
| T656 | 171-175 | Chemical | denotes | atom | http://purl.obolibrary.org/obo/CHEBI_33250 |
| T657 | 190-208 | Chemical | denotes | omega-3 fatty acid | http://purl.obolibrary.org/obo/CHEBI_25681 |
| T658 | 198-208 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T659 | 204-208 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T660 | 214-228 | Chemical | denotes | linolenic acid | http://purl.obolibrary.org/obo/CHEBI_25048|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T662 | 224-228 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T663 | 270-288 | Chemical | denotes | omega-6 fatty acid | http://purl.obolibrary.org/obo/CHEBI_36009 |
| T664 | 278-288 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T665 | 284-288 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T666 | 289-302 | Chemical | denotes | linoleic acid | http://purl.obolibrary.org/obo/CHEBI_17351 |
| T667 | 298-302 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T668 | 364-377 | Chemical | denotes | Linoleic acid | http://purl.obolibrary.org/obo/CHEBI_17351 |
| T669 | 373-377 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T670 | 394-408 | Chemical | denotes | linolenic acid | http://purl.obolibrary.org/obo/CHEBI_25048|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T672 | 404-408 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T673 | 423-444 | Chemical | denotes | essential fatty acids | http://purl.obolibrary.org/obo/CHEBI_59549 |
| T674 | 433-444 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T675 | 439-444 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T676 | 446-450 | Chemical | denotes | EFAs | http://purl.obolibrary.org/obo/CHEBI_59549 |
| T677 | 644-658 | Chemical | denotes | linolenic acid | http://purl.obolibrary.org/obo/CHEBI_25048|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T679 | 654-658 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T680 | 707-728 | Chemical | denotes | eicosapentaenoic acid | http://purl.obolibrary.org/obo/CHEBI_36006 |
| T681 | 724-728 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T682 | 748-751 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T683 | 757-777 | Chemical | denotes | docosahexaenoic acid | http://purl.obolibrary.org/obo/CHEBI_36005 |
| T684 | 773-777 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T685 | 797-800 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T689 | 865-884 | Chemical | denotes | omega-6 fatty acids | http://purl.obolibrary.org/obo/CHEBI_36009 |
| T690 | 873-884 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T691 | 879-884 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T692 | 948-964 | Chemical | denotes | arachidonic acid | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T693 | 960-964 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T694 | 984-998 | Chemical | denotes | linolenic acid | http://purl.obolibrary.org/obo/CHEBI_25048|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T696 | 994-998 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T697 | 1016-1025 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T698 | 1029-1042 | Chemical | denotes | linoleic acid | http://purl.obolibrary.org/obo/CHEBI_17351 |
| T699 | 1038-1042 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T700 | 1133-1136 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T701 | 1141-1144 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T705 | 1229-1240 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T706 | 1235-1240 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T707 | 1280-1294 | Chemical | denotes | linolenic acid | http://purl.obolibrary.org/obo/CHEBI_25048|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T709 | 1290-1294 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T710 | 1321-1324 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T714 | 1329-1332 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T715 | 1389-1400 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T716 | 1395-1400 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T717 | 1455-1468 | Chemical | denotes | phospholipids | http://purl.obolibrary.org/obo/CHEBI_16247 |
| T718 | 1580-1591 | Chemical | denotes | eicosanoids | http://purl.obolibrary.org/obo/CHEBI_23899 |
| T719 | 1675-1684 | Chemical | denotes | endocrine | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T720 | 1733-1744 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T721 | 1795-1800 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T722 | 1858-1867 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T723 | 1937-1972 | Chemical | denotes | specialized pro-resolving mediators | http://purl.obolibrary.org/obo/CHEBI_140399 |
| T724 | 1974-1978 | Chemical | denotes | SPMs | http://purl.obolibrary.org/obo/CHEBI_140399 |
| T725 | 1997-2006 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T726 | 2025-2049 | Chemical | denotes | immunosuppressive agents | http://purl.obolibrary.org/obo/CHEBI_35705 |
| T727 | 2131-2144 | Chemical | denotes | antimicrobial | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T728 | 2182-2186 | Chemical | denotes | SPMs | http://purl.obolibrary.org/obo/CHEBI_140399 |
