PMC:7574920 / 28733-29619 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T122","span":{"begin":80,"end":83},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T70","span":{"begin":320,"end":322},"obj":"Disease"}],"attributes":[{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0017178"}],"text":"Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T256","span":{"begin":60,"end":61},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T257","span":{"begin":72,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T258","span":{"begin":451,"end":452},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T259","span":{"begin":566,"end":567},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T260","span":{"begin":641,"end":642},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T65","span":{"begin":882,"end":884},"obj":"Chemical"}],"attributes":[{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T169","span":{"begin":8,"end":10},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T170","span":{"begin":146,"end":148},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T171","span":{"begin":296,"end":298},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T172","span":{"begin":351,"end":353},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T173","span":{"begin":525,"end":527},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T174","span":{"begin":802,"end":804},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T175","span":{"begin":851,"end":853},"obj":"http://purl.obolibrary.org/obo/GO_0001171"}],"text":"Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T209","span":{"begin":59,"end":232},"obj":"Sentence"},{"id":"T210","span":{"begin":233,"end":371},"obj":"Sentence"},{"id":"T211","span":{"begin":372,"end":644},"obj":"Sentence"},{"id":"T212","span":{"begin":645,"end":886},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3)."}