PMC:7574920 / 27234-30181 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7574920","sourcedb":"PMC","sourceid":"7574920","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7574920","text":"Testing clinical samples with the swab–to–RT-LAMP assay\nOn the basis of these preliminary experiments, we decided to use swab samples either directly without any treatment (direct swab–to–RT-LAMP assay) or after heat treatment for 5 min at 95°C (hot swab–to–RT-LAMP assay). As an additional precaution, we kept the samples in the cold (using an ice-cold metal block) whenever possible. For testing large numbers of clinical samples, we performed the RT-LAMP assay using several 96-well plates. In total, we tested 209 different samples using the hot swab–to–RT-LAMP assay, and of these, 131 samples also were tested by the direct swab–to–RT-LAMP assay. Many samples were tested twice but using aliquots withdrawn at different time points (usually within 24 hours) from the swab samples stored at 4°C. This resulted in 235 direct swab–to–RT-LAMP assay measurements and 343 hot swab–to–RT-LAMP assay measurements (Fig. 5A). The hot swab–to–RT-LAMP assay detected a color change in the majority of samples with a CT \u003c 30 with high sensitivity, whereas the direct swab–to–RT-LAMP assay only exhibited a high sensitivity for samples with a CT \u003c 25 (Fig. 5 and Table 3). The heat treatment rendered the RT-LAMP assay more stringent as it reduced false positives and more sensitive for samples with a CT of 25 to 30. We found that some positive samples did not induce a color change but did so when assayed a second time. We therefore would recommend running this assay using technical duplicates.\nFig. 5 Swab–to–RT-LAMP assay of clinical pharyngeal swab samples.\n(A) Skipping a prior RNA isolation step, pharyngeal swab samples were subjected to the RT-LAMP assay either directly (left) or after 5 min of heat treatment at 95°C (right). For each sample, scatter plots are used to compare the swab–to–RT-LAMP assay results (ΔOD values) with the results of RT-qPCR (CT values). The measurement time point was 30 min after the start of the 65°C incubation. (B) Shown is the sensitivity (right) and specificity (left) of the swab–to–RT-LAMP assay [derived from the data in (A)] using the decision threshold indicated by the horizontal gray line in (A). Specificity and sensitivity values (thick lines) are shown with their 95% confidence intervals (boxes) as in Fig. 3, with blue indicating the direct swab–to–RT-LAMP assay and red indicating the hot swab–to–RT-LAMP assay. (Also see table S3).\nTable 3 Shown is RT-qPCR and RT-LAMP testing of 592 clinical samples stratified into CT value bins (see Fig. 5A).\nFig. 5A and table S3 show specificity and sensitivity values calculated from these numbers.\nHot swab–to–RT-LAMP RT-LAMP\nCT Pos Neg Sum\nRT-qPCR Pos 0–25 38 4 42\n25–30 17 5 22\n30–35 5 23 28\n35–40 0 36 36\nNeg Neg 1 214 215\nSum 61 282 343\nDirect swab–to–RT-LAMP RT-LAMP\nCT Pos Neg Sum\nRT-qPCR Pos 0–25 15 1 16\n25–30 6 11 17\n30–35 2 21 23\n35–40 3 23 26\nNeg Neg 9 144 153\nSum 35 200 235","divisions":[{"label":"title","span":{"begin":0,"end":55}},{"label":"p","span":{"begin":56,"end":1490}},{"label":"figure","span":{"begin":1491,"end":2385}},{"label":"label","span":{"begin":1491,"end":1497}},{"label":"caption","span":{"begin":1499,"end":2385}},{"label":"title","span":{"begin":1499,"end":1557}},{"label":"p","span":{"begin":1558,"end":2385}},{"label":"label","span":{"begin":2386,"end":2393}},{"label":"caption","span":{"begin":2395,"end":2592}},{"label":"title","span":{"begin":2395,"end":2500}},{"label":"p","span":{"begin":2501,"end":2592}},{"label":"tr","span":{"begin":2593,"end":2623}},{"label":"td","span":{"begin":2593,"end":2613}},{"label":"td","span":{"begin":2615,"end":2623}},{"label":"tr","span":{"begin":2624,"end":2644}},{"label":"td","span":{"begin":2624,"end":2627}},{"label":"td","span":{"begin":2628,"end":2632}},{"label":"td","span":{"begin":2634,"end":2638}},{"label":"td","span":{"begin":2640,"end":2644}},{"label":"tr","span":{"begin":2645,"end":2676}},{"label":"td","span":{"begin":2645,"end":2653}},{"label":"td","span":{"begin":2654,"end":2658}},{"label":"td","span":{"begin":2660,"end":2665}},{"label":"td","span":{"begin":2667,"end":2669}},{"label":"td","span":{"begin":2671,"end":2672}},{"label":"td","span":{"begin":2674,"end":2676}},{"label":"tr","span":{"begin":2677,"end":2693}},{"label":"td","span":{"begin":2677,"end":2683}},{"label":"td","span":{"begin":2684,"end":2686}},{"label