PMC:7556165 / 46924-48790 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7556165","sourcedb":"PMC","sourceid":"7556165","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7556165","text":"Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2. Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD. To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch. In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1). Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b). In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020). The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020). Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a). This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host. Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases. Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.","tracks":[{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T82","span":{"begin":20,"end":32},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T83","span":{"begin":514,"end":526},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A82","pred":"meddra_id","subj":"T82","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"},{"id":"A83","pred":"meddra_id","subj":"T83","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"},{"subj":"T82","pred":"source","obj":"LitCovid-sample-MedDRA"},{"subj":"T83","pred":"source","obj":"LitCovid-sample-MedDRA"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T158","span":{"begin":249,"end":256},"obj":"Chemical"},{"id":"T159","span":{"begin":1101,"end":1108},"obj":"Chemical"},{"id":"T160","span":{"begin":1677,"end":1684},"obj":"Chemical"}],"attributes":[{"id":"A158","pred":"chebi_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T158","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T159","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T160","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T231","span":{"begin":52,"end":62},"obj":"Species"},{"id":"T232","span":{"begin":52,"end":56},"obj":"Species"},{"id":"T233","span":{"begin":149,"end":159},"obj":"Species"},{"id":"T234","span":{"begin":149,"end":153},"obj":"Species"},{"id":"T235","span":{"begin":620,"end":630},"obj":"Species"},{"id":"T236","span":{"begin":620,"end":624},"obj":"Species"},{"id":"T237","span":{"begin":689,"end":697},"obj":"Species"},{"id":"T238","span":{"begin":689,"end":693},"obj":"Species"},{"id":"T239","span":{"begin":869,"end":879},"obj":"Species"},{"id":"T240","span":{"begin":869,"end":873},"obj":"Species"},{"id":"T241","span":{"begin":917,"end":927},"obj":"Species"},{"id":"T242","span":{"begin":917,"end":921},"obj":"Species"},{"id":"T243","span":{"begin":951,"end":959},"obj":"Species"},{"id":"T244","span":{"begin":951,"end":955},"obj":"Species"},{"id":"T245","span":{"begin":1088,"end":1098},"obj":"Species"},{"id":"T246","span":{"begin":1088,"end":1092},"obj":"Species"},{"id":"T247","span":{"begin":1148,"end":1152},"obj":"Species"},{"id":"T248","span":{"begin":1215,"end":1225},"obj":"Species"},{"id":"T249","span":{"begin":1215,"end":1219},"obj":"Species"},{"id":"T250","span":{"begin":1284,"end":1292},"obj":"Species"},{"id":"T251","span":{"begin":1284,"end":1288},"obj":"Species"},{"id":"T252","span":{"begin":1462,"end":1472},"obj":"Species"},{"id":"T253","span":{"begin":1462,"end":1466},"obj":"Species"},{"id":"T254","span":{"begin":1477,"end":1485},"obj":"Species"},{"id":"T255","span":{"begin":1477,"end":1481},"obj":"Species"},{"id":"T256","span":{"begin":1521,"end":1531},"obj":"Species"},{"id":"T257","span":{"begin":1521,"end":1525},"obj":"Species"},{"id":"T258","span":{"begin":1834,"end":1844},"obj":"Species"},{"id":"T259","span":{"begin":1834,"end":1838},"obj":"Species"}],"attributes":[{"id":"A232","pred":"ncbi_taxonomy_id","subj":"T232","obj":"NCBItxid:694009"},{"id":"A245","pred":"ncbi_taxonomy_id","subj":"T245","obj":"NCBItxid:2697049"},{"id":"A248","pred":"ncbi_taxonomy_id","subj":"T248","obj":"NCBItxid:2697049"},{"id":"A253","pred":"ncbi_taxonomy_id","subj":"T253","obj":"NCBItxid:694009"},{"id":"A237","pred":"ncbi_taxonomy_id","subj":"T237","obj":"NCBItxid:694009"},{"id":"A238","pred":"ncbi_taxonomy_id","subj":"T238","obj":"NCBItxid:694009"},{"id":"A252","pred":"ncbi_taxonomy_id","subj":"T252","obj":"NCBItxid:2697049"},{"id":"A234","pred":"ncbi_taxonomy_id","subj":"T234","obj":"NCBItxid:694009"},{"id":"A246","pred":"ncbi_taxonomy_id","subj":"T246","obj":"NCBItxid:694009"},{"id":"A257","pred":"ncbi_taxonomy_id","subj":"T257","obj":"NCBItxid:694009"},{"id":"A241","pred":"ncbi_taxonomy_id","subj":"T241","obj":"NCBItxid:2697049"},{"id":"A256","pred":"ncbi_taxonomy_id","subj":"T256","obj":"NCBItxid:2697049"},{"id":"A259","pred":"ncbi_taxonomy_id","subj":"T259","obj":"NCBItxid:694009"},{"id":"A254","pred":"ncbi_taxonomy_id","subj":"T254","obj":"NCBItxid:694009"},{"id":"A231","pred":"ncbi_taxonomy_id","subj":"T231","obj":"NCBItxid:2697049"},{"id":"A250","pred":"ncbi_taxonomy_id","subj":"T250","obj":"NCBItxid:694009"},{"id":"A242","pred":"ncbi_taxonomy_id","subj":"T242","obj":"NCBItxid:694009"},{"id":"A235","pred":"ncbi_taxonomy_id","subj":"T235","obj":"NCBItxid:2697049"},{"id":"A233","pred":"ncbi_taxonomy_id","subj":"T233","obj":"NCBItxid:2697049"},{"id":"A243","pred":"ncbi_taxonomy_id","subj":"T243","obj":"NCBItxid:694009"},{"id":"A244","pred":"ncbi_taxonomy_id","subj":"T244","obj":"NCBItxid:694009"},{"id":"A251","pred":"ncbi_taxonomy_id","subj":"T251","obj":"NCBItxid:694009"},{"id":"A239","pred":