PMC:7571312 / 14269-21126 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7571312","sourcedb":"PMC","sourceid":"7571312","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7571312","text":"Irreversible Inhibitors of SARS CoV-1 3CLpro\nThe warhead reactivity and binding affinity to P1′ are both important design considerations to ensure specificity of irreversible inhibitors. Krantz has demonstrated that the inherent chemical reactivity of acyloxymethylketones can be tuned to inhibit cysteine proteases through the modulation of substituent effects on the carboxylate leaving group.37 The importance of leaving group “strength” was confirmed by the strong dependence between the pKa of the leaving carboxylate and cathepsin B enzyme inhibition. These otherwise weak electrophiles are elegant “quiescent” inhibitors that harness the very same interactions with catalytic residues that lead to proteolysis rate acceleration. Molecular modeling of a 2,6-dichlorobenzoate design with SARS CoV-1 3CLpro indicated that a low strain conformation of the ketone carbonyl was aligned in the oxyanion hole and the substituted benzoate is accommodated within the P1′ site. A series of acyloxymethylketone derivatives were prepared, as depicted in Table 1.\nTable 1 SARS CoV-1 3CLpro Inhibition Data for Acyloxymethylketone Inhibitors\n    SARS CoV-1 3CLpro FRETa\nentry R kobs/I (M–1 s–1) IC50 (nM)\n12   283,039 ± 22,586  \n13 Me   220 ± 0.5\n14 cyc-propyl   182 ± 6\n15 tert-butyl   230 ± 5\n16 Ph   86 ± 3\n17 4-OMe-Ph   79 ± 3\n18 4-Me-Ph   87 ± 2\n19 4-CN-Ph   53 ± 1\n20 4-F-Ph   82 ± 3\n21 4-Cl-Ph   97 ± 3\n22 2,6-(Cl)2-Ph 62,993 ± 2,501  \n23 2,6-(F)2-Ph 12,776 ± 594  \n24 2-OH-4-Cl-Ph 11,525 ± 40  \n25 2-F, 4-CN-Ph 13,321 ± 2,309  \n26 2,6-(Me)2-Ph   74 ± 4\n27 2,6-(MeO)2-Ph   205 ± 2\n28 2-CN-Ph   17 ± 2\na See the Experimental Section for details on assay methods; the values were calculated from at least eight data points with at least two independent determinations. As expected, chloromethylketone 12 is a potent irreversible inhibitor of SARS CoV-1 3CLpro. Compounds 22–25 possess the most electron-deficient benzoate leaving groups and display kinetics consistent with irreversible inhibition. The remaining entries appear to be reversible inhibitors in the time scale of the assay, with 28 possessing the most potent IC50. A crystal structure (PDB code 6XHN)38 of 28 in complex with SARS CoV-1 3CLpro at 2.25 Å shows a covalent adduct, which demonstrates the bimodal activity of certain acyloxy inhibitors (Figure 4). In this structure, the electron density for the 2-cyanobenzoate moiety is absent and the 3CLpro active-site cysteine (Cys145) sulfur forms a covalent bond to the methylene carbon (1.8 Å C–S bond length). The ketone carbonyl is positioned within the oxyanion hole and as such engaging in hydrogen bonds with backbone NH groups of Gly143 and Cys145. A detailed analysis of an extended hydrogen bond network from catalytic His41 reveals that the side-chain imidazole serves as a hydrogen bond donor to the interior of the protease. Specifically, the imidazole hydrogen is directed toward a lone pair electron acceptor from a structural water. We can conclude that this water must be an acceptor to His41 as one of the water hydrogens is engaged with acceptor electrons on the side chain of Asp187, and the second hydrogen engages a terminating acceptor backbone carbonyl on Asp176 through a short network that includes the side chains of an internal, neutral His164 and Thr175.\nFigure 4 Cocrystal structure of the covalent adduct of 28 bound to SARS CoV-1 3CLpro (PDB code 6XHN). The Connolly surface for the inhibitor binding pocket is shown in gray. The bonds are represented as dashed lines, with the bond length between heavy atoms depicted. The 2,6-dichlorobenzoate derivative 22 displays the highest levels of potency in the SARS CoV-1 3CLpro and in antiviral cytopathic effect assays in Vero 76 cells (EC50 = 0.29 ± 0.19 μM).39 We note here that the assay in Vero 76 cells provided data establishing antiviral activity, but the translation of potency measured in Vero cells, which have high efflux potential, to the potency achievable in human lung cells was unknown (vide infra). As expected, 22 possesses low levels of reactivity toward endogenous nucleophiles such as glutathione (t1/2 \u003e 60 min)40 and exhibits high levels of stability in human plasma (t1/2 \u003e 240 min).41 Although 22 displays a promising activity profile, it possesses very poor solubility in clinically relevant IV vehicle formulations, thus limiting its development as an IV clinical agent.\nTo improve the solubility characteristics of inhibitors incorporating the lipophilic 2,6-dichlorobenzoate, a limited set of inhibitors containing smaller or more polar amine capping fragments were prepared (Table 2). Replacement of the 4-methoxy indole cap present in 22 with a benzimidazole provided 31. This inhibitor displayed potent irreversible inhibition kinetics but did not improve solubility compared to 22. Reduction in the size of the P2 capping element as represented by 29 and 30 provided derivatives that possessed weak reversible SARS CoV-1 3CLpro inhibition.\nTable 2 SARS CoV-1 3CLpro Inhibition Data for P3-Modified Acyloxymethylketone Inhibitors\na See the Experimental Section for details on assay methods; the values were calculated from at least eight data points with at least two independent determinations. Another design to replace the 4-methoxy indole was the (2R)-tetrahydrofuran-2-carboxylate, which molecular modeling suggested could make additional favorable protein interactions with a Gln189 side chain and led to the preparation of 3. Initially, this derivative appeared to display reversible binding kinetics. However, further kinetic studies of compound 3 with the SARS CoV-1 3CLpro protein demonstrated irreversible time-dependent inactivation of this enzyme (kobs/I = 5834 ± 151 M–1 s–1). Additionally, 3 possessed potent antiviral activity in Vero cells (EC50 = 2.4 μM) and solubility in vehicle formulations almost 20-fold higher than 22. Evaluation of the pharmacokinetic profile of 3 in rat suggested that this inhibitor possessed properties potentially sufficient for an IV continuous infusion dosing paradigm.42\nAlthough irreversible inhibition can provide an extended pharmacodynamic effect when protein resynthesis rate is slow compared to drug clearance, such extended effects for 3CLpro inhibition were not necessarily expected. The 3CLpro-mediated proteolysis of newly expressed viral polyproteins is essential to virus replication; however, this activity only occurs during a single step in the virus life cycle that closely follows each cell infection. Viral particles themselves are not reliant on 3CLpro activity nor are the remaining coronavirus life cycle steps. Each event of cell infection initiates newly synthesized 3CLpro. Because detailed kinetics of this process are not understood, reversible and irreversible inhibitors were investigated