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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 651-656 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T2 665-670 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T3 856-861 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 2910-2919 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T5 3799-3807 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T6 3903-3908 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T7 3969-3972 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T8 4269-4274 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T9 4283-4288 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T10 4955-4961 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T11 5215-5221 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T12 5232-5236 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T13 5451-5456 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T14 5467-5472 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T15 5492-5497 Body_part denotes Chest http://purl.org/sig/ont/fma/fma9576
T16 5625-5630 Body_part denotes Organ http://purl.org/sig/ont/fma/fma67498
T17 7000-7003 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T18 7330-7335 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T19 7472-7480 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T20 7500-7503 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T21 7611-7616 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T22 7796-7799 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T23 8768-8773 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T24 9133-9138 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T25 9718-9723 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T26 9840-9845 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T27 10492-10499 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 10886-10889 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T29 11672-11677 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T30 12579-12584 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T31 12827-12832 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T32 13011-13028 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T33 13157-13165 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T34 13372-13377 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T35 13583-13591 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T36 15488-15499 Body_part denotes solid organ http://purl.org/sig/ont/fma/fma55670
T37 16370-16375 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T38 17134-17139 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T39 17563-17567 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T40 17664-17669 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T41 18072-18080 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T42 18274-18279 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T43 18287-18292 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T44 18425-18433 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T45 19342-19347 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T46 21377-21382 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T47 21459-21464 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T48 21830-21835 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T49 22152-22156 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T50 22760-22765 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T51 23496-23504 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T52 23780-23785 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T53 24246-24258 Body_part denotes Colonization http://purl.org/sig/ont/fma/fma14543
T54 24512-24524 Body_part denotes Colonization http://purl.org/sig/ont/fma/fma14543
T55 25277-25283 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T56 25424-25429 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T57 25582-25598 Body_part denotes White blood cell http://purl.org/sig/ont/fma/fma62852
T58 25594-25598 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 25679-25689 Body_part denotes Neutrophil http://purl.org/sig/ont/fma/fma62860
T60 25770-25780 Body_part denotes Lymphocyte http://purl.org/sig/ont/fma/fma62863
T61 25871-25881 Body_part denotes Hemoglobin http://purl.org/sig/ont/fma/fma62293
T62 25958-25966 Body_part denotes Platelet http://purl.org/sig/ont/fma/fma62851
T63 26228-26235 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 26815-26819 Body_part denotes Body http://purl.org/sig/ont/fma/fma256135
T65 26896-26901 Body_part denotes Organ http://purl.org/sig/ont/fma/fma67498
T66 27325-27330 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T67 27349-27354 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T68 27572-27577 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T69 28981-28993 Body_part denotes Colonization http://purl.org/sig/ont/fma/fma14543
T70 29871-29876 Body_part denotes Organ http://purl.org/sig/ont/fma/fma67498

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 651-656 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 665-670 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T3 856-861 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 3903-3908 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T5 4269-4274 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 4283-4288 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T7 4955-4961 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T8 5215-5221 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T9 5451-5456 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 5467-5472 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T11 5492-5497 Body_part denotes Chest http://purl.obolibrary.org/obo/UBERON_0001443
T12 5625-5630 Body_part denotes Organ http://purl.obolibrary.org/obo/UBERON_0000062
T13 7330-7335 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T14 7611-7616 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T15 8768-8773 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T16 9133-9138 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T17 9718-9723 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T18 9840-9845 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T19 11672-11677 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T20 12579-12584 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T21 12827-12832 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T22 13011-13028 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T23 13372-13377 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T24 15494-15499 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T25 16370-16375 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T26 17134-17139 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T27 17664-17669 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T28 18274-18279 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T29 18287-18292 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T30 19342-19347 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T31 21377-21382 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T32 21459-21464 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T33 21830-21835 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T34 22152-22156 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T35 22760-22765 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T36 23780-23785 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T37 25277-25283 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T38 25424-25429 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T39 25588-25593 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T40 26896-26901 Body_part denotes Organ http://purl.obolibrary.org/obo/UBERON_0000062
T41 27325-27330 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T42 27349-27354 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T43 27572-27577 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T44 29871-29876 Body_part denotes Organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 7-15 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 94-107 Disease denotes Aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T3 193-215 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T4 202-215 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T5 217-219 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T6 281-289 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 382-384 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T8 388-396 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 434-442 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 1027-1029 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T11 1080-1082 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T12 1168-1176 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1279-1281 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T14 1643-1646 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T15 2044-2047 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T16 2205-2227 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T17 2214-2227 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T18 2229-2231 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T19 2471-2479 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 2633-2641 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 2666-2701 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T22 2672-2701 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T23 2703-2707 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T24 2778-2780 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T25 3044-3057 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T26 3058-3066 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 3153-3155 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T28 3321-3329 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 3351-3364 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T30 3366-3370 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T31 3599-3607 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 3687-3702 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T33 3693-3702 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 4427-4436 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35 4440-4448 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 4646-4654 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 4888-4896 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 5144-5152 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T39 5154-5190 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T40 5154-5166 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T41 5168-5190 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T42 5192-5209 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T43 5215-5229 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T45 6876-6884 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 8567-8575 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T47 8627-8631 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T48 9239-9252 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T49 9387-9400 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T50 9636-9644 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T51 9654-9658 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T52 9941-9943 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T53 10233-10246 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T54 10292-10305 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T55 10528-10541 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T56 10746-10768 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T57 10755-10768 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T58 12346-12348 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T59 12427-12429 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T60 13260-13262 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T61 13319-13321 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T62 13651-13653 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T63 13694-13696 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T64 13789-13797 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T65 13798-13807 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 13859-13872 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T67 13931-13944 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T68 14054-14063 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T69 14082-14084 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T70 14192-14205 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T71 14273-14295 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T72 14282-14295 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T73 14346-14348 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T74 14559-14561 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T75 14732-14748 Disease denotes fungal infection http://purl.obolibrary.org/obo/MONDO_0002041
T76 14739-14748 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 14822-14825 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T78 14928-14936 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T79 14997-15005 Disease denotes Sars-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 15012-15021 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T81 15022-15032 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T82 15078-15081 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T83 15161-15163 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T84 15202-15204 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T85 15548-15551 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T86 15564-15566 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T87 15737-15750 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T88 15919-15936 Disease denotes FUNgal infections http://purl.obolibrary.org/obo/MONDO_0002041
T89 16033-16036 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T90 16090-16098 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 16104-16113 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T92 16198-16206 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 16230-16234 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T94 16532-16540 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 16647-16656 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 16679-16681 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T97 16689-16697 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 17035-17037 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T99 18484-18504 Disease denotes respiratory diseases http://purl.obolibrary.org/obo/MONDO_0005087
T100 18560-18573 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T101 18586-18588 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T102 18693-18702 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 18727-18729 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T104 18740-18742 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T105 18754-18756 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T106 18776-18778 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T107 19524-19527 Disease denotes IFD http://purl.obolibrary.org/obo/MONDO_0009852
T108 19542-19544 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T109 19604-19616 Disease denotes Pneumocystis http://purl.obolibrary.org/obo/MONDO_0019121
T110 19640-19650 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T111 20024-20037 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T112 21400-21408 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 21424-21446 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T114 21433-21446 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T115 21494-21502 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 21529-21551 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T117 21538-21551 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T118 21688-21696 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 21789-21811 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T120 21798-21811 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T121 21865-21873 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 21900-21922 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T123 21909-21922 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T124 22073-22095 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T125 22082-22095 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T126 22799-22801 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T127 23743-23745 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T128 23762-23764 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T129 23833-23835 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T130 23960-23968 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T131 23983-23987 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T132 24224-24233 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T133 24277-24279 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T134 24299-24301 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T135 24318-24320 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T136 24476-24489 Disease denotes Aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T137 24552-24574 Disease denotes Invasive Aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T138 24561-24574 Disease denotes Aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T139 24948-24956 Disease denotes Diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T140 25003-25015 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T141 25068-25074 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T142 25152-25174 Disease denotes Cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T143 25216-25253 Disease denotes Chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005002
T144 25236-25253 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T145 25269-25291 Disease denotes Chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T146 25277-25291 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T148 26648-26670 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T149 26657-26670 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T150 26678-26691 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T151 27513-27521 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 27536-27540 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T153 27587-27589 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T154 27916-27925 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 28288-28297 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T156 28341-28350 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T157 28394-28403 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T158 28447-28456 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T159 28500-28509 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T160 28556-28565 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T161 28570-28579 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T162 28584-28593 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T163 28628-28637 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T164 28662-28671 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T165 28733-28742 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T166 28743-28745 Disease denotes IA http://purl.obolibrary.org/obo/MONDO_0000240
T167 28747-28769 Disease denotes Invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T168 28756-28769 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T169 28851-28859 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 28871-28875 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T171 28945-28958 Disease denotes Aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T172 29021-29043 Disease denotes Invasive Aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T173 29030-29043 Disease denotes Aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T174 29666-29688 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T175 29675-29688 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T176 29696-29709 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 25-26 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 125-126 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T3 261-262 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 431-433 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T5 651-656 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6 651-656 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T7 730-739 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonized
T8 856-861 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T9 856-861 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T10 935-936 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 987-989 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T12 1128-1129 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1184-1185 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1247-1256 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonized
