PMC:7558333 / 8520-9966 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7558333","sourcedb":"PMC","sourceid":"7558333","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7558333","text":"3.1. Patient Aspergillus Status\nA cohort of 45 COVID-19 intubated and mechanically ventilated patients for ARDS was followed. Patients benefited from a systematic screening for Aspergillus. Overall, 211 respiratory samples (culture and PCR) and 32 serum samples (GM detection and Aspergillus PCR) were collected. The mean number of respiratory samples until patient discharge from ICU was 3.8 (median = 3).\nWe categorized these 45 patients according to the AspICU algorithm and propose two alternative classification methods presented in Table 1: the AspICU algorithm associated to PCR results in respiratory and serum samples, and a modified AspICU proposal. Thirty patients did not present any biological criteria of aspergillosis with any of the algorithms. According to the AspICU classification incorporating PCR detection, 15 were classified as having putative aspergillosis because they met all criteria reported by Blot et al., i.e., compatible clinical signs, abnormal thoracic medical imaging on CT scan and positive screening for Aspergillus on respiratory samples. However, in this particular context of COVID-19 with all ARDS patients presenting compatible clinical signs and abnormal chest CT imaging in all likelihood lacking specificity, we decided to use a modified AspICU algorithm taking into account blood markers; we classified eight patients as colonized and seven patients with a putative/probable IA (Table 1 and Table 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