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PMC:7556165 / 25680-30689 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T61 359-371 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T62 438-441 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T63 490-504 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T64 798-801 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T65 1171-1184 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T66 1263-1266 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T67 1702-1715 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T68 1793-1796 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T69 3855-3858 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T70 4828-4831 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T91 490-504 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T94 1171-1184 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T96 1702-1715 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T98 1930-1940 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T99 2484-2496 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T100 3285-3296 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T101 3488-3495 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T102 3496-3499 Chemical denotes Ala http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217
T104 3608-3615 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 3882-3892 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T106 3924-3934 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T107 3955-3965 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T108 4015-4025 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T109 4112-4121 Chemical denotes apelin-13 http://purl.obolibrary.org/obo/CHEBI_147395|http://purl.obolibrary.org/obo/CHEBI_80131
T111 4126-4137 Chemical denotes neurotensin http://purl.obolibrary.org/obo/CHEBI_147362|http://purl.obolibrary.org/obo/CHEBI_7542
T113 4139-4150 Chemical denotes dynorphin A http://purl.obolibrary.org/obo/CHEBI_4727
T114 4163-4170 Chemical denotes ghrelin http://purl.obolibrary.org/obo/CHEBI_75431
T115 4201-4209 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T77 607-612 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T79 3045-3050 Species denotes human NCBItxid:9606
T80 3818-3824 Species denotes sepsis NCBItxid:137507

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T164 0-42 Sentence denotes ACE2, the RAAS System and Cardioprotection
T165 43-307 Sentence denotes After the initial discovery of ACE2 in the heart and kidney, it is now clear that it is widely distributed in tissues (section Tissue Distribution of ACE2), where it exerts many physiological effects and may be involved in pathophysiological events (Turner, 2015).
T166 308-514 Sentence denotes The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II).
T167 515-741 Sentence denotes The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinning of the left ventricular wall.
T168 742-873 Sentence denotes Interestingly, in this knockout model disruption of the ACE pathway could rescue the myocardial phenotype (Crackower et al., 2002).
T169 874-1009 Sentence denotes In another study, a selective ACE2 knockout model showed high blood pressure, worsened by the infusion of Ang-II (Gurley et al., 2006).
T170 1010-1148 Sentence denotes As a matter of fact, ACE2 displays its carboxypeptidase activity converting Ang-II to a heptapeptide, namely Ang1–7 (Turner et al., 2004).
T171 1149-1357 Sentence denotes ACE2 can also convert angiotensin I (Ang-I) to the non apeptide Ang1–9, which is in turn converted into Ang1–7 by ACE, competing with Ang-I and thus further decreasing Ang-II (Arendse et al., 2019; Figure 3).
T172 1358-1563 Sentence denotes Ang1–7 has been demonstrated to bind to the MasR receptor, which was initially regarded as an orphan receptor, since the use of a MasR antagonist caused inhibition of Ang1–7 effects (Alenina et al., 2008).
T173 1564-1797 Sentence denotes FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE.
T174 1798-1901 Sentence denotes ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs).
T175 1902-2040 Sentence denotes ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm.
T176 2041-2392 Sentence denotes In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177 2393-2640 Sentence denotes Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178 2641-2828 Sentence denotes In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179 2829-3163 Sentence denotes In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).
T180 3164-3229 Sentence denotes Additional players contribute to ACE2-mediated cardio-protection.
T181 3230-3424 Sentence denotes Another substrate of ACE2 carboxypeptidase activity is Angiotensin A (Ang-A), identified in 2008, which has a similar, although less potent, vasopressor effect as AngII (Jankowski et al., 2007).
T182 3425-3568 Sentence denotes The product of the enzymatic reaction catalyzed by ACE2 is the peptide Ala-Ang (1–7) also known as alamandine (Lautner et al., 2013; Figure 3).
T183 3569-3704 Sentence denotes Alamandine receptor is a Mas-related G-protein coupled receptor, known as MrgD, which is expressed in cardiomyocytes and blood vessels.
T184 3705-3847 Sentence denotes MrgD knockout animals develop a severe cardiopathy and alamandine showed a cardioprotective effect in a model of sepsis (Santos et al., 2019).
T185 3848-4078 Sentence denotes Unlike ACE, ACE2 is not active on bradykinin, but it can degrade the active bradykinin metabolite des-Arg9 bradykinin (DABK), blocking the signaling pathway of the B1 bradykinin receptor (Vickers et al., 2002; Sodhi et al., 2018).
T186 4079-4186 Sentence denotes Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015).
T187 4187-4389 Sentence denotes Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013).
T188 4390-4654 Sentence denotes ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015).
T189 4655-5009 Sentence denotes On the whole these findings suggest that ACE2 might exert antihypertensive and/or cardioprotective effects by different mechanisms, namely: (i) limiting the availability of ACE substrates, (ii) degrading Ang-II, (iii) activating the Ang1-7/MasR and/or Alamandine/MrgD pathways, (iv) interfering with other substrates, such as DABK and apelins (Figure 3).

