PMC:7561592 / 2430-3254 JSONTXT

{"project":"2_test","denotations":[{"id":"33063245-27704550-28118","span":{"begin":263,"end":264},"obj":"27704550"},{"id":"33063245-22554162-28118","span":{"begin":263,"end":264},"obj":"22554162"},{"id":"33063245-26173937-28118","span":{"begin":263,"end":264},"obj":"26173937"},{"id":"33063245-26173937-28119","span":{"begin":577,"end":578},"obj":"26173937"},{"id":"33063245-22677416-28119","span":{"begin":577,"end":578},"obj":"22677416"},{"id":"33063245-16100296-28119","span":{"begin":577,"end":578},"obj":"16100296"},{"id":"33063245-18691989-28120","span":{"begin":775,"end":776},"obj":"18691989"}],"text":"The use of food and drinks as vehicles for medicine co-administration is common practice to deliver a specific dose and improve compliance, yet the scientific rationale for selecting a particular type of vehicle for mixing with the medicine is often not evident (3–5). The majority of vehicles suggested for medicine co-administration seem to be recommended more on the basis of their taste and texture for the paediatric population rather than their impact on in vivo drug product performance. In addition to the possible negative effects on dose accuracy (as often reported (5–7)), drug manipulation and mixing with different food and drinks can also affect drug stability, solubility and bioavailability, ultimately leading to either sub-therapeutic or toxic drug levels (8–10). These effects are still often unaddressed."}