PMC:7565665 / 45809-47945 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7565665","sourcedb":"PMC","sourceid":"7565665","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7565665","text":"The lack of functional CFTR in macrophages results in an increased production of inflammatory cytokines, and impaired pathogen clearance capacity. The diminished expression of HLA-DQ and HLA-DR (MHC-II molecules) on monocytes derived from ΔF508-CFTR homozygous CF subjects [166], might explain the impaired pathogen clearance ability of CF macrophages. In addition, CFTR deficiency has been implicated in diminished Treg effector function and a more pronounced Th2-biased immune response [167]. The CF defect has also been shown to affect the activation of neutrophils [168], which are the cells responsible for the first line of defense in the airways. Although, airway epithelial cells and lung-resident macrophages sense the invading pathogens and secrete a plethora of factors to induce the recruitment and activation of neutrophils, neutrophils from CF subjects have diminished phagocytic potentials by virtue of the reduced cell surface expression of toll-like receptors (TLRs) and disrupted chloride transport to the phagolysosome [169,170]. Thus the CFTR mutation in CF results in impaired bacterial killing [171]. Moreover, CF neutrophils also demonstrate an increased capacity to release their primary granule contents such as MPO and neutrophil elastase (NE). The uncontrolled release of these enzymes causes lung tissue damage and severe airway inflammation. We have shown that P. aeruginosa LPS-induced MPO levels can be reduced by treatment with the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), plausibly by restoring the trafficking of ΔF508-CFTR, suggesting that a functional CFTR is required to keep a tab on uncontrolled neutrophil activation [172]. Mechanistically, an absence or dysfunction of CFTR in neutrophils results in the deactivation of the guanosine triphosphate (GTP)-binding protein Rab27a, which causes impaired granule exocytosis [168,172]. Several studies now agree that the pharmacological inhibition of CFTR or the mutant ΔF508-CFTR is sufficient to cause deregulated neutrophil activation via the activation of the NFκB pathway, resulting in hyperinflammation [172].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T314","span":{"begin":31,"end":42},"obj":"Body_part"},{"id":"T315","span":{"begin":94,"end":103},"obj":"Body_part"},{"id":"T316","span":{"begin":176,"end":179},"obj":"Body_part"},{"id":"T317","span":{"begin":187,"end":190},"obj":"Body_part"},{"id":"T318","span":{"begin":195,"end":198},"obj":"Body_part"},{"id":"T319","span":{"begin":216,"end":225},"obj":"Body_part"},{"id":"T320","span":{"begin":340,"end":351},"obj":"Body_part"},{"id":"T321","span":{"begin":557,"end":568},"obj":"Body_part"},{"id":"T322","span":{"begin":590,"end":595},"obj":"Body_part"},{"id":"T323","span":{"begin":671,"end":687},"obj":"Body_part"},{"id":"T324","span":{"begin":682,"end":687},"obj":"Body_part"},{"id":"T325","span":{"begin":692,"end":696},"obj":"Body_part"},{"id":"T326","span":{"begin":706,"end":717},"obj":"Body_part"},{"id":"T327","span":{"begin":825,"end":836},"obj":"Body_part"},{"id":"T328","span":{"begin":838,"end":849},"obj":"Body_part"},{"id":"T329","span":{"begin":930,"end":942},"obj":"Body_part"},{"id":"T330","span":{"begin":930,"end":934},"obj":"Body_part"},{"id":"T331","span":{"begin":1136,"end":1147},"obj":"Body_part"},{"id":"T332","span":{"begin":1245,"end":1255},"obj":"Body_part"},{"id":"T333","span":{"begin":1320,"end":1324},"obj":"Body_part"},{"id":"T334","span":{"begin":1325,"end":1331},"obj":"Body_part"},{"id":"T335","span":{"begin":1404,"end":1407},"obj":"Body_part"},{"id":"T336","span":{"begin":1464,"end":1471},"obj":"Body_part"},{"id":"T337","span":{"begin":1672,"end":1682},"obj":"Body_part"},{"id":"T338","span":{"begin":1755,"end":1766},"obj":"Body_part"},{"id":"T339","span":{"begin":1839,"end":1846},"obj":"Body_part"},{"id":"T340","span":{"begin":2037,"end":2047},"obj":"Body_part"}],"attributes":[{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma84079"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A332","pred":"fma_id","subj":"T332","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A333","pred":"fma_id","subj":"T333","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A334","pred":"fma_id","subj":"T334","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A335","pred":"fma_id","subj":"T335","obj":"http://purl.org/sig/ont/fma/fma82785"},{"id":"A336","pred":"fma_id","subj":"T336","obj":"http://purl.org/sig/ont/fma/fma74413"},{"id":"A337","pred":"fma_id","subj":"T337","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A338","pred":"fma_id","subj":"T338","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A339","pred":"fma_id","subj":"T339","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A340","pred":"fma_id","subj":"T340","obj":"http://purl.org/sig/ont/fma/fma62860"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T316","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T338","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T339","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T340","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T81","span":{"begin":692,"end":696},"obj":"Body_part"},{"id":"T82","span":{"begin":1320,"end":1324},"obj":"Body_part"},{"id":"T83","span":{"begin":1325,"end":1331},"obj":"Body_part"}],"attributes":[{"id":"A81","pred":"uberon_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A82","pred":"uberon_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A83","pred":"uberon_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T358","span":{"begin":261,"end":263},"obj":"Disease"},{"id":"T359","span":{"begin":