T15 1392-1393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 1648-1651 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T17 1684-1685 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 2162-2165 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T19 2177-2178 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 2331-2334 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T21 3024-3036 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T22 3406-3413 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T23 3903-3908 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T24 3903-3908 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T25 4133-4142 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T26 4269-4274 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T27 4269-4274 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T28 4402-4414 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T29 4643-4644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 4736-4737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 5215-5221 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T32 5215-5221 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T33 5215-5221 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T34 5440-5441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 5451-5456 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T36 5451-5456 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T37 5485-5490 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T38 5492-5497 http://www.ebi.ac.uk/efo/EFO_0000965 denotes Chest
T39 5625-5630 http://purl.obolibrary.org/obo/UBERON_0003103 denotes Organ
T40 7033-7038 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 7055-7056 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 7073-7079 http://purl.obolibrary.org/obo/OBI_0000968 denotes device
T43 7113-7114 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T44 7141-7142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 7306-7311 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T46 7709-7710 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 7725-7731 http://purl.obolibrary.org/obo/OBI_0000968 denotes device
T48 7814-7815 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 8003-8007 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T50 8027-8032 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T51 8136-8140 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T52 8142-8147 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Tests
T53 8262-8267 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T54 8400-8408 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was
T55 8552-8553 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T56 8564-8566 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T57 8670-8671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 8948-8950 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T59 9152-9153 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 9718-9723 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T61 9792-9793 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 9840-9845 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T63 9840-9845 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T64 9887-9896 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonized
T65 9921-9922 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 10135-10137 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T67 10260-10272 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T68 10329-10330 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 10358-10362 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T70 10358-10362 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T71 10944-10945 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 11128-11129 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T73 11250-11251 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T74 11348-11349 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 11406-11407 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 11624-11625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 11672-11677 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T78 11672-11677 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T79 11706-11707 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80 11730-11731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81 11760-11761 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 11787-11788 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 11835-11836 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 12037-12038 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 12102-12107 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Tests
T86 12194-12196 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T87 12335-12336 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 12350-12352 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T89 12508-12517 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonized
T90 12579-12584 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T91 12656-12657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 12760-12769 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonized
T93 12797-12798 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 12909-12910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 12974-12975 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 13094-13095 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 13104-13116 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T98 13166-13177 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing was
T99 13333-13334 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 13522-13523 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 13702-13714 http://purl.obolibrary.org/obo/UBERON_0001155 denotes in colonized
T102 14031-14032 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 14065-14077 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T104 14217-14229 http://purl.obolibrary.org/obo/UBERON_0001155 denotes in colonized
T105 14244-14246 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T106 14326-14327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 14414-14423 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonized
T108 14492-14493 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 14621-14624 http://purl.obolibrary.org/obo/CLO_0050509 denotes 2/7
T110 14838-14839 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 15242-15243 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 15494-15499 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T113 15707-15708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 15999-16000 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 16133-16134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T116 16370-16375 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T117 16630-16642 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T118 16669-16670 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T119 16698-16701 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T120 16721-16722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T121 16892-16893 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T122 17051-17052 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T123 17071-17072 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 17134-17139 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T125 17134-17139 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T126 17389-17390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 17463-17465 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T128 17563-17567 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T129 17664-17669 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T130 17664-17669 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T131 18081-18088 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T132 18113-18125 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T133 18165-18177 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T134 18287-18292 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T135 18287-18292 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T136 18434-18441 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T137 18519-18520 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 18704-18716 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T139 18800-18801 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 19283-19284 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T141 19392-19393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T142 19408-19411 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T143 19451-19453 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T144 19936-19938 http://purl.obolibrary.org/obo/CLO_0050050 denotes s1
T145 19946-19948 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T146 21377-21382 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T147 21459-21464 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T148 21471-21472 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 21575-21576 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T150 21603-21604 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T151 21729-21730 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 21830-21835 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T153 21842-21843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T154 21991-21993 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T155 22008-22013 http://www.ebi.ac.uk/efo/EFO_0000265 denotes (D) a
T156 22113-22118 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T157 22152-22156 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T158 22152-22156 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T159 22293-22294 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T160 22514-22526 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T161 22735-22736 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 22760-22765 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T163 22760-22765 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T164 23505-23512 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T165 23780-23785 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T166 23780-23785 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T167 23957-23959 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T168 24235-24237 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T169 24246-24258 http://purl.obolibrary.org/obo/UBERON_0001155 denotes Colonization
T170 24468-24470 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T171 24512-24524 http://purl.obolibrary.org/obo/UBERON_0001155 denotes Colonization
T172 24611-24613 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T173 24635-24637 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T174 24752-24754 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T175 24786-24788 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T176 25187-25194 http://purl.obolibrary.org/obo/CLO_0054060 denotes (10) 2
T177 25277-25283 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T178 25277-25283 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T179 25277-25283 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T180 25424-25429 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T181 25424-25429 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T182 25424-25429 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T183 25424-25429 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T184 25457-25459 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T185 25485-25488 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T186 25523-25525 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T187 25571-25574 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T188 25588-25593 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T189 25594-25598 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T190 25937-25939 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T191 26027-26030 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T192 26104-26108 http://purl.obolibrary.org/obo/CLO_0001442 denotes 6–12
T193 26111-26113 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T194 26166-26169 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T195 26172-26174 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T196 26285-26288 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T197 26347-26350 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T198 26373-26375 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T199 26437-26439 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T200 26465-26467 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T201 26504-26506 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T202 26596-26604 http://purl.obolibrary.org/obo/CLO_0008192 denotes n (%). P
T203 26634-26646 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T204 26703-26709 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T205 26765-26769 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T206 26896-26901 http://purl.obolibrary.org/obo/UBERON_0003103 denotes Organ
T207 26928-26936 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T208 26928-26936 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T209 27151-27153 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T210 27510-27512 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T211 27816-27820 http://purl.obolibrary.org/obo/CLO_0001407 denotes 5 2
T212 27854-27858 http://purl.obolibrary.org/obo/CLO_0050507 denotes 2 2
T213 27863-27867 http://purl.obolibrary.org/obo/CLO_0053733 denotes 1 1
T214 28078-28082 http://purl.obolibrary.org/obo/CLO_0054055 denotes 7 1
T215 28125-28129 http://purl.obolibrary.org/obo/CLO_0053733 denotes 1 1
T216 28157-28169 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T217 28205-28217 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T218 28256-28268 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T219 28269-28271 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T220 28309-28321 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T221 28362-28374 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T222 28375-28383 http://purl.obolibrary.org/obo/CLO_0001010 denotes 13 0 1
T223 28415-28427 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T224 28468-28480 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T225 28521-28533 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T226 28537-28539 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T227 28617-28619 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T228 28622-28624 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T229 28707-28720 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonizations
T230 28722-28724 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T231 28937-28939 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T232 28981-28993 http://purl.obolibrary.org/obo/UBERON_0001155 denotes Colonization
T233 29119-29121 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T234 29131-29133 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T235 29180-29182 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T236 29191-29193 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T237 29208-29210 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T238 29260-29267 http://purl.obolibrary.org/obo/CLO_0001188 denotes 20 (44)
T239 29327-29331 http://purl.obolibrary.org/obo/CLO_0001405 denotes 5–11
T240 29354-29356 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T241 29462-29464 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T242 29471-29473 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T243 29491-29493 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T244 29498-29500 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T245 29614-29622 http://purl.obolibrary.org/obo/CLO_0008192 denotes n (%). P
T246 29652-29664 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T247 29721-29727 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T248 29783-29787 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T249 29871-29876 http://purl.obolibrary.org/obo/UBERON_0003103 denotes Organ

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 2672-2692 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 5154-5166 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T3 5168-5190 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 5215-5229 Phenotype denotes kidney disease http://purl.obolibrary.org/obo/HP_0000112
T5 5610-5616 Phenotype denotes Sepsis http://purl.obolibrary.org/obo/HP_0100806
T6 16353-16358 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T7 16370-16380 Phenotype denotes chest pain http://purl.obolibrary.org/obo/HP_0100749
T8 16390-16397 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T9 16399-16409 Phenotype denotes hemoptysis http://purl.obolibrary.org/obo/HP_0002105
T10 16424-16449 Phenotype denotes respiratory insufficiency http://purl.obolibrary.org/obo/HP_0002093
T11 25003-25015 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T12 25068-25074 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T13 25152-25174 Phenotype denotes Cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T14 25216-25253 Phenotype denotes Chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/HP_0006510
T15 25269-25291 Phenotype denotes Chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 3687-3702 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T2 4989-5010 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T3 4997-5010 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4 6937-6942 http://purl.obolibrary.org/obo/GO_0019835 denotes Lysis
T5 12665-12683 http://purl.obolibrary.org/obo/GO_0016046 denotes detection of fungi

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 671-684 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T2 3387-3400 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T3 3402-3404 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T4 3755-3768 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T5 3770-3772 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T6 3928-3930 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T7 4289-4291 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T8 5996-5998 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T9 7356-7358 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T10 7369-7371 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T11 8783-8785 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T12 11798-11800 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T13 12811-12813 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T14 13389-13391 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T15 17185-17187 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T16 17648-17650 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T17 18280-18282 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T18 18455-18457 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T19 23797-23799 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T20 23911-23913 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T21 23915-23928 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T22 27303-27316 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T23 27318-27320 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T24 27373-27375 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T25 27386-27388 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T26 27692-27694 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Is the COVID-19 Pandemic a Good Time to Include Aspergillus Molecular Detection to Categorize Aspergillosis in ICU Patients?
T2 125-149 Sentence denotes A Monocentric Experience
T3 151-159 Sentence denotes Abstract
T4 160-175 Sentence denotes (1) Background:
T5 176-320 Sentence denotes The diagnosis of invasive aspergillosis (IA) in an intensive care unit (ICU) remains a challenge and the COVID-19 epidemic makes it even harder.
T6 321-430 Sentence denotes Here, we evaluated Aspergillus PCR input to help classifying IA in SARS-CoV-2-infected patients. (2) Methods:
T7 431-548 Sentence denotes 45 COVID-19 patients were prospectively monitored twice weekly for Aspergillus markers and anti-Aspergillus serology.
T8 549-685 Sentence denotes We evaluated the concordance between (I) Aspergillus PCR and culture in respiratory samples, and (II) blood PCR and serum galactomannan.
T9 686-798 Sentence denotes Patients were classified as putative/proven/colonized using AspICU algorithm and two other methods. (3) Results:
T10 799-963 Sentence denotes The concordance of techniques applied on respiratory and blood samples was moderate (kappa = 0.58 and kappa = 0.63, respectively), with a higher sensitivity of PCR.
