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PMC:7556165 / 2579-4653 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T7 13-42 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T8 44-47 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T9 162-175 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T10 238-241 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T11 342-345 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T12 478-481 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T13 563-566 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T14 704-717 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T15 770-773 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T16 786-800 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T17 955-958 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T18 2059-2073 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T6 13-24 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T7 100-108 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T8 113-121 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T9 162-175 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T11 180-190 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T12 704-717 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T14 1089-1101 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T20 1057-1065 Species denotes SARS-CoV NCBItxid:694009
T21 1057-1061 Species denotes SARS NCBItxid:694009
T22 1192-1202 Species denotes SARS-CoV-2 NCBItxid:2697049
T23 1192-1196 Species denotes SARS NCBItxid:694009
T24 1244-1252 Species denotes COVID-19 NCBItxid:2697049
T25 1432-1440 Species denotes COVID-19 NCBItxid:2697049
T26 1711-1721 Species denotes SARS-CoV-2 NCBItxid:2697049
T27 1711-1715 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T19 0-12 Sentence denotes Introduction
T20 13-191 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 192-465 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 466-546 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 547-618 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 619-718 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 719-785 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 786-985 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 986-1158 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 1159-1373 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 1374-1615 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 1616-1795 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 1796-1903 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 1904-2074 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 451-456 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T7 1629-1633 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
100 162-175 Gene denotes angiotensin I Gene:183
101 180-190 Gene denotes bradykinin Gene:3827
102 238-241 Gene denotes ACE Gene:1636
103 342-345 Gene denotes ACE Gene:1636
104 478-481 Gene denotes ACE Gene:1636
105 377-399 Disease denotes cardiovascular disease MESH:D002318
106 423-435 Disease denotes hypertension MESH:D006973
107 440-464 Disease denotes congestive heart failure MESH:D006333
122 597-601 Gene denotes ACE2 Gene:59272
123 704-717 Gene denotes angiotensin I Gene:183
124 770-773 Gene denotes ACE Gene:1636
125 859-863 Gene denotes ACE2 Gene:59272
126 897-901 Gene denotes ACE2 Gene:59272
127 955-958 Gene denotes ACE Gene:1636
128 994-998 Gene denotes ACE2 Gene:59272
129 1153-1157 Gene denotes ACE2 Gene:59272
130 1294-1298 Gene denotes ACE2 Gene:59272
131 1144-1152 Gene denotes membrane Gene:43740571
132 1057-1065 Species denotes SARS-CoV Tax:694009
133 1192-1202 Species denotes SARS-CoV-2 Tax:2697049
134 563-566 Gene denotes ACE Gene:11421
135 1244-1252 Disease denotes COVID-19 MESH:C000657245
144 1549-1553 Gene denotes ACE2 Gene:59272
145 1669-1673 Gene denotes ACE2 Gene:59272
146 1689-1693 Gene denotes ACE2 Gene:59272
147 1711-1721 Species denotes SARS-CoV-2 Tax:2697049
148 1374-1386 Disease denotes Hypertension MESH:D006973
149 1432-1440 Disease denotes COVID-19 MESH:C000657245
150 1506-1518 Disease denotes hypertension MESH:D006973
151 1525-1537 Disease denotes hypertensive MESH:D006973
153 1873-1877 Gene denotes ACE2 Gene:59272
98 13-42 Gene denotes Angiotensin-converting enzyme Gene:1636
99 44-47 Gene denotes ACE Gene:1636