equally.","divisions":[{"label":"title","span":{"begin":0,"end":44}},{"label":"p","span":{"begin":45,"end":1056}},{"label":"table-wrap","span":{"begin":1057,"end":1823}},{"label":"label","span":{"begin":1057,"end":1064}},{"label":"caption","span":{"begin":1066,"end":1134}},{"label":"title","span":{"begin":1066,"end":1134}},{"label":"table","span":{"begin":1135,"end":1656}},{"label":"tr","span":{"begin":1135,"end":1164}},{"label":"th","span":{"begin":1135,"end":1136}},{"label":"th","span":{"begin":1138,"end":1139}},{"label":"th","span":{"begin":1141,"end":1164}},{"label":"tr","span":{"begin":1165,"end":1202}},{"label":"th","span":{"begin":1165,"end":1170}},{"label":"th","span":{"begin":1172,"end":1173}},{"label":"th","span":{"begin":1175,"end":1191}},{"label":"th","span":{"begin":1193,"end":1202}},{"label":"tr","span":{"begin":1203,"end":1229}},{"label":"td","span":{"begin":1203,"end":1206}},{"label":"td","span":{"begin":1207,"end":1208}},{"label":"td","span":{"begin":1210,"end":1226}},{"label":"td","span":{"begin":1228,"end":1229}},{"label":"tr","span":{"begin":1230,"end":1250}},{"label":"td","span":{"begin":1230,"end":1233}},{"label":"td","span":{"begin":1234,"end":1236}},{"label":"td","span":{"begin":1238,"end":1239}},{"label":"td","span":{"begin":1241,"end":1250}},{"label":"tr","span":{"begin":1251,"end":1277}},{"label":"td","span":{"begin":1251,"end":1254}},{"label":"td","span":{"begin":1255,"end":1265}},{"label":"td","span":{"begin":1267,"end":1268}},{"label":"td","span":{"begin":1270,"end":1277}},{"label":"tr","span":{"begin":1278,"end":1304}},{"label":"td","span":{"begin":1278,"end":1281}},{"label":"td","span":{"begin":1282,"end":1292}},{"label":"td","span":{"begin":1294,"end":1295}},{"label":"td","span":{"begin":1297,"end":1304}},{"label":"tr","span":{"begin":1305,"end":1322}},{"label":"td","span":{"begin":1305,"end":1308}},{"label":"td","span":{"begin":1309,"end":1311}},{"label":"td","span":{"begin":1313,"end":1314}},{"label":"td","span":{"begin":1316,"end":1322}},{"label":"tr","span":{"begin":1323,"end":1346}},{"label":"td","span":{"begin":1323,"end":1326}},{"label":"td","span":{"begin":1327,"end":1335}},{"label":"td","span":{"begin":1337,"end":1338}},{"label":"td","span":{"begin":1340,"end":1346}},{"label":"tr","span":{"begin":1347,"end":1369}},{"label":"td","span":{"begin":1347,"end":1350}},{"label":"td","span":{"begin":1351,"end":1358}},{"label":"td","span":{"begin":1360,"end":1361}},{"label":"td","span":{"begin":1363,"end":1369}},{"label":"tr","span":{"begin":1370,"end":1392}},{"label":"td","span":{"begin":1370,"end":1373}},{"label":"td","span":{"begin":1374,"end":1381}},{"label":"td","span":{"begin":1383,"end":1384}},{"label":"td","span":{"begin":1386,"end":1392}},{"label":"tr","span":{"begin":1393,"end":1414}},{"label":"td","span":{"begin":1393,"end":1396}},{"label":"td","span":{"begin":1397,"end":1403}},{"label":"td","span":{"begin":1405,"end":1406}},{"label":"td","span":{"begin":1408,"end":1414}},{"label":"tr","span":{"begin":1415,"end":1437}},{"label":"td","span":{"begin":1415,"end":1418}},{"label":"td","span":{"begin":1419,"end":1426}},{"label":"td","span":{"begin":1428,"end":1429}},{"label":"td","span":{"begin":1431,"end":1437}},{"label":"tr","span":{"begin":1438,"end":1473}},{"label":"td","span":{"begin":1438,"end":1441}},{"label":"td","span":{"begin":1442,"end":1454}},{"label":"td","span":{"begin":1456,"end":1470}},{"label":"td","span":{"begin":1472,"end":1473}},{"label":"tr","span":{"begin":1474,"end":1506}},{"label":"td","span":{"begin":1474,"end":1477}},{"label":"td","span":{"begin":1478,"end":1489}},{"label":"td","span":{"begin":1491,"end":1503}},{"label":"td","span":{"begin":1505,"end":1506}},{"label":"tr","span":{"begin":1507,"end":1539}},{"label":"td","span":{"begin":1507,"end":1510}},{"label":"td","span":{"begin":1511,"end":1523}},{"label":"td","span":{"begin":1525,"end":1536}},{"label":"td","span":{"begin":1538,"end":1539}},{"label":"tr","span":{"begin":1540,"end":1575}},{"label":"td","span":{"begin":1540,"end":1543}},{"label":"td","span":{"begin":1544,"end":1556}},{"label":"td","span":{"begin":1558,"end":1572}},{"label":"td","span":{"begin":1574,"end":1575}},{"label":"tr","span":{"begin":1576,"end":1603}},{"label":"td","span":{"begin":1576,"end":1579}},{"label":"td","span":{"begin":1580,"end":1592}},{"label":"td","span":{"begin":1594,"end":1595}},{"label":"td","span":{"begin":1597,"end":1603}},{"label":"tr","span":{"begin":1604,"end":1633}},{"label":"td","span":{"begin":1604,"end":1607}},{"label":"td","span":{"begin":1608,"end":1621}},{"label":"td","span":{"begin":1623,"end":1624}},{"label":"td","span":{"begin":1626,"end":1633}},{"label":"tr","span":{"begin":1634,"end":1656}},{"label":"td","span":{"begin":1634,"end":1637}},{"label":"td","span":{"begin":1638,"end":1645}},{"label":"td","span":{"begin":1647,"end":1648}},{"label":"td","span":{"begin":1650,"end":1656}},{"label":"table-wrap-foot","span":{"begin":1657,"end":1823}},{"label":"footnote","span":{"begin":1657,"end":1823}},{"label":"label","span":{"begin":1657,"end":1658}},{"label":"p","span":{"begin":1660,"end":1823}},{"label":"p","span":{"begin":1824,"end":3353}},{"label":"figure","span":{"begin":3354,"end":3622}},{"label":"label","span":{"begin":3354,"end":3362}},{"label":"caption","span":{"begin":3364,"end":3622}},{"label":"p","span":{"begin":3364,"end":3622}},{"label":"p","span":{"begin":3623,"end":4446}},{"label":"p","span":{"begin":4447,"end":5021}},{"label":"table-wrap","span":{"begin":5022,"end":5278}},{"label":"label","span":{"begin":5022,"end":5029}},{"label":"caption","span":{"begin":5031,"end":5111}},{"label":"title","span":{"begin":5031,"end":5111}},{"label":"table-wrap-foot","span":{"begin":5112,"end":5278}},{"label":"footnote","span":{"begin":5112,"end":5278}},{"label":"label","span":{"begin":5112,"end":5113}},{"label":"p","span":{"begin":5115,"end":5278}},{"label":"p","span":{"begin":5279,"end":6102}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T49380","span":{"begin":297,"end":305},"obj":"Body_part"},{"id":"T87686","span":{"begin":2487,"end":2495},"obj":"Body_part"},{"id":"T47943","span":{"begin":2565,"end":2568},"obj":"Body_part"},{"id":"T89780","span":{"begin":2686,"end":2694},"obj":"Body_part"},{"id":"T71020","span":{"begin":3229,"end":3237},"obj":"Body_part"},{"id":"T29395","span":{"begin":3779,"end":3784},"obj":"Body_part"},{"id":"T77718","span":{"begin":3851,"end":3856},"obj":"Body_part"},{"id":"T39660","span":{"begin":3952,"end":3957},"obj":"Body_part"},{"id":"T54465","span":{"begin":4028,"end":4032},"obj":"Body_part"},{"id":"T44584","span":{"begin":4033,"end":4038},"obj":"Body_part"},{"id":"T80152","span":{"begin":4232,"end":4238},"obj":"Body_part"},{"id":"T12289","span":{"begin":5437,"end":5444},"obj":"Body_part"},{"id":"T15026","span":{"begin":5666,"end":5673},"obj":"Body_part"},{"id":"T44316","span":{"begin":5834,"end":5839},"obj":"Body_part"},{"id":"T16632","span":{"begin":6188,"end":6195},"obj":"Body_part"},{"id":"T93878","span":{"begin":6535,"end":6539},"obj":"Body_part"},{"id":"T88519","span":{"begin":6679,"end":6683},"obj":"Body_part"}],"attributes":[{"id":"A56883","pred":"fma_id","subj":"T49380","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A44223","pred":"fma_id","subj":"T87686","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A96537","pred":"fma_id","subj":"T47943","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A4534","pred":"fma_id","subj":"T89780","obj":"http://purl.org/sig/ont/fma/fma13478"},{"id":"A7931","pred":"fma_id","subj":"T71020","obj":"http://purl.org/sig/ont/fma/fma13478"},{"id":"A90816","pred":"fma_id","subj":"T29395","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A27107","pred":"fma_id","subj":"T77718","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A30244","pred":"fma_id","subj":"T39660","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A93544","pred":"fma_id","subj":"T54465","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A89775","pred":"fma_id","subj":"T44584","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A75513","pred":"fma_id","subj":"T80152","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A87633","pred":"fma_id","subj":"T12289","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A83326","pred":"fma_id","subj":"T15026","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A30322","pred":"fma_id","subj":"T44316","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A91543","pred":"fma_id","subj":"T16632","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A52903","pred":"fma_id","subj":"T93878","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A47703","pred":"fma_id","subj":"T88519","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T49380","