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PMC:7556165 / 27721-28843 JSON TXT

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LitCovid-sample-CHEBI

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T99	443-455	Chemical	denotes	nitric oxide	http://purl.obolibrary.org/obo/CHEBI_16480

LitCovid-sample-PD-NCBITaxon

Id	Subject	Object	Predicate	Lexical cue	ncbi_taxonomy_id
T79	1004-1009	Species	denotes	human	NCBItxid:9606

LitCovid-sample-sentences

Id	Subject	Object	Predicate	Lexical cue
T176	0-351	Sentence	denotes	In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177	352-599	Sentence	denotes	Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178	600-787	Sentence	denotes	In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179	788-1122	Sentence	denotes	In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).

LitCovid-sample-Pubtator

Id	Subject	Object	Predicate	Lexical cue	pubann:denotes
737	22-26	Gene	denotes	ACE2	Gene:59272
738	379-383	Gene	denotes	ACE2	Gene:59272
739	955-959	Gene	denotes	ACE2	Gene:59272
740	34-38	Gene	denotes	MasR	Gene:116511
741	1004-1009	Species	denotes	human	Tax:9606
742	1021-1029	Species	denotes	patients	Tax:9606
743	443-455	Chemical	denotes	nitric oxide	MESH:D009569
744	690-712	Disease	denotes	myocardial hypertrophy	MESH:D006332
745	760-781	Disease	denotes	myocardial infarction	MESH:D009203
746	1042-1050	Disease	denotes	ischemic	MESH:D007511
747	1054-1076	Disease	denotes	dilated cardiomyopathy	MESH:D002311

LitCovid-sample-UniProt

Id	Subject	Object	Predicate	Lexical cue	uniprot_id
T2233	22-26	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T2234	379-383	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T2235	487-493	Protein	denotes	smooth	https://www.uniprot.org/uniprot/Q9VPM8\|https://www.uniprot.org/uniprot/P91682\|https://www.uniprot.org/uniprot/B7FNK1
T2238	955-959	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id	Subject	Object	Predicate	Lexical cue
T76	166-176	http://purl.obolibrary.org/obo/IDO_0000607	denotes	production
T77	251-255	http://purl.obolibrary.org/obo/CL_0000000	denotes	cell
T78	256-262	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T79	501-506	http://purl.obolibrary.org/obo/CL_0000000	denotes	cells

LitCovid-sample-PD-FMA

Id	Subject	Object	Predicate	Lexical cue	fma_id
T259	101-115	Body_part	denotes	cardiomyocytes	http://purl.org/sig/ont/fma/fma14067
T260	157-165	Body_part	denotes	cytokine	http://purl.org/sig/ont/fma/fma84050
T261	193-207	Body_part	denotes	cardiomyocytes	http://purl.org/sig/ont/fma/fma14067
T262	251-255	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T263	478-506	Body_part	denotes	vascular smooth muscle cells	http://purl.org/sig/ont/fma/fma284560
T264	501-506	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T265	728-742	Body_part	denotes	left ventricle	http://purl.org/sig/ont/fma/fma7101

LitCovid-sample-PD-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T62	760-781	Disease	denotes	myocardial infarction	http://purl.obolibrary.org/obo/MONDO_0005068
T63	783-785	Disease	denotes	MI	http://purl.obolibrary.org/obo/MONDO_0005068
T64	1054-1076	Disease	denotes	dilated cardiomyopathy	http://purl.obolibrary.org/obo/MONDO_0005021

LitCovid-sample-PD-MAT

Id	Subject	Object	Predicate	Lexical cue
T106	487-500	http://purl.obolibrary.org/obo/MAT_0000303	denotes	smooth muscle
T107	494-500	http://purl.obolibrary.org/obo/MAT_0000025	denotes	muscle
T108	733-742	http://purl.obolibrary.org/obo/MAT_0000497	denotes	ventricle
T109	1010-1016	http://purl.obolibrary.org/obo/MAT_0000036	denotes	hearts

LitCovid-sample-PD-GO-BP-0

Id	Subject	Object	Predicate	Lexical cue
T72	143-152	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T73	157-176	http://purl.obolibrary.org/obo/GO_0001816	denotes	cytokine production
T74	251-262	http://purl.obolibrary.org/obo/GO_0016049	denotes	cell growth
T75	256-262	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T76	507-527	http://purl.obolibrary.org/obo/GO_1990874	denotes	(VSMC) proliferation

LitCovid-sample-PD-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T18	760-781	Phenotype	denotes	myocardial infarction	http://purl.obolibrary.org/obo/HP_0001658
T19	783-785	Phenotype	denotes	MI	http://purl.obolibrary.org/obo/HP_0001658
T20	1054-1076	Phenotype	denotes	dilated cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001644

LitCovid-sample-GO-BP

Id	Subject	Object	Predicate	Lexical cue
T74	143-152	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T75	157-176	http://purl.obolibrary.org/obo/GO_0001816	denotes	cytokine production
T76	251-262	http://purl.obolibrary.org/obo/GO_0016049	denotes	cell growth
T77	256-262	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T78	429-441	http://purl.obolibrary.org/obo/GO_0042311	denotes	vasodilation
T79	507-527	http://purl.obolibrary.org/obo/GO_1990874	denotes	(VSMC) proliferation

LitCovid-PD-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T18	760-781	Phenotype	denotes	myocardial infarction	http://purl.obolibrary.org/obo/HP_0001658
T19	783-785	Phenotype	denotes	MI	http://purl.obolibrary.org/obo/HP_0001658
T20	1054-1076	Phenotype	denotes	dilated cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001644

LitCovid-PubTator

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
737	22-26	Gene	denotes	ACE2	Gene:59272
738	379-383	Gene	denotes	ACE2	Gene:59272
739	955-959	Gene	denotes	ACE2	Gene:59272
740	34-38	Gene	denotes	MasR	Gene:116511
741	1004-1009	Species	denotes	human	Tax:9606
742	1021-1029	Species	denotes	patients	Tax:9606
743	443-455	Chemical	denotes	nitric oxide	MESH:D009569
744	690-712	Disease	denotes	myocardial hypertrophy	MESH:D006332
745	760-781	Disease	denotes	myocardial infarction	MESH:D009203
746	1042-1050	Disease	denotes	ischemic	MESH:D007511
747	1054-1076	Disease	denotes	dilated cardiomyopathy	MESH:D002311

LitCovid-sentences

Id	Subject	Object	Predicate	Lexical cue
T176	0-351	Sentence	denotes	In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177	352-599	Sentence	denotes	Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178	600-787	Sentence	denotes	In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179	788-1122	Sentence	denotes	In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).