PMC:7556165 / 29754-30199 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7556165","sourcedb":"PMC","sourceid":"7556165","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7556165","text":"18).\nOther substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015). Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013). ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, A","tracks":[{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T109","span":{"begin":38,"end":47},"obj":"Chemical"},{"id":"T111","span":{"begin":52,"end":63},"obj":"Chemical"},{"id":"T113","span":{"begin":65,"end":76},"obj":"Chemical"},{"id":"T114","span":{"begin":89,"end":96},"obj":"Chemical"},{"id":"T115","span":{"begin":127,"end":135},"obj":"Chemical"}],"attributes":[{"id":"A109","pred":"chebi_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/CHEBI_147395"},{"id":"A110","pred":"chebi_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/CHEBI_80131"},{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_147362"},{"id":"A112","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_7542"},{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_4727"},{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_75431"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"subj":"T109","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T111","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T113","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T114","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T115","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T186","span":{"begin":5,"end":112},"obj":"Sentence"},{"id":"T187","span":{"begin":113,"end":315},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T186","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T187","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T122","span":{"begin":258,"end":263},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"uberon_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"subj":"T122","pred":"source","obj":"LitCovid-sample-PD-UBERON"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"794","span":{"begin":25,"end":29},"obj":"Gene"},{"id":"795","span":{"begin":52,"end":63},"obj":"Gene"},{"id":"796","span":{"begin":139,"end":145},"obj":"Gene"},{"id":"797","span":{"begin":190,"end":194},"obj":"Gene"},{"id":"798","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"801","span":{"begin":349,"end":355},"obj":"Gene"},{"id":"802","span":{"begin":65,"end":76},"obj":"Chemical"},{"id":"803","span":{"begin":89,"end":96},"obj":"Chemical"},{"id":"804","span":{"begin":258,"end":271},"obj":"Disease"}],"attributes":[{"id":"A794","pred":"pubann:denotes","subj":"794","obj":"Gene:59272"},{"id":"A795","pred":"pubann:denotes","subj":"795","obj":"Gene:4922"},{"id":"A796","pred":"pubann:denotes","subj":"796","obj":"Gene:8862"},{"id":"A797","pred":"pubann:denotes","subj":"797","obj":"Gene:59272"},{"id":"A798","pred":"pubann:denotes","subj":"798","obj":"Gene:59272"},{"id":"A801","pred":"pubann:denotes","subj":"801","obj":"Gene:8862"},{"id":"A803","pred":"pubann:denotes","subj":"803","obj":"MESH:D054439"},{"id":"A804","pred":"pubann:denotes","subj":"804","obj":"MESH:D006333"},{"subj":"794","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"795","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"796","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"797","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"798","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"801","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"802","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"803","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"804","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2366","span":{"begin":25,"end":29},"obj":"Protein"},{"id":"T2367","span":{"begin":38,"end":47},"obj":"Protein"},{"id":"T2373","span":{"begin":52,"end":63},"obj":"Protein"},{"id":"T2386","span":{"begin":65,"end":83},"obj":"Protein"},{"id":"T2394","span":{"begin":89,"end":96},"obj":"Protein"},{"id":"T2417","span":{"begin":139,"end":145},"obj":"Protein"},{"id":"T2424","span":{"begin":190,"end":194},"obj":"Protein"},{"id":"T2425","span":{"begin":316,"end":320},"obj":"Protein"},{"id":"T2426","span":{"begin":349,"end":355},"obj":"Protein"}],"attributes":[{"id":"A2366","pred":"uniprot_id","subj":"T2366","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2367","pred":"uniprot_id","subj":"T2367","obj":"https://www.uniprot.org/uniprot/Q9ULZ1"},{"id":"A2368","pred":"uniprot_id","subj":"T2367","obj":"https://www.uniprot.org/uniprot/Q9TUI9"},{"id":"A2369","pred":"uniprot_id","subj":"T2367","obj":"https://www.uniprot.org/uniprot/Q9R0R4"},{"id":"A2370","pred":"uniprot_id","subj":"T2367","obj":"https://www.uniprot.org/uniprot/Q9R0R3"},{"id":"A2371","pred":"uniprot_id","subj":"T2367","obj":"https://www.uniprot.org/uniprot/Q8WU89"},{"id":"A2372","pred":"uniprot_id","subj":"T2367","obj":"https://www.uniprot.org/uniprot/Q4VY08"},{"id":"A2373","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/Q9TS28"},{"id":"A2374","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/Q9QV80"},{"id":"A2375","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/Q9D3P9"},{"id":"A2376","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/Q3ZCG0"},{"id":"A2377","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P81796"},{"id":"A2378","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P41536"},{"id":"A2379","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P32560"},{"id":"A2380","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P31745"},{"id":"A2381","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P30990"},{"id":"A2382","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P20068"},{"id":"A2383","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P13724"},{"id":"A2384","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P10673"},{"id":"A2385","pred":"uniprot_id","subj":"T2373","obj":"https://www.uniprot.org/uniprot/P01156"},{"id":"A2386","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/Q95104"},{"id":"A2387","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/Q63193"},{"id":"A2388","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/Q60478"},{"id":"A2389","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/P06300"},{"id":"A2390","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/P01214"},{"id":"A2391","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/P01213"},{"id":"A2392","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/O35417"},{"id":"A2393","pred":"uniprot_id","subj":"T2386","obj":"https://www.uniprot.org/uniprot/A8K0Q3"},{"id":"A2394","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9WUZ1"},{"id":"A2395","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9QYH7"},{"id":"A2396","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9GKY6"},{"id":"A2397","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9GKY5"},{"id":"A2398","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9GKY4"},{"id":"A2399","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9ET69"},{"id":"A2400","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9EQX0"},{"id":"A2401","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9BEF8"},{"id":"A2402","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9BEF7"},{"id":"A2403","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9BDJ6"},{"id":"A2404","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q9BDG8"},{"id":"A2405","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q90W22"},{"id":"A2406","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q8JFY4"},{"id":"A2407","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q8AUU1"},{"id":"A2408","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q76IQ4"},{"id":"A2409","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q76HE2"},{"id":"A2410","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q6BEG7"},{"id":"A2411","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q6BEG6"},{"id":"A2412","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q6BEG5"},{"id":"A2413","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q2I0G0"},{"id":"A2414","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/Q0VH85"},{"id":"A2415","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/A5X8W4"},{"id":"A2416","pred":"uniprot_id","subj":"T2394","obj":"https://www.uniprot.org/uniprot/A0MLS4"},{"id":"A2417","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q9ULZ1"},{"id":"A2418","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q9TUI9"},{"id":"A2419","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q9R0R4"},{"id":"A2420","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q9R0R3"},{"id":"A2421","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q8WU89"},{"id":"A2422","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q4VY08"},{"id":"A2423","pred":"uniprot_id","subj":"T2417","obj":"https://www.uniprot.org/uniprot/Q4TTN8"},{"id":"A2424","pred":"uniprot_id","subj":"T2424","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2425","pred":"uniprot_id","subj":"T2425","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2426","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q9ULZ1"},{"id":"A2427","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q9TUI9"},{"id":"A2428","