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T87686","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T47943","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T89780","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T71020","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29395","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T77718","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39660","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T54465","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T44584","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T80152","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12289","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15026","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T44316","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16632","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T93878","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T88519","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":2123,"end":2128},"obj":"Body_part"},{"id":"T3","span":{"begin":4028,"end":4032},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T49","span":{"begin":27,"end":31},"obj":"Disease"},{"id":"T50","span":{"begin":793,"end":797},"obj":"Disease"},{"id":"T51","span":{"begin":1066,"end":1070},"obj":"Disease"},{"id":"T52","span":{"begin":1141,"end":1145},"obj":"Disease"},{"id":"T53","span":{"begin":1897,"end":1901},"obj":"Disease"},{"id":"T54","span":{"begin":2244,"end":2248},"obj":"Disease"},{"id":"T55","span":{"begin":3422,"end":3426},"obj":"Disease"},{"id":"T56","span":{"begin":3708,"end":3712},"obj":"Disease"},{"id":"T57","span":{"begin":4992,"end":4996},"obj":"Disease"},{"id":"T58","span":{"begin":5031,"end":5035},"obj":"Disease"},{"id":"T59","span":{"begin":5648,"end":5652},"obj":"Disease"},{"id":"T60","span":{"begin":6540,"end":6549},"obj":"Disease"},{"id":"T61","span":{"begin":6684,"end":6693},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T28229","span":{"begin":92,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0008285"},{"id":"T30736","span":{"begin":194,"end":197},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T42783","span":{"begin":537,"end":538},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T59953","span":{"begin":758,"end":759},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T67520","span":{"begin":826,"end":827},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T69080","span":{"begin":964,"end":966},"obj":"http://purl.obolibrary.org/obo/CLO_0008285"},{"id":"T29047","span":{"begin":974,"end":975},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T27082","span":{"begin":1183,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0007437"},{"id":"T89112","span":{"begin":1183,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T44311","span":{"begin":1183,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0007449"},{"id":"T11842","span":{"begin":1183,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T68824","span":{"begin":1183,"end":1186},"obj":"http://purl.obolibrary.org/obo/CLO_0052399"},{"id":"T53118","span":{"begin":1187,"end":1190},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T18679","span":{"begin":1234,"end":1236},"obj":"http://purl.obolibrary.org/obo/CLO_0007653"},{"id":"T64538","span":{"begin":1347,"end":1349},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T67844","span":{"begin":1353,"end":1355},"obj":"http://purl.obolibrary.org/obo/CLO_0007653"},{"id":"T54087","span":{"begin":1421,"end":1423},"obj":"http://purl.obolibrary.org/obo/CLO_0052906"},{"id":"T91151","span":{"begin":1438,"end":1440},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T73065","span":{"begin":1446,"end":1451},"obj":"http://purl.obolibrary.org/obo/CLO_0002488"},{"id":"T12274","span":{"begin":1482,"end":1486},"obj":"http://purl.obolibrary.org/obo/CLO_0002972"},{"id":"T81297","span":{"begin":1518,"end":1520},"obj":"http://purl.obolibrary.org/obo/CLO_0052906"},{"id":"T26335","span":{"begin":1585,"end":1587},"obj":"http://purl.obolibrary.org/obo/CLO_0007653"},{"id":"T57513","span":{"begin":1604,"end":1606},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T77214","span":{"begin":1657,"end":1658},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T43067","span":{"begin":1862,"end":1863},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T17773","span":{"begin":1926,"end":1928},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T88669","span":{"begin":2184,"end":2185},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51542","span":{"begin":2270,"end":2271},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T17790","span":{"begin":2278,"end":2279},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T86458","span":{"begin":2328,"end":2336},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T80470","span":{"begin":2475,"end":2481},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T34478","span":{"begin":2518,"end":2519},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T81268","span":{"begin":2563,"end":2564},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15335","span":{"begin":2727,"end":2728},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T62436","span":{"begin":2853,"end":2854},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T40750","span":{"begin":2964,"end":2965},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8354","span":{"begin":2999,"end":3000},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T75567","span":{"begin":3206,"end":3207},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T94234","span":{"begin":3265,"end":3266},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T35747","span":{"begin":3659,"end":3661},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T36376","span":{"begin":3771,"end":3778},"obj":"http://purl.obolibrary.org/obo/CLO_0009526"},{"id":"T60100","span":{"begin":3779,"end":3784},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T41307","span":{"begin":3843,"end":3850},"obj":"http://purl.obolibrary.org/obo/CLO_0009526"},{"id":"T44344","span":{"begin":3851,"end":3856},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T95747","span":{"begin":3894,"end":3902},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T41737","span":{"begin":3947,"end":3951},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T58120","span":{"begin":3947,"end":3951},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T23029","span":{"begin":3952,"end":3957},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T96607","span":{"begin":4022,"end":4027},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T31340","span":{"begin":4028,"end":4032},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T79444","span":{"begin":4028,"end":4032},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T79987","span":{"begin":4033,"end":4038},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T84247","span":{"begin":4078,"end":4080},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T92769","span":{"begin":4226,"end":4231},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T56673","span":{"begin":4232,"end":4238},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T32052","span":{"begin":4256,"end":4258},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T59638","span":{"begin":4268,"end":4270},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T18074","span":{"begin":4280,"end":4281},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T19548","span":{"begin":4292,"end":4300},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T94580","span":{"begin":4554,"end":4555},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9015","span":{"begin":4715,"end":4717},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T67341","span":{"begin":4723,"end":4724},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T16805","span":{"begin":4