> top > docs > PMC:7565665 > spans > 45809-47945 > annotations

PMC:7565665 / 45809-47945 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T314 31-42 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T315 94-103 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T316 176-179 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T317 187-190 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T318 195-198 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T319 216-225 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T320 340-351 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T321 557-568 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T322 590-595 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T323 671-687 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T324 682-687 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T325 692-696 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T326 706-717 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T327 825-836 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T328 838-849 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T329 930-942 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T330 930-934 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 1136-1147 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T332 1245-1255 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T333 1320-1324 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T334 1325-1331 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T335 1404-1407 Body_part denotes LPS http://purl.org/sig/ont/fma/fma82785
T336 1464-1471 Body_part denotes histone http://purl.org/sig/ont/fma/fma74413
T337 1672-1682 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T338 1755-1766 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T339 1839-1846 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T340 2037-2047 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T81 692-696 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T82 1320-1324 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T83 1325-1331 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T358 261-263 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T359 337-339 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T360 499-501 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T361 855-857 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T362 1075-1077 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T363 1133-1135 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T364 1357-1369 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T525 23-27 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T526 216-225 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T527 245-249 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T528 366-370 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T529 382-385 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T530 416-420 http://purl.obolibrary.org/obo/CL_0000792 denotes Treg
T531 443-444 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T532 509-512 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T533 543-553 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T534 590-595 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T535 645-652 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airways
T536 664-670 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T537 671-696 http://purl.obolibrary.org/obo/CL_0000082 denotes epithelial cells and lung
T538 759-760 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T539 811-821 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T540 883-893 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T541 930-934 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T542 1058-1062 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T543 1237-1240 http://purl.obolibrary.org/obo/PR_000010543 denotes MPO
T544 1266-1268 http://purl.obolibrary.org/obo/CLO_0008149 denotes NE
T545 1320-1324 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T546 1320-1324 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T547 1350-1356 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T548 1416-1419 http://purl.obolibrary.org/obo/PR_000010543 denotes MPO
T549 1590-1594 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T550 1612-1613 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T551 1625-1629 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T552 1650-1651 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T553 1683-1693 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T554 1747-1751 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T555 1972-1976 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T556 1997-2001 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T557 2048-2058 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T558 2067-2077 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T559 2088-2089 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T244 180-182 Chemical denotes DQ http://purl.obolibrary.org/obo/CHEBI_73827
T245 191-193 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T246 199-201 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T247 202-211 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T248 421-429 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T249 998-1006 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T250 1266-1268 Chemical denotes NE http://purl.obolibrary.org/obo/CHEBI_73824
T251 1404-1407 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T254 1464-1471 Chemical denotes histone http://purl.obolibrary.org/obo/CHEBI_15358
T255 1491-1500 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T256 1502-1533 Chemical denotes suberoylanilide hydroxamic acid http://purl.obolibrary.org/obo/CHEBI_45716
T257 1518-1533 Chemical denotes hydroxamic acid http://purl.obolibrary.org/obo/CHEBI_24650
T258 1529-1533 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T259 1535-1539 Chemical denotes SAHA http://purl.obolibrary.org/obo/CHEBI_45716
T260 1802-1824 Chemical denotes guanosine triphosphate http://purl.obolibrary.org/obo/CHEBI_15996
T261 1802-1811 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T262 1812-1824 Chemical denotes triphosphate http://purl.obolibrary.org/obo/CHEBI_18036
T263 1826-1829 Chemical denotes GTP http://purl.obolibrary.org/obo/CHEBI_15996|http://purl.obolibrary.org/obo/CHEBI_37565
T265 1839-1846 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T266 2085-2087 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1135 23-27 Gene denotes CFTR Gene:1080
1136 245-249 Gene denotes CFTR Gene:1080
1137 1058-1062 Gene denotes CFTR Gene:1080
1138 1237-1240 Gene denotes MPO Gene:4353
1139 1245-1264 Gene denotes neutrophil elastase Gene:1991
1140 1416-1419 Gene denotes MPO Gene:4353
1141 1590-1594 Gene denotes CFTR Gene:1080
1142 1625-1629 Gene denotes CFTR Gene:1080
1143 1747-1751 Gene denotes CFTR Gene:1080
1144 1847-1853 Gene denotes Rab27a Gene:5873
1145 1972-1976 Gene denotes CFTR Gene:1080
1146 1997-2001 Gene denotes CFTR Gene:1080
1147 2085-2089 Gene denotes NFκB Gene:4790
1148 416-420 Chemical denotes Treg
1149 461-464 Chemical denotes Th2
1150 998-1006 Chemical denotes chloride MESH:D002712
1151 1502-1533 Chemical denotes suberoylanilide hydroxamic acid MESH:D000077337
1152 1802-1824 Chemical denotes guanosine triphosphate MESH:D006160
1153 1826-1829 Chemical denotes GTP MESH:D006160
1154 366-381 Disease denotes CFTR deficiency MESH:D007153
1155 499-508 Disease denotes CF defect MESH:D003550
1156 1133-1147 Disease denotes CF neutrophils MESH:D003550
1157 1357-1369 Disease denotes inflammation MESH:D007249
1158 1393-1407 Disease denotes aeruginosa LPS MESH:C536528
1159 1868-1895 Disease denotes impaired granule exocytosis MESH:C531691