| T729 | 2200-2218 | Chemical | denotes | omega-3 fatty acid | http://purl.obolibrary.org/obo/CHEBI_25681 |
| T730 | 2208-2218 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T731 | 2214-2218 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T732 | 2220-2223 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T733 | 2228-2231 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T737 | 2251-2260 | Chemical | denotes | resolvins | http://purl.obolibrary.org/obo/CHEBI_132120 |
| T47450 | 2489-2500 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T57233 | 2495-2500 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T26611 | 2501-2512 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T55451 | 2513-2522 | Chemical | denotes | resolvins | http://purl.obolibrary.org/obo/CHEBI_132120 |
| T90199 | 2656-2660 | Chemical | denotes | SPMs | http://purl.obolibrary.org/obo/CHEBI_140399 |
| T19336 | 3014-3018 | Chemical | denotes | SPMs | http://purl.obolibrary.org/obo/CHEBI_140399 |
| T1204 | 3206-3210 | Chemical | denotes | SPMs | http://purl.obolibrary.org/obo/CHEBI_140399 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T116 | 5-15 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | Metabolism |
| T117 | 1029-1053 | http://purl.obolibrary.org/obo/GO_0043651 | denotes | linoleic acid metabolism |
| T118 | 1043-1053 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T119 | 1917-1929 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T120 | 2081-2102 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T121 | 2461-2473 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T122 | 2540-2571 | http://purl.obolibrary.org/obo/GO_1902623 | denotes | inhibiting neutrophil migration |
| T123 | 2551-2571 | http://purl.obolibrary.org/obo/GO_1990266 | denotes | neutrophil migration |
| T124 | 2614-2626 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T125 | 2726-2747 | http://purl.obolibrary.org/obo/GO_0042119 | denotes | neutrophil activation |
| T126 | 2828-2840 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T127 | 2912-2934 | http://purl.obolibrary.org/obo/GO_0050766 | denotes | stimulate phagocytosis |
| T128 | 2922-2934 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T129 | 3073-3082 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T130 | 3073-3082 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T131 | 3164-3190 | http://purl.obolibrary.org/obo/GO_0050728 | denotes | anti-inflammatory response |
| T132 | 3169-3190 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T133 | 3229-3248 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | cytokine production |
| T134 | 3377-3389 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | sequestering |
| T135 | 3454-3466 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T277 | 0-4 | Sentence | denotes | 6.1. |
| T278 | 5-29 | Sentence | denotes | Metabolism and Functions |
| T279 | 30-176 | Sentence | denotes | Omega-3 fatty acids are a family of polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond at the omega−3 carbon atom. |
| T280 | 177-363 | Sentence | denotes | The simplest omega-3 fatty acid is α-linolenic acid (18:3n-3), which is synthesized from the omega-6 fatty acid linoleic acid (18:2n-6) by desaturation, catalysed by delta-15 desaturase. |
| T281 | 364-502 | Sentence | denotes | Linoleic acid (18:2n-6) and α-linolenic acid (18:3n-3) are essential fatty acids (EFAs), meaning that they must be obtained from the diet. |
| T282 | 503-609 | Sentence | denotes | Indeed, they are synthesized by plants and cannot be synthesized sufficiently by the human organism [190]. |
| T283 | 610-802 | Sentence | denotes | However, animals can metabolize α-linolenic acid by further desaturation and elongation to yield eicosapentaenoic acid (20:5n-3; known as EPA) and docosahexaenoic acid (22:6n-3; known as DHA). |
| T284 | 803-965 | Sentence | denotes | It is important to note that the same enzymes are employed by omega-6 fatty acids for their metabolic pathways, which leads to the production of arachidonic acid. |
| T285 | 966-1075 | Sentence | denotes | This means that α-linolenic acid is a competitive inhibitor of linoleic acid metabolism and vice versa [191]. |
| T286 | 1076-1211 | Sentence | denotes | However, it has been demonstrated that the conversion to EPA and DHA is generally poor in humans, with reported rates of less than 15%. |
| T287 | 1212-1274 | Sentence | denotes | Therefore, these fatty acids must be supplied with food [192]. |
| T288 | 1275-1380 | Sentence | denotes | Alfa-linolenic acid is present in plant oils, DHA and EPA are present in fish, fish oils, and krill oils. |
| T289 | 1381-1512 | Sentence | denotes | Omega-3 fatty acids play important roles in the body as components of the phospholipids that form the structures of cell membranes. |
| T290 | 1513-1699 | Sentence | denotes | Furthermore, they provide energy for the body and are used to form eicosanoids, exercising several functions in the body’s cardiovascular, pulmonary, immune, and endocrine systems [189]. |
