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PMC:7589163 / 1725-5066 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T9 20-33 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T10 46-50 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T11 213-217 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T12 219-235 Body_part denotes mucous membranes http://purl.org/sig/ont/fma/fma85355
T13 266-282 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T14 277-282 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 331-344 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T16 382-386 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T17 425-438 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T18 836-840 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 882-891 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T20 957-965 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T21 1105-1110 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 1118-1123 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T23 1292-1297 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 1958-1963 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 1996-2001 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26 2032-2036 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27 2082-2092 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T28 3179-3192 Body_part denotes Immune system http://purl.org/sig/ont/fma/fma9825

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T4 20-33 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T5 213-217 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T6 219-235 Body_part denotes mucous membranes http://purl.obolibrary.org/obo/UBERON_0000344
T7 331-344 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T8 425-438 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T9 3179-3192 Body_part denotes Immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T10 59-69 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T11 594-604 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T12 864-880 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T13 1460-1469 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 1902-1912 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T15 2161-2171 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T16 2275-2284 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T17 2385-2401 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T18 2494-2503 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T19 2532-2556 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T20 2558-2566 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 2589-2636 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T22 2589-2622 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T23 2638-2646 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 2824-2834 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T25 3040-3056 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T26 3232-3248 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T12 20-33 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T13 154-155 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 213-217 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T15 213-217 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T16 213-217 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T17 213-217 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T18 213-217 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T19 219-235 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucous membranes
T20 266-276 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T21 277-282 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22 331-344 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T23 357-366 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T24 425-438 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T25 836-840 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T26 1103-1110 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T27 1118-1123 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28 1292-1297 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T29 1452-1453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 1956-1963 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T31 1994-2001 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T32 2013-2014 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 2030-2036 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T34 2052-2053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 2214-2215 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 2297-2298 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 2406-2407 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 2651-2653 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T39 2876-2885 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T40 3040-3045 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 3179-3192 http://purl.obolibrary.org/obo/UBERON_0002405 denotes Immune system

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T23 410-419 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T24 957-965 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T25 1045-1052 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T26 1143-1151 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T27 1652-1660 Chemical denotes vitamins http://purl.obolibrary.org/obo/CHEBI_33229
T28 1689-1697 Chemical denotes minerals http://purl.obolibrary.org/obo/CHEBI_46662
T29 1773-1787 Chemical denotes micronutrients http://purl.obolibrary.org/obo/CHEBI_27027
T30 2363-2377 Chemical denotes micronutrients http://purl.obolibrary.org/obo/CHEBI_27027
T31 2704-2717 Chemical denotes micronutrient http://purl.obolibrary.org/obo/CHEBI_27027
T32 2751-2765 Chemical denotes micronutrients http://purl.obolibrary.org/obo/CHEBI_27027
T33 2960-2974 Chemical denotes micronutrients http://purl.obolibrary.org/obo/CHEBI_27027

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T5 627-642 http://purl.obolibrary.org/obo/GO_0045087 denotes Innate immunity
T6 864-880 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T7 967-982 http://purl.obolibrary.org/obo/GO_0045087 denotes Innate immunity
T8 1387-1393 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T9 1607-1622 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T10 1740-1755 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 2246-2261 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T12 2385-2401 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T13 3232-3248 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 1884-1912 Phenotype denotes susceptibility to infections http://purl.obolibrary.org/obo/HP_0002719

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T12 0-2 Sentence denotes 1.
T13 3-15 Sentence denotes Introduction
T14 16-117 Sentence denotes The immune system defends the body against infectious agents and other internal and external insults.
T15 118-287 Sentence denotes The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1].
T16 288-420 Sentence denotes If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules.
T17 421-528 Sentence denotes The immune system integrates two fundamental response mechanisms: the innate response and the acquired one.
T18 529-626 Sentence denotes Innate responses occur to the same extent however many times the infectious agent is encountered.
T19 627-806 Sentence denotes Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs).
T20 807-966 Sentence denotes The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins.
T21 967-1063 Sentence denotes Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors.
T22 1064-1111 Sentence denotes Adaptive immunity is specific to T and B cells.
T23 1112-1336 Sentence denotes These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly.
T24 1337-1478 Sentence denotes The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4].
T25 1479-1629 Sentence denotes It is today acknowledged that an adequate nutritional status is crucial for the development, maintenance, and expression of the immune response [5,6].
T26 1630-1756 Sentence denotes Micronutrients (i.e., vitamins and nutritionally essential minerals) influence and support every stage of the immune response.
T27 1757-1913 Sentence denotes Deficiencies of micronutrients can affect both innate and adaptive immunity, causing immunosuppression and thus increasing the susceptibility to infections.
T28 1914-2147 Sentence denotes In addition, mucosal-associated invariant T cells (MAIT), which are innate-like T cells expressing a semi-invariant T cell receptor, play a role in polarizing adaptive lymphocyte function, and contribute to metabolic dysfunction [7].
T29 2148-2241 Sentence denotes Furthermore, infections and an inadequate nutritional status have a synergistic relationship.
T30 2242-2384 Sentence denotes The immune response itself to an infection exacerbates a poor nutritional state and causes an increase in the demand for micronutrients [8,9].
T31 2385-2655 Sentence denotes Viral infections are a leading cause of morbidity and mortality worldwide [10], as is shown by both seasonal influenza, and the recent outbreak of coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [11].
T32 2656-2731 Sentence denotes Many people of all ages have single or multiple micronutrient deficiencies.
T33 2732-2866 Sentence denotes Supplementation of micronutrients may play an important role in enhancing the resistance to infections, restoring the immune function.
T34 2867-3057 Sentence denotes The main objective of this manuscript is to discuss our present knowledge of the efficacy of micronutrients in supporting immunity, particularly with respect to respiratory virus infections.
T35 3058-3250 Sentence denotes PubMed was used to search for all of the studies published up to April 2020 using keywords such as “Micronutrients” and “Immune system” and “Micronutrients” and “Respiratory viral infections”.
T36 3251-3341 Sentence denotes The search was limited to articles published in English that provided evidence-based data.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
32 864-880 Disease denotes viral infections MESH:D001102
33 1460-1469 Disease denotes infection MESH:D007239
45 2589-2636 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
46 2638-2648 Species denotes SARS-CoV-2 Tax:2697049
47 2494-2503 Species denotes influenza Tax:11309
48 1902-1912 Disease denotes infections MESH:D007239
49 2121-2142 Disease denotes metabolic dysfunction MESH:D008659
50 2161-2171 Disease denotes infections MESH:D007239
51 2275-2284 Disease denotes infection MESH:D007239
52 2385-2401 Disease denotes Viral infections MESH:D001102
53 2439-2448 Disease denotes mortality MESH:D003643
54 2532-2556 Disease denotes coronavirus disease 2019 MESH:C000657245
55 2558-2566 Disease denotes COVID-19 MESH:C000657245
61 2661-2667 Species denotes people Tax:9606
62 3220-3231 Species denotes Respiratory Tax:12814
63 2824-2834 Disease denotes infections MESH:D007239
64 3028-3056 Disease denotes respiratory virus infections
65 3232-3248 Disease denotes viral infections MESH:D001102