":"td","span":{"begin":2688,"end":2689}},{"label":"td","span":{"begin":2691,"end":2693}},{"label":"tr","span":{"begin":2694,"end":2710}},{"label":"td","span":{"begin":2694,"end":2700}},{"label":"td","span":{"begin":2701,"end":2702}},{"label":"td","span":{"begin":2704,"end":2706}},{"label":"td","span":{"begin":2708,"end":2710}},{"label":"tr","span":{"begin":2711,"end":2727}},{"label":"td","span":{"begin":2711,"end":2717}},{"label":"td","span":{"begin":2718,"end":2719}},{"label":"td","span":{"begin":2721,"end":2723}},{"label":"td","span":{"begin":2725,"end":2727}},{"label":"tr","span":{"begin":2728,"end":2750}},{"label":"td","span":{"begin":2728,"end":2732}},{"label":"td","span":{"begin":2733,"end":2737}},{"label":"td","span":{"begin":2739,"end":2740}},{"label":"td","span":{"begin":2742,"end":2745}},{"label":"td","span":{"begin":2747,"end":2750}},{"label":"tr","span":{"begin":2751,"end":2768}},{"label":"td","span":{"begin":2751,"end":2755}},{"label":"td","span":{"begin":2756,"end":2758}},{"label":"td","span":{"begin":2760,"end":2763}},{"label":"td","span":{"begin":2765,"end":2768}},{"label":"tr","span":{"begin":2769,"end":2802}},{"label":"td","span":{"begin":2769,"end":2792}},{"label":"td","span":{"begin":2794,"end":2802}},{"label":"tr","span":{"begin":2803,"end":2823}},{"label":"td","span":{"begin":2803,"end":2806}},{"label":"td","span":{"begin":2807,"end":2811}},{"label":"td","span":{"begin":2813,"end":2817}},{"label":"td","span":{"begin":2819,"end":2823}},{"label":"tr","span":{"begin":2824,"end":2855}},{"label":"td","span":{"begin":2824,"end":2832}},{"label":"td","span":{"begin":2833,"end":2837}},{"label":"td","span":{"begin":2839,"end":2844}},{"label":"td","span":{"begin":2846,"end":2848}},{"label":"td","span":{"begin":2850,"end":2851}},{"label":"td","span":{"begin":2853,"end":2855}},{"label":"tr","span":{"begin":2856,"end":2872}},{"label":"td","span":{"begin":2856,"end":2862}},{"label":"td","span":{"begin":2863,"end":2864}},{"label":"td","span":{"begin":2866,"end":2868}},{"label":"td","span":{"begin":2870,"end":2872}},{"label":"tr","span":{"begin":2873,"end":2889}},{"label":"td","span":{"begin":2873,"end":2879}},{"label":"td","span":{"begin":2880,"end":2881}},{"label":"td","span":{"begin":2883,"end":2885}},{"label":"td","span":{"begin":2887,"end":2889}},{"label":"tr","span":{"begin":2890,"end":2906}},{"label":"td","span":{"begin":2890,"end":2896}},{"label":"td","span":{"begin":2897,"end":2898}},{"label":"td","span":{"begin":2900,"end":2902}},{"label":"td","span":{"begin":2904,"end":2906}},{"label":"tr","span":{"begin":2907,"end":2929}},{"label":"td","span":{"begin":2907,"end":2911}},{"label":"td","span":{"begin":2912,"end":2916}},{"label":"td","span":{"begin":2918,"end":2919}},{"label":"td","span":{"begin":2921,"end":2924}},{"label":"td","span":{"begin":2926,"end":2929}},{"label":"td","span":{"begin":2930,"end":2934}},{"label":"td","span":{"begin":2935,"end":2937}},{"label":"td","span":{"begin":2939,"end":2942}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T122","span":{"begin":1579,"end":1582},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T70","span":{"begin":1819,"end":1821},"obj":"Disease"}],"attributes":[{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0017178"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T243","span":{"begin":0,"end":7},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T244","span":{"begin":390,"end":397},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T245","span":{"begin":507,"end":513},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T246","span":{"begin":609,"end":615},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T247","span":{"begin":671,"end":677},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T248","span":{"begin":796,"end":799},"obj":"http://purl.obolibrary.org/obo/CLO_0001387"},{"id":"T249","span":{"begin":961,"end":962},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T250","span":{"begin":1008,"end":1009},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T251","span":{"begin":1097,"end":1098},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T252","span":{"begin":1133,"end":1134},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T253","span":{"begin":1292,"end":1293},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T254","span":{"begin":1361,"end":1362},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T255","span":{"begin":1400,"end":1401},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T256","span":{"begin":1559,"end":1560},