860,"end":4862},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T11594","span":{"begin":4893,"end":4895},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T58796","span":{"begin":5112,"end":5113},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T39597","span":{"begin":5463,"end":5464},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T24511","span":{"begin":5764,"end":5767},"obj":"http://purl.obolibrary.org/obo/CLO_0007437"},{"id":"T12434","span":{"begin":5764,"end":5767},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T28200","span":{"begin":5764,"end":5767},"obj":"http://purl.obolibrary.org/obo/CLO_0007449"},{"id":"T54715","span":{"begin":5764,"end":5767},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T71311","span":{"begin":5764,"end":5767},"obj":"http://purl.obolibrary.org/obo/CLO_0052399"},{"id":"T97946","span":{"begin":5768,"end":5771},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T96800","span":{"begin":5817,"end":5825},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T32450","span":{"begin":5829,"end":5833},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T14088","span":{"begin":5829,"end":5833},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T54297","span":{"begin":5834,"end":5839},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T91837","span":{"begin":5922,"end":5924},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T99824","span":{"begin":6410,"end":6415},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T45488","span":{"begin":6443,"end":6451},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T66631","span":{"begin":6471,"end":6472},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29691","span":{"begin":6492,"end":6497},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T82549","span":{"begin":6535,"end":6539},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T68545","span":{"begin":6604,"end":6612},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T85347","span":{"begin":6679,"end":6683},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T28229","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30736","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T42783","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59953","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67520","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69080","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29047","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27082","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44311","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11842","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68824","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53118","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18679","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64538","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67844","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54087","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91151","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T73065","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12274","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T81297","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26335","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57513","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T77214","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T43067","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17773","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88669","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T51542","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17790","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86458","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T80470","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T34478","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T81268","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15335","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62436","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40750","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8354","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T75567","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T94234","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T35747","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36376","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60100","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41307","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44344","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T95747","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41737","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58120","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23029","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T96607","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31340","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T79444","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T79987","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T84247","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92769","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56673","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32052","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59638","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18074","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19548","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T94580","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9015","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67341","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16805","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11594","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58796","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39597","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24511","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12434","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28200","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54715","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71311","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T97946","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T96800","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32450","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14088","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54297","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91837","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T99824","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T45488","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66631","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29691","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T82549","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68545","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85347","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T234","span":{"begin":92,"end":94},"obj":"Chemical"},{"id":"T235","span":{"begin":175,"end":185},"obj":"Chemical"},{"id":"T236","span":{"begin":297,"end":305},"obj":"Chemical"},{"id":"T237","span":{"begin":389,"end":394},"obj":"Chemical"},{"id":"T238","span":{"begin":424,"end":429},"obj":"Chemical"},{"id":"T239","span":{"begin":579,"end":592},"obj":"Chemical"},{"id":"T240","span":{"begin":617,"end":627},"obj":"Chemical"},{"id":"T241","span":{"begin":760,"end":780},"obj":"Chemical"},{"id":"T242","span":{"begin":859,"end":865},"obj":"Chemical"},{"id":"T243","span":{"begin":866,"end":874},"obj":"Chemical"},{"id":"T244","span":{"begin":928,"end":936},"obj":"Chemical"},{"id":"T245","span":{"begin":964,"end":966},"obj":"Chemical"},