T11 964-1030 Sentence denotes According to AspICU, 9/45 patients were classified as putative IA.
T12 1031-1177 Sentence denotes When incorporating PCR results, 15 were putative IA because they met all criteria, probably with a lack of specificity in the context of COVID-19.
T13 1178-1298 Sentence denotes Using a modified AspICU algorithm, eight patients were classified as colonized and seven as putative IA. (4) Conclusion:
T14 1299-1420 Sentence denotes An appreciation of the fungal burden using PCR and Aspergillus serology was added to propose a modified AspICU algorithm.
T15 1421-1556 Sentence denotes This proof of concept seemed relevant, as it was in agreement with the outcome of patients, but will need validation in larger cohorts.
T16 1558-1560 Sentence denotes 1.
T17 1561-1573 Sentence denotes Introduction
T18 1574-1756 Sentence denotes Molecular tools as diagnostic criteria for invasive fungal diseases (IFD) has long been questioned because of a lack of reproducibility and insufficient standardization of protocols.
T19 1757-1974 Sentence denotes Thanks to initiatives such as FPCRI (www.fpcri.eu [1]) and to the dramatic improvement of the quality assessment of molecular technics, Aspergillus PCR is now included in the new EORTC criteria for classification [2].
T20 1975-2147 Sentence denotes Regarding intensive care units (ICU) patients, the classification of IFD mainly refers on criteria adapted from neutropenic patients or relies on single center experiences.
T21 2148-2275 Sentence denotes One algorithm has emerged as a valuable tool to classify invasive aspergillosis (IA) in ICU patients: the AspICU algorithm [3].
T22 2276-2543 Sentence denotes This classification is considered as robust because it has been evaluated in patients for whom autopsy results were available, but it is quite awkward to use in routine practice, particularly in COVID-19 patients with clinical and CT-scan signs hard to interpret [4].
T23 2544-2625 Sentence denotes Besides, it does not include molecular markers, which are now used routinely [5].
T24 2626-2920 Sentence denotes During COVID-19, patients presenting an acute respiratory distress syndrome (ARDS) shared risk factors and underlying diseases classically reported for IA, such as intubation and mechanical ventilation, corticosteroid therapy, immunological storm with high production of inflammatory cytokines.
T25 2921-3110 Sentence denotes Warnings following preliminary cohort studies from various countries prompted the monitoring of fungal colonization and co-infections in SARS-CoV-2-infected patients hospitalized in an ICU.
T26 3111-3268 Sentence denotes However, the entry criterion for putative IA, according to Blot et al., is an Aspergillus-positive culture endotracheal aspirate, which may lack specificity.
T27 3269-3511 Sentence denotes In the recent review by Arastehfar et al. [6], many COVID-19-associated pulmonary aspergillosis (CAPA) benefited from galactomannan (GM) testing of bronchoalveolar fluid (BALF) or even of tracheal aspirates (not approved by the manufacturer).
T28 3512-3703 Sentence denotes However, some laboratories, such as ours, have stopped various manipulations of highly SARS-CoV-2-infected samples in order to limit the exposure of laboratory technicians to viral infection.
T29 3704-3880 Sentence denotes Then, direct examination of respiratory samples or galactomannan (GM) determination in broncho-alveolar lavage have thus been replaced by the systematic use of molecular tools.
T30 3881-4122 Sentence denotes While performances of blood biomarkers such as GM, (1-3)β-d-glucan (BDG) or Aspergillus DNA detection are well evaluated in neutropenic patients, their clinical value is far less known in other conditions and still need evaluation in an ICU.
T31 4123-4292 Sentence denotes Here, our objective was to evaluate the concordance between molecular detection of Aspergillus in respiratory and culture and concordance between blood PCR and serum GM.
T32 4293-4458 Sentence denotes We also aimed at assessing the ability of Aspergillus PCRs to help categorizing patients in the continuum of colonization to invasive infection in COVID-19 patients.
T33 4459-4513 Sentence denotes Arguments to complement AspICU criteria are suggested.
T34 4515-4517 Sentence denotes 2.
T35 4518-4539 Sentence denotes Materials and Methods
T36 4541-4545 Sentence denotes 2.1.
T37 4546-4568 Sentence denotes Population of Patients
T38 4569-4782 Sentence denotes Forty-five intubated and mechanically ventilated patients hospitalized in a “COVID-19 ICU” of Rennes teaching hospital were screened for this study and benefited from a systematic monitoring to detect Aspergillus.
T39 4783-4871 Sentence denotes The hospital’s ethics committee (N 20-56 obtained the 30 April 2020) approved the study.
T40 4872-5054 Sentence denotes The presence of SARS-CoV-2 in respiratory specimens (nasal and pharyngeal swabs or sputum) was detected by real time reverse transcription-polymerase chain reaction (RT-PCR) methods.
T41 5055-5395 Sentence denotes The following data were recorded: age, patient’s preexisting condition (current smoking, diabetes, hypertension, cardiovascular disease, pulmonary disease, and kidney disease), body mass index, ICU length of stay, duration of mechanical ventilation, ventilator-free days at day 28, need for prone position ventilation, and death in the ICU.
T42 5396-5491 Sentence denotes Initial clinical laboratory workup included a complete blood count and serum biochemical tests.
T43 5492-5553 Sentence denotes Chest CT scans were performed during the ICU hospitalization.
T44 5554-5756 Sentence denotes The Simplified Acute Physiology Score (SAPS II) and the Sepsis-Related Organ Failure Assessment (SOFA) score at admission in ICU, at day 7 and 14 days after admission were used to assess severity [7,8].
T45 5758-5762 Sentence denotes 2.2.
T46 5763-5784 Sentence denotes Aspergillus Detection
T47 5785-6056 Sentence denotes Respiratory samples, either bronchial or endotracheal aspirates or bronchoalveolar lavages, were systematic twice weekly and Aspergillus detection was performed using culture and real-time quantitative PCR, but GM was not performed to avoid any risk of lab contamination.
T48 6057-6161 Sentence denotes Briefly, respiratory samples were first digested using v/v digestEUR (Eurobio) for 30 min under shaking.
T49 6162-6374 Sentence denotes Mycological culture were performed after centrifugation of fluidified samples by inoculation of 100–200 µL of pellet on Sabouraud-Chloramphenicol dextrose Agar plates, and incubated for 7 days at 30 °C and 37 °C.
T50 6375-6620 Sentence denotes Mold identification at genus or species complex level was performed microscopically, and confirmed at species level using MALDI-ToF mass spectrometry (MALDI Biotyper, Bruker France, Marne-la-Vallée, France), after fungal material extraction [9].
T51 6621-6784 Sentence denotes Spectrum profiles were then submitted to the Mass Spectrometry Identification (MSI) online database for definitive identification (https://msi.happy-dev.fr/ [10]).
T52 6785-7089 Sentence denotes For molecular detection, 200 µL of plain fluidified respiratory sample underwent immediate SARS-CoV-2 inactivation by heating at 56 °C overnight in ATL Lysis buffer (Qiagen, Saint-Quentin Fallavier, France), before DNA extraction using the EZ1 DSP virus kit (Qiagen) on a EZ1 Advanced XL device (Qiagen).
T53 7090-7210 Sentence denotes Molecular detection of A. fumigatus was done using a 28S rDNA Aspergillus-targeted PCR, as previously published [11,12].
T54 7211-7560 Sentence denotes In case of Aspergillus positive culture and/or positive PCR in respiratory samples, additional tests were performed on serum, i.e., detection of GM (Platelia GM Aspergillus, Biorad, Marnes-la-Coquette, France), Aspergillus PCR and detection of anti-Aspergillus antibody by ELISA (Platelia IgG Aspergillus, Biorad) and in-house immunoelectrophoresis.
T55 7561-7795 Sentence denotes Briefly, Aspergillus PCR was performed on 1 mL of serum extracted using MagNA Pure 24 Total NA Isolation kit (Roche diagnostics, Meylan, France) on a MagNA Pure 24 device (Roche diagnostics), according to manufacturer recommendations.
T56 7796-7832 Sentence denotes DNA was eluted in a volume of 50 µL.
T57 7834-7838 Sentence denotes 2.3.
T58 7839-7859 Sentence denotes Statistical Analysis
T59 7860-8008 Sentence denotes Continuous variables were expressed as median (interquartile range, IQR) and compared using the nonparametric Mann–Whitney U or Kruskal–Wallis test.
T60 8009-8087 Sentence denotes Dunn’s correction tests were performed if multiple comparisons were requested.
T61 8088-8141 Sentence denotes Qualitative data were compared using Chi-square test.
T62 8142-8205 Sentence denotes Tests were two-sided with significance set at α less than 0.05.
T63 8206-8356 Sentence denotes Concordance between categorical results from diagnostic tests was performed using the percent agreement coefficient and Cohen’s kappa coefficient (κ).
T64 8357-8419 Sentence denotes When comparing quantitative data, an ANOVA test was performed.
T65 8420-8506 Sentence denotes All data were analyzed with GraphPad Prism 8.4 (GraphPad Software, La Jolla, CA, USA).
T66 8508-8510 Sentence denotes 3.
T67 8511-8518 Sentence denotes Results
T68 8520-8524 Sentence denotes 3.1.
T69 8525-8551 Sentence denotes Patient Aspergillus Status
T70 8552-8645 Sentence denotes A cohort of 45 COVID-19 intubated and mechanically ventilated patients for ARDS was followed.
T71 8646-8709 Sentence denotes Patients benefited from a systematic screening for Aspergillus.
T72 8710-8832 Sentence denotes Overall, 211 respiratory samples (culture and PCR) and 32 serum samples (GM detection and Aspergillus PCR) were collected.
T73 8833-8926 Sentence denotes The mean number of respiratory samples until patient discharge from ICU was 3.8 (median = 3).
T74 8927-9179 Sentence denotes We categorized these 45 patients according to the AspICU algorithm and propose two alternative classification methods presented in Table 1: the AspICU algorithm associated to PCR results in respiratory and serum samples, and a modified AspICU proposal.
