PMC:7571312 / 29939-30356
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T63 | 215-222 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T73 | 109-113 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T74 | 324-328 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T289 | 76-77 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T535 | 11-13 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
| T536 | 215-222 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T189 | 0-417 | Sentence | denotes | The closed S3 is the only significant conformational difference compared to a recently reported structure of SARS CoV-2 3CLpro inhibited by α-ketoamides.8 The energetics of this extended interaction, the associated protein conformation stabilities, or warhead difference may contribute to the 3-order-of-magnitude increased SARS CoV-2 3CLpro potency of HMK 4 (see below) compared to that of the referenced ketoamides. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 719 | 109-119 | Species | denotes | SARS CoV-2 | Tax:2697049 |
| 720 | 324-334 | Species | denotes | SARS CoV-2 | Tax:2697049 |
| 746 | 140-152 | Chemical | denotes | α-ketoamides | |
| 747 | 406-416 | Chemical | denotes | ketoamides |