"ncbi_taxonomy_id","subj":"T239","obj":"NCBItxid:2697049"},{"id":"A236","pred":"ncbi_taxonomy_id","subj":"T236","obj":"NCBItxid:694009"},{"id":"A240","pred":"ncbi_taxonomy_id","subj":"T240","obj":"NCBItxid:694009"},{"id":"A255","pred":"ncbi_taxonomy_id","subj":"T255","obj":"NCBItxid:694009"},{"id":"A247","pred":"ncbi_taxonomy_id","subj":"T247","obj":"NCBItxid:694009"},{"id":"A249","pred":"ncbi_taxonomy_id","subj":"T249","obj":"NCBItxid:694009"},{"id":"A258","pred":"ncbi_taxonomy_id","subj":"T258","obj":"NCBItxid:2697049"},{"subj":"T231","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T232","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T233","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T234","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T235","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T236","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T237","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T238","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T239","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T240","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T241","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T242","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T243","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T244","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T245","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T246","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T247","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T248","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T249","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T250","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T251","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T252","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T253","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T254","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T255","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T256","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T257","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T258","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T259","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T288","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T289","span":{"begin":78,"end":164},"obj":"Sentence"},{"id":"T290","span":{"begin":165,"end":325},"obj":"Sentence"},{"id":"T291","span":{"begin":326,"end":440},"obj":"Sentence"},{"id":"T292","span":{"begin":441,"end":589},"obj":"Sentence"},{"id":"T293","span":{"begin":590,"end":781},"obj":"Sentence"},{"id":"T294","span":{"begin":782,"end":999},"obj":"Sentence"},{"id":"T295","span":{"begin":1000,"end":1177},"obj":"Sentence"},{"id":"T296","span":{"begin":1178,"end":1421},"obj":"Sentence"},{"id":"T297","span":{"begin":1422,"end":1748},"obj":"Sentence"},{"id":"T298","span":{"begin":1749,"end":1866},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T288","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T289","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T290","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T291","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T292","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T293","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T294","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T295","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T296","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T297","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T298","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T139","span":{"begin":1395,"end":1408},"obj":"Body_part"}],"attributes":[{"id":"A139","pred":"uberon_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"subj":"T139","pred":"source","obj":"LitCovid-sample-PD-UBERON"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1301","span":{"begin":72,"end":76},"obj":"Gene"},{"id":"1302","span":{"begin":391,"end":395},"obj":"Gene"},{"id":"1303","span":{"begin":660,"end":664},"obj":"Gene"},{"id":"1304","span":{"begin":892,"end":896},"obj":"Gene"},{"id":"1305","span":{"begin":1051,"end":1055},"obj":"Gene"},{"id":"1306","span":{"begin":1574,"end":1578},"obj":"Gene"},{"id":"1307","span":{"begin":1153,"end":1154},"obj":"Gene"},{"id":"1308","span":{"begin":1099,"end":1100},"obj":"Gene"},{"id":"1309","span":{"begin":247,"end":248},"obj":"Gene"},{"id":"1310","span":{"begin":52,"end":62},"obj":"Species"},{"id":"1311","span":{"begin":149,"end":159},"obj":"Species"},{"id":"1312","span":{"begin":620,"end":630},"obj":"Species"},{"id":"1313","span":{"begin":689,"end":697},"obj":"Species"},{"id":"1314","span":{"begin":869,"end":879},"obj":"Species"},{"id":"1315","span":{"begin":917,"end":927},"obj":"Species"},{"id":"1316","span":{"begin":951,"end":959},"obj":"Species"},{"id":"1317","span":{"begin":1088,"end":1098},"obj":"Species"},{"id":"1318","span":{"begin":1215,"end":1225},"obj":"Species"},{"id":"1319","span":{"begin":1284,"end":1292},"obj":"Species"},{"id":"1320","span":{"begin":1462,"end":1472},"obj":"Species"},{"id":"1321","span":{"begin":1477,"end":1485},"obj":"Species"},{"id":"1322","span":{"begin":1521,"end":1531},"obj":"Species"},{"id":"1323","span":{"begin":1834,"end":1844},"obj":"Species"}],"attributes":[{"id":"A1319","pred":"pubann:denotes","subj":"1319","obj":"Tax:694009"},{"id":"A1320","pred":"pubann:denotes","subj":"1320","obj":"Tax:2697049"},{"id":"A1316","pred":"pubann:denotes","subj":"1316","obj":"Tax:694009"},{"id":"A1304","pred":"pubann:denotes","subj":"1304","obj":"Gene:59272"},{"id":"A1305","pred":"pubann:denotes","subj":"1305","obj":"Gene:59272"},{"id":"A1309","pred":"pubann:denotes","subj":"1309","obj":"Gene:43740568"},{"id":"A1318","pred":"pubann:denotes","subj":"1318","obj":"Tax:2697049"},{"id":"A1306","pred":"pubann:denotes","subj":"1306","obj":"Gene:59272"},{"id":"A1308","pred":"pubann:denotes","subj":"1308","obj":"Gene:43740568"},{"id":"A1313","pred":"pubann:denotes","subj":"1313","obj":"Tax:694009"},{"id":"A1317","pred":"pubann:denotes","subj":"1317","obj":"Tax:2697049"},{"id":"A1302","pred":"pubann:denotes","subj":"1302","obj":"Gene:59272"},{"id":"A1315","pred":"pubann:denotes","subj":"1315","obj":"Tax:2697049"},{"id":"A1314","pred":"pubann:denotes","subj":"1314","obj":"Tax:2697049"},{"id":"A1312","pred":"pubann:denotes","subj":"1312","obj":"Tax:2697049"},{"id":"A1321","pred":"pubann:denotes","subj":"1321","obj":"Tax:694009"},{"id":"A1311","pred":"pubann:denotes","subj":"1311","obj":"Tax:2697049"},{"id":"A1322","pred":"pubann:denotes","subj":"1322","obj":"Tax:2697049"},{"id":"A1310","pred":"pubann:denotes","subj":"1310","obj":"Tax:2697049"},{"id":"A1307","pred":"pubann:denotes","subj":"1307","obj":"Gene:43740568"},{"id":"A1301","pred":"pubann:denotes","subj":"1301","obj":"Gene:59272"},{"id":"A1323","pred":"pubann:denotes","subj":"1323","obj":"Tax:2697049"},{"id":"A1303","pred":"pubann:denotes","subj":"1303","obj":"Gene:59272"},{"subj":"1301","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1302","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1303","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1304","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1305","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1306","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1307","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1308","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1309","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1310","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1311","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1312","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1313","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1314","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1315","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1316","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1317","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1318","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1319","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1320","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1321","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1322","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1323","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T5092","span":{"begin":63,"end":66},"obj":"Protein"},{"id":"T5101","span":{"begin":72,"end":76},"obj":"Protein"},{"id":"T5102","span":{"begin":160,"end":163},"obj":"Protein"},{"id":"T5111","span":{"begin":247,"end":256},"obj":"Protein"},{"id":"T5144","span":{"begin":266,"end":269},"obj":"Protein"},{"id":"T5153","span":{"begin":391,"end":395},"obj":"Protein"},{"id":"T5154","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T5163","span":{"begin":631,"end":634},"obj":"Protein"},{"id":"T5172","span":{"begin":660,"end":664},"obj":"Protein"},{"id":"T5173","span":{"begin":698,"end":701},"obj":"Protein"},{"id":"T5182","span":{"begin":892,"end":896},"obj":"Protein"},{"id":"T5183","span":{"begin":1051,"end":1055},"obj":"Protein"},{"id":"T5184","span":{"begin":1099,"end":1108},"obj":"Protein"},{"id":"T5217","span":{"begin":1226,"end":1229},"obj":"Protein"},{"id":"T5226","span":{"begin":1293,"end":1296},"obj":"Protein"},{"id":"T5235","span":{"begin":1574,"end":1578},"obj":"Protein"},{"id":"T5236","span":{"begin":1612,"end":1615},"obj":"Protein"},{"id":"T5245","span":{"begin":1675,"end":1684},"obj":"Protein"}],"attributes":[{"id":"A5092","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5093","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5094","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5095","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5096","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5097","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5098","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5099","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5100","pred":"uniprot_id","subj":"T5092","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5101","pred":"uniprot_id","subj":"T5101","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5102","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5103","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5104","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5105","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5106","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5107","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5108","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5109","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5110","pred":"uniprot_id","subj":"T5102","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5111","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A5112","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A5113","