PMC:7571312 / 0-436
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7571312","sourcedb":"PMC","sourceid":"7571312","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7571312","text":"Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19\n\nAbstract\nThe novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002. Both SARS coronavirus genomes encode two overlapping large polyproteins, which are cle","divisions":[{"label":"article-title","span":{"begin":0,"end":126}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T66277","span":{"begin":372,"end":379},"obj":"Body_part"}],"attributes":[{"id":"A21703","pred":"fma_id","subj":"T66277","obj":"http://purl.org/sig/ont/fma/fma84116"},{"subj":"T66277","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":118,"end":126},"obj":"Disease"},{"id":"T2","span":{"begin":167,"end":175},"obj":"Disease"},{"id":"T3","span":{"begin":220,"end":224},"obj":"Disease"},{"id":"T4","span":{"begin":277,"end":281},"obj":"Disease"},{"id":"T5","span":{"begin":300,"end":333},"obj":"Disease"},{"id":"T6","span":{"begin":335,"end":339},"obj":"Disease"},{"id":"T7","span":{"begin":355,"end":359},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T56090","span":{"begin":214,"end":219},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T56090","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":13,"end":19},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_17087"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":126},"obj":"Sentence"},{"id":"T2","span":{"begin":128,"end":136},"obj":"Sentence"},{"id":"T3","span":{"begin":137,"end":349},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3","span":{"begin":49,"end":60},"obj":"Species"},{"id":"4","span":{"begin":13,"end":19},"obj":"Chemical"},{"id":"5","span":{"begin":118,"end":126},"obj":"Disease"},{"id":"19","span":{"begin":220,"end":230},"obj":"Species"},{"id":"20","span":{"begin":277,"end":285},"obj":"Species"},{"id":"21","span":{"begin":355,"end":371},"obj":"Species"},{"id":"28","span":{"begin":141,"end":166},"obj":"Disease"},{"id":"29","span":{"begin":167,"end":175},"obj":"Disease"},{"id":"30","span":{"begin":307,"end":333},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:11118"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D007659"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:C000657245"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Tax:2697049"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"Tax:694009"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Tax:694009"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:C000657245"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:C000657245"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D012120"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4","pred":"source","obj":"LitCovid-PubTator"},{"subj":"5","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9893","default":true},{"id":"LitCovid-PD-MONDO","color":"#93a7ec"},{"id":"LitCovid-PD-CLO","color":"#c1ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93db"},{"id":"LitCovid-sentences","color":"#93ece3"},{"id":"LitCovid-PubTator","color":"#ecc993"}]}]}}