T75 9180-9280 Sentence denotes Thirty patients did not present any biological criteria of aspergillosis with any of the algorithms.
T76 9281-9596 Sentence denotes According to the AspICU classification incorporating PCR detection, 15 were classified as having putative aspergillosis because they met all criteria reported by Blot et al., i.e., compatible clinical signs, abnormal thoracic medical imaging on CT scan and positive screening for Aspergillus on respiratory samples.
T77 9597-9966 Sentence denotes However, in this particular context of COVID-19 with all ARDS patients presenting compatible clinical signs and abnormal chest CT imaging in all likelihood lacking specificity, we decided to use a modified AspICU algorithm taking into account blood markers; we classified eight patients as colonized and seven patients with a putative/probable IA (Table 1 and Table 2).
T78 9968-9972 Sentence denotes 3.2.
T79 9973-10025 Sentence denotes Demographic, Clinical and Biological Characteristics
T80 10026-10138 Sentence denotes Demographic, clinical and biological baseline characteristics at admission are detailed in Table 3 and Table S1.
T81 10139-10307 Sentence denotes Basic demographic characteristics were well-balanced between the three groups of patients (no aspergillosis, Aspergillus colonization, putative/probable aspergillosis).
T82 10308-10396 Sentence denotes Of note, we observed a high proportion (71.1%) of male patients in the study population.
T83 10397-10549 Sentence denotes Clinical and biological baseline data did not differ among the three groups, except C-reactive protein which was higher in the “no aspergillosis” group.
T84 10550-10769 Sentence denotes Regarding the severity scores at admission, no differences were observed either, among the groups of patients, but SAPS II and SOFA scores at day one tended to be higher in patients with putative invasive aspergillosis.
T85 10771-10775 Sentence denotes 3.3.
T86 10776-10807 Sentence denotes Concordance of Diagnostic Tools
T87 10808-10885 Sentence denotes Table 4 gathers the results of the techniques used for Aspergillus detection.
T88 10886-11028 Sentence denotes DNA detection by PCR showed the highest sensitivity, with a number of positive respiratory samples near twice higher, compared to the culture.
T89 11029-11263 Sentence denotes Only one sample grew in culture, whereas PCR was negative, but the species obtained in culture was A. tubingensis (Nigri complex species), which is theoretically not amplified when using the 28S-targeted PCR specific for A. fumigatus.
T90 11264-11523 Sentence denotes Interestingly, the correlation between cultural and molecular quantification showed a significant difference between the two techniques, with a mean Cq threshold of 32.6 ± 0.7 when cultures were negative, highlighting the higher sensitivity of PCR (Figure 1).
T91 11524-11661 Sentence denotes Overall, the concordance coefficient between PCR and culture on respiratory samples was 90.52% with a Cohen’s Kappa coefficient of 0.588.
T92 11662-11751 Sentence denotes Regarding blood samples, three patients had a positive detection of a systemic biomarker:
T93 11752-11811 Sentence denotes 3/3 had a positive PCR and 2/3 had a positive GM (Table 5).
T94 11812-11936 Sentence denotes All three patients had a simultaneous detection of Aspergillus in respiratory samples by culture (n = 2) and/or PCR (n = 3).
T95 11937-12074 Sentence denotes Overall, the concordance coefficient between PCR and culture on respiratory samples was 93.75% with a Cohen’s Kappa coefficient of 0.632.
T96 12076-12080 Sentence denotes 3.4.
T97 12081-12150 Sentence denotes Relevance of Various Tests and Categorization of Patients and Outcome
T98 12151-12251 Sentence denotes Table 6 presents the classification of the 45 patients using original or modified AspICU algorithms.
T99 12252-12369 Sentence denotes It appears that using an AspICU algorithm, nine patients were considered as having a putative IA (22% of the cohort).
T100 12370-12603 Sentence denotes When including PCR, the number of patients with putative IA would increase from 9 to 15 (33%) patients, while most patients might be only colonized because all presented compatible clinical signs and abnormal chest CT scan (Table 5).
T101 12604-12770 Sentence denotes Regarding Aspergillus detection, eight patients had a single detection of fungi using culture and/or PCR in respiratory samples and thus were classified as colonized.
T102 12771-12933 Sentence denotes One of these patients had a concomitant GM detection in serum (index = 0.551), was not treated and is still alive, thus was considered as a false positive result.
T103 12934-13072 Sentence denotes Finally, seven (16%) patients presented a heavy burden of Aspergillus in the respiratory tract with repeated positive cultures and/or PCR.
T104 13073-13216 Sentence denotes In order to rule out a chronic colonization before the episode, an anti-Aspergillus antibody testing was performed and showed negative results.
T105 13217-13436 Sentence denotes These patients were classified as putative IA, and three of them could even be considered as probable IA because of a positive biomarker of angioinvasion (serum PCR and/or GM) in agreement with EORTC/MSG classification.
T106 13437-13561 Sentence denotes Interestingly, following these classification criteria, CT scan abnormalities showed a gradation according to patient group.
T107 13562-13827 Sentence denotes Diffuse reticular or alveolar opacities were observed in patients classified as probable IA (Figure 2), nodules in half of putative IA, and in colonized patients, only non-specific and hard to interpret signs in the context of COVID-19 infection could be described.
T108 13828-14095 Sentence denotes In addition, putative/probable aspergillosis patients appeared more severely ill than patients without aspergillosis, since SOFA score at day seven was significantly higher in this group (p = 0.01) with a continuum between no infection, colonization and IA (Table 5).
T109 14096-14307 Sentence denotes Similarly, the mean ICU length of stay increased significantly from 12 days in patients without aspergillosis to 23 days in colonized patients, and 27 days in putative/probable invasive aspergillosis (p = 0.02).
T110 14308-14404 Sentence denotes All patients with a putative/probable IA were treated either with voriconazole or isavuconazole.
T111 14405-14462 Sentence denotes Only one colonized patient was treated with voriconazole.
T112 14463-14677 Sentence denotes Six patients died; there was a trend towards higher mortality in the group of putative/probable IA compared to uninfected patients, although not significant (2/7; 28.6%) versus 4/30 (13.3%), respectively (Table 7).
T113 14679-14681 Sentence denotes 4.
T114 14682-14692 Sentence denotes Discussion
T115 14693-14916 Sentence denotes In France, the global burden of severe fungal infection is estimated at approximately 1,000,000 (1.47%) cases each year [13] and IFD account for a higher risk of mortality in patients with co-morbidities from 9 to 40% [14].
T116 14917-15090 Sentence denotes During the COVID-19 pandemic, warning messages considering similarities between Sars-CoV-2 and influenza infections stressed the importance of vigilance towards IFD [15,16].
T117 15091-15184 Sentence denotes Local experiences are now published and show high numbers of putative IA [17,18,19,20,21,22].
T118 15185-15350 Sentence denotes The diagnosis of IA still remains challenging because of a wide diversity of underlying conditions and growing number of criteria, particularly biological tools [6].
T119 15351-15644 Sentence denotes In deeply immunosuppressed patients, such as neutropenic patients, patients under antineoplastic and prolonged corticosteroid therapy or solid organ transplantation, criteria for classification of IFD and notably IA have recently been revised incorporating Aspergillus molecular detection [2].
T120 15645-15814 Sentence denotes In ICU, the AspICU algorithm published by Blot et al., [3] is a robust and helpful tool for aspergillosis classification but needs to be more evaluated and even updated.
T121 15815-16068 Sentence denotes In order to address limitations of the various classification definitions for ICU patients, the ongoing FUNgal infections Definitions in ICU patients (FUNDICU) project aims to develop a standard set of definitions for IFD in critically ill patients [5].
T122 16069-16189 Sentence denotes The breaking news of SARS-CoV-2 co-infection urges the need for a critical analysis of the criteria of AspICU algorithm.
T123 16190-16665 Sentence denotes Indeed, COVID-19 patients, particularly ARDS patients with mechanical ventilation, present with compatible clinical signs as depicted by the algorithm (refractory fever, pleuritic chest pain and rub, dyspnea, hemoptysis and worsening respiratory insufficiency, see [3] for full description) and CT-scan signs are hard to interpret because of COVID-19 CT-scan presentation, leading to absence or very poor discrimination between Aspergillus colonization and infection [19,23].
T124 16666-16874 Sentence denotes As a result, IA during COVID-19 has been reported with a possible overestimated high prevalence (until 30%), as favorable outcomes have been described in patients who did not receive any antifungal treatment.
T125 16875-17226 Sentence denotes In order to have a well-balanced patient management, limiting unnecessary and costly antifungal treatments while not neglecting the life-threatening feature of IA, we included A. fumigatus PCR as a monitoring tool for fungal detection in both respiratory and blood samples in addition to classical culture and GM approaches but with some restrictions.
T126 17227-17307 Sentence denotes As expected, PCR allowed detecting Aspergillus in much more respiratory samples.
T127 17308-17467 Sentence denotes We previously showed that PCR improved the detection of Aspergillus in BAL, with a particular added value in ICU patients compared to hematology patients [11].
T128 17468-17619 Sentence denotes Furthermore, PCR using in-house but also marketed kits is also capable of identifying specific gene mutations associated with azole resistance [11,24].
T129 17620-17749 Sentence denotes Besides, the sensitivity of GM detection in blood is less sensitive in ICU than for patients with hematological malignancies [5].
T130 17750-17890 Sentence denotes Here, the higher sensitivity of Aspergillus detection also incites us to adopt modified criteria for case definition to gain in specificity.
T131 17891-18352 Sentence denotes Two major changes were introduced to modify the granularity of the classification: (i) the first one is to combine Aspergillus detection in respiratory samples and anti-Aspergillus antibody testing, to distinguish chronic colonization (positive serology) from acute massive colonization (negative serology) and (ii) the second is to introduce of obvious biomarkers of angioinvasion (serum GM and blood PCR), similar to those of the EORTC/MSG classification [2].