{"id":"T246","span":{"begin":1259,"end":1265},"obj":"Chemical"},{"id":"T247","span":{"begin":1282,"end":1292},"obj":"Chemical"},{"id":"T248","span":{"begin":1287,"end":1292},"obj":"Chemical"},{"id":"T249","span":{"begin":1309,"end":1311},"obj":"Chemical"},{"id":"T250","span":{"begin":1333,"end":1335},"obj":"Chemical"},{"id":"T251","span":{"begin":1356,"end":1358},"obj":"Chemical"},{"id":"T252","span":{"begin":1379,"end":1381},"obj":"Chemical"},{"id":"T253","span":{"begin":1401,"end":1403},"obj":"Chemical"},{"id":"T254","span":{"begin":1421,"end":1423},"obj":"Chemical"},{"id":"T255","span":{"begin":1424,"end":1426},"obj":"Chemical"},{"id":"T256","span":{"begin":1447,"end":1449},"obj":"Chemical"},{"id":"T257","span":{"begin":1452,"end":1454},"obj":"Chemical"},{"id":"T258","span":{"begin":1487,"end":1489},"obj":"Chemical"},{"id":"T259","span":{"begin":1518,"end":1520},"obj":"Chemical"},{"id":"T260","span":{"begin":1521,"end":1523},"obj":"Chemical"},{"id":"T261","span":{"begin":1554,"end":1556},"obj":"Chemical"},{"id":"T262","span":{"begin":1590,"end":1592},"obj":"Chemical"},{"id":"T263","span":{"begin":1619,"end":1621},"obj":"Chemical"},{"id":"T264","span":{"begin":1643,"end":1645},"obj":"Chemical"},{"id":"T265","span":{"begin":1884,"end":1893},"obj":"Chemical"},{"id":"T266","span":{"begin":1949,"end":1957},"obj":"Chemical"},{"id":"T267","span":{"begin":1968,"end":1976},"obj":"Chemical"},{"id":"T268","span":{"begin":2100,"end":2110},"obj":"Chemical"},{"id":"T269","span":{"begin":2356,"end":2366},"obj":"Chemical"},{"id":"T270","span":{"begin":2402,"end":2410},"obj":"Chemical"},{"id":"T271","span":{"begin":2487,"end":2495},"obj":"Chemical"},{"id":"T272","span":{"begin":2505,"end":2511},"obj":"Chemical"},{"id":"T273","span":{"begin":2541,"end":2550},"obj":"Chemical"},{"id":"T276","span":{"begin":2551,"end":2557},"obj":"Chemical"},{"id":"T278","span":{"begin":2587,"end":2593},"obj":"Chemical"},{"id":"T279","span":{"begin":2594,"end":2602},"obj":"Chemical"},{"id":"T280","span":{"begin":2666,"end":2674},"obj":"Chemical"},{"id":"T281","span":{"begin":2695,"end":2697},"obj":"Chemical"},{"id":"T283","span":{"begin":2762,"end":2770},"obj":"Chemical"},{"id":"T284","span":{"begin":2833,"end":2842},"obj":"Chemical"},{"id":"T286","span":{"begin":2855,"end":2863},"obj":"Chemical"},{"id":"T287","span":{"begin":2869,"end":2874},"obj":"Chemical"},{"id":"T288","span":{"begin":2926,"end":2935},"obj":"Chemical"},{"id":"T290","span":{"begin":2936,"end":2944},"obj":"Chemical"},{"id":"T291","span":{"begin":2976,"end":2993},"obj":"Chemical"},{"id":"T293","span":{"begin":2976,"end":2984},"obj":"Chemical"},{"id":"T294","span":{"begin":2985,"end":2993},"obj":"Chemical"},{"id":"T295","span":{"begin":3012,"end":3017},"obj":"Chemical"},{"id":"T296","span":{"begin":3045,"end":3050},"obj":"Chemical"},{"id":"T297","span":{"begin":3062,"end":3070},"obj":"Chemical"},{"id":"T298","span":{"begin":3094,"end":3099},"obj":"Chemical"},{"id":"T299","span":{"begin":3126,"end":3134},"obj":"Chemical"},{"id":"T300","span":{"begin":3189,"end":3197},"obj":"Chemical"},{"id":"T301","span":{"begin":3220,"end":3228},"obj":"Chemical"},{"id":"T302","span":{"begin":3238,"end":3246},"obj":"Chemical"},{"id":"T303","span":{"begin":3486,"end":3495},"obj":"Chemical"},{"id":"T304","span":{"begin":3607,"end":3612},"obj":"Chemical"},{"id":"T305","span":{"begin":3627,"end":3647},"obj":"Chemical"},{"id":"T306","span":{"begin":3733,"end":3742},"obj":"Chemical"},{"id":"T307","span":{"begin":3884,"end":3893},"obj":"Chemical"},{"id":"T308","span":{"begin":4134,"end":4146},"obj":"Chemical"},{"id":"T309","span":{"begin":4155,"end":4166},"obj":"Chemical"},{"id":"T311","span":{"begin":4367,"end":4369},"obj":"Chemical"},{"id":"T312","span":{"begin":4428,"end":4430},"obj":"Chemical"},{"id":"T313","span":{"begin":4492,"end":4502},"obj":"Chemical"},{"id":"T314","span":{"begin":4532,"end":4552},"obj":"Chemical"},{"id":"T315","span":{"begin":4571,"end":4581},"obj":"Chemical"},{"id":"T316","span":{"begin":4615,"end":4620},"obj":"Chemical"},{"id":"T317","span":{"begin":4685,"end":4692},"obj":"Chemical"},{"id":"T319","span":{"begin":4693,"end":4699},"obj":"Chemical"},{"id":"T321","span":{"begin":4725,"end":4738},"obj":"Chemical"},{"id":"T323","span":{"begin":4757,"end":4766},"obj":"Chemical"},{"id":"T324","span":{"begin":4893,"end":4895},"obj":"Chemical"},{"id":"T325","span":{"begin":5311,"end":5318},"obj":"Chemical"},{"id":"T327","span":{"begin":5319,"end":5325},"obj":"Chemical"},{"id":"T329","span":{"begin":5339,"end":5354},"obj":"Chemical"},{"id":"T330","span":{"begin":5437,"end":5444},"obj":"Chemical"},{"id":"T331","span":{"begin":5666,"end":5673},"obj":"Chemical"},{"id":"T332","span":{"begin":5807,"end":5816},"obj":"Chemical"},{"id":"T333","span":{"begin":6000,"end":6009},"obj":"Chemical"},{"id":"T334","span":{"begin":6061,"end":6063},"obj":"Chemical"},{"id":"T335","span":{"begin":6188,"end":6195},"obj":"Chemical"},{"id":"T336","span":{"begin":6233,"end":6237},"obj":"Chemical"},{"id":"T337","span":{"begin":6820,"end":6830},"obj":"Chemical"}],"attributes":[{"id":"A234","pred":"chebi_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/CHEBI_60949"},{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A236","pred":"chebi_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A237","pred":"chebi_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A238","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A239","pred":"chebi_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/CHEBI_59739"},{"id":"A240","pred":"chebi_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A241","pred":"chebi_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/CHEBI_48624"},{"id":"A242","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_17087"},{"id":"A243","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_23019"},{"id":"A244","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_16150"},{"id":"A245","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_60949"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_26308"},{"id":"A247","pred":"chebi_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/CHEBI_30355"},{"id":"A248","pred":"chebi_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/CHEBI_41264"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_23116"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_23116"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_23116"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A267","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_16150"},{"id":"A268","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A269","pred":"chebi_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A270","pred":"chebi_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A271","pred":"chebi_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_26833"},{"id":"A273","pred":"chebi_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/CHEBI_29357"},{"id":"A274","pred":"chebi_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/CHEBI_29358"},{"id":"A275","pred":"chebi_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/CHEBI_50728"},{"id":"A276","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_27594"},{"id":"A277","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_33415"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_17087"},{"id":"A279","pred":"chebi_id","subj":"T279","obj":"http://purl.obolibrary.org/obo/CHEBI_23019"},{"id":"A280","pred":"chebi_id","subj":"T280","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A281","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_29339"},{"id":"A282","pred":"chebi_id","subj":"T281","obj":"http://purl.obolibrary.org/obo/CHEBI_73424"},{"id":"A283","pred":"chebi_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A284","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_14434"},{"id":"A285","pred":"chebi_