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A5114","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A5115","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A5116","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A5117","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A5118","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A5119","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A5120","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A5121","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A5122","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A5123","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A5124","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A5125","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A5126","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A5127","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A5128","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A5129","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A5130","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A5131","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A5132","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A5133","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A5134","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A5135","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A5136","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A5137","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A5138","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A5139","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A5140","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A5141","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A5142","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A5143","pred":"uniprot_id","subj":"T5111","obj":"https://www.uniprot.org/uniprot/A5A6L9"},{"id":"A5144","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5145","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5146","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5147","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5148","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5149","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5150","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5151","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5152","pred":"uniprot_id","subj":"T5144","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5153","pred":"uniprot_id","subj":"T5153","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5154","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5155","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5156","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5157","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5158","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5159","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5160","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5161","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5162","pred":"uniprot_id","subj":"T5154","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5163","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5164","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5165","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5166","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5167","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5168","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5169","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5170","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5171","pred":"uniprot_id","subj":"T5163","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5172","pred":"uniprot_id","subj":"T5172","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5173","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5174","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5175","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5176","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5177","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5178","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5179","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5180","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5181","pred":"uniprot_id","subj":"T5173","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5182","pred":"uniprot_id","subj":"T5182","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5183","pred":"uniprot_id","subj":"T5183","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5184","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A5185","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A5186","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A5187","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A5188","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A5189","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A5190","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A5191","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A5192","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A5193","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A5194","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A5195","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A5196","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A5197","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