PMC:7565665 / 9787-10102 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T52","span":{"begin":103,"end":107},"obj":"Body_part"}],"attributes":[{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":103,"end":107},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T97","span":{"begin":1,"end":3},"obj":"Disease"},{"id":"T98","span":{"begin":92,"end":94},"obj":"Disease"},{"id":"T99","span":{"begin":103,"end":115},"obj":"Disease"}],"attributes":[{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T100","span":{"begin":18,"end":19},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T101","span":{"begin":39,"end":40},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T102","span":{"begin":103,"end":107},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T103","span":{"begin":103,"end":107},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T104","span":{"begin":131,"end":139},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T105","span":{"begin":160,"end":164},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T106","span":{"begin":187,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T107","span":{"begin":306,"end":307},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T37","span":{"begin":36,"end":38},"obj":"Chemical"},{"id":"T40","span":{"begin":289,"end":292},"obj":"Chemical"}],"attributes":[{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A38","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A39","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PubTator","denotations":[{"id":"227","span":{"begin":36,"end":40},"obj":"Gene"},{"id":"228","span":{"begin":160,"end":164},"obj":"Gene"},{"id":"230","span":{"begin":4,"end":8},"obj":"Species"},{"id":"237","span":{"begin":103,"end":115},"obj":"Disease"}],"attributes":[{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"Gene:18033"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Gene:12638"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Tax:10090"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D008171"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T42","span":{"begin":103,"end":115},"obj":"Phenotype"}],"attributes":[{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0002088"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T112","span":{"begin":50,"end":71},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T113","span":{"begin":76,"end":88},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T114","span":{"begin":160,"end":164},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T115","span":{"begin":222,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0002250"},{"id":"T116","span":{"begin":289,"end":304},"obj":"http://purl.obolibrary.org/obo/GO_0006811"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}

{"project":"LitCovid-sentences","denotations":[{"id":"T46","span":{"begin":125,"end":305},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" CF mice leads to a more pronounced NFκB-mediated inflammatory response and pathogenesis of CF-related lung disease [51,58]. Thus, membrane-resident functional CFTR is demonstrated to be a critical regulator of innate and adaptive immune responses, in addition to its classical role as an ion transporter.\nA recent "}