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/CHEBI_16069"},{"id":"A286","pred":"chebi_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A287","pred":"chebi_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A288","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_14434"},{"id":"A289","pred":"chebi_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/CHEBI_16069"},{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_17654"},{"id":"A292","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_39143"},{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A294","pred":"chebi_id","subj":"T294","obj":"http://purl.obolibrary.org/obo/CHEBI_15339"},{"id":"A295","pred":"chebi_id","subj":"T295","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A296","pred":"chebi_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A297","pred":"chebi_id","subj":"T297","obj":"http://purl.obolibrary.org/obo/CHEBI_15339"},{"id":"A298","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_15339"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_15339"},{"id":"A302","pred":"chebi_id","subj":"T302","obj":"http://purl.obolibrary.org/obo/CHEBI_23019"},{"id":"A303","pred":"chebi_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A305","pred":"chebi_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/CHEBI_48624"},{"id":"A306","pred":"chebi_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A307","pred":"chebi_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A308","pred":"chebi_id","subj":"T308","obj":"http://purl.obolibrary.org/obo/CHEBI_59740"},{"id":"A309","pred":"chebi_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/CHEBI_16856"},{"id":"A310","pred":"chebi_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/CHEBI_57925"},{"id":"A311","pred":"chebi_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A312","pred":"chebi_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A313","pred":"chebi_id","subj":"T313","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A314","pred":"chebi_id","subj":"T314","obj":"http://purl.obolibrary.org/obo/CHEBI_48624"},{"id":"A315","pred":"chebi_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A316","pred":"chebi_id","subj":"T316","obj":"http://purl.obolibrary.org/obo/CHEBI_32952"},{"id":"A317","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_32772"},{"id":"A318","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_44520"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_16881"},{"id":"A320","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_35581"},{"id":"A321","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_36622"},{"id":"A322","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_41275"},{"id":"A323","pred":"chebi_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A324","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A325","pred":"chebi_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/CHEBI_32772"},{"id":"A326","pred":"chebi_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/CHEBI_44520"},{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_16881"},{"id":"A328","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_35581"},{"id":"A329","pred":"chebi_id","subj":"T329","obj":"http://purl.obolibrary.org/obo/CHEBI_26911"},{"id":"A330","pred":"chebi_id","subj":"T330","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A331","pred":"chebi_id","subj":"T331","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A332","pred":"chebi_id","subj":"T332","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A333","pred":"chebi_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A334","pred":"chebi_id","subj":"T334","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A335","pred":"chebi_id","subj":"T335","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A336","pred":"chebi_id","subj":"T336","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A337","pred":"chebi_id","subj":"T337","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T290","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T291","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T293","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T294","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T298","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T299","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T300","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T301","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T302","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T303","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T304","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T305","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T306","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T307","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T309","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T311","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T312","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T313","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T316","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T8","span":{"begin":705,"end":716},"obj":"http://purl.obolibrary.org/obo/GO_0006508"},{"id":"T9","span":{"begin":3912,"end":3923},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T10","span":{"begin":3975,"end":3981},"obj":"http://purl.obolibrary.org/obo/GO_0140352"},{"id":"T11","span":{"begin":3975,"end":3981},"obj":"http://purl.obolibrary.org/obo/GO_0140115"},{"id":"T12","span":{"begin":6344,"end":6355},"obj":"http://purl.obolibrary.org/obo/GO_0006508"}],"attributes":[{"subj":"T8","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T77","span":{"begin":0,"end":44},"obj":"Sentence"},{"id":"T78","span":{"begin":45,"end":186},"obj":"Sentence"},{"id":"T79","span":{"begin":187,"end":557},"obj":"Sentence"},{"id":"T80","span":{"begin":558,"end":735},"obj":"Sentence"},{"id":"T81","span":{"begin":736,"end":973},"obj":"Sentence"},{"id":"T82","span":{"begin":974,"end":1056},"obj":"Sentence"},{"id":"T83","span":{"begin":1057,"end":1134},"obj":"Sentence"},{"id":"T84","span":{"begin":1135,"end":1164},"obj":"Sentence"},{"id":"T85","span":{"begin":1165,"end":1202},"obj":"Sentence"},{"id":"T86","span":{"begin":1203,"end":1229},"obj":"Sentence"},{"id":"T87","span":{"begin":1230,"end":1250},"obj":"Sentence"},{"id":"T88","span":{"begin":1251,"end":1277},"obj":"Sentence"},{"id":"T89","span":{"begin":1278,"end":1304},"obj":"Sentence"},{"id":"T90","span":{"begin":1305,"end":1322},"obj":"Sentence"},{"id":"T91","span":{"begin":1323,"end":1346},"obj":"Sentence"},{"id":"T92","span":{"begin":1347,"end":1369},"obj":"Sentence"},{"id":"T93","span":{"begin":1370,"end":1392},"obj":"Sentence"},{"id":"T94","span":{"begin":1393,"end":1414},"obj":"Sentence"},{"id":"T95","span":{"begin":1415,"end":1437},"obj":"Sentence"},{"id":"T96","span":{"begin":1438,"end":1473},"obj":"Sentence"},{"id":"T97","span":{"begin":1474,"end":1506},"obj":"Sentence"},{"id":"T98","span":{"begin":1507,"end":1539},"obj":"Sentence"},{"id":"T99","span":{"begin":1540,"end":1575},"obj":"Sentence"},{"id":"T100","span":{"begin":1576,"end":1603},"obj":"Sentence"},{"id":"T101","span":{"begin":1604,"end":1633},"obj":"Sentence"},{"id":"T102","span":{"begin":1634,"end":1656},"obj":"Sentence"},{"id":"T103","span":{"begin":1657,"end":1823},"obj":"Sentence"},{"id":"T104","span":{"begin":1824,"end":1915},"obj":"Sentence"},{"id":"T105","span":{"begin":1916,"end":2053},"obj":"Sentence"},{"id":"T106","span":{"begin":2054,"end":2183},"obj":"Sentence"},{"id":"T107","span":{"begin":2184,"end":2378},"obj":"Sentence"},{"id":"T108","span":{"begin":2379,"end":2582},"obj":"Sentence"},{"id":"T109","span":{"begin":2583,"end":2726},"obj":"Sentence"},{"id":"T110","span":{"begin":2727,"end":2907},"obj":"Sentence"},{"id":"T111","span":{"begin":2908,"end":3018},"obj":"Sentence"},{"id":"T112","span":