PMC:7556165 / 27721-28843 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T99","span":{"begin":443,"end":455},"obj":"Chemical"}],"attributes":[{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T79","span":{"begin":1004,"end":1009},"obj":"Species"}],"attributes":[{"id":"A79","pred":"ncbi_taxonomy_id","subj":"T79","obj":"NCBItxid:9606"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T176","span":{"begin":0,"end":351},"obj":"Sentence"},{"id":"T177","span":{"begin":352,"end":599},"obj":"Sentence"},{"id":"T178","span":{"begin":600,"end":787},"obj":"Sentence"},{"id":"T179","span":{"begin":788,"end":1122},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"737","span":{"begin":22,"end":26},"obj":"Gene"},{"id":"738","span":{"begin":379,"end":383},"obj":"Gene"},{"id":"739","span":{"begin":955,"end":959},"obj":"Gene"},{"id":"740","span":{"begin":34,"end":38},"obj":"Gene"},{"id":"741","span":{"begin":1004,"end":1009},"obj":"Species"},{"id":"742","span":{"begin":1021,"end":1029},"obj":"Species"},{"id":"743","span":{"begin":443,"end":455},"obj":"Chemical"},{"id":"744","span":{"begin":690,"end":712},"obj":"Disease"},{"id":"745","span":{"begin":760,"end":781},"obj":"Disease"},{"id":"746","span":{"begin":1042,"end":1050},"obj":"Disease"},{"id":"747","span":{"begin":1054,"end":1076},"obj":"Disease"}],"attributes":[{"id":"A742","pred":"pubann:denotes","subj":"742","obj":"Tax:9606"},{"id":"A740","pred":"pubann:denotes","subj":"740","obj":"Gene:116511"},{"id":"A738","pred":"pubann:denotes","subj":"738","obj":"Gene:59272"},{"id":"A747","pred":"pubann:denotes","subj":"747","obj":"MESH:D002311"},{"id":"A739","pred":"pubann:denotes","subj":"739","obj":"Gene:59272"},{"id":"A744","pred":"pubann:denotes","subj":"744","obj":"MESH:D006332"},{"id":"A741","pred":"pubann:denotes","subj":"741","obj":"Tax:9606"},{"id":"A743","pred":"pubann:denotes","subj":"743","obj":"MESH:D009569"},{"id":"A745","pred":"pubann:denotes","subj":"745","obj":"MESH:D009203"},{"id":"A746","pred":"pubann:denotes","subj":"746","obj":"MESH:D007511"},{"id":"A737","pred":"pubann:denotes","subj":"737","obj":"Gene:59272"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2233","span":{"begin":22,"end":26},"obj":"Protein"},{"id":"T2234","span":{"begin":379,"end":383},"obj":"Protein"},{"id":"T2235","span":{"begin":487,"end":493},"obj":"Protein"},{"id":"T2238","span":{"begin":955,"end":959},"obj":"Protein"}],"attributes":[{"id":"A2233","pred":"uniprot_id","subj":"T2233","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2234","pred":"uniprot_id","subj":"T2234","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2235","pred":"uniprot_id","subj":"T2235","obj":"https://www.uniprot.org/uniprot/Q9VPM8"},{"id":"A2236","pred":"uniprot_id","subj":"T2235","obj":"https://www.uniprot.org/uniprot/P91682"},{"id":"A2237","pred":"uniprot_id","subj":"T2235","obj":"https://www.uniprot.org/uniprot/B7FNK1"},{"id":"A2238","pred":"uniprot_id","subj":"T2238","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T76","span":{"begin":166,"end":176},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T77","span":{"begin":251,"end":255},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T78","span":{"begin":256,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T79","span":{"begin":501,"end":506},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T259","span":{"begin":101,"end":115},"obj":"Body_part"},{"id":"T260","span":{"begin":157,"end":165},"obj":"Body_part"},{"id":"T261","span":{"begin":193,"end":207},"obj":"Body_part"},{"id":"T262","span":{"begin":251,"end":255},"obj":"Body_part"},{"id":"T263","span":{"begin":478,"end":506},"obj":"Body_part"},{"id":"T264","span":{"begin":501,"end":506},"obj":"Body_part"},{"id":"T265","span":{"begin":728,"end":742},"obj":"Body_part"}],"attributes":[{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma14067"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma14067"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma284560"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma7101"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T62","span":{"begin":760,"end":781},"obj":"Disease"},{"id":"T63","span":{"begin":783,"end":785},"obj":"Disease"},{"id":"T64","span":{"begin":1054,"end":1076},"obj":"Disease"}],"attributes":[{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