A5198","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A5199","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A5200","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A5201","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A5202","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A5203","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A5204","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A5205","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A5206","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A5207","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A5208","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A5209","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A5210","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A5211","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A5212","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A5213","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A5214","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A5215","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A5216","pred":"uniprot_id","subj":"T5184","obj":"https://www.uniprot.org/uniprot/A5A6L9"},{"id":"A5217","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5218","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5219","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5220","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5221","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5222","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5223","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5224","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5225","pred":"uniprot_id","subj":"T5217","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5226","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5227","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5228","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5229","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5230","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5231","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5232","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5233","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5234","pred":"uniprot_id","subj":"T5226","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5235","pred":"uniprot_id","subj":"T5235","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5236","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q63492"},{"id":"A5237","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q63491"},{"id":"A5238","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q62815"},{"id":"A5239","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q62691"},{"id":"A5240","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/Q01542"},{"id":"A5241","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/P27732"},{"id":"A5242","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/O09024"},{"id":"A5243","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/O09023"},{"id":"A5244","pred":"uniprot_id","subj":"T5236","obj":"https://www.uniprot.org/uniprot/O09022"},{"id":"A5245","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIP0"},{"id":"A5246","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN9"},{"id":"A5247","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN8"},{"id":"A5248","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN7"},{"id":"A5249","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UIN6"},{"id":"A5250","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9UBH8"},{"id":"A5251","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH8"},{"id":"A5252","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH7"},{"id":"A5253","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH6"},{"id":"A5254","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH5"},{"id":"A5255","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NRH4"},{"id":"A5256","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NPG5"},{"id":"A5257","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NPE0"},{"id":"A5258","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q9NP52"},{"id":"A5259","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q95IF9"},{"id":"A5260","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8N5P3"},{"id":"A5261","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8IZU6"},{"id":"A5262","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8IZU5"},{"id":"A5263","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q8IZU4"},{"id":"A5264","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q86Z04"},{"id":"A5265","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q7YR44"},{"id":"A5266","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q7LA71"},{"id":"A5267","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q7LA70"},{"id":"A5268","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q5STD2"},{"id":"A5269","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q5SQ85"},{"id":"A5270","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q1XI16"},{"id":"A5271","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q1XI12"},{"id":"A5272","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/Q15517"},{"id":"A5273","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/O43509"},{"id":"A5274","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/O19084"},{"id":"A5275","