T132 18353-18597 Sentence denotes Of note, the combination of positive culture, positive anti-Aspergillus antibody testing and positive GM in the context of chronic respiratory diseases characterized a transition step from chronic pulmonary aspergillosis to probable IA [25,26].
T133 18598-18919 Sentence denotes Using this refined classification, we were able to categorize our patients in five classes: no infection, colonization, putative IA, probable IA and proven IA (no case of proven IA in the cohort), with a better relevance than the initial AspICU classification, and better specificity than the AspICU + PCR classification.
T134 18920-19091 Sentence denotes The decision of antifungal treatment onset was taken according to this modified AspICU classification and the outcome observed gives confidence in this patient management.
T135 19092-19282 Sentence denotes Of course, the limitation of this work is the relatively small number of patients and should be evaluated on larger cohorts in order to correctly analyze the performance of this alternative.
T136 19283-19454 Sentence denotes A remaining question is also to determine the place of the serum biomarker (1,3)-β-d-glucan in ICU patients, a question that has recently been raised by Honoré et al. [27]
T137 19455-19651 Sentence denotes In conclusion, molecular techniques are now key tools for monitoring IFD, particularly IA as recently updated in the EORTC/MSG definitions, but also Pneumocystis jirovecii or mucorales infections.
T138 19652-19758 Sentence denotes Here, we suggest some adaptations of the AspICU clinical algorithm to gain in sensitivity and specificity.
T139 19759-19833 Sentence denotes Large multicentric data are needed to confirm this proof of concept study.
T140 19835-19858 Sentence denotes Supplementary Materials
T141 19859-19949 Sentence denotes The following are available online at https://www.mdpi.com/2309-608X/6/3/105/s1, Table S1:
T142 19950-20069 Sentence denotes Clinical and biological features of the 9 patients classified as putative aspergillosis according to Blot et al., 2012.
T143 20070-20106 Sentence denotes Click here for additional data file.
T144 20108-20128 Sentence denotes Author Contributions
T145 20129-20791 Sentence denotes Conceptualization, J.-P.G., F.R., H.G., J.-M.T. and F.R.-G.; Data curation, J.-P.G., H.G., R.P., M.L. and F.R.-G.; Formal analysis, J.-P.G., F.R., H.G., M.L., J.-M.T. and F.R.-G.; Investigation, J.-P.G., F.R., H.G., K.P., P.L.B., R.P., E.P., S.B., M.L.S., Y.L.T., P.S., M.L. and J.-M.T.; Methodology, J.-P.G., F.R., H.G.and F.R.-G.; Project administration, J.-P.G.; Resources, J.-P.G, F.R., H.G., K.P., P.L.B., R.P., E.P., S.B., M.L.S., Y.L.T., P.S., M.L., J.-M.T. and F.R.-G.; Software, F.R.; Supervision, J.-P.G. and F.R.-G.; Validation, J.-P.G., Y.L.T. and F.R.-G.; Writing—original draft, J.-P.G. and F.R.-G.; Writing—review & editing, F.R., H.G. and J.-M.T.
T146 20792-20868 Sentence denotes All authors have read and agreed to the published version of the manuscript.
T147 20870-20877 Sentence denotes Funding
T148 20878-20921 Sentence denotes This research received no external funding.
T149 20923-20944 Sentence denotes Conflicts of Interest
T150 20945-21034 Sentence denotes J.-P.G. received funds for communications and congress attendance from Pfizer and Gilead.
T151 21035-21095 Sentence denotes The other authors declare they have no conflict of interest.
T152 21097-21216 Sentence denotes Figure 1 Correlation between molecular and cultural quantification of Aspergillus burden in respiratory samples (rare:
T153 21217-21236 Sentence denotes 1–2 CFU/plate; few:
T154 21237-21339 Sentence denotes 2–5; numerous: >5). * significantly different with p < 0.05. ** significantly different with p < 0.01.
T155 21340-21447 Sentence denotes Figure 2 Computed tomography of the chest of patients with COVID-19 with secondary invasive aspergillosis.
T156 21448-21820 Sentence denotes Unenhanced chest CT in a 59-year-old man with COVID-19 and biological markers of invasive aspergillosis performed at baseline (A) and at 12-day follow-up (B) showing subpleural ground-glass and reticular opacities presumed to correspond to COVID-19 lesions (arrowheads) as well as a right apical consolidation area presumed to correspond to invasive aspergillosis (arrow).
T157 21821-22182 Sentence denotes Enhanced chest CT in a 69-year-old man with COVID-19 and biological markers of invasive aspergillosis showing at baseline (C) ground-glass opacities (arrowheads), and at 11-day follow-up (D) a left postero-basal consolidation presumed to correspond to invasive aspergillosis (arrow). (346-mm field of view, 512 × 512 image matrix, lung window (W1600/L-500 HU)).
T158 22183-22321 Sentence denotes Table 1 Diagnostic criteria of the AspICU clinical algorithm according to Blot et al., 2012, and proposal of a modified AspICU algorithm.
T159 22322-22499 Sentence denotes Classification AspICU According to Blot et al., 2012 [3] AspICU Algorithm Incorporating PCR Modified AspICU Algorithm Incorporating PCR, Serology and Angioinvasion Biomarkers
T160 22500-22775 Sentence denotes Definition of colonization Aspergillus-positive culture endotracheal aspirate alone Aspergillus-positive culture/PCR endotracheal aspirate alone Aspergillus-positive culture/PCR endotracheal aspirate in one sample, not confirmed on a second sample or using blood biomarker
T161 22776-22822 Sentence denotes Definition of putative IA >1 criterion among:
T162 22823-22825 Sentence denotes 1.
T163 22826-22879 Sentence denotes Aspergillus-positive culture endotracheal aspirate 2.
T164 22880-22908 Sentence denotes Compatible clinical signs 3.
T165 22909-22966 Sentence denotes Abnormal thoracic medical imaging on CT scan or X-ray 4a.
T166 22967-22991 Sentence denotes Host risk factors Or 4b.
T167 22992-23100 Sentence denotes Semiquantitative Aspergillus-positive culture of BAL fluid + positive direct microscopy >1 criterion among:
T168 23101-23103 Sentence denotes 1.
T169 23104-23161 Sentence denotes Aspergillus-positive culture/PCR endotracheal aspirate 2.
T170 23162-23190 Sentence denotes Compatible clinical signs 3.
T171 23191-23248 Sentence denotes Abnormal thoracic medical imaging on CT scan or X-ray 4a.
T172 23249-23273 Sentence denotes Host risk factors Or 4b.
T173 23274-23386 Sentence denotes Semiquantitative Aspergillus-positive culture/PCR of BAL fluid + positive direct microscopy >1 criterion among:
T174 23387-23389 Sentence denotes 1.
T175 23390-23515 Sentence denotes Aspergillus-positive culture/PCR endotracheal aspirate in repeated samples with negative anti-Aspergillus antibody testing 2.
T176 23516-23544 Sentence denotes Compatible clinical signs 3.
T177 23545-23602 Sentence denotes Abnormal thoracic medical imaging on CT scan or X-ray 4a.
T178 23603-23627 Sentence denotes Host risk factors Or 4b.
T179 23628-23719 Sentence denotes Semiquantitative Aspergillus-positive culture/PCR of BAL fluid + positive direct microscopy
T180 23720-23811 Sentence denotes Definition of probable IA - - Putative IA + one positive blood biomarker (GM and/or PCR)
T181 23812-23910 Sentence denotes Definition of proven IA Positive histopathology Positive histopathology Positive histopathology
T182 23911-23929 Sentence denotes GM: galactomannan.
T183 23930-24042 Sentence denotes Table 2 Classification of 45 COVID-19 patients with ARDS according to AspICU and to modified AspICU algorithms.
T184 24043-24220 Sentence denotes Classification AspICU According to Blot et al., 2012 [3] AspICU Algorithm Incorporating PCR Modified AspICU Algorithm Incorporating PCR, Serology and Angioinvasion Biomarkers
T185 24221-24245 Sentence denotes No infection 36 30 30
T186 24246-24267 Sentence denotes Colonization 0 0 8
T187 24268-24289 Sentence denotes Putative IA 9 15 4
T188 24290-24310 Sentence denotes Probable IA - - 3
T189 24311-24329 Sentence denotes Proven IA 0 0 0
T190 24330-24420 Sentence denotes Table 3 Demographic characteristics and clinical and biological baseline characteristics.
