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PMC:7556165 / 46924-48790 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T82 20-32 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T83 514-526 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T158 249-256 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T159 1101-1108 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 1677-1684 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T231 52-62 Species denotes SARS-CoV-2 NCBItxid:2697049
T232 52-56 Species denotes SARS NCBItxid:694009
T233 149-159 Species denotes SARS-CoV-2 NCBItxid:2697049
T234 149-153 Species denotes SARS NCBItxid:694009
T235 620-630 Species denotes SARS-CoV-2 NCBItxid:2697049
T236 620-624 Species denotes SARS NCBItxid:694009
T237 689-697 Species denotes SARS-CoV NCBItxid:694009
T238 689-693 Species denotes SARS NCBItxid:694009
T239 869-879 Species denotes SARS-CoV-2 NCBItxid:2697049
T240 869-873 Species denotes SARS NCBItxid:694009
T241 917-927 Species denotes SARS-CoV-2 NCBItxid:2697049
T242 917-921 Species denotes SARS NCBItxid:694009
T243 951-959 Species denotes SARS-CoV NCBItxid:694009
T244 951-955 Species denotes SARS NCBItxid:694009
T245 1088-1098 Species denotes SARS-CoV-2 NCBItxid:2697049
T246 1088-1092 Species denotes SARS NCBItxid:694009
T247 1148-1152 Species denotes SARS NCBItxid:694009
T248 1215-1225 Species denotes SARS-CoV-2 NCBItxid:2697049
T249 1215-1219 Species denotes SARS NCBItxid:694009
T250 1284-1292 Species denotes SARS-CoV NCBItxid:694009
T251 1284-1288 Species denotes SARS NCBItxid:694009
T252 1462-1472 Species denotes SARS-CoV-2 NCBItxid:2697049
T253 1462-1466 Species denotes SARS NCBItxid:694009
T254 1477-1485 Species denotes SARS-CoV NCBItxid:694009
T255 1477-1481 Species denotes SARS NCBItxid:694009
T256 1521-1531 Species denotes SARS-CoV-2 NCBItxid:2697049
T257 1521-1525 Species denotes SARS NCBItxid:694009
T258 1834-1844 Species denotes SARS-CoV-2 NCBItxid:2697049
T259 1834-1838 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T288 0-77 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 78-164 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 165-325 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 326-440 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 441-589 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 590-781 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 782-999 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 1000-1177 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 1178-1421 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 1422-1748 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 1749-1866 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T139 1395-1408 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1301 72-76 Gene denotes ACE2 Gene:59272
1302 391-395 Gene denotes ACE2 Gene:59272
1303 660-664 Gene denotes ACE2 Gene:59272
1304 892-896 Gene denotes ACE2 Gene:59272
1305 1051-1055 Gene denotes ACE2 Gene:59272
1306 1574-1578 Gene denotes ACE2 Gene:59272
1307 1153-1154 Gene denotes S Gene:43740568
1308 1099-1100 Gene denotes S Gene:43740568
1309 247-248 Gene denotes S Gene:43740568
1310 52-62 Species denotes SARS-CoV-2 Tax:2697049
1311 149-159 Species denotes SARS-CoV-2 Tax:2697049
1312 620-630 Species denotes SARS-CoV-2 Tax:2697049
1313 689-697 Species denotes SARS-CoV Tax:694009
1314 869-879 Species denotes SARS-CoV-2 Tax:2697049
1315 917-927 Species denotes SARS-CoV-2 Tax:2697049
1316 951-959 Species denotes SARS-CoV Tax:694009
1317 1088-1098 Species denotes SARS-CoV-2 Tax:2697049
1318 1215-1225 Species denotes SARS-CoV-2 Tax:2697049
1319 1284-1292 Species denotes SARS-CoV Tax:694009
1320 1462-1472 Species denotes SARS-CoV-2 Tax:2697049
1321 1477-1485 Species denotes SARS-CoV Tax:694009
1322 1521-1531 Species denotes SARS-CoV-2 Tax:2697049
1323 1834-1844 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T5092 63-66 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5101 72-76 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5102 160-163 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5111 247-256 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5144 266-269 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5153 391-395 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5154 396-399 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5163 631-634 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5172 660-664 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5173 698-701 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5182 892-896 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5183 1051-1055 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5184 1099-1108 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5217 1226-1229 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5226 1293-1296 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5235 1574-1578 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5236 1612-1615 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5245 1675-1684 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T190 910-915 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T191 1416-1420 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T192 1733-1737 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T193 1855-1859 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T194 1860-1865 http://purl.obolibrary.org/obo/CL_0000000 denotes cells

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T382 249-256 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T383 910-915 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T384 1101-1108 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T385 1395-1408 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T386 1677-1684 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T387 1860-1865 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T211 52-62 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T212 52-56 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T213 149-159 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T214 149-153 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 620-630 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T216 620-624 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 689-697 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T218 689-693 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T219 869-879 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T220 869-873 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 917-927 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T222 917-921 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 951-959 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 951-955 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T225 1088-1098 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T226 1088-1092 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 1148-1152 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T228 1215-1225 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T229 1215-1219 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 1284-1292 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T231 1284-1288 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T232 1462-1472 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T233 1462-1466 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T234 1477-1485 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T235 1477-1481 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 1521-1531 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T237 1521-1525 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 1834-1844 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T239 1834-1838 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T14 441-444 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T15 441-444 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T16 441-444 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T17 441-444 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T18 441-444 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T19 441-444 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T20 441-444 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T21 441-444 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T22 441-444 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T23 441-444 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1301 72-76 Gene denotes ACE2 Gene:59272
1302 391-395 Gene denotes ACE2 Gene:59272
1303 660-664 Gene denotes ACE2 Gene:59272
1304 892-896 Gene denotes ACE2 Gene:59272
1305 1051-1055 Gene denotes ACE2 Gene:59272
1306 1574-1578 Gene denotes ACE2 Gene:59272
1307 1153-1154 Gene denotes S Gene:43740568
1308 1099-1100 Gene denotes S Gene:43740568
1309 247-248 Gene denotes S Gene:43740568
1310 52-62 Species denotes SARS-CoV-2 Tax:2697049
1311 149-159 Species denotes SARS-CoV-2 Tax:2697049
1312 620-630 Species denotes SARS-CoV-2 Tax:2697049
1313 689-697 Species denotes SARS-CoV Tax:694009
1314 869-879 Species denotes SARS-CoV-2 Tax:2697049
1315 917-927 Species denotes SARS-CoV-2 Tax:2697049
1316 951-959 Species denotes SARS-CoV Tax:694009
1317 1088-1098 Species denotes SARS-CoV-2 Tax:2697049
1318 1215-1225 Species denotes SARS-CoV-2 Tax:2697049
1319 1284-1292 Species denotes SARS-CoV Tax:694009
1320 1462-1472 Species denotes SARS-CoV-2 Tax:2697049
1321 1477-1485 Species denotes SARS-CoV Tax:694009
1322 1521-1531 Species denotes SARS-CoV-2 Tax:2697049
1323 1834-1844 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T288 0-77 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 78-164 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 165-325 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 326-440 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 441-589 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 590-781 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 782-999 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 1000-1177 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 1178-1421 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 1422-1748 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 1749-1866 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.