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T150 761-769 Phenotype denotes plethora http://purl.obolibrary.org/obo/HP_0001050

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T622 23-27 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T623 245-249 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T624 366-370 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T625 472-487 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T626 998-1016 http://purl.obolibrary.org/obo/GO_0006821 denotes chloride transport
T627 1007-1016 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T628 1058-1062 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T629 1357-1369 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T630 1590-1594 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T631 1625-1629 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T632 1672-1693 http://purl.obolibrary.org/obo/GO_0042119 denotes neutrophil activation
T633 1747-1751 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T634 1885-1895 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis
T635 1972-1976 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T636 1997-2001 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T637 2037-2058 http://purl.obolibrary.org/obo/GO_0042119 denotes neutrophil activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T241 0-146 Sentence denotes The lack of functional CFTR in macrophages results in an increased production of inflammatory cytokines, and impaired pathogen clearance capacity.
T242 147-352 Sentence denotes The diminished expression of HLA-DQ and HLA-DR (MHC-II molecules) on monocytes derived from ΔF508-CFTR homozygous CF subjects [166], might explain the impaired pathogen clearance ability of CF macrophages.
T243 353-494 Sentence denotes In addition, CFTR deficiency has been implicated in diminished Treg effector function and a more pronounced Th2-biased immune response [167].
T244 495-653 Sentence denotes The CF defect has also been shown to affect the activation of neutrophils [168], which are the cells responsible for the first line of defense in the airways.
T245 654-1048 Sentence denotes Although, airway epithelial cells and lung-resident macrophages sense the invading pathogens and secrete a plethora of factors to induce the recruitment and activation of neutrophils, neutrophils from CF subjects have diminished phagocytic potentials by virtue of the reduced cell surface expression of toll-like receptors (TLRs) and disrupted chloride transport to the phagolysosome [169,170].
T246 1049-1122 Sentence denotes Thus the CFTR mutation in CF results in impaired bacterial killing [171].
T247 1123-1270 Sentence denotes Moreover, CF neutrophils also demonstrate an increased capacity to release their primary granule contents such as MPO and neutrophil elastase (NE).
T248 1271-1370 Sentence denotes The uncontrolled release of these enzymes causes lung tissue damage and severe airway inflammation.
T249 1371-1700 Sentence denotes We have shown that P. aeruginosa LPS-induced MPO levels can be reduced by treatment with the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), plausibly by restoring the trafficking of ΔF508-CFTR, suggesting that a functional CFTR is required to keep a tab on uncontrolled neutrophil activation [172].
T250 1701-1906 Sentence denotes Mechanistically, an absence or dysfunction of CFTR in neutrophils results in the deactivation of the guanosine triphosphate (GTP)-binding protein Rab27a, which causes impaired granule exocytosis [168,172].
T251 1907-2136 Sentence denotes Several studies now agree that the pharmacological inhibition of CFTR or the mutant ΔF508-CFTR is sufficient to cause deregulated neutrophil activation via the activation of the NFκB pathway, resulting in hyperinflammation [172].