T191 24421-24591 Sentence denotes Demographic Characteristics All Patients (n = 45) No Aspergillosis (n = 30) Aspergillus Colonization (n = 8) Putative/Probable Invasive Aspergillosis (n = 7) p Value
T192 24592-24656 Sentence denotes Age, years 60 (53–71) 59 (54–68) 53 (51–71) 70 (63–75) 0.14
T193 24657-24746 Sentence denotes SexMen Women 32 (71.1)13 (28.9) 21 (70)9 (30) 7 (87.5)1 (12.5) 4 (57.1)3 (42.8) 0.42
T194 24747-24824 Sentence denotes BMI 27 (24.4–31.4) 27.5 (24.7–32.3) 27 (25.2–30.7) 25.2 (23.2–26.4) 0.99
T195 24825-24877 Sentence denotes Current smoking 3 (6.7) 2 (4.4) 0 1 (12.5) 0.54
T196 24878-24899 Sentence denotes Coexisting conditions
T197 24900-24947 Sentence denotes Any 31 (68.9) 19 (63) 6 (75) 6 (85.7) 0.47
T198 24948-25002 Sentence denotes Diabetes 17 (37.8) 12 (40) 3 (37.5) 2 (28.6) 0.74
T199 25003-25061 Sentence denotes Hypertension 15 (33.3) 7 (23.3) 5 (62.5) 3 (42.9) 0.1
T200 25062-25104 Sentence denotes Solid cancer 1 (2.2) 1 (3.3) 0 0 0.77
T201 25105-25151 Sentence denotes Hemopathy 2 (4.4) 1 (3.3) 0 1 (14.3) 0.54
T202 25152-25215 Sentence denotes Cardiovascular disease 3 (6.7) 3 (10) 2 (25) 2 (28.6) 0.34
T203 25216-25268 Sentence denotes Chronic obstructive pulmonary disease 0 0 0 0 -
T204 25269-25335 Sentence denotes Chronic kidney disease 4 (8.9) 2 (6.7) 1 (12.5) 1 (14.3) 0.83
T205 25336-25423 Sentence denotes Temperature (°C) 38 (37–38.9) 37.5 (337–38.4) 38.2 (37.9–39) 38.2 (37.7–38.8) 0.29
T206 25424-25503 Sentence denotes Heart rate (/min) 100 (80–110) 94 (80–110) 104 (100–110) 102 (85–119) 0.63
T207 25504-25581 Sentence denotes Systolic pressure 94 (87–107) 93 (85–105) 103 (100–109) 90 (82–102) 0.34
T208 25582-25678 Sentence denotes White blood cell count (109/L) 9.8 (6.8–12.9) 9.7 (6.9–13) 9.9 (7–10.7) 9.9 (6.7–12.9) 0.97
T209 25679-25769 Sentence denotes Neutrophil count (109/L) 7.9 (4.5–10.8) 7 (4.9–10.5) 8.5 (5.2–8.6) 5.6 (3.5–10.4) 0.8
T210 25770-25870 Sentence denotes Lymphocyte count (109/L) 0.81 (0.58–1.11) 0.83 (0.53–1.14) 0.7 (0.63–1.1) 0.72 (0.58–0.81) 0.87
T211 25871-25957 Sentence denotes Hemoglobin (g/L) 10.8 (9.5–12.5) 10 (9.4–12) 11.8 (10.6–13.6) 11 (10.5–13.6) 0.12
T212 25958-26046 Sentence denotes Platelet count (109/L) 264 (194–357) 282 (220–364) 244 (184–347) 162 (129–262) 0.12
T213 26047-26137 Sentence denotes Total bilirubin concentration (µmol/L) 8 (5.5–12) 8.5 (6–12) 11 (9–13) 7 (5.5–8) 0.72
T214 26138-26216 Sentence denotes Creatinine (µmol/L) 81 (53–162) 71 (51–109) 81 (73–173) 101 (82–184) 0.15
T215 26217-26314 Sentence denotes C-reactive protein (CRP) (mg/L) 157 (112–263) 155 (112–265) 112 (102–131) 112 (109–178) 0.03
T216 26315-26400 Sentence denotes Ratio of PaO2 to FiO2 152 (100–181) 164 (107–214) 120 (94–214) 136 (72–155) 0.25
T217 26401-26477 Sentence denotes SAPS II score on day 1 42 (31–57) 35 (30–58) 42 (21–55) 43 (35–82) 0.55
T218 26478-26543 Sentence denotes SOFA score on day 1 7 (2–11) 7 (4–10) 5 (2–10) 9 (2–12) 0.76
T219 26544-26602 Sentence denotes Data are presented as median (IQR: interquartiles), n (%).
T220 26603-26794 Sentence denotes P values comparing Aspergillus colonization, invasive aspergillosis and no aspergillosis groups are tested by Kruskal–Wallis (continuous variables) or Chi-square test (categorical variables).
T221 26795-26814 Sentence denotes Abbreviations: BMI:
T222 26815-26840 Sentence denotes Body mass index; SAPS II:
T223 26841-26884 Sentence denotes Simplified Acute Physiology Score II; SOFA:
T224 26885-26952 Sentence denotes Sequential Organ Failure Assessment, PaO2: arterial oxygen tension.
T225 26953-27065 Sentence denotes Table 4 Concordance of PCR and cultures on respiratory samples (n = 211) to detect the presence of Aspergillus.
T226 27066-27128 Sentence denotes Respiratory Samples Positive Culture Negative Culture Total
T227 27129-27153 Sentence denotes Positive PCR 15 19 34
T228 27154-27181 Sentence denotes Negative PCR 1 * 176 177
T229 27182-27201 Sentence denotes Total 16 191 211
T230 27202-27266 Sentence denotes * positive culture with Aspergillus tubingensis (Nigri section).
T231 27267-27348 Sentence denotes Table 5 Concordance of 28S PCR and galactomannan (GM) in serum samples (n = 32).
T232 27349-27395 Sentence denotes Serum Samples Positive GM Negative GM Total
T233 27396-27417 Sentence denotes Positive PCR 2 1 3
T234 27418-27441 Sentence denotes Negative PCR 1 28 29
T235 27442-27458 Sentence denotes Total 3 29 32
T236 27459-27541 Sentence denotes Table 6 Mycological results and classification of 45 COVID-19 patients with ARDS.
T237 27542-27617 Sentence denotes Patient Respiratory Samples Serum Samples IA Classification According to
T238 27618-27809 Sentence denotes Aspergillus Positive Culture (nb Samples) Positive 28S PCR (nb Samples) GM Index > 0.5 (nb Samples) Positive 28S PCR (nb Samples) AspICU (Blot et al., 2012) AspICU + PCR Modified AspICU
T239 27810-27853 Sentence denotes 1 5 5 2 2 putative putative probable
T240 27854-27897 Sentence denotes 2 2 2 1 1 putative putative probable
T241 27898-27945 Sentence denotes 3 0 3 0 1 no infection putative probable
T242 27946-27989 Sentence denotes 4 4 6 0 0 putative putative putative
T243 27990-28033 Sentence denotes 5 4 4 0 0 putative putative putative
T244 28034-28077 Sentence denotes 6 2 5 0 0 putative putative putative
T245 28078-28121 Sentence denotes 7 1 5 0 0 putative putative putative
T246 28122-28169 Sentence denotes 8 1 1 0 0 putative putative colonization
T247 28170-28217 Sentence denotes 9 1 0 1 0 putative putative colonization
T248 28218-28268 Sentence denotes 10 1 * 0 0 0 putative putative colonization
T249 28269-28321 Sentence denotes 11 0 1 0 0 no infection putative colonization
T250 28322-28374 Sentence denotes 12 0 1 0 0 no infection putative colonization
T251 28375-28427 Sentence denotes 13 0 1 0 0 no infection putative colonization
T252 28428-28480 Sentence denotes 14 0 1 0 0 no infection putative colonization
T253 28481-28533 Sentence denotes 15 0 1 0 0 no infection putative colonization
T254 28534-28593 Sentence denotes 16–45 0 0 0 0 no infection no infection no infection
T255 28594-28742 Sentence denotes Total 9 putative (22%) 36 no infection 15 putative (33%)30 no infection 3 probable (7%) 4 putative (9%) 8 colonizations (18%) 30 no infection
T256 28743-28746 Sentence denotes IA.
T257 28747-28815 Sentence denotes Invasive aspergillosis, 1 * Aspergillus tubingensis (Nigri section).
T258 28816-28908 Sentence denotes Table 7 Outcomes of patients with COVID-19-associated ARDS according to Aspergillus status.
T259 28909-29060 Sentence denotes Outcomes All Patients (n = 45) No Aspergillosis (n = 30) Aspergillus Colonization (n = 8) Putative/Probable Invasive Aspergillosis (n = 7) p Value
T260 29061-29147 Sentence denotes Duration of mechanical ventilation 17 (9–24) 17 (7–24) 18 (10–21) 18 (12–30) 0.66
T261 29148-29228 Sentence denotes Ventilator free days at day 28 11 (4–19) 11 (4–21) 10 (7–18) 10 (0–16) 0.64
T262 29229-29302 Sentence denotes Prone positioning ventilation 20 (44) 12 (46) 3 (37.5) 5 (71.4) 0.29
T263 29303-29370 Sentence denotes SOFA score on day 7 7 (5–11) 6 (5–10) 8 (7–10) 11 (10–12) 0.01
T264 29371-29434 Sentence denotes SOFA score on day 14 7 (2–10) 7 (2–9) 3 (1–7) 9 (2–12) 0.2
T265 29435-29507 Sentence denotes ICU length of stay 20 (12–27) 12 (11–23) 23 (16–51) 27 (20–36) 0.02
T266 29508-29561 Sentence denotes Death in ICU 6 (13.3) 4 (13.3) 0 2 * (28.6) 0.27
T267 29562-29620 Sentence denotes Data are presented as median (IQR: interquartiles), n (%).
T268 29621-29812 Sentence denotes P values comparing Aspergillus colonization, invasive aspergillosis and no aspergillosis groups are tested by Kruskal Wallis (continuous variables) or Chi-square test (categorical variables).