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T257","span":{"begin":1571,"end":1572},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T258","span":{"begin":1950,"end":1951},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T259","span":{"begin":2065,"end":2066},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T260","span":{"begin":2140,"end":2141},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T261","span":{"begin":2424,"end":2431},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T262","span":{"begin":2691,"end":2693},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T263","span":{"begin":2697,"end":2699},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T264","span":{"begin":2711,"end":2713},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T265","span":{"begin":2721,"end":2723},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T266","span":{"begin":2725,"end":2727},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T267","span":{"begin":2850,"end":2855},"obj":"http://purl.obolibrary.org/obo/CLO_0001046"},{"id":"T268","span":{"begin":2866,"end":2868},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T269","span":{"begin":2876,"end":2878},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T270","span":{"begin":2890,"end":2892},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T271","span":{"begin":2935,"end":2937},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"attributes":[{"subj":"T243","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T65","span":{"begin":2381,"end":2383},"obj":"Chemical"},{"id":"T66","span":{"begin":2519,"end":2521},"obj":"Chemical"}],"attributes":[{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T158","span":{"begin":42,"end":44},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T159","span":{"begin":188,"end":190},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T160","span":{"begin":258,"end":260},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T161","span":{"begin":450,"end":452},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T162","span":{"begin":558,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T163","span":{"begin":638,"end":640},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T164","span":{"begin":837,"end":839},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T165","span":{"begin":884,"end":886},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T166","span":{"begin":938,"end":940},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T167","span":{"begin":1068,"end":1070},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T168","span":{"begin":1197,"end":1199},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T169","span":{"begin":1507,"end":1509},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T170","span":{"begin":1645,"end":1647},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T171","span":{"begin":1795,"end":1797},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T172","span":{"begin":1850,"end":1852},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T173","span":{"begin":2024,"end":2026},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T174","span":{"begin":2301,"end":2303},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T175","span":{"begin":2350,"end":2352},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T176","span":{"begin":2404,"end":2406},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T177","span":{"begin":2416,"end":2418},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T178","span":{"begin":2605,"end":2607},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T179","span":{"begin":2616,"end":2618},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T180","span":{"begin":2645,"end":2647},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T181","span":{"begin":2784,"end":2786},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T182","span":{"begin":2795,"end":2797},"obj":"http://purl.obolibrary.org/obo/GO_0001171"},{"id":"T183","span":{"begin":2824,"end":2826},"obj":"http://purl.obolibrary.org/obo/GO_0001171"}],"attributes":[{"subj":"T158","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T173","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T175","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T176","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T178","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T179","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T180","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T181","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