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/B0UYZ7"},{"id":"A5276","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/B0S7V2"},{"id":"A5277","pred":"uniprot_id","subj":"T5245","obj":"https://www.uniprot.org/uniprot/A5A6L9"},{"subj":"T5092","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5101","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5102","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5111","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5144","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5153","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5154","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5163","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5172","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5173","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5182","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5183","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5184","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5217","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5226","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5235","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5236","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5245","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T190","span":{"begin":910,"end":915},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T191","span":{"begin":1416,"end":1420},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T192","span":{"begin":1733,"end":1737},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T193","span":{"begin":1855,"end":1859},"obj":"http://purl.obolibrary.org/obo/IDO_0000531"},{"id":"T194","span":{"begin":1860,"end":1865},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"attributes":[{"subj":"T190","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T191","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T192","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T193","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T194","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T382","span":{"begin":249,"end":256},"obj":"Body_part"},{"id":"T383","span":{"begin":910,"end":915},"obj":"Body_part"},{"id":"T384","span":{"begin":1101,"end":1108},"obj":"Body_part"},{"id":"T385","span":{"begin":1395,"end":1408},"obj":"Body_part"},{"id":"T386","span":{"begin":1677,"end":1684},"obj":"Body_part"},{"id":"T387","span":{"begin":1860,"end":1865},"obj":"Body_part"}],"attributes":[{"id":"A382","pred":"fma_id","subj":"T382","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A383","pred":"fma_id","subj":"T383","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A384","pred":"fma_id","subj":"T384","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A385","pred":"fma_id","subj":"T385","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A386","pred":"fma_id","subj":"T386","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A387","pred":"fma_id","subj":"T387","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T382","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T383","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T384","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T385","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T386","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T387","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T211","span":{"begin":52,"end":62},"obj":"Disease"},{"id":"T212","span":{"begin":52,"end":56},"obj":"Disease"},{"id":"T213","span":{"begin":149,"end":159},"obj":"Disease"},{"id":"T214","span":{"begin":149,"end":153},"obj":"Disease"},{"id":"T215","span":{"begin":620,"end":630},"obj":"Disease"},{"id":"T216","span":{"begin":620,"end":624},"obj":"Disease"},{"id":"T217","span":{"begin":689,"end":697},"obj":"Disease"},{"id":"T218","span":{"begin":689,"end":693},"obj":"Disease"},{"id":"T219","span":{"begin":869,"end":879},"obj":"Disease"},{"id":"T220","span":{"begin":869,"end":873},"obj":"Disease"},{"id":"T221","span":{"begin":917,"end":927},"obj":"Disease"},{"id":"T222","span":{"begin":917,"end":921},"obj":"Disease"},{"id":"T223","span":{"begin":951,"end":959},"obj":"Disease"},{"id":"T224","span":{"begin":951,"end":955},"obj":"Disease"},{"id":"T225","span":{"begin":1088,"end":1098},"obj":"Disease"},{"id":"T226","span":{"begin":1088,"end":1092},"obj":"Disease"},{"id":"T227","span":{"begin":1148,"end":1152},"obj":"Disease"},{"id":"T228","span":{"begin":1215,"end":1225},"obj":"Disease"},{"id":"T229","span":{"begin":1215,"end":1219},"obj":"Disease"},{"id":"T230","span":{"begin":1284,"end":1292},"obj":"Disease"},{"id":"T231","span":{"begin":1284,"end":1288},"obj":"Disease"},{"id":"T232","span":{"begin":1462,"end":1472},"obj":"Disease"},{"id":"T233","span":{"begin":1462,"end":1466},"obj":"Disease"},{"id":"T234","span":{"begin":1477,"end":1485},"obj":"Disease"},{"id":"T235","span":{"begin":1477,"end":1481},"obj":"Disease"},{"id":"T236","span":{"begin":1521,"end":1531},"obj":"Disease"},{"id":"T237","span":{"begin":1521,"end":1525},"obj":"Disease"},{"id":"T238","span":{"begin":1834,"end":1844},"obj":"Disease"},{"id":"T239","span":{"begin":1834,"end":1838},"obj":"Disease"}],"attributes":[{"id":"A226","pred":"mondo_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A223","pred":"mondo_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A224","pred":"mondo_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A229","pred":"mondo