| T291 | 1700-1794 | Sentence | denotes | Both omega-3 and omega-6-derived metabolites have important immune-regulatory functions [193]. |
| T292 | 1795-1990 | Sentence | denotes | PUFAs represent substrates for the enzymatically production of molecules that play an important role in the resolution of inflammation, named specialized pro-resolving mediators (SPMs) [194,195]. |
| T293 | 1991-2181 | Sentence | denotes | These molecules are distinct from immunosuppressive agents because they contribute to the inflammatory response resolution but also display antimicrobial action promoting host defence [196]. |
| T294 | 2182-2287 | Sentence | denotes | SPMs derived from omega-3 fatty acid (EPA and DHA) are classified as resolvins, protectins, and maresins. |
| T295 | 2288-2480 | Sentence | denotes | These pro-resolving mediators are important in supporting immune cell functions to neutralize and eliminate pathogens and play a crucial role in promoting the resolution of inflammation [197]. |
| T296 | 2481-2642 | Sentence | denotes | Omega-3 fatty acids metabolites resolvins are effective in inhibiting neutrophil migration, reducing further neutrophil entry in the inflammation site [198,199]. |
| T297 | 2643-2787 | Sentence | denotes | Furthermore, SPMs exercise a potent anti-inflammatory action, also reducing tissue neutrophil activation and preventing tissue damage [197,200]. |
| T298 | 2788-3000 | Sentence | denotes | In order to obtain tissue resolution of inflammation, it is essential the clearance of apoptotic neutrophils and protectins stimulate phagocytosis of apoptotic cells mediated by macrophages [201,202,203,204,205]. |
| T299 | 3001-3159 | Sentence | denotes | Furthermore, SPMs stimulate natural killer cells to trigger granulocyte apoptosis, accelerating the clearance of apoptotic polymorphonuclear leukocytes [206]. |
| T300 | 3160-3249 | Sentence | denotes | The anti-inflammatory response is promoted by SPMs also by dampening cytokine production. |
| T301 | 3250-3473 | Sentence | denotes | A study of Ariel et al. suggests that pro-resolving mediators upregulate CCR5 expression on apoptotic, activated T cells, thus sequestering pro-inflammatory cytokines, and promoting the resolution of the inflammation [207]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1180 | 30-49 | Chemical | denotes | Omega-3 fatty acids | MESH:D015525 |
| 1181 | 66-93 | Chemical | denotes | polyunsaturated fatty acids | MESH:D005231 |
| 1182 | 95-100 | Chemical | denotes | PUFAs | MESH:D005231 |
| 1183 | 164-170 | Chemical | denotes | carbon | MESH:D002244 |
| 1184 | 190-208 | Chemical | denotes | omega-3 fatty acid | MESH:D015525 |
| 1185 | 212-228 | Chemical | denotes | α-linolenic acid | MESH:D017962 |
| 1186 | 270-288 | Chemical | denotes | omega-6 fatty acid | MESH:D043371 |
| 1187 | 289-302 | Chemical | denotes | linoleic acid | MESH:D019787 |
| 1206 | 588-593 | Species | denotes | human | Tax:9606 |
| 1207 | 1166-1172 | Species | denotes | humans | Tax:9606 |
| 1208 | 364-377 | Chemical | denotes | Linoleic acid | MESH:D019787 |
| 1209 | 392-408 | Chemical | denotes | α-linolenic acid | MESH:D017962 |
| 1210 | 423-444 | Chemical | denotes | essential fatty acids | MESH:D005228 |
| 1211 | 446-450 | Chemical | denotes | EFAs | MESH:D005228 |
| 1212 | 642-658 | Chemical | denotes | α-linolenic acid | MESH:D017962 |
| 1213 | 707-728 | Chemical | denotes | eicosapentaenoic acid | MESH:D015118 |
| 1214 | 757-777 | Chemical | denotes | docosahexaenoic acid | MESH:D004281 |
| 1215 | 797-800 | Chemical | denotes | DHA | MESH:C027493 |
| 1216 | 865-884 | Chemical | denotes | omega-6 fatty acids | MESH:D043371 |
| 1217 | 948-964 | Chemical | denotes | arachidonic acid | MESH:D016718 |
| 1218 | 982-998 | Chemical | denotes | α-linolenic acid | MESH:D017962 |
| 1219 | 1029-1042 | Chemical | denotes | linoleic acid | MESH:D019787 |
| 1220 | 1141-1144 | Chemical | denotes | DHA | MESH:C027493 |
| 1221 | 1229-1240 | Chemical | denotes | fatty acids | MESH:D005227 |
| 1222 | 1275-1294 | Chemical | denotes | Alfa-linolenic acid | |
| 1223 | 1321-1324 | Chemical | denotes | DHA | MESH:C027493 |
| 1233 | 1381-1400 | Chemical | denotes | Omega-3 fatty acids | MESH:D015525 |
| 1234 | 1455-1468 | Chemical | denotes | phospholipids | MESH:D010743 |
| 1235 | 1580-1591 | Chemical | denotes | eicosanoids | MESH:D015777 |
| 1236 | 1705-1712 | Chemical | denotes | omega-3 | |
| 1237 | 1717-1732 | Chemical | denotes | omega-6-derived | |
| 1238 | 2200-2218 | Chemical | denotes | omega-3 fatty acid | MESH:D015525 |
| 1239 | 2228-2231 | Chemical | denotes | DHA | MESH:C027493 |
| 1240 | 1917-1929 | Disease | denotes | inflammation | MESH:D007249 |
| 1241 | 2461-2473 | Disease | denotes | inflammation | MESH:D007249 |
| 1247 | 3323-3327 | Gene | denotes | CCR5 | Gene:1234 |
| 1248 | 2481-2500 | Chemical | denotes | Omega-3 fatty acids | MESH:D015525 |
| 1249 | 2614-2626 | Disease | denotes | inflammation | MESH:D007249 |
| 1250 | 2828-2840 | Disease | denotes | inflammation | MESH:D007249 |
| 1251 | 3454-3466 | Disease | denotes | inflammation | MESH:D007249 |