PMC:7571312 / 29939-30356 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T63","span":{"begin":215,"end":222},"obj":"Body_part"}],"attributes":[{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T73","span":{"begin":109,"end":113},"obj":"Disease"},{"id":"T74","span":{"begin":324,"end":328},"obj":"Disease"}],"attributes":[{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T289","span":{"begin":76,"end":77},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T535","span":{"begin":11,"end":13},"obj":"Chemical"},{"id":"T536","span":{"begin":215,"end":222},"obj":"Chemical"}],"attributes":[{"id":"A535","pred":"chebi_id","subj":"T535","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"},{"id":"A536","pred":"chebi_id","subj":"T536","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides."}

{"project":"LitCovid-sentences","denotations":[{"id":"T189","span":{"begin":0,"end":417},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides."}

{"project":"LitCovid-PubTator","denotations":[{"id":"719","span":{"begin":109,"end":119},"obj":"Species"},{"id":"720","span":{"begin":324,"end":334},"obj":"Species"},{"id":"746","span":{"begin":140,"end":152},"obj":"Chemical"},{"id":"747","span":{"begin":406,"end":416},"obj":"Chemical"}],"attributes":[{"id":"A719","pred":"tao:has_database_id","subj":"719","obj":"Tax:2697049"},{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides."}