PMC:7556165 / 72748-73224 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T198","span":{"begin":20,"end":27},"obj":"Chemical"},{"id":"T199","span":{"begin":159,"end":166},"obj":"Chemical"},{"id":"T200","span":{"begin":179,"end":190},"obj":"Chemical"},{"id":"T201","span":{"begin":207,"end":214},"obj":"Chemical"},{"id":"T202","span":{"begin":334,"end":345},"obj":"Chemical"},{"id":"T203","span":{"begin":402,"end":412},"obj":"Chemical"}],"attributes":[{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A199","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T407","span":{"begin":436,"end":450},"obj":"Species"}],"attributes":[{"id":"A407","pred":"ncbi_taxonomy_id","subj":"T407","obj":"NCBItxid:749906"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T429","span":{"begin":0,"end":54},"obj":"Sentence"},{"id":"T430","span":{"begin":55,"end":245},"obj":"Sentence"},{"id":"T431","span":{"begin":246,"end":358},"obj":"Sentence"},{"id":"T432","span":{"begin":359,"end":476},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T154","span":{"begin":152,"end":158},"obj":"Body_part"}],"attributes":[{"id":"A154","pred":"uberon_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1992","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"1993","span":{"begin":96,"end":100},"obj":"Gene"},{"id":"1994","span":{"begin":138,"end":148},"obj":"Gene"},{"id":"1995","span":{"begin":207,"end":214},"obj":"Gene"},{"id":"1996","span":{"begin":261,"end":265},"obj":"Gene"},{"id":"1997","span":{"begin":367,"end":371},"obj":"Gene"},{"id":"1998","span":{"begin":436,"end":450},"obj":"Species"},{"id":"1999","span":{"begin":292,"end":309},"obj":"Disease"}],"attributes":[{"id":"A1994","pred":"pubann:denotes","subj":"1994","obj":"Gene:57393"},{"id":"A1992","pred":"pubann:denotes","subj":"1992","obj":"Gene:59272"},{"id":"A1998","pred":"pubann:denotes","subj":"1998","obj":"Tax:749906"},{"id":"A1996","pred":"pubann:denotes","subj":"1996","obj":"Gene:59272"},{"id":"A1993","pred":"pubann:denotes","subj":"1993","obj":"Gene:59272"},{"id":"A1999","pred":"pubann:denotes","subj":"1999","obj":"MESH:D006250"},{"id":"A1997","pred":"pubann:denotes","subj":"1997","obj":"Gene:59272"},{"id":"A1995","pred":"pubann:denotes","subj":"1995","obj":"Gene:3630"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T6257","span":{"begin":0,"end":4},"obj":"Protein"},{"id":"T6258","span":{"begin":96,"end":100},"obj":"Protein"},{"id":"T6259","span":{"begin":138,"end":148},"obj":"Protein"},{"id":"T6267","span":{"begin":207,"end":214},"obj":"Protein"},{"id":"T6372","span":{"begin":261,"end":265},"obj":"Protein"},{"id":"T6373","span":{"begin":367,"end":371},"obj":"Protein"}],"attributes":[{"id":"A6257","pred":"uniprot_id","subj":"T6257","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6258","pred":"uniprot_id","subj":"T6258","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6259","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q9HBJ8"},{"id":"A6260","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q9ESG4"},{"id":"A6261","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q9ESG3"},{"id":"A6262","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q6UW07"},{"id":"A6263","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q6AYY2"},{"id":"A6264","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q3UFF6"},{"id":"A6265","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/Q0VCT4"},{"id":"A6266","pred":"uniprot_id","subj":"T6259","obj":"https://www.uniprot.org/uniprot/B2R9M1"},{"id":"A6267","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9W7R2"},{"id":"A6268","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9W653"},{"id":"A6269","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9TSJ5"},{"id":"A6270","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9TQY8"},{"id":"A6271","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9TQY7"},{"id":"A6272","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9PRR2"},{"id":"A6273","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9PRR1"},{"id":"A6274","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q9NDE7"},{"id":"A6275","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q98TA8"},{"id":"A6276","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q91XI3"},{"id":"A6277","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q91479"},{"id":"A6278","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q91478"},{"id":"A6279","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q91477"},{"id":"A6280","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q8WNW6"},{"id":"A6281","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q8HXV2"},{"id":"A6282","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q6YK33"},{"id":"A6283","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q62587"},{"id":"A6284","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q5EEX2"},{"id":"A6285","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q53YX4"},{"id":"A6286","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q504H9"},{"id":"A6287","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/Q10995"},{"id":"A6288","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P81881"},{"id":"A6289","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P81423"},{"id":"A6290","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P81025"},{"id":"A6291","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P69048"},{"id":"A6292","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