{"begin":3019,"end":3353},"obj":"Sentence"},{"id":"T113","span":{"begin":3354,"end":3456},"obj":"Sentence"},{"id":"T114","span":{"begin":3457,"end":3528},"obj":"Sentence"},{"id":"T115","span":{"begin":3529,"end":3622},"obj":"Sentence"},{"id":"T116","span":{"begin":3623,"end":4064},"obj":"Sentence"},{"id":"T117","span":{"begin":4065,"end":4446},"obj":"Sentence"},{"id":"T118","span":{"begin":4447,"end":4663},"obj":"Sentence"},{"id":"T119","span":{"begin":4664,"end":4751},"obj":"Sentence"},{"id":"T120","span":{"begin":4752,"end":4863},"obj":"Sentence"},{"id":"T121","span":{"begin":4864,"end":5021},"obj":"Sentence"},{"id":"T122","span":{"begin":5022,"end":5111},"obj":"Sentence"},{"id":"T123","span":{"begin":5112,"end":5278},"obj":"Sentence"},{"id":"T124","span":{"begin":5279,"end":5515},"obj":"Sentence"},{"id":"T125","span":{"begin":5516,"end":5591},"obj":"Sentence"},{"id":"T126","span":{"begin":5592,"end":5773},"obj":"Sentence"},{"id":"T127","span":{"begin":5774,"end":5925},"obj":"Sentence"},{"id":"T128","span":{"begin":5926,"end":6102},"obj":"Sentence"},{"id":"T129","span":{"begin":6103,"end":6323},"obj":"Sentence"},{"id":"T130","span":{"begin":6324,"end":6550},"obj":"Sentence"},{"id":"T131","span":{"begin":6551,"end":6664},"obj":"Sentence"},{"id":"T132","span":{"begin":6665,"end":6729},"obj":"Sentence"},{"id":"T133","span":{"begin":6730,"end":6857},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T77","pred":"source","obj":"LitCovid-sentences"},{"subj":"T78","pred":"source","obj":"LitCovid-sentences"},{"subj":"T79","pred":"source","obj":"LitCovid-sentences"},{"subj":"T80","pred":"source","obj":"LitCovid-sentences"},{"subj":"T81","pred":"source","obj":"LitCovid-sentences"},{"subj":"T82","pred":"source","obj":"LitCovid-sentences"},{"subj":"T83","pred":"source","obj":"LitCovid-sentences"},{"subj":"T84","pred":"source","obj":"LitCovid-sentences"},{"subj":"T85","pred":"source","obj":"LitCovid-sentences"},{"subj":"T86","pred":"source","obj":"LitCovid-sentences"},{"subj":"T87","pred":"source","obj":"LitCovid-sentences"},{"subj":"T88","pred":"source","obj":"LitCovid-sentences"},{"subj":"T89","pred":"source","obj":"LitCovid-sentences"},{"subj":"T90","pred":"source","obj":"LitCovid-sentences"},{"subj":"T91","pred":"source","obj":"LitCovid-sentences"},{"subj":"T92","pred":"source","obj":"LitCovid-sentences"},{"subj":"T93","pred":"source","obj":"LitCovid-sentences"},{"subj":"T94","pred":"source","obj":"LitCovid-sentences"},{"subj":"T95","pred":"source","obj":"LitCovid-sentences"},{"subj":"T96","pred":"source","obj":"LitCovid-sentences"},{"subj":"T97","pred":"source","obj":"LitCovid-sentences"},{"subj":"T98","pred":"source","obj":"LitCovid-sentences"},{"subj":"T99","pred":"source","obj":"LitCovid-sentences"},{"subj":"T100","pred":"source","obj":"LitCovid-sentences"},{"subj":"T101","pred":"source","obj":"LitCovid-sentences"},{"subj":"T102","pred":"source","obj":"LitCovid-sentences"},{"subj":"T103","pred":"source","obj":"LitCovid-sentences"},{"subj":"T104","pred":"source","obj":"LitCovid-sentences"},{"subj":"T105","pred":"source","obj":"LitCovid-sentences"},{"subj":"T106","pred":"source","obj":"LitCovid-sentences"},{"subj":"T107","pred":"source","obj":"LitCovid-sentences"},{"subj":"T108","pred":"source","obj":"LitCovid-sentences"},{"subj":"T109","pred":"source","obj":"LitCovid-sentences"},{"subj":"T110","pred":"source","obj":"LitCovid-sentences"},{"subj":"T111","pred":"source","obj":"LitCovid-sentences"},{"subj":"T112","pred":"source","obj":"LitCovid-sentences"},{"subj":"T113","pred":"source","obj":"LitCovid-sentences"},{"subj":"T114","pred":"source","obj":"LitCovid-sentences"},{"subj":"T115","pred":"source","obj":"LitCovid-sentences"},{"subj":"T116","pred":"source","obj":"LitCovid-sentences"},{"subj":"T117","pred":"source","obj":"LitCovid-sentences"},{"subj":"T118","pred":"source","obj":"LitCovid-sentences"},{"subj":"T119","pred":"source","obj":"LitCovid-sentences"},{"subj":"T120","pred":"source","obj":"LitCovid-sentences"},{"subj":"T121","pred":"source","obj":"LitCovid-sentences"},{"subj":"T122","pred":"source","obj":"LitCovid-sentences"},{"subj":"T123","pred":"source","obj":"LitCovid-sentences"},{"subj":"T124","pred":"source","obj":"LitCovid-sentences"},{"subj":"T125","pred":"source","obj":"LitCovid-sentences"},{"subj":"T126","pred":"source","obj":"LitCovid-sentences"},{"subj":"T127","pred":"source","obj":"LitCovid-sentences"},{"subj":"T128","pred":"source","obj":"LitCovid-sentences"},{"subj":"T129","pred":"source","obj":"LitCovid-sentences"},{"subj":"T130","pred":"source","obj":"LitCovid-sentences"},{"subj":"T131","pred":"source","obj":"LitCovid-sentences"},{"subj":"T132","pred":"source","obj":"LitCovid-sentences"},{"subj":"T133","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"403","span":{"begin":27,"end":35},"obj":"Species"},{"id":"414","span":{"begin":527,"end":538},"obj":"Gene"},{"id":"415","span":{"begin":793,"end":801},"obj":"Species"},{"id":"416","span":{"begin":187,"end":193},"obj":"Chemical"},{"id":"417","span":{"begin":252,"end":272},"obj":"Chemical"},{"id":"418","span":{"begin":369,"end":380},"obj":"Chemical"},{"id":"419","span":{"begin":511,"end":522},"obj":"Chemical"},{"id":"420","span":{"begin":760,"end":780},"obj":"Chemical"},{"id":"421","span":{"begin":859,"end":865},"obj":"Chemical"},{"id":"422","span":{"begin":928,"end":936},"obj":"Chemical"},{"id":"423","span":{"begin":986,"end":1005},"obj":"Chemical"},{"id":"426","span":{"begin":1141,"end":1149},"obj":"Species"},{"id":"427","span":{"begin":1175,"end":1179},"obj":"Species"},{"id":"430","span":{"begin":1066,"end":1074},"obj":"Species"},{"id":"431","span":{"begin":1104,"end":1123},"obj":"Chemical"},{"id":"461","span":{"begin":1897,"end":1905},"obj":"Species"},{"id":"462","span":{"begin":2244,"end":2252},"obj":"Species"},{"id":"463","span":{"begin":1837,"end":1855},"obj":"Chemical"},{"id":"464","span":{"begin":1968,"end":1976},"obj":"Chemical"},{"id":"465","span":{"begin":2427,"end":2442},"obj":"Chemical"},{"id":"466","span":{"begin":2487,"end":2495},"obj":"Chemical"},{"id":"467","span":{"begin":2497,"end":2503},"obj":"Chemical"},{"id":"468","span":{"begin":2505,"end":2511},"obj":"Chemical"},{"id":"469","span":{"begin":2551,"end":2557},"obj":"Chemical"},{"id":"470","span":{"begin":2587,"end":2593},"obj":"Chemical"},{"id":"471","span":{"begin":2666,"end":2674},"obj":"Chemical"},{"id":"472","span":{"begin":2708,"end":2714},"obj":"Chemical"},{"id":"473","span":{"begin":2719,"end":2725},"obj":"Chemical"},{"id":"474","span":{"begin":2762,"end":2770},"obj":"Chemical"},{"id":"475","span":{"begin":2799,"end":2804},"obj":"Chemical"},{"id":"476","span":{"begin":2833,"end":2842},"obj":"Chemical"},{"id":"477","span":{"begin":2855,"end":2863},"obj":"Chemical"},{"id":"478","span":{"begin":2926,"end":2935},"obj":"Chemical"},{"id":"479","span":{"begin":2936,"end":2944},"obj":"Chemical"},{"id":"480","span":{"begin":3012,"end":3017},"obj":"Chemical"},{"id":"481","span":{"begin":3045,"end":3050},"obj":"Chemical"},{"id":"482","span":{"begin":3074,"end":3079},"obj":"Chemical"},{"id":"483","span":{"begin":3094,"end":3099},"obj":"Chemical"},{"id":"484","span":{"begin":3100,"end":3109},"obj":"Chemical"},{"id":"485","span":{"begin":3166,"end":3172},"obj":"Chemical"},{"id":"486","span":{"begin":3189,"end":3197},"obj":"Chemical"},{"id":"487","span":{"begin":3250,"end":3256},"obj":"Chemical"},{"id":"488","span":{"begin":3335,"end":3341},"obj":"Chemical"},{"id":"489","span":{"begin":3346,"end":3352},"obj":"Chemical"},{"id":"491","span":{"begin":3422,"end":3430},"obj":"Species"},{"id":"497","span":{"begin":3708,"end":3716},"obj":"Species"},{"id":"498","span":{"begin":4022,"end":4027},"obj":"Species"},{"id":"499","span":{"begin":4226,"end":4231},"obj":"Species"},{"id":"500","span":{"begin":3627,"end":3647},"obj":"Chemical"},{"id":"501","span":{"begin":4155,"end":4166},"obj":"Chemical"},{"id":"509