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q9R0R4"},{"id":"A2429","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q9R0R3"},{"id":"A2430","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q8WU89"},{"id":"A2431","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q4VY08"},{"id":"A2432","pred":"uniprot_id","subj":"T2426","obj":"https://www.uniprot.org/uniprot/Q4TTN8"},{"subj":"T2366","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2367","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2373","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2386","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2394","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2417","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2424","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2425","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T2426","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T270","span":{"begin":52,"end":63},"obj":"Body_part"},{"id":"T271","span":{"begin":258,"end":263},"obj":"Body_part"}],"attributes":[{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma83371"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma7088"},{"subj":"T270","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T271","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T65","span":{"begin":258,"end":271},"obj":"Disease"}],"attributes":[{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005252"},{"subj":"T65","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T113","span":{"begin":258,"end":263},"obj":"http://purl.obolibrary.org/obo/MAT_0000036"}],"attributes":[{"subj":"T113","pred":"source","obj":"LitCovid-sample-PD-MAT"}]},{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T22","span":{"begin":258,"end":271},"obj":"Phenotype"}],"attributes":[{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0001635"},{"subj":"T22","pred":"source","obj":"LitCovid-sample-PD-HP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T22","span":{"begin":258,"end":271},"obj":"Phenotype"}],"attributes":[{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0001635"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"794","span":{"begin":25,"end":29},"obj":"Gene"},{"id":"795","span":{"begin":52,"end":63},"obj":"Gene"},{"id":"796","span":{"begin":139,"end":145},"obj":"Gene"},{"id":"797","span":{"begin":190,"end":194},"obj":"Gene"},{"id":"798","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"801","span":{"begin":349,"end":355},"obj":"Gene"},{"id":"802","span":{"begin":65,"end":76},"obj":"Chemical"},{"id":"803","span":{"begin":89,"end":96},"obj":"Chemical"},{"id":"804","span":{"begin":258,"end":271},"obj":"Disease"}],"attributes":[{"id":"A794","pred":"tao:has_database_id","subj":"794","obj":"Gene:59272"},{"id":"A795","pred":"tao:has_database_id","subj":"795","obj":"Gene:4922"},{"id":"A796","pred":"tao:has_database_id","subj":"796","obj":"Gene:8862"},{"id":"A797","pred":"tao:has_database_id","subj":"797","obj":"Gene:59272"},{"id":"A798","pred":"tao:has_database_id","subj":"798","obj":"Gene:59272"},{"id":"A801","pred":"tao:has_database_id","subj":"801","obj":"Gene:8862"},{"id":"A803","pred":"tao:has_database_id","subj":"803","obj":"MESH:D054439"},{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"MESH:D006333"},{"subj":"794","pred":"source","obj":"LitCovid-PubTator"},{"subj":"795","pred":"source","obj":"LitCovid-PubTator"},{"subj":"796","pred":"source","obj":"LitCovid-PubTator"},{"subj":"797","pred":"source","obj":"LitCovid-PubTator"},{"subj":"798","pred":"source","obj":"LitCovid-PubTator"},{"subj":"801","pred":"source","obj":"LitCovid-PubTator"},{"subj":"802","pred":"source","obj":"LitCovid-PubTator"},{"subj":"803","pred":"source","obj":"LitCovid-PubTator"},{"subj":"804","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T186","span":{"begin":5,"end":112},"obj":"Sentence"},{"id":"T187","span":{"begin":113,"end":315},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T186","pred":"source","obj":"LitCovid-sentences"},{"subj":"T187","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-CHEBI","color":"#ecb793","default":true},{"id":"LitCovid-sample-sentences","color":"#9d93ec"},{"id":"LitCovid-sample-PD-UBERON","color":"#a2ec93"},{"id":"LitCovid-sample-Pubtator","color":"#ec93bc"},{"id":"LitCovid-sample-UniProt","color":"#93d6ec"},{"id":"LitCovid-sample-PD-FMA","color":"#ece793"},{"id":"LitCovid-sample-PD-MONDO","color":"#cd93ec"},{"id":"LitCovid-sample-PD-MAT","color":"#93ecb3"},{"id":"LitCovid-sample-PD-HP","color":"#ec9993"},{"id":"LitCovid-PD-HP","color":"#93a6ec"},{"id":"LitCovid-PubTator","color":"#c0ec93"},{"id":"LitCovid-sentences","color":"#ec93da"}]}]}}