P69047"},{"id":"A6293","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P69046"},{"id":"A6294","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P69045"},{"id":"A6295","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68992"},{"id":"A6296","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68991"},{"id":"A6297","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68990"},{"id":"A6298","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68989"},{"id":"A6299","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68988"},{"id":"A6300","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68987"},{"id":"A6301","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68245"},{"id":"A6302","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P68243"},{"id":"A6303","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67974"},{"id":"A6304","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67973"},{"id":"A6305","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67972"},{"id":"A6306","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67971"},{"id":"A6307","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67970"},{"id":"A6308","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67969"},{"id":"A6309","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P67968"},{"id":"A6310","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P51463"},{"id":"A6311","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P42633"},{"id":"A6312","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P41522"},{"id":"A6313","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P31887"},{"id":"A6314","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P30410"},{"id":"A6315","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P30407"},{"id":"A6316","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P30406"},{"id":"A6317","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P29335"},{"id":"A6318","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P23187"},{"id":"A6319","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P21563"},{"id":"A6320","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P18109"},{"id":"A6321","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P17715"},{"id":"A6322","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P14806"},{"id":"A6323","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P13190"},{"id":"A6324","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P12708"},{"id":"A6325","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P12705"},{"id":"A6326","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P12704"},{"id":"A6327","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P12703"},{"id":"A6328","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P10604"},{"id":"A6329","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P0C236"},{"id":"A6330","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P09536"},{"id":"A6331","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P09477"},{"id":"A6332","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P09476"},{"id":"A6333","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P07454"},{"id":"A6334","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P07453"},{"id":"A6335","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P06306"},{"id":"A6336","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P04667"},{"id":"A6337","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01342"},{"id":"A6338","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01341"},{"id":"A6339","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01340"},{"id":"A6340","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01339"},{"id":"A6341","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01336"},{"id":"A6342","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01335"},{"id":"A6343","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01334"},{"id":"A6344","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01333"},{"id":"A6345","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01332"},{"id":"A6346","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01331"},{"id":"A6347","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01330"},{"id":"A6348","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01329"},{"id":"A6349","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01328"},{"id":"A6350","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01327"},{"id":"A6351","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01324"},{"id":"A6352","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01321"},{"id":"A6353","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01320"},{"id":"A6354","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01319"},{"id":"A6355","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01318"},{"id":"A6356","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01317"},{"id":"A6357","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01316"},{"id":"A6358","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01315"},{"id":"A6359","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01314"},{"id":"A6360","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01313"},{"id":"A6361","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01312"},{"id":"A6362","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01311"},{"id":"A6363","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01310"},{"id