","span":{"begin":5004,"end":5009},"obj":"Gene"},{"id":"510","span":{"begin":4992,"end":5000},"obj":"Species"},{"id":"511","span":{"begin":4532,"end":4552},"obj":"Chemical"},{"id":"512","span":{"begin":4615,"end":4620},"obj":"Chemical"},{"id":"513","span":{"begin":4683,"end":4699},"obj":"Chemical"},{"id":"514","span":{"begin":4725,"end":4738},"obj":"Chemical"},{"id":"515","span":{"begin":4893,"end":4895},"obj":"Chemical"},{"id":"518","span":{"begin":5031,"end":5039},"obj":"Species"},{"id":"519","span":{"begin":5081,"end":5100},"obj":"Chemical"},{"id":"526","span":{"begin":5648,"end":5656},"obj":"Species"},{"id":"527","span":{"begin":5744,"end":5748},"obj":"Species"},{"id":"528","span":{"begin":5976,"end":5979},"obj":"Species"},{"id":"529","span":{"begin":5309,"end":5325},"obj":"Chemical"},{"id":"530","span":{"begin":5334,"end":5368},"obj":"Chemical"},{"id":"531","span":{"begin":5465,"end":5471},"obj":"Chemical"},{"id":"536","span":{"begin":6635,"end":6646},"obj":"Species"},{"id":"537","span":{"begin":6275,"end":6281},"obj":"Chemical"},{"id":"538","span":{"begin":6540,"end":6549},"obj":"Disease"},{"id":"539","span":{"begin":6684,"end":6693},"obj":"Disease"}],"attributes":[{"id":"A403","pred":"tao:has_database_id","subj":"403","obj":"Tax:694009"},{"id":"A414","pred":"tao:has_database_id","subj":"414","obj":"Gene:1508"},{"id":"A415","pred":"tao:has_database_id","subj":"415","obj":"Tax:694009"},{"id":"A421","pred":"tao:has_database_id","subj":"421","obj":"MESH:D007659"},{"id":"A422","pred":"tao:has_database_id","subj":"422","obj":"MESH:D001565"},{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"Tax:694009"},{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"Tax:59530"},{"id":"A430","pred":"tao:has_database_id","subj":"430","obj":"Tax:694009"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"Tax:694009"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"Tax:694009"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"MESH:D001565"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"MESH:D003545"},{"id":"A468","pred":"tao:has_database_id","subj":"468","obj":"MESH:D013455"},{"id":"A469","pred":"tao:has_database_id","subj":"469","obj":"MESH:D002244"},{"id":"A470","pred":"tao:has_database_id","subj":"470","obj":"MESH:D007659"},{"id":"A471","pred":"tao:has_database_id","subj":"471","obj":"MESH:D006859"},{"id":"A474","pred":"tao:has_database_id","subj":"474","obj":"MESH:D006859"},{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"MESH:C029899"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"MESH:D006859"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"MESH:C029899"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"MESH:D006859"},{"id":"A480","pred":"tao:has_database_id","subj":"480","obj":"MESH:D014867"},{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D014867"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"MESH:D014867"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"MESH:D006859"},{"id":"A486","pred":"tao:has_database_id","subj":"486","obj":"MESH:D006859"},{"id":"A491","pred":"tao:has_database_id","subj":"491","obj":"Tax:694009"},{"id":"A497","pred":"tao:has_database_id","subj":"497","obj":"Tax:694009"},{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"Tax:9606"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"Tax:9606"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"MESH:D005978"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"Tax:694009"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"MESH:D000588"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"MESH:C031000"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"MESH:C020845"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"Tax:694009"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"Tax:694009"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"Tax:59530"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Tax:10116"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"Tax:11118"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"MESH:D007239"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"MESH:D007239"},{"subj":"403","pred":"source","obj":"LitCovid-PubTator"},{"subj":"414","pred":"source","obj":"LitCovid-PubTator"},{"subj":"415","pred":"source","obj":"LitCovid-PubTator"},{"subj":"416","pred":"source","obj":"LitCovid-PubTator"},{"subj":"417","pred":"source","obj":"LitCovid-PubTator"},{"subj":"418","pred":"source","obj":"LitCovid-PubTator"},{"subj":"419","pred":"source","obj":"LitCovid-PubTator"},{"subj":"420","pred":"source","obj":"LitCovid-PubTator"},{"subj":"421","pred":"source","obj":"LitCovid-PubTator"},{"subj":"422","pred":"source","obj":"LitCovid-PubTator"},{"subj":"423","pred":"source","obj":"LitCovid-PubTator"},{"subj":"426","pred":"source","obj":"LitCovid-PubTator"},{"subj":"427","pred":"source","obj":"LitCovid-PubTator"},{"subj":"430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"461","pred":"source","obj":"LitCovid-PubTator"},{"subj":"462","pred":"source","obj":"LitCovid-PubTator"},{"subj":"463","pred":"source","obj":"LitCovid-PubTator"},{"subj":"464","pred":"source","obj":"LitCovid-PubTator"},{"subj":"465","pred":"source","obj":"LitCovid-PubTator"},{"subj":"466","pred":"source","obj":"LitCovid-PubTator"},{"subj":"467","pred":"source","obj":"LitCovid-PubTator"},{"subj":"468","pred":"source","obj":"LitCovid-PubTator"},{"subj":"469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"471","pred":"source","obj":"LitCovid-PubTator"},{"subj":"472","pred":"source","obj":"LitCovid-PubTator"},{"subj":"473","pred":"source","obj":"LitCovid-PubTator"},{"subj":"474","pred":"source","obj":"LitCovid-PubTator"},{"subj":"475","pred":"source","obj":"LitCovid-PubTator"},{"subj":"476","pred":"source","obj":"LitCovid-PubTator"},{"subj":"477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"479","pred":"source","obj":"LitCovid-PubTator"},{"subj":"480","pred":"source","obj":"LitCovid-PubTator"},{"subj":"481","pred":"source","obj":"LitCovid-PubTator"},{"subj":"482","pred":"source","obj":"LitCovid-PubTator"},{"subj":"483","pred":"source","obj":"LitCovid-PubTator"},{"subj":"484","pred":"source","obj":"LitCovid-PubTator"},{"subj":"485","pred":"source","obj":"LitCovid-PubTator"},{"subj":"486","pred":"source","obj":"LitCovid-PubTator"},{"subj":"487","pred":"source","obj":"LitCovid-PubTator"},{"subj":"488","pred":"source","obj":"LitCovid-PubTator"},{"subj":"489","pred":"source","obj":"LitCovid-PubTator"},{"subj":"491","pred":"source","obj":"LitCovid-PubTator"},{"subj":"497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"515","pred":"source","obj":"LitCovid-PubTator"},{"subj":"518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"519","pred":"source","obj":"LitCovid-PubTator"},{"subj":"526","pred":"source","obj":"LitCovid-PubTator"},{"subj":"527","pred":"source","obj":"LitCovid-PubTator"},{"subj":"528","pred":"source","obj":"LitCovid-PubTator"},{"subj":"529","pred":"source","obj":"LitCovid-PubTator"},{"subj":"530","pred":"source","obj":"LitCovid-PubTator"},{"subj":"531","pred":"source","obj":"LitCovid-PubTator"},{"subj":"536","pred":"source","obj":"LitCovid-PubTator"},{"subj":"537","pred":"source","obj":"LitCovid-PubTator"},{"subj":"538","pred":"source","obj":"LitCovid-PubTator"},{"subj":"539","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"33054210-2029515-61913457","span":{"begin":395,"end":397},"obj":"2029515"}],"attributes":[{"subj":"33054210-2029515-61913457","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecd293","default":true},{"id":"LitCovid-PD-UBERON","color":"#b893ec"},{"id":"LitCovid-PD-MONDO","color":"#93ec9e"},{"id":"LitCovid-PD-CLO","color":"#ec93a2"},{"id":"LitCovid-PD-CHEBI","color":"#93bcec"},{"id":"LitCovid-PD-GO-BP","color":"#d6ec93"},{"id":"LitCovid-sentences","color":"#e893ec"},{"id":"LitCovid-PubTator","color":"#93ecce"},{"id":"2_test","color":"#ecb493"}]}]}}