337,"end":339},"obj":"Disease"},{"id":"T360","span":{"begin":499,"end":501},"obj":"Disease"},{"id":"T361","span":{"begin":855,"end":857},"obj":"Disease"},{"id":"T362","span":{"begin":1075,"end":1077},"obj":"Disease"},{"id":"T363","span":{"begin":1133,"end":1135},"obj":"Disease"},{"id":"T364","span":{"begin":1357,"end":1369},"obj":"Disease"}],"attributes":[{"id":"A358","pred":"mondo_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A359","pred":"mondo_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A360","pred":"mondo_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A361","pred":"mondo_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A362","pred":"mondo_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A363","pred":"mondo_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A364","pred":"mondo_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"subj":"T358","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T359","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T360","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T361","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T362","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T363","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T364","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T525","span":{"begin":23,"end":27},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T526","span":{"begin":216,"end":225},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T527","span":{"begin":245,"end":249},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T528","span":{"begin":366,"end":370},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T529","span":{"begin":382,"end":385},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T530","span":{"begin":416,"end":420},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T531","span":{"begin":443,"end":444},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T532","span":{"begin":509,"end":512},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T533","span":{"begin":543,"end":553},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T534","span":{"begin":590,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T535","span":{"begin":645,"end":652},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T536","span":{"begin":664,"end":670},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T537","span":{"begin":671,"end":696},"obj":"http://purl.obolibrary.org/obo/CL_0000082"},{"id":"T538","span":{"begin":759,"end":760},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T539","span":{"begin":811,"end":821},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T540","span":{"begin":883,"end":893},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T541","span":{"begin":930,"end":934},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T542","span":{"begin":1058,"end":1062},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T543","span":{"begin":1237,"end":1240},"obj":"http://purl.obolibrary.org/obo/PR_000010543"},{"id":"T544","span":{"begin":1266,"end":1268},"obj":"http://purl.obolibrary.org/obo/CLO_0008149"},{"id":"T545","span":{"begin":1320,"end":1324},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T546","span":{"begin":1320,"end":1324},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T547","span":{"begin":1350,"end":1356},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T548","span":{"begin":1416,"end":1419},"obj":"http://purl.obolibrary.org/obo/PR_000010543"},{"id":"T549","span":{"begin":1590,"end":1594},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T550","span":{"begin":1612,"end":1613},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T551","span":{"begin":1625,"end":1629},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T552","span":{"begin":1650,"end":1651},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T553","span":{"begin":1683,"end":1693},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T554","span":{"begin":1747,"end":1751},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T555","span":{"begin":1972,"end":1976},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T556","span":{"begin":1997,"end":2001},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T557","span":{"begin":2048,"end":2058},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T558","span":{"begin":2067,"end":2077},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T559","span":{"begin":2088,"end":2089},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T525","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T526","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T527","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T528","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T529","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T530","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T531","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T532","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T533","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T534","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T535","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T536","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T537","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T538","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T539","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T540","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T541","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T542","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T543","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T544","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T545","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T546","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