T182","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T183","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"T198","span":{"begin":56,"end":273},"obj":"Sentence"},{"id":"T199","span":{"begin":274,"end":385},"obj":"Sentence"},{"id":"T200","span":{"begin":386,"end":493},"obj":"Sentence"},{"id":"T201","span":{"begin":494,"end":652},"obj":"Sentence"},{"id":"T202","span":{"begin":653,"end":800},"obj":"Sentence"},{"id":"T203","span":{"begin":801,"end":921},"obj":"Sentence"},{"id":"T204","span":{"begin":922,"end":1164},"obj":"Sentence"},{"id":"T205","span":{"begin":1165,"end":1309},"obj":"Sentence"},{"id":"T206","span":{"begin":1310,"end":1414},"obj":"Sentence"},{"id":"T207","span":{"begin":1415,"end":1490},"obj":"Sentence"},{"id":"T208","span":{"begin":1491,"end":1557},"obj":"Sentence"},{"id":"T209","span":{"begin":1558,"end":1731},"obj":"Sentence"},{"id":"T210","span":{"begin":1732,"end":1870},"obj":"Sentence"},{"id":"T211","span":{"begin":1871,"end":2143},"obj":"Sentence"},{"id":"T212","span":{"begin":2144,"end":2385},"obj":"Sentence"},{"id":"T213","span":{"begin":2386,"end":2500},"obj":"Sentence"},{"id":"T214","span":{"begin":2501,"end":2592},"obj":"Sentence"},{"id":"T215","span":{"begin":2593,"end":2623},"obj":"Sentence"},{"id":"T216","span":{"begin":2624,"end":2644},"obj":"Sentence"},{"id":"T217","span":{"begin":2645,"end":2676},"obj":"Sentence"},{"id":"T218","span":{"begin":2677,"end":2693},"obj":"Sentence"},{"id":"T219","span":{"begin":2694,"end":2710},"obj":"Sentence"},{"id":"T220","span":{"begin":2711,"end":2727},"obj":"Sentence"},{"id":"T221","span":{"begin":2728,"end":2750},"obj":"Sentence"},{"id":"T222","span":{"begin":2751,"end":2768},"obj":"Sentence"},{"id":"T223","span":{"begin":2769,"end":2802},"obj":"Sentence"},{"id":"T224","span":{"begin":2803,"end":2823},"obj":"Sentence"},{"id":"T225","span":{"begin":2824,"end":2855},"obj":"Sentence"},{"id":"T226","span":{"begin":2856,"end":2872},"obj":"Sentence"},{"id":"T227","span":{"begin":2873,"end":2889},"obj":"Sentence"},{"id":"T228","span":{"begin":2890,"end":2906},"obj":"Sentence"},{"id":"T229","span":{"begin":2907,"end":2929},"obj":"Sentence"},{"id":"T230","span":{"begin":2930,"end":2947},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T197","pred":"source","obj":"LitCovid-sentences"},{"subj":"T198","pred":"source","obj":"LitCovid-sentences"},{"subj":"T199","pred":"source","obj":"LitCovid-sentences"},{"subj":"T200","pred":"source","obj":"LitCovid-sentences"},{"subj":"T201","pred":"source","obj":"LitCovid-sentences"},{"subj":"T202","pred":"source","obj":"LitCovid-sentences"},{"subj":"T203","pred":"source","obj":"LitCovid-sentences"},{"subj":"T204","pred":"source","obj":"LitCovid-sentences"},{"subj":"T205","pred":"source","obj":"LitCovid-sentences"},{"subj":"T206","pred":"source","obj":"LitCovid-sentences"},{"subj":"T207","pred":"source","obj":"LitCovid-sentences"},{"subj":"T208","pred":"source","obj":"LitCovid-sentences"},{"subj":"T209","pred":"source","obj":"LitCovid-sentences"},{"subj":"T210","pred":"source","obj":"LitCovid-sentences"},{"subj":"T211","pred":"source","obj":"LitCovid-sentences"},{"subj":"T212","pred":"source","obj":"LitCovid-sentences"},{"subj":"T213","pred":"source","obj":"LitCovid-sentences"},{"subj":"T214","pred":"source","obj":"LitCovid-sentences"},{"subj":"T215","pred":"source","obj":"LitCovid-sentences"},{"subj":"T216","pred":"source","obj":"LitCovid-sentences"},{"subj":"T217","pred":"source","obj":"LitCovid-sentences"},{"subj":"T218","pred":"source","obj":"LitCovid-sentences"},{"subj":"T219","pred":"source","obj":"LitCovid-sentences"},{"subj":"T220","pred":"source","obj":"LitCovid-sentences"},{"subj":"T221","pred":"source","obj":"LitCovid-sentences"},{"subj":"T222","pred":"source","obj":"LitCovid-sentences"},{"subj":"T223","pred":"source","obj":"LitCovid-sentences"},{"subj":"T224","pred":"source","obj":"LitCovid-sentences"},{"subj":"T225","pred":"source","obj":"LitCovid-sentences"},{"subj":"T226","pred":"source","obj":"LitCovid-sentences"},{"subj":"T227","pred":"source","obj":"LitCovid-sentences"},{"subj":"T228","pred":"source","obj":"LitCovid-sentences"},{"subj":"T229","pred":"source","obj":"LitCovid-sentences"},{"subj":"T230","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecdd","default":true},{"id":"LitCovid-PD-MONDO","color":"#ecc393"},{"id":"LitCovid-PD-CLO","color":"#a993ec"},{"id":"LitCovid-PD-CHEBI","color":"#97ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93b1"},{"id":"LitCovid-sentences","color":"#93cbec"}]}]}}