005021"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005068"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0005068"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T106","span":{"begin":487,"end":500},"obj":"http://purl.obolibrary.org/obo/MAT_0000303"},{"id":"T107","span":{"begin":494,"end":500},"obj":"http://purl.obolibrary.org/obo/MAT_0000025"},{"id":"T108","span":{"begin":733,"end":742},"obj":"http://purl.obolibrary.org/obo/MAT_0000497"},{"id":"T109","span":{"begin":1010,"end":1016},"obj":"http://purl.obolibrary.org/obo/MAT_0000036"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T72","span":{"begin":143,"end":152},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T73","span":{"begin":157,"end":176},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T74","span":{"begin":251,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T75","span":{"begin":256,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T76","span":{"begin":507,"end":527},"obj":"http://purl.obolibrary.org/obo/GO_1990874"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T18","span":{"begin":760,"end":781},"obj":"Phenotype"},{"id":"T19","span":{"begin":783,"end":785},"obj":"Phenotype"},{"id":"T20","span":{"begin":1054,"end":1076},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001658"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0001658"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T74","span":{"begin":143,"end":152},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T75","span":{"begin":157,"end":176},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T76","span":{"begin":251,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T77","span":{"begin":256,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T78","span":{"begin":429,"end":441},"obj":"http://purl.obolibrary.org/obo/GO_0042311"},{"id":"T79","span":{"begin":507,"end":527},"obj":"http://purl.obolibrary.org/obo/GO_1990874"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":760,"end":781},"obj":"Phenotype"},{"id":"T19","span":{"begin":783,"end":785},"obj":"Phenotype"},{"id":"T20","span":{"begin":1054,"end":1076},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001658"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0001658"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"737","span":{"begin":22,"end":26},"obj":"Gene"},{"id":"738","span":{"begin":379,"end":383},"obj":"Gene"},{"id":"739","span":{"begin":955,"end":959},"obj":"Gene"},{"id":"740","span":{"begin":34,"end":38},"obj":"Gene"},{"id":"741","span":{"begin":1004,"end":1009},"obj":"Species"},{"id":"742","span":{"begin":1021,"end":1029},"obj":"Species"},{"id":"743","span":{"begin":443,"end":455},"obj":"Chemical"},{"id":"744","span":{"begin":690,"end":712},"obj":"Disease"},{"id":"745","span":{"begin":760,"end":781},"obj":"Disease"},{"id":"746","span":{"begin":1042,"end":1050},"obj":"Disease"},{"id":"747","span":{"begin":1054,"end":1076},"obj":"Disease"}],"attributes":[{"id":"A737","pred":"tao:has_database_id","subj":"737","obj":"Gene:59272"},{"id":"A738","pred":"tao:has_database_id","subj":"738","obj":"Gene:59272"},{"id":"A739","pred":"tao:has_database_id","subj":"739","obj":"Gene:59272"},{"id":"A740","pred":"tao:has_database_id","subj":"740","obj":"Gene:116511"},{"id":"A741","pred":"tao:has_database_id","subj":"741","obj":"Tax:9606"},{"id":"A742","pred":"tao:has_database_id","subj":"742","obj":"Tax:9606"},{"id":"A743","pred":"tao:has_database_id","subj":"743","obj":"MESH:D009569"},{"id":"A744","pred":"tao:has_database_id","subj":"744","obj":"MESH:D006332"},{"id":"A745","pred":"tao:has_database_id","subj":"745","obj":"MESH:D009203"},{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"MESH:D007511"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"MESH:D002311"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T176","span":{"begin":0,"end":351},"obj":"Sentence"},{"id":"T177","span":{"begin":352,"end":599},"obj":"Sentence"},{"id":"T178","span":{"begin":600,"end":787},"obj":"Sentence"},{"id":"T179","span":{"begin":788,"end":1122},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016). Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008). In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI). In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005)."}