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T142 13-42 Protein denotes Angiotensin-converting enzyme https://www.uniprot.org/uniprot/Q9VJV3|https://www.uniprot.org/uniprot/Q9TX66|https://www.uniprot.org/uniprot/Q9NKE4|https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6Q4G4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q27572|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q10715|https://www.uniprot.org/uniprot/Q10714|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/A4V0P3
T174 44-47 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T199 162-175 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T216 180-190 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T253 238-241 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T278 342-345 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T303 478-481 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T328 563-566 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T353 597-601 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T354 704-717 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T371 770-773 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T396 859-863 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T397 897-901 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T398 955-958 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T423 994-998 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T424 1083-1101 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T528 1153-1157 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T529 1294-1298 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T530 1549-1553 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T531 1669-1673 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T532 1689-1693 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T533 1873-1877 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T12 392-399 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T13 1066-1071 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 1203-1208 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 1362-1366 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T16 1441-1455 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T17 1585-1591 http://purl.obolibrary.org/obo/BFO_0000030 denotes object

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T14 113-121 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T15 451-456 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T16 1089-1101 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T17 1362-1366 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 1629-1633 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T24 377-399 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T25 423-435 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T26 440-464 Disease denotes congestive heart failure http://purl.obolibrary.org/obo/MONDO_0005009
T27 1057-1065 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 1057-1061 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T29 1192-1202 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T30 1192-1196 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T31 1244-1252 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T32 1374-1386 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T33 1432-1440 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 1506-1518 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T35 1711-1721 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T36 1711-1715 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T5 414-422 http://purl.obolibrary.org/obo/MAT_0000034 denotes arterial
T6 451-456 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T7 1629-1633 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T7 78-88 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T8 1320-1330 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 377-399 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 423-435 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 440-464 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 1374-1386 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 1506-1518 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T7 78-88 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T8 1320-1330 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 377-399 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 423-435 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 440-464 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 1374-1386 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 1506-1518 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
98 13-42 Gene denotes Angiotensin-converting enzyme Gene:1636
99 44-47 Gene denotes ACE Gene:1636
100 162-175 Gene denotes angiotensin I Gene:183
101 180-190 Gene denotes bradykinin Gene:3827
102 238-241 Gene denotes ACE Gene:1636
103 342-345 Gene denotes ACE Gene:1636
104 478-481 Gene denotes ACE Gene:1636
105 377-399 Disease denotes cardiovascular disease MESH:D002318
106 423-435 Disease denotes hypertension MESH:D006973
107 440-464 Disease denotes congestive heart failure MESH:D006333
122 597-601 Gene denotes ACE2 Gene:59272
123 704-717 Gene denotes angiotensin I Gene:183
124 770-773 Gene denotes ACE Gene:1636
125 859-863 Gene denotes ACE2 Gene:59272
126 897-901 Gene denotes ACE2 Gene:59272
127 955-958 Gene denotes ACE Gene:1636
128 994-998 Gene denotes ACE2 Gene:59272
129 1153-1157 Gene denotes ACE2 Gene:59272
130 1294-1298 Gene denotes ACE2 Gene:59272
131 1144-1152 Gene denotes membrane Gene:43740571
132 1057-1065 Species denotes SARS-CoV Tax:694009
133 1192-1202 Species denotes SARS-CoV-2 Tax:2697049
134 563-566 Gene denotes ACE Gene:11421
135 1244-1252 Disease denotes COVID-19 MESH:C000657245
144 1549-1553 Gene denotes ACE2 Gene:59272
145 1669-1673 Gene denotes ACE2 Gene:59272
146 1689-1693 Gene denotes ACE2 Gene:59272
147 1711-1721 Species denotes SARS-CoV-2 Tax:2697049
148 1374-1386 Disease denotes Hypertension MESH:D006973
149 1432-1440 Disease denotes COVID-19 MESH:C000657245
150 1506-1518 Disease denotes hypertension MESH:D006973
151 1525-1537 Disease denotes hypertensive MESH:D006973
153 1873-1877 Gene denotes ACE2 Gene:59272

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T19 0-12 Sentence denotes Introduction
T20 13-191 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 192-465 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 466-546 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 547-618 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 619-718 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 719-785 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 786-985 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 986-1158 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 1159-1373 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 1374-1615 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 1616-1795 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 1796-1903 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 1904-2074 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.