T547","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T548","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T549","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T550","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T551","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T552","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T553","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T554","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T555","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T556","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T557","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T558","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T559","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T244","span":{"begin":180,"end":182},"obj":"Chemical"},{"id":"T245","span":{"begin":191,"end":193},"obj":"Chemical"},{"id":"T246","span":{"begin":199,"end":201},"obj":"Chemical"},{"id":"T247","span":{"begin":202,"end":211},"obj":"Chemical"},{"id":"T248","span":{"begin":421,"end":429},"obj":"Chemical"},{"id":"T249","span":{"begin":998,"end":1006},"obj":"Chemical"},{"id":"T250","span":{"begin":1266,"end":1268},"obj":"Chemical"},{"id":"T251","span":{"begin":1404,"end":1407},"obj":"Chemical"},{"id":"T254","span":{"begin":1464,"end":1471},"obj":"Chemical"},{"id":"T255","span":{"begin":1491,"end":1500},"obj":"Chemical"},{"id":"T256","span":{"begin":1502,"end":1533},"obj":"Chemical"},{"id":"T257","span":{"begin":1518,"end":1533},"obj":"Chemical"},{"id":"T258","span":{"begin":1529,"end":1533},"obj":"Chemical"},{"id":"T259","span":{"begin":1535,"end":1539},"obj":"Chemical"},{"id":"T260","span":{"begin":1802,"end":1824},"obj":"Chemical"},{"id":"T261","span":{"begin":1802,"end":1811},"obj":"Chemical"},{"id":"T262","span":{"begin":1812,"end":1824},"obj":"Chemical"},{"id":"T263","span":{"begin":1826,"end":1829},"obj":"Chemical"},{"id":"T265","span":{"begin":1839,"end":1846},"obj":"Chemical"},{"id":"T266","span":{"begin":2085,"end":2087},"obj":"Chemical"}],"attributes":[{"id":"A244","pred":"chebi_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/CHEBI_73827"},{"id":"A245","pred":"chebi_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A247","pred":"chebi_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A248","pred":"chebi_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_17996"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_73824"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_16412"},{"id":"A252","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_52603"},{"id":"A253","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_89981"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_15358"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_45716"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_24650"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_45716"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_15996"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_16750"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_18036"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_15996"},{"id":"A264","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_37565"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A267","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A268","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1135","span":{"begin":23,"end":27},"obj":"Gene"},{"id":"1136","span":{"begin":245,"end":249},"obj":"Gene"},{"id":"1137","span":{"begin":1058,"end":1062},"obj":"Gene"},{"id":"1138","span":{"begin":1237,"end":1240},"obj":"Gene"},{"id":"1139","span":{"begin":1245,"end":1264},"obj":"Gene"},{"id":"1140","span":{"begin":1416,"end":1419},"obj":"Gene"},{"id":"1141","span":{"begin":1590,"end":1594},"obj":"Gene"},{"id":"1142","span":{"begin":1625,"end":1629},"obj":"Gene"},{"id":"1143","span":{"begin":1747,"end":1751},"obj":"Gene"},{"id":"1144","span":{"begin":1847,"end":1853},"obj":"Gene"},{"id":"1145","span":{"begin":1972,"end":1976},"obj":"Gene"},{"id":"1146","span":{"begin":1997,"end":2001},"obj":"Gene"},{"id":"1147","span":{"begin":2085,"end":2089},"obj":"Gene"},{"id":"1148","span":{"begin":416,"end":420},"obj":"Chemical"},{"id":"1149","span":{"begin":461,"end":464},"obj":"Chemical"},{"id":"1150","span":{"begin":998,"end":1006},"obj":"Chemical"},{"id":"1151","span":{"begin":1502,"end":1533},"obj":"Chemical"},{"id":"1152","span":{"begin":1802,"end":1824},"obj":"Chemical"},{"id":"1153","span":{"begin":1826,"end":1829},"obj":"Chemical"},{"id":"1154","span":{"begin":366,"end":381},"obj":"Disease"},{"id":"1155","span":{"begin":499,"end":508},"obj":"Disease"},{"id":"1156","span":{"begin":1133,"end":1147},"obj":"Disease"},{"id":"1157","span":{"begin":1357,"end":1369},"obj":"Disease"},{"id":"1158","span":{"begin":1393,"end":1407},"obj":"Disease"},{"id":"1159","span":{"begin":1868,"end":1895},"obj":"Disease"}],"attributes":[{"id":"A1135","pred":"tao:has_database_id","subj":"1135","obj":"Gene:1080"},{"id":"A1136","pred":"tao:has_database_id","subj":"1136","obj":"Gene:1080"},{"id":"A1137","pred":"tao:has_database_id","subj":"1137","obj":"Gene:1080"},{"id":"A1138","pred":"tao:has_database_id","subj":"1138","obj":"Gene:4353"},{"id":"A1139","pred":"tao:has_database_id","subj":"1139","obj":"Gene:1991"},{"id":"A1140","pred":"tao:has_database_id","subj":"1140","obj":"Gene:4353"},{"id":"A1141","pred":"tao:has_database_id","subj":"1141","obj":"Gene:1080"},{"id":"A1142","pred":"tao:has_database_id","subj":"1142","obj":"Gene:1080"},{"id":"A1143","pred":"tao:has_database_id","subj":"1143","obj":"Gene:1080"},{"id":"A1144","pred":"tao:has_database_id","subj":"1144","obj":"Gene:5873"},{"id":"A1145","pred":"tao:has_database_id","subj":"1145","obj":"Gene:1080"},{"id":"A1146","pred":"tao