_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A227","pred":"mondo_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A216","pred":"mondo_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A222","pred":"mondo_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A228","pred":"mondo_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A230","pred":"mondo_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A220","pred":"mondo_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A221","pred":"mondo_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A239","pred":"mondo_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A219","pred":"mondo_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A217","pred":"mondo_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A232","pred":"mondo_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A231","pred":"mondo_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A225","pred":"mondo_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A218","pred":"mondo_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T211","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T212","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T213","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T214","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T215","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T216","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T217","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T218","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T219","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T220","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T221","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T222","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T223","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T224","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T225","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T226","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T227","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T228","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T229","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T230","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T231","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T232","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T233","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T234","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T235","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T236","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T237","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T238","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T239","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-Glycan","denotations":[{"id":"T14","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G02780QX"},{"id":"T15","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G18425DX"},{"id":"T16","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G18630JE"},{"id":"T17","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G87301QZ"},{"id":"T18","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G01004IT"},{"id":"T19","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G39790GW"},{"id":"T20","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G68183GR"},{"id":"T21","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G42928BB"},{"id":"T22","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G51134HC"},{"id":"T23","span":{"begin":441,"end":444},"obj":"https://glytoucan.org/Structures/Glycans/G54702VY"}],"attributes":[{"subj":"T14","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T15","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T16","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T17","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T18","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T19","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T20","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T21","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T22","pred":"source","obj":"LitCovid-sample-Glycan"},{"subj":"T23","pred":"source","obj":"LitCovid-sample-Glycan"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1301","span":{"begin":72,"end":76},"obj":"Gene"},{"id":"1302","span":{"begin":391,"end":395},"obj":"Gene"},{"id":"1303","span":{"begin":660,"end":664},"obj":"Gene"},{"id":"1304","span":{"begin":892,"end":896},"obj":"Gene"},{"id":"1305","span":{"begin":1051,"end":1055},"obj":"Gene"},{"id":"1306","span":{"begin":1574,"end":1578},"obj":"Gene"},{"id":"1307","span":{"begin":1153,"end":1154},"obj":"Gene"},{"id":"1308","span":{"begin":1099,"end":1100},"obj":"Gene"},{"id":"1309","span":{"begin":247,"end":248},"obj":"Gene"},{"id":"1310","span":{"begin":52,"end":62},"obj":"Species"},{"id":"1311","span":{"begin":149,"end":159},"obj":"Species"},{"id":"1312","span":{"begin":620,"end":630},"obj":"Species"},{"id":"1313","span":{"begin":689,"end":697},"obj":"Species"},{"id":"1314","span":{"begin":869,"end":879},"obj":"Species"},{"id":"1315","span":{"begin":917,"end":927},"obj":"Species"},{"id":"1316","span":{"begin":951,"end":959},"obj":"Species"},{"id":"1317","span":{"begin":1088,"end":1098},"obj":"Species"},{"id":"1318","span":{"begin":1215,"end":1225},"obj":"Species"},{"id":"1319","span":{"begin":1284,"end":1292},"obj":"Species"},{"id":"1320","span":