":"A6364","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01309"},{"id":"A6365","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/P01308"},{"id":"A6366","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/O73727"},{"id":"A6367","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/O42485"},{"id":"A6368","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/C0HJU0"},{"id":"A6369","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/C0HJT9"},{"id":"A6370","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/C0HJI4"},{"id":"A6371","pred":"uniprot_id","subj":"T6267","obj":"https://www.uniprot.org/uniprot/C0HJI1"},{"id":"A6372","pred":"uniprot_id","subj":"T6372","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A6373","pred":"uniprot_id","subj":"T6373","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T300","span":{"begin":302,"end":309},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T465","span":{"begin":20,"end":27},"obj":"Body_part"},{"id":"T466","span":{"begin":152,"end":158},"obj":"Body_part"},{"id":"T467","span":{"begin":159,"end":166},"obj":"Body_part"},{"id":"T468","span":{"begin":179,"end":190},"obj":"Body_part"},{"id":"T469","span":{"begin":207,"end":214},"obj":"Body_part"},{"id":"T470","span":{"begin":334,"end":345},"obj":"Body_part"},{"id":"T471","span":{"begin":402,"end":412},"obj":"Body_part"},{"id":"T472","span":{"begin":426,"end":431},"obj":"Body_part"},{"id":"T473","span":{"begin":436,"end":439},"obj":"Body_part"}],"attributes":[{"id":"A473","pred":"fma_id","subj":"T473","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A468","pred":"fma_id","subj":"T468","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A471","pred":"fma_id","subj":"T471","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A467","pred":"fma_id","subj":"T467","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A469","pred":"fma_id","subj":"T469","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A470","pred":"fma_id","subj":"T470","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A466","pred":"fma_id","subj":"T466","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A465","pred":"fma_id","subj":"T465","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A472","pred":"fma_id","subj":"T472","obj":"http://purl.org/sig/ont/fma/fma7199"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T430","span":{"begin":292,"end":309},"obj":"Disease"}],"attributes":[{"id":"A430","pred":"mondo_id","subj":"T430","obj":"http://purl.obolibrary.org/obo/MONDO_0009324"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T142","span":{"begin":152,"end":158},"obj":"http://purl.obolibrary.org/obo/MAT_0000119"},{"id":"T143","span":{"begin":436,"end":439},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T156","span":{"begin":207,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0030073"},{"id":"T157","span":{"begin":215,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T158","span":{"begin":334,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0080144"},{"id":"T159","span":{"begin":346,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T160","span":{"begin":402,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0006865"},{"id":"T161","span":{"begin":413,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T161","span":{"begin":207,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0030073"},{"id":"T162","span":{"begin":215,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T163","span":{"begin":334,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0080144"},{"id":"T164","span":{"begin":346,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T165","span":{"begin":402,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0006865"},{"id":"T166","span":{"begin":413,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1992","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"1993","span":{"begin":96,"end":100},"obj":"Gene"},{"id":"1994","span":{"begin":138,"end":148},"obj":"Gene"},{"id":"1995","span":{"begin":207,"end":214},"obj":"Gene"},{"id":"1996","span":{"begin":261,"end":265},"obj":"Gene"},{"id":"1997","span":{"begin":367,"end":371},"obj":"Gene"},{"id":"1998","span":{"begin":436,"end":450},"obj":"Species"},{"id":"1999","span":{"begin":292,"end":309},"obj":"Disease"}],"attributes":[{"id":"A1992","pred":"tao:has_database_id","subj":"1992","obj":"Gene:59272"},{"id":"A1993","pred":"tao:has_database_id","subj":"1993","obj":"Gene:59272"},{"id":"A1994","pred":"tao:has_database_id","subj":"1994","obj":"Gene:57393"},{"id":"A1995","pred":"tao:has_database_id","subj":"1995","obj":"Gene:3630"},{"id":"A1996","pred":"tao:has_database_id","subj":"1996","obj":"Gene:59272"},{"id":"A1997","pred":"tao:has_database_id","subj":"1997","obj":"Gene:59272"},{"id":"A1998","pred":"tao:has_database_id","subj":"1998","obj":"Tax:749906"},{"id":"A1999","pred":"tao:has_database_id","subj":"1999","obj":"MESH:D006250"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T429","span":{"begin":0,"end":54},"obj":"Sentence"},{"id":"T430","span":{"begin":55,"end":245},"obj":"Sentence"},{"id":"T431","span":{"begin":246,"end":358},"obj":"Sentence"},{"id":"T432","span":{"begin":359,"end":476},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ACE2 is a multiform protein (Feng et al., 2010, 2011). As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013). Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis. Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012)."}