:has_database_id","subj":"1146","obj":"Gene:1080"},{"id":"A1147","pred":"tao:has_database_id","subj":"1147","obj":"Gene:4790"},{"id":"A1150","pred":"tao:has_database_id","subj":"1150","obj":"MESH:D002712"},{"id":"A1151","pred":"tao:has_database_id","subj":"1151","obj":"MESH:D000077337"},{"id":"A1152","pred":"tao:has_database_id","subj":"1152","obj":"MESH:D006160"},{"id":"A1153","pred":"tao:has_database_id","subj":"1153","obj":"MESH:D006160"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"MESH:D007153"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"MESH:D003550"},{"id":"A1156","pred":"tao:has_database_id","subj":"1156","obj":"MESH:D003550"},{"id":"A1157","pred":"tao:has_database_id","subj":"1157","obj":"MESH:D007249"},{"id":"A1158","pred":"tao:has_database_id","subj":"1158","obj":"MESH:C536528"},{"id":"A1159","pred":"tao:has_database_id","subj":"1159","obj":"MESH:C531691"},{"subj":"1135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1153","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1154","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1155","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1156","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1157","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1158","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1159","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T150","span":{"begin":761,"end":769},"obj":"Phenotype"}],"attributes":[{"id":"A150","pred":"hp_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/HP_0001050"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T622","span":{"begin":23,"end":27},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T623","span":{"begin":245,"end":249},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T624","span":{"begin":366,"end":370},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T625","span":{"begin":472,"end":487},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T626","span":{"begin":998,"end":1016},"obj":"http://purl.obolibrary.org/obo/GO_0006821"},{"id":"T627","span":{"begin":1007,"end":1016},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T628","span":{"begin":1058,"end":1062},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T629","span":{"begin":1357,"end":1369},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T630","span":{"begin":1590,"end":1594},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T631","span":{"begin":1625,"end":1629},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T632","span":{"begin":1672,"end":1693},"obj":"http://purl.obolibrary.org/obo/GO_0042119"},{"id":"T633","span":{"begin":1747,"end":1751},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T634","span":{"begin":1885,"end":1895},"obj":"http://purl.obolibrary.org/obo/GO_0006887"},{"id":"T635","span":{"begin":1972,"end":1976},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T636","span":{"begin":1997,"end":2001},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T637","span":{"begin":2037,"end":2058},"obj":"http://purl.obolibrary.org/obo/GO_0042119"}],"attributes":[{"subj":"T622","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T623","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T624","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T625","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T626","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T627","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T628","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T629","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T630","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T631","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T632","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T633","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T634","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T635","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T636","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T637","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T241","span":{"begin":0,"end":146},"obj":"Sentence"},{"id":"T242","span":{"begin":147,"end":352},"obj":"Sentence"},{"id":"T243","span":{"begin":353,"end":494},"obj":"Sentence"},{"id":"T244","span":{"begin":495,"end":653},"obj":"Sentence"},{"id":"T245","span":{"begin":654,"end":1048},"obj":"Sentence"},{"id":"T246","span":{"begin":1049,"end":1122},"obj":"Sentence"},{"id":"T247","span":{"begin":1123,"end":1270},"obj":"Sentence"},{"id":"T248","span":{"begin":1271,"end":1370},"obj":"Sentence"},{"id":"T249","span":{"begin":1371,"end":1700},"obj":"Sentence"},{"id":"T250","span":{"begin":1701,"end":1906},"obj":"Sentence"},{"id":"T251","span":{"begin":1907,"end":2136},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T241","pred":"source","obj":"LitCovid-sentences"},{"subj":"T242","pred":"source","obj":"LitCovid-sentences"},{"subj":"T243","pred":"source","obj":"LitCovid-sentences"},{"subj":"T244","pred":"source","obj":"LitCovid-sentences"},{"subj":"T245","pred":"source","obj":"LitCovid-sentences"},{"subj":"T246","pred":"source","obj":"LitCovid-sentences"},{"subj":"T247","pred":"source","obj":"LitCovid-sentences"},{"subj":"T248","pred":"source","obj":"LitCovid-sentences"},{"subj":"T249","pred":"source","obj":"LitCovid-sentences"},{"subj":"T250","pred":"source","obj":"LitCovid-sentences"},{"subj":"T251","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#b0ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93ca"},{"id":"LitCovid-PD-MONDO","color":"#93e5ec"},{"id":"LitCovid-PD-CLO","color":"#ecd993"},{"id":"LitCovid-PD-CHEBI","color":"#bf93ec"},{"id":"LitCovid-PubTator","color":"#93eca5"},{"id":"LitCovid-PD-HP","color":"#ec939a"},{"id":"LitCovid-PD-GO-BP","color":"#93b4ec"},{"id":"LitCovid-sentences","color":"#ceec93"}]}]}}