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PMC:7571312 / 84758-85937 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T609 551-552 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T610 700-701 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T611 720-722 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T612 1133-1135 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T613 1141-1143 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T614 1171-1176 http://purl.obolibrary.org/obo/CLO_0007706 denotes M – H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1402 34-37 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1403 68-74 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1405 75-81 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1406 82-87 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1407 88-96 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1408 98-111 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1409 115-122 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1411 125-131 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1413 132-141 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1414 132-134 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1415 135-141 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1416 144-155 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1418 246-249 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1419 280-286 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1421 287-293 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1422 294-299 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1423 322-332 Chemical denotes 2-oxoethyl http://purl.obolibrary.org/obo/CHEBI_46886
T1424 336-343 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1426 344-353 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1427 344-346 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1428 347-353 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1429 356-367 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1431 410-413 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1432 444-450 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1434 451-457 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1435 459-461 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T1436 463-482 Chemical denotes tert-butoxycarbonyl http://purl.obolibrary.org/obo/CHEBI_48502
T1437 484-486 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T1438 487-493 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1440 643-651 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1441 652-667 Chemical denotes dichloromethane http://purl.obolibrary.org/obo/CHEBI_15767
T1442 725-727 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1443 742-747 Chemical denotes CDCl3 http://purl.obolibrary.org/obo/CHEBI_85365
T1444 760-762 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1445 774-776 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1446 819-821 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1447 845-847 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1824 859-861 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1449 885-887 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1450 899-901 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1451 918-920 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1452 932-934 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1453 1050-1052 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1454 1095-1097 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1455 1109-1111 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1456 1133-1135 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T1457 1141-1143 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T498 0-155 Sentence denotes N-((1S)-1-{[((1S)-3-(Benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-N-methyl-1H-indole-2-carboxamide
T499 156-569 Sentence denotes Following the procedure described for the preparation of N-[(1S)-2-[((1S)-3-(benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]-4-methoxy-1H-indole-2-carboxamide but substituting N1-((1S)-3-(benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-N2-(tert-butoxycarbonyl)-N2-methyl-l-leucinamide and making noncritical variations provided a crude brown oil.
T500 570-724 Sentence denotes This material was purified by Biotage flash chromatography, eluting with methanol/dichloromethane to afford the title compound as a clear oil, 67 mg, 48%.
T501 725-1179 Sentence denotes 1H NMR (400 MHz, CDCl3) δ 9.83 (s, 1H), 7.95 (s, 1H), 7.26–7.36 (m, 5H), 7.18 (t, J = 8.0 Hz, 1H), 7.04 (d, J = 8.3 Hz, 1H), 7.00 (s, 1H), 6.48 (d, J = 7.8 Hz, 1H), 5.87 (s, 1H), 5.18–5.27 (m, 1H), 4.70 (s, 1H), 4.50–4.63 (m, 2H), 4.16–4.36 (m, 2H), 3.93 (s, 3H), 3.32 (s, 3H), 3.03–3.18 (m, 2H), 2.22 (s, 2H), 1.91–2.02 (m, 1H), 1.81 (t, J = 7.3 Hz, 3H), 1.66–1.72 (m, 1H), 1.55 (s, 1H), 0.87–1.01 (m, 6H); MS (API-ES−) for C32H40N4O6m/z 576.7 (M – H)−.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1696 643-651 Chemical denotes methanol MESH:D000432
1697 652-667 Chemical denotes dichloromethane MESH:D008752