PMC:7565665 / 13983-15074
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T76 | 418-429 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T77 | 584-604 | Body_part | denotes | alveolar macrophages | http://purl.org/sig/ont/fma/fma83023 |
| T78 | 817-835 | Body_part | denotes | lipopolysaccharide | http://purl.org/sig/ont/fma/fma82785 |
| T79 | 837-840 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T80 | 930-933 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T81 | 971-975 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T82 | 1044-1047 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T83 | 1071-1075 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T22 | 971-975 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T23 | 1071-1075 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T127 | 15-39 | Disease | denotes | Streptococcus pneumoniae | http://purl.obolibrary.org/obo/MONDO_0005972 |
| T128 | 44-54 | Disease | denotes | pneumoniae | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T129 | 118-127 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T130 | 165-174 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T131 | 341-351 | Disease | denotes | pneumoniae | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T132 | 352-361 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T133 | 514-523 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T134 | 658-679 | Disease | denotes | Klebsiella pneumoniae | http://purl.obolibrary.org/obo/MONDO_0030602 |
| T135 | 944-956 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T136 | 976-982 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T137 | 1076-1082 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T162 | 175-184 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T163 | 267-270 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T164 | 557-567 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T165 | 768-771 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T166 | 804-813 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T167 | 852-853 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T168 | 883-891 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T169 | 909-917 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
| T170 | 971-975 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T171 | 971-975 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T172 | 1005-1015 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T173 | 1071-1075 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T174 | 1071-1075 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T49 | 817-835 | Chemical | denotes | lipopolysaccharide | http://purl.obolibrary.org/obo/CHEBI_16412 |
| T50 | 837-840 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T53 | 864-869 | Chemical | denotes | toxin | http://purl.obolibrary.org/obo/CHEBI_27026 |
| T54 | 930-933 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T57 | 1044-1047 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 356 | 15-39 | Species | denotes | Streptococcus pneumoniae | Tax:1313 |
| 357 | 41-54 | Species | denotes | S. pneumoniae | Tax:1313 |
| 358 | 338-351 | Species | denotes | S. pneumoniae | Tax:1313 |
| 359 | 608-630 | Species | denotes | Pseudomonas aeruginosa | Tax:287 |
| 360 | 632-645 | Species | denotes | P. aeruginosa | Tax:287 |
| 361 | 658-679 | Species | denotes | Klebsiella pneumoniae | Tax:573 |
| 362 | 817-835 | Chemical | denotes | lipopolysaccharide | MESH:D008070 |
| 363 | 118-127 | Disease | denotes | pneumonia | MESH:D011014 |
| 364 | 165-174 | Disease | denotes | infection | MESH:D007239 |
| 365 | 352-361 | Disease | denotes | infection | MESH:D007239 |
| 366 | 514-523 | Disease | denotes | pneumonia | MESH:D011014 |
| 367 | 944-956 | Disease | denotes | inflammation | MESH:D007249 |
| 368 | 971-982 | Disease | denotes | lung injury | MESH:D055370 |
| 369 | 1071-1082 | Disease | denotes | lung injury | MESH:D055370 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T54 | 29-39 | Phenotype | denotes | pneumoniae | http://purl.obolibrary.org/obo/HP_0002090 |
| T55 | 44-54 | Phenotype | denotes | pneumoniae | http://purl.obolibrary.org/obo/HP_0002090 |
| T56 | 118-127 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T57 | 341-351 | Phenotype | denotes | pneumoniae | http://purl.obolibrary.org/obo/HP_0002090 |
| T58 | 514-523 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T59 | 669-679 | Phenotype | denotes | pneumoniae | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T182 | 189-198 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T183 | 189-198 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T184 | 229-244 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T185 | 305-314 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T186 | 305-314 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T187 | 402-414 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T188 | 455-464 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T189 | 455-464 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T190 | 495-510 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T191 | 571-580 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T192 | 571-580 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T193 | 702-713 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T194 | 791-800 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T195 | 791-800 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T196 | 944-956 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T197 | 1019-1028 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T198 | 1019-1028 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T199 | 1032-1047 | http://purl.obolibrary.org/obo/GO_0032496 | denotes | response to LPS |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T68 | 0-253 | Sentence | denotes | In the case of Streptococcus pneumoniae (S. pneumoniae), which is the most common pathogen causing community acquired pneumonia [76], studies have demonstrated that infection activates the autophagy pathway as part of the body’s immune response [77,78]. |
| T69 | 254-524 | Sentence | denotes | Recently, it has been shown that this induction of autophagy makes the clearance of S. pneumoniae infection more effective by enhancing the rate of phagocytosis by neutrophils [78], demonstrating that autophagy is necessary for an effective immune response in pneumonia. |
| T70 | 525-751 | Sentence | denotes | Studies have also exhibited the activation of autophagy in alveolar macrophages by Pseudomonas aeruginosa (P. aeruginosa) [5,79] and Klebsiella pneumoniae [46,79] to induce the degradation of these pathogens in phagolysosomes. |
| T71 | 752-918 | Sentence | denotes | Moreover, there has been evidence that autophagy is activated by lipopolysaccharide (LPS), which is a bacterial toxin on the outer membrane of Gram-negative bacteria. |
| T72 | 919-1091 | Sentence | denotes | Typically, LPS can cause inflammation that leads to lung injury [80,81]; however, the activation of autophagy in response to LPS was shown to attenuate lung injury [82,83]. |