PMC:7571312 / 124168-125246 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T21","span":{"begin":6,"end":11},"obj":"Body_part"},{"id":"T22","span":{"begin":34,"end":39},"obj":"Body_part"},{"id":"T23","span":{"begin":184,"end":189},"obj":"Body_part"},{"id":"T24","span":{"begin":250,"end":254},"obj":"Body_part"},{"id":"T25","span":{"begin":324,"end":328},"obj":"Body_part"},{"id":"T26","span":{"begin":492,"end":497},"obj":"Body_part"},{"id":"T27","span":{"begin":559,"end":564},"obj":"Body_part"},{"id":"T28","span":{"begin":754,"end":759},"obj":"Body_part"},{"id":"T29","span":{"begin":813,"end":818},"obj":"Body_part"},{"id":"T30","span":{"begin":1013,"end":1018},"obj":"Body_part"},{"id":"T31","span":{"begin":1072,"end":1077},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T137","span":{"begin":0,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0052043"},{"id":"T138","span":{"begin":0,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0052044"},{"id":"T139","span":{"begin":0,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0052045"},{"id":"T140","span":{"begin":34,"end":39},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T141","span":{"begin":184,"end":189},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T142","span":{"begin":250,"end":254},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T143","span":{"begin":324,"end":328},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T144","span":{"begin":456,"end":462},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T145","span":{"begin":492,"end":497},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T146","span":{"begin":514,"end":520},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T147","span":{"begin":559,"end":564},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T148","span":{"begin":717,"end":723},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T149","span":{"begin":754,"end":759},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T150","span":{"begin":813,"end":818},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T151","span":{"begin":974,"end":980},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T152","span":{"begin":1013,"end":1018},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T153","span":{"begin":1072,"end":1077},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T57484","span":{"begin":55,"end":65},"obj":"Chemical"},{"id":"T51593","span":{"begin":55,"end":61},"obj":"Chemical"},{"id":"T86896","span":{"begin":368,"end":371},"obj":"Chemical"},{"id":"T37376","span":{"begin":429,"end":440},"obj":"Chemical"},{"id":"T67078","span":{"begin":690,"end":701},"obj":"Chemical"},{"id":"T96579","span":{"begin":947,"end":958},"obj":"Chemical"}],"attributes":[{"id":"A88789","pred":"chebi_id","subj":"T57484","obj":"http://purl.obolibrary.org/obo/CHEBI_31991"},{"id":"A54223","pred":"chebi_id","subj":"T51593","obj":"http://purl.obolibrary.org/obo/CHEBI_15882"},{"id":"A88611","pred":"chebi_id","subj":"T86896","obj":"http://purl.obolibrary.org/obo/CHEBI_37958"},{"id":"A30322","pred":"chebi_id","subj":"T37376","obj":"http://purl.obolibrary.org/obo/CHEBI_86370"},{"id":"A39488","pred":"chebi_id","subj":"T67078","obj":"http://purl.obolibrary.org/obo/CHEBI_86370"},{"id":"A15195","pred":"chebi_id","subj":"T96579","obj":"http://purl.obolibrary.org/obo/CHEBI_86370"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":250,"end":260},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}

{"project":"LitCovid-sentences","denotations":[{"id":"T671","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T672","span":{"begin":84,"end":309},"obj":"Sentence"},{"id":"T673","span":{"begin":310,"end":565},"obj":"Sentence"},{"id":"T674","span":{"begin":566,"end":819},"obj":"Sentence"},{"id":"T675","span":{"begin":820,"end":1078},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2163","span":{"begin":222,"end":231},"obj":"Species"},{"id":"2164","span":{"begin":55,"end":65},"obj":"Chemical"},{"id":"2165","span":{"begin":195,"end":203},"obj":"Disease"},{"id":"2166","span":{"begin":274,"end":287},"obj":"Disease"},{"id":"2167","span":{"begin":727,"end":735},"obj":"Disease"},{"id":"2168","span":{"begin":828,"end":840},"obj":"Disease"},{"id":"2169","span":{"begin":0,"end":5},"obj":"CellLine"}],"attributes":[{"id":"A2163","pred":"tao:has_database_id","subj":"2163","obj":"Tax:11137"},{"id":"A2164","pred":"tao:has_database_id","subj":"2164","obj":"MESH:D010637"},{"id":"A2165","pred":"tao:has_database_id","subj":"2165","obj":"MESH:D007239"},{"id":"A2166","pred":"tao:has_database_id","subj":"2166","obj":"MESH:D007239"},{"id":"A2167","pred":"tao:has_database_id","subj":"2167","obj":"MESH:D007239"},{"id":"A2168","pred":"tao:has_database_id","subj":"2168","obj":"MESH:D064420"},{"id":"A2169","pred":"tao:has_database_id","subj":"2169","obj":"CVCL:0440"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}

{"project":"2_test","denotations":[{"id":"33054210-3409223-61913464","span":{"begin":389,"end":391},"obj":"3409223"}],"text":"MRC-5 cells were plated at 10 000 cells per well using phenol red-free MEM (Gibco). Various concentrations of compound (320, 100, 33, 10, 3.3, 1.0, 0.3, or 0.1 μM) were added, and the cells were infected with an amount of hCoV 229E, which caused 80% cell death in 4 days or mock-infected with the medium only. After 4 days, cell viability was determined using the XTT dye reduction method.53 Data are expressed as the percent of neutral red or luminescent signal in wells of compound-treated cells compared to the signal in wells of uninfected, compound-free cells. The 50% effective concentration (EC50) is calculated as the concentration of the compound that increases the percent of the neutral red or luminescent signal in infected, compound-treated cells to 50% of that produced by uninfected, compound-free cells. The 50% cytotoxicity concentration (CC50) is calculated as the concentration of the compound that decreases the percent of the neutral red or luminescent signal in uninfected, compound-treated cells to 50% of that produced in uninfected, compound-free cells."}