T269 29813-29832 Sentence denotes Abbreviations: ICU:
T270 29833-29859 Sentence denotes Intensive Care Unit, SOFA:
T271 29860-29925 Sentence denotes Sequential Organ Failure Assessment, * 1 putative and 1 probable.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 115-123 Species denotes Patients Tax:9606
4 48-59 Species denotes Aspergillus Tax:746128
5 7-15 Disease denotes COVID-19 MESH:C000657245
23 408-416 Species denotes patients Tax:9606
24 443-451 Species denotes patients Tax:9606
25 686-694 Species denotes Patients Tax:9606
26 990-998 Species denotes patients Tax:9606
27 1219-1227 Species denotes patients Tax:9606
28 1503-1511 Species denotes patients Tax:9606
29 340-351 Species denotes Aspergillus Tax:746128
30 498-509 Species denotes Aspergillus Tax:746128
31 527-538 Species denotes Aspergillus Tax:746128
32 590-601 Species denotes Aspergillus Tax:746128
33 1350-1361 Species denotes Aspergillus Tax:746128
34 671-684 Chemical denotes galactomannan MESH:C012990
35 193-215 Disease denotes invasive aspergillosis MESH:D055744
36 281-289 Disease denotes COVID-19 MESH:C000657245
37 388-407 Disease denotes SARS-CoV-2-infected MESH:C000657245
38 434-442 Disease denotes COVID-19 MESH:C000657245
39 1168-1176 Disease denotes COVID-19 MESH:C000657245
50 2012-2020 Species denotes patients Tax:9606
51 2099-2107 Species denotes patients Tax:9606
52 2240-2248 Species denotes patients Tax:9606
53 2353-2361 Species denotes patients Tax:9606
54 2480-2488 Species denotes patients Tax:9606
55 1893-1904 Species denotes Aspergillus Tax:746128
56 1617-1641 Disease denotes invasive fungal diseases MESH:D000072742
57 2087-2098 Disease denotes neutropenic MESH:D009503
58 2205-2227 Disease denotes invasive aspergillosis MESH:D055744
59 2471-2479 Disease denotes COVID-19 MESH:C000657245
82 2643-2651 Species denotes patients Tax:9606
83 3078-3086 Species denotes patients Tax:9606
84 4017-4025 Species denotes patients Tax:9606
85 3189-3200 Species denotes Aspergillus Tax:746128
86 3957-3968 Species denotes Aspergillus Tax:746128
87 3387-3400 Chemical denotes galactomannan MESH:C012990
88 3402-3404 Chemical denotes GM MESH:C012990
89 3755-3768 Chemical denotes galactomannan MESH:C012990
90 3770-3772 Chemical denotes GM MESH:C012990
91 3928-3930 Chemical denotes GM MESH:C012990
92 3937-3947 Chemical denotes β-d-glucan
93 3949-3952 Chemical denotes BDG MESH:C480180
94 2633-2641 Disease denotes COVID-19 MESH:C000657245
95 2666-2701 Disease denotes acute respiratory distress syndrome MESH:D012128
96 2703-2707 Disease denotes ARDS MESH:D012128
97 3041-3054 Disease denotes co-infections MESH:D060085
98 3058-3077 Disease denotes SARS-CoV-2-infected MESH:C000657245
99 3321-3329 Disease denotes COVID-19 MESH:C000657245
100 3341-3364 Disease denotes pulmonary aspergillosis MESH:D055732
101 3599-3618 Disease denotes SARS-CoV-2-infected MESH:C000657245
102 3687-3702 Disease denotes viral infection MESH:D001102
103 4005-4016 Disease denotes neutropenic MESH:D009503
111 4373-4381 Species denotes patients Tax:9606
112 4449-4457 Species denotes patients Tax:9606
113 4206-4217 Species denotes Aspergillus Tax:746128
114 4335-4346 Species denotes Aspergillus Tax:746128
115 4289-4291 Chemical denotes GM MESH:C012990
116 4418-4436 Disease denotes invasive infection MESH:D007239
117 4440-4448 Disease denotes COVID-19 MESH:C000657245
121 4618-4626 Species denotes patients Tax:9606
122 4770-4781 Species denotes Aspergillus Tax:746128
123 4646-4654 Disease denotes COVID-19 MESH:C000657245
125 4888-4898 Species denotes SARS-CoV-2 Tax:2697049
134 5094-5101 Species denotes patient Tax:9606
135 5144-5152 Disease denotes diabetes MESH:D003920
136 5154-5166 Disease denotes hypertension MESH:D006973
137 5168-5190 Disease denotes cardiovascular disease MESH:D002318
138 5192-5209 Disease denotes pulmonary disease MESH:D008171
139 5215-5229 Disease denotes kidney disease MESH:D007674
140 5378-5383 Disease denotes death MESH:D003643
141 5610-5638 Disease denotes Sepsis-Related Organ Failure MESH:D009102
143 5763-5774 Species denotes Aspergillus Tax:746128
146 5910-5921 Species denotes Aspergillus Tax:746128
147 5996-5998 Chemical denotes GM MESH:C012990
149 6282-6321 Chemical denotes Sabouraud-Chloramphenicol dextrose Agar
154 6876-6886 Species denotes SARS-CoV-2 Tax:2697049
155 7113-7125 Species denotes A. fumigatus Tax:746128
156 7152-7163 Species denotes Aspergillus Tax:746128
157 6933-6942 Disease denotes ATL Lysis MESH:D015275
165 7222-7233 Species denotes Aspergillus Tax:746128
166 7422-7433 Species denotes Aspergillus Tax:746128
167 7460-7471 Species denotes Aspergillus Tax:746128
168 7570-7581 Species denotes Aspergillus Tax:746128
169 7356-7358 Chemical denotes GM MESH:C012990
170 7360-7383 Disease denotes Platelia GM Aspergillus MESH:C562602
171 7491-7515 Disease denotes Platelia IgG Aspergillus MESH:D017099
174 8525-8532 Species denotes Patient Tax:9606
175 8533-8544 Species denotes Aspergillus Tax:746128
183 8614-8622 Species denotes patients Tax:9606
184 8646-8654 Species denotes Patients Tax:9606
185 8878-8885 Species denotes patient Tax:9606
186 8697-8708 Species denotes Aspergillus Tax:746128
187 8800-8811 Species denotes Aspergillus Tax:746128
188 8567-8575 Disease denotes COVID-19 MESH:C000657245
189 8627-8631 Disease denotes ARDS MESH:D012128
200 8951-8959 Species denotes patients Tax:9606
201 9187-9195 Species denotes patients Tax:9606
202 9659-9667 Species denotes patients Tax:9606
203 9875-9883 Species denotes patients Tax:9606
204 9907-9915 Species denotes patients Tax:9606
205 9561-9572 Species denotes Aspergillus Tax:746128
206 9239-9252 Disease denotes aspergillosis MESH:D001228
207 9387-9400 Disease denotes aspergillosis MESH:D001228
208 9636-9644 Disease denotes COVID-19 MESH:C000657245
209 9654-9658 Disease denotes ARDS MESH:D012128
220 10481-10499 Gene denotes C-reactive protein Gene:1401
221 10220-10228 Species denotes patients Tax:9606
222 10363-10371 Species denotes patients Tax:9606
223 10651-10659 Species denotes patients Tax:9606
224 10723-10731 Species denotes patients Tax:9606
225 10248-10259 Species denotes Aspergillus Tax:746128
226 10233-10246 Disease denotes aspergillosis MESH:D001228
227 10292-10305 Disease denotes aspergillosis MESH:D001228
228 10528-10541 Disease denotes aspergillosis MESH:D001228
229 10746-10768 Disease denotes invasive aspergillosis MESH:D055744
233 11128-11142 Species denotes A. tubingensis Tax:5068
234 11250-11262 Species denotes A. fumigatus Tax:746128
235 10863-10874 Species denotes Aspergillus Tax:746128
240 11693-11701 Species denotes patients Tax:9606
241 11822-11830 Species denotes patients Tax:9606
242 11863-11874 Species denotes Aspergillus Tax:746128
243 11798-11800 Chemical denotes GM MESH:C012990
245 12130-12138 Species denotes Patients Tax:9606
259 12197-12205 Species denotes patients Tax:9606
260 12300-12308 Species denotes patients Tax:9606
261 12404-12412 Species denotes patients Tax:9606
262 12464-12472 Species denotes patients Tax:9606
263 12485-12493 Species denotes patients Tax:9606
264 12643-12651 Species denotes patients Tax:9606
265 12784-12792 Species denotes patients Tax:9606
266 12955-12963 Species denotes patients Tax:9606
267 13223-13231 Species denotes patients Tax:9606
268 12614-12625 Species denotes Aspergillus Tax:746128
269 12992-13003 Species denotes Aspergillus Tax:746128
270 13145-13156 Species denotes Aspergillus Tax:746128
271 12811-12813 Chemical denotes GM MESH:C012990
277 13547-13554 Species denotes patient Tax:9606
278 13619-13627 Species denotes patients Tax:9606
279 13715-13723 Species denotes patients Tax:9606
280 13789-13797 Disease denotes COVID-19 MESH:C000657245
281 13798-13807 Disease denotes infection MESH:D007239
300 13873-13881 Species denotes patients Tax:9606
301 13914-13922 Species denotes patients Tax:9606
302 14175-14183 Species denotes patients Tax:9606
303 14230-14238 Species denotes patients Tax:9606
304 14312-14320 Species denotes patients Tax:9606
305 14424-14431 Species denotes patient Tax:9606
306 14467-14475 Species denotes patients Tax:9606
307 14585-14593 Species denotes patients Tax:9606
308 14374-14386 Chemical denotes voriconazole MESH:D065819
309 14390-14403 Chemical denotes isavuconazole MESH:C508735
310 14449-14461 Chemical denotes voriconazole MESH:D065819
311 13859-13872 Disease denotes aspergillosis MESH:D001228
312 13931-13944 Disease denotes aspergillosis MESH:D001228
313 14054-14063 Disease denotes infection MESH:D007239
314 14192-14205 Disease denotes aspergillosis MESH:D001228
315 14273-14295 Disease denotes invasive aspergillosis MESH:D055744
316 14476-14480 Disease denotes died MESH:D003643
317 14515-14524 Disease denotes mortality MESH:D003643
324 14868-14876 Species denotes patients Tax:9606
325 14997-15007 Species denotes Sars-CoV-2 Tax:2697049
326 14732-14748 Disease denotes fungal infection MESH:D009181
327 14855-14864 Disease denotes mortality MESH:D003643
328 14928-14936 Disease denotes COVID-19 MESH:C000657245
329 15022-15032 Disease denotes infections MESH:D007239
341 15378-15386 Species denotes patients Tax:9606