{"begin":1462,"end":1472},"obj":"Species"},{"id":"1321","span":{"begin":1477,"end":1485},"obj":"Species"},{"id":"1322","span":{"begin":1521,"end":1531},"obj":"Species"},{"id":"1323","span":{"begin":1834,"end":1844},"obj":"Species"}],"attributes":[{"id":"A1301","pred":"tao:has_database_id","subj":"1301","obj":"Gene:59272"},{"id":"A1302","pred":"tao:has_database_id","subj":"1302","obj":"Gene:59272"},{"id":"A1303","pred":"tao:has_database_id","subj":"1303","obj":"Gene:59272"},{"id":"A1304","pred":"tao:has_database_id","subj":"1304","obj":"Gene:59272"},{"id":"A1305","pred":"tao:has_database_id","subj":"1305","obj":"Gene:59272"},{"id":"A1306","pred":"tao:has_database_id","subj":"1306","obj":"Gene:59272"},{"id":"A1307","pred":"tao:has_database_id","subj":"1307","obj":"Gene:43740568"},{"id":"A1308","pred":"tao:has_database_id","subj":"1308","obj":"Gene:43740568"},{"id":"A1309","pred":"tao:has_database_id","subj":"1309","obj":"Gene:43740568"},{"id":"A1310","pred":"tao:has_database_id","subj":"1310","obj":"Tax:2697049"},{"id":"A1311","pred":"tao:has_database_id","subj":"1311","obj":"Tax:2697049"},{"id":"A1312","pred":"tao:has_database_id","subj":"1312","obj":"Tax:2697049"},{"id":"A1313","pred":"tao:has_database_id","subj":"1313","obj":"Tax:694009"},{"id":"A1314","pred":"tao:has_database_id","subj":"1314","obj":"Tax:2697049"},{"id":"A1315","pred":"tao:has_database_id","subj":"1315","obj":"Tax:2697049"},{"id":"A1316","pred":"tao:has_database_id","subj":"1316","obj":"Tax:694009"},{"id":"A1317","pred":"tao:has_database_id","subj":"1317","obj":"Tax:2697049"},{"id":"A1318","pred":"tao:has_database_id","subj":"1318","obj":"Tax:2697049"},{"id":"A1319","pred":"tao:has_database_id","subj":"1319","obj":"Tax:694009"},{"id":"A1320","pred":"tao:has_database_id","subj":"1320","obj":"Tax:2697049"},{"id":"A1321","pred":"tao:has_database_id","subj":"1321","obj":"Tax:694009"},{"id":"A1322","pred":"tao:has_database_id","subj":"1322","obj":"Tax:2697049"},{"id":"A1323","pred":"tao:has_database_id","subj":"1323","obj":"Tax:2697049"},{"subj":"1301","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1302","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1303","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1304","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1305","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1306","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1307","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1308","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1309","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1310","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1311","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1312","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1313","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1314","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1315","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1316","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1317","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1318","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1319","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1320","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1321","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1322","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1323","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T288","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T289","span":{"begin":78,"end":164},"obj":"Sentence"},{"id":"T290","span":{"begin":165,"end":325},"obj":"Sentence"},{"id":"T291","span":{"begin":326,"end":440},"obj":"Sentence"},{"id":"T292","span":{"begin":441,"end":589},"obj":"Sentence"},{"id":"T293","span":{"begin":590,"end":781},"obj":"Sentence"},{"id":"T294","span":{"begin":782,"end":999},"obj":"Sentence"},{"id":"T295","span":{"begin":1000,"end":1177},"obj":"Sentence"},{"id":"T296","span":{"begin":1178,"end":1421},"obj":"Sentence"},{"id":"T297","span":{"begin":1422,"end":1748},"obj":"Sentence"},{"id":"T298","span":{"begin":1749,"end":1866},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T288","pred":"source","obj":"LitCovid-sentences"},{"subj":"T289","pred":"source","obj":"LitCovid-sentences"},{"subj":"T290","pred":"source","obj":"LitCovid-sentences"},{"subj":"T291","pred":"source","obj":"LitCovid-sentences"},{"subj":"T292","pred":"source","obj":"LitCovid-sentences"},{"subj":"T293","pred":"source","obj":"LitCovid-sentences"},{"subj":"T294","pred":"source","obj":"LitCovid-sentences"},{"subj":"T295","pred":"source","obj":"LitCovid-sentences"},{"subj":"T296","pred":"source","obj":"LitCovid-sentences"},{"subj":"T297","pred":"source","obj":"LitCovid-sentences"},{"subj":"T298","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-MedDRA","color":"#ecb893","default":true},{"id":"LitCovid-sample-CHEBI","color":"#9e93ec"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#a1ec93"},{"id":"LitCovid-sample-sentences","color":"#ec93bb"},{"id":"LitCovid-sample-PD-UBERON","color":"#93d5ec"},{"id":"LitCovid-sample-Pubtator","color":"#ece993"},{"id":"LitCovid-sample-UniProt","color":"#cf93ec"},{"id":"LitCovid-sample-PD-IDO","color":"#93ecb5"},{"id":"LitCovid-sample-PD-FMA","color":"#ec9b93"},{"id":"LitCovid-sample-PD-MONDO","color":"#93a5ec"},{"id":"LitCovid-sample-Glycan","color":"#bfec93"},{"id":"LitCovid-PubTator","color":"#ec93d9"},{"id":"LitCovid-sentences","color":"#93ece5"}]}]}}