342 15408-15416 Species denotes patients Tax:9606
343 15897-15905 Species denotes patients Tax:9606
344 15956-15964 Species denotes patients Tax:9606
345 16055-16063 Species denotes patients Tax:9606
346 15608-15619 Species denotes Aspergillus Tax:746128
347 15418-15426 Species denotes patients Tax:9606
348 15396-15407 Disease denotes neutropenic MESH:D009503
349 15737-15750 Disease denotes aspergillosis MESH:D001228
350 15919-15936 Disease denotes FUNgal infections MESH:D009181
351 16040-16054 Disease denotes critically ill MESH:D016638
368 16090-16100 Species denotes SARS-CoV-2 Tax:2697049
369 16207-16215 Species denotes patients Tax:9606
370 16235-16243 Species denotes patients Tax:9606
371 16820-16828 Species denotes patients Tax:9606
372 16618-16629 Species denotes Aspergillus Tax:746128
373 16104-16113 Disease denotes infection MESH:D007239
374 16198-16206 Disease denotes COVID-19 MESH:C000657245
375 16230-16234 Disease denotes ARDS MESH:D012128
376 16353-16358 Disease denotes fever MESH:D005334
377 16360-16380 Disease denotes pleuritic chest pain MESH:D002637
378 16390-16397 Disease denotes dyspnea MESH:D004417
379 16399-16409 Disease denotes hemoptysis MESH:D006469
380 16424-16449 Disease denotes respiratory insufficiency MESH:D012131
381 16532-16540 Disease denotes COVID-19 MESH:C000657245
382 16647-16656 Disease denotes infection MESH:D007239
383 16689-16697 Disease denotes COVID-19 MESH:C000657245
403 16908-16915 Species denotes patient Tax:9606
404 17051-17063 Species denotes A. fumigatus Tax:746128
405 17421-17429 Species denotes patients Tax:9606
406 17453-17461 Species denotes patients Tax:9606
407 17704-17712 Species denotes patients Tax:9606
408 17262-17273 Species denotes Aspergillus Tax:746128
409 17364-17375 Species denotes Aspergillus Tax:746128
410 17782-17793 Species denotes Aspergillus Tax:746128
411 18006-18017 Species denotes Aspergillus Tax:746128
412 18060-18071 Species denotes Aspergillus Tax:746128
413 18413-18424 Species denotes Aspergillus Tax:746128
414 17185-17187 Chemical denotes GM MESH:C012990
415 17594-17599 Chemical denotes azole MESH:D001393
416 17648-17650 Chemical denotes GM MESH:C012990
417 18280-18282 Chemical denotes GM MESH:C012990
418 18455-18457 Chemical denotes GM MESH:C012990
419 17718-17744 Disease denotes hematological malignancies MESH:D019337
420 18484-18504 Disease denotes respiratory diseases MESH:D012140
421 18550-18573 Disease denotes pulmonary aspergillosis MESH:D055732
428 18664-18672 Species denotes patients Tax:9606
429 19072-19079 Species denotes patient Tax:9606
430 19165-19173 Species denotes patients Tax:9606
431 19382-19390 Species denotes patients Tax:9606
432 19358-19374 Chemical denotes (1,3)-β-d-glucan MESH:C480180
433 18693-18702 Disease denotes infection MESH:D007239
436 19604-19626 Species denotes Pneumocystis jirovecii Tax:42068
437 19640-19650 Disease denotes infections MESH:D007239
440 19992-20000 Species denotes patients Tax:9606
441 20024-20037 Disease denotes aspergillosis MESH:D001228
531 21168-21179 Species denotes Aspergillus Tax:746128
542 21386-21394 Species denotes patients Tax:9606
543 21400-21408 Disease denotes COVID-19 MESH:C000657245
544 21424-21446 Disease denotes invasive aspergillosis MESH:D055744
545 21494-21502 Disease denotes COVID-19 MESH:C000657245
546 21529-21551 Disease denotes invasive aspergillosis MESH:D055744
547 21688-21696 Disease denotes COVID-19 MESH:C000657245
548 21789-21811 Disease denotes invasive aspergillosis MESH:D055744
549 21865-21873 Disease denotes COVID-19 MESH:C000657245
550 21900-21922 Disease denotes invasive aspergillosis MESH:D055744
551 22073-22095 Disease denotes invasive aspergillosis MESH:D055744
562 22528-22539 Species denotes Aspergillus Tax:746128
563 22586-22597 Species denotes Aspergillus Tax:746128
564 22648-22659 Species denotes Aspergillus Tax:746128
565 22826-22837 Species denotes Aspergillus Tax:746128
566 23009-23020 Species denotes Aspergillus Tax:746128
567 23104-23115 Species denotes Aspergillus Tax:746128
568 23291-23302 Species denotes Aspergillus Tax:746128
569 23390-23401 Species denotes Aspergillus Tax:746128
570 23484-23495 Species denotes Aspergillus Tax:746128
571 23645-23656 Species denotes Aspergillus Tax:746128
574 23911-23913 Chemical denotes GM MESH:C012990
575 23915-23928 Chemical denotes galactomannan MESH:C012990
577 24224-24233 Disease denotes infection MESH:D007239
581 23969-23977 Species denotes patients Tax:9606
582 23960-23968 Disease denotes COVID-19 MESH:C000657245
583 23983-23987 Disease denotes ARDS MESH:D012128
598 26217-26235 Gene denotes C-reactive protein Gene:1401
599 26237-26240 Gene denotes CRP Gene:1401
600 24454-24462 Species denotes Patients Tax:9606
601 24664-24669 Species denotes Women Tax:9606
602 24500-24511 Species denotes Aspergillus Tax:746128
603 26138-26148 Chemical denotes Creatinine MESH:D003404
604 24552-24574 Disease denotes Invasive Aspergillosis MESH:D055744
605 24948-24956 Disease denotes Diabetes MESH:D003920
606 25003-25015 Disease denotes Hypertension MESH:D006973
607 25068-25074 Disease denotes cancer MESH:D009369
608 25105-25114 Disease denotes Hemopathy
609 25152-25174 Disease denotes Cardiovascular disease MESH:D002318
610 25216-25253 Disease denotes Chronic obstructive pulmonary disease MESH:D029424
611 25269-25291 Disease denotes Chronic kidney disease MESH:D051436
616 26622-26633 Species denotes Aspergillus Tax:746128
617 26937-26943 Chemical denotes oxygen MESH:D010100
618 26648-26670 Disease denotes invasive aspergillosis MESH:D055744
619 26678-26691 Disease denotes aspergillosis MESH:D001228
621 27053-27064 Species denotes Aspergillus Tax:746128
623 27226-27249 Species denotes Aspergillus tubingensis Tax:5068
626 27373-27385 Chemical denotes GM Negative
627 27386-27388 Chemical denotes GM MESH:C012990
630 27303-27316 Chemical denotes galactomannan MESH:C012990
631 27318-27320 Chemical denotes GM MESH:C012990
646 27542-27549 Species denotes Patient Tax:9606
647 27618-27629 Species denotes Aspergillus Tax:746128
648 27916-27925 Disease denotes infection MESH:D007239
649 28288-28297 Disease denotes infection MESH:D007239
650 28341-28350 Disease denotes infection MESH:D007239
651 28394-28403 Disease denotes infection MESH:D007239
652 28447-28456 Disease denotes infection MESH:D007239
653 28500-28509 Disease denotes infection MESH:D007239
654 28556-28565 Disease denotes infection MESH:D007239
655 28570-28579 Disease denotes infection MESH:D007239
656 28584-28593 Disease denotes infection MESH:D007239
657 28628-28637 Disease denotes infection MESH:D007239
658 28662-28671 Disease denotes infection MESH:D007239
659 28733-28742 Disease denotes infection MESH:D007239
663 27522-27530 Species denotes patients Tax:9606
664 27513-27521 Disease denotes COVID-19 MESH:C000657245
665 27536-27540 Disease denotes ARDS MESH:D012128
668 28775-28798 Species denotes Aspergillus tubingensis Tax:5068
669 28747-28769 Disease denotes Invasive aspergillosis MESH:D055744
674 28923-28931 Species denotes Patients Tax:9606
675 28969-28980 Species denotes Aspergillus Tax:746128
676 29021-29043 Disease denotes Invasive Aspergillosis MESH:D055744
677 29508-29513 Disease denotes Death MESH:D003643
682 28837-28845 Species denotes patients Tax:9606
683 28889-28900 Species denotes Aspergillus Tax:746128
684 28851-28859 Disease denotes COVID-19 MESH:C000657245
685 28871-28875 Disease denotes ARDS MESH:D012128
689 29640-29651 Species denotes Aspergillus Tax:746128
690 29666-29688 Disease denotes invasive aspergillosis MESH:D055744
691 29696-29709 Disease denotes aspergillosis MESH:D001228

2_test

Id Subject Object Predicate Lexical cue
32664423-22517788-60101693 2272-2273 22517788 denotes 3
32664423-28954783-60101694 2540-2541 28954783 denotes 4
32664423-8254858-60101695 5751-5752 8254858 denotes 7
32664423-31775846-60101696 5753-5754 31775846 denotes 8
32664423-28637907-60101697 6779-6781 28637907 denotes 10
32664423-29248586-60101698 7203-7205 29248586 denotes 11
32664423-14766869-60101699 7206-7208 14766869 denotes 12
32664423-27887809-60101700 14814-14816 27887809 denotes 13
32664423-24960557-60101701 14912-14914 24960557 denotes 14
32664423-32835328-60101702 15083-15085 32835328 denotes 15
32664423-32307254-60101703 15086-15088 32307254 denotes 16
32664423-32339350-60101704 15171-15173 32339350 denotes 19
32664423-32396381-60101705 15177-15179 32396381 denotes 21
32664423-32224310-60101706 15180-15182 32224310 denotes 22
32664423-22517788-60101707 15701-15702 22517788 denotes 3
32664423-22517788-60101708 16456-16457 22517788 denotes 3
32664423-32339350-60101709 16658-16660 32339350 denotes 19
32664423-32488446-60101710 16661-16663 32488446 denotes 23
32664423-29248586-60101711 17463-17465 29248586 denotes 11
32664423-29248586-60101712 17612-17614 29248586 denotes 11
32664423-25903571-60101713 17615-17617 25903571 denotes 24
32664423-17906086-60101714 18590-18592 17906086 denotes 25
32664423-26699723-60101715 18593-18595 26699723 denotes 26
32664423-32503673-60101716 19451-19453 32503673 denotes 27