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T114 86-91 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T115 96-102 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T116 170-176 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 936-941 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T118 1860-1866 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T119 1878-1883 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T120 1885-1892 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T121 3690-3703 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T122 4332-4337 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
675 0-4 Gene denotes ACE2 Gene:59272
688 74-78 Gene denotes ACE2 Gene:59272
689 193-197 Gene denotes ACE2 Gene:59272
690 322-326 Gene denotes ACE2 Gene:59272
691 416-420 Gene denotes ACE2 Gene:59272
692 438-441 Gene denotes ACE Gene:1636
693 490-504 Gene denotes angiotensin II Gene:183
694 539-543 Gene denotes ACE2 Gene:70008
695 620-624 Gene denotes ACE2 Gene:70008
696 798-801 Gene denotes ACE Gene:1636
697 904-908 Gene denotes ACE2 Gene:70008
698 607-612 Species denotes mouse Tax:10090
699 587-597 Species denotes transgenic Tax:10090
705 1031-1035 Gene denotes ACE2 Gene:59272
706 1149-1153 Gene denotes ACE2 Gene:59272
707 1263-1266 Gene denotes ACE Gene:1636
708 1488-1492 Gene denotes MasR Gene:116511
709 1402-1406 Gene denotes MasR Gene:116511
718 1574-1578 Gene denotes ACE2 Gene:59272
719 1600-1604 Gene denotes ACE2 Gene:59272
720 1663-1669 Gene denotes ANG II Gene:24179
721 1702-1715 Gene denotes angiotensin I Gene:183
722 1793-1796 Gene denotes ACE Gene:1636
723 1902-1906 Gene denotes ACE2 Gene:59272
724 1946-1951 Gene denotes BKB1R Gene:623
725 1815-1819 Gene denotes MasR Gene:116511
737 2063-2067 Gene denotes ACE2 Gene:59272
738 2420-2424 Gene denotes ACE2 Gene:59272
739 2996-3000 Gene denotes ACE2 Gene:59272
740 2075-2079 Gene denotes MasR Gene:116511
741 3045-3050 Species denotes human Tax:9606
742 3062-3070 Species denotes patients Tax:9606
743 2484-2496 Chemical denotes nitric oxide MESH:D009569
744 2731-2753 Disease denotes myocardial hypertrophy MESH:D006332
745 2801-2822 Disease denotes myocardial infarction MESH:D009203
746 3083-3091 Disease denotes ischemic MESH:D007511
747 3095-3117 Disease denotes dilated cardiomyopathy MESH:D002311
760 3197-3201 Gene denotes ACE2 Gene:59272
761 3251-3255 Gene denotes ACE2 Gene:59272
762 3476-3480 Gene denotes ACE2 Gene:59272
763 3643-3647 Gene denotes MrgD Gene:116512
764 3705-3709 Gene denotes MrgD Gene:116512
765 3285-3298 Chemical denotes Angiotensin A
766 3300-3305 Chemical denotes Ang-A
767 3496-3503 Chemical denotes Ala-Ang
768 3524-3534 Chemical denotes alamandine MESH:C581752
769 3760-3770 Chemical denotes alamandine MESH:C581752
770 3744-3755 Disease denotes cardiopathy MESH:C536187
771 3818-3824 Disease denotes sepsis MESH:D018805
777 3855-3858 Gene denotes ACE Gene:1636
778 3860-3864 Gene denotes ACE2 Gene:59272
779 3882-3892 Gene denotes bradykinin Gene:3827
780 3924-3934 Gene denotes bradykinin Gene:3827
781 4012-4034 Gene denotes B1 bradykinin receptor Gene:623
794 4099-4103 Gene denotes ACE2 Gene:59272
795 4126-4137 Gene denotes neurotensin Gene:4922
796 4213-4219 Gene denotes apelin Gene:8862
797 4264-4268 Gene denotes ACE2 Gene:59272
798 4390-4394 Gene denotes ACE2 Gene:59272
799 4518-4522 Gene denotes ACE2 Gene:59272
800 4527-4533 Gene denotes Apelin Gene:8862
801 4423-4429 Gene denotes apelin Gene:8862
802 4139-4150 Chemical denotes dynorphin A
803 4163-4170 Chemical denotes ghrelin MESH:D054439
804 4332-4345 Disease denotes heart failure MESH:D006333
805 4597-4609 Disease denotes hypertension MESH:D006973
811 4696-4700 Gene denotes ACE2 Gene:59272
812 4828-4831 Gene denotes ACE Gene:1636
813 4918-4922 Gene denotes MrgD Gene:116512
814 4895-4899 Gene denotes MasR Gene:116511
815 4907-4917 Chemical denotes Alamandine MESH:C581752

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2000 0-4 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2001 74-78 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2002 193-197 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2003 322-326 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2004 416-420 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2005 438-441 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2030 490-504 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2047 539-543 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2048 620-624 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2049 798-801 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2074 904-908 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2075 1031-1035 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2076 1049-1065 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2077 1149-1153 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2078 1171-1184 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2095 1263-1266 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2120 1574-1578 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2121 1600-1604 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2122 1618-1634 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2123 1674-1678 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2133 1702-1715 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2150 1783-1787 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2160 1793-1796 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2185 1798-1802 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2195 1902-1906 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2196 1930-1940 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2233 2063-2067 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2234 2420-2424 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2235 2528-2534 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T2238 2996-3000 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2239 3197-3201 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2240 3251-3255 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2241 3256-3272 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2242 3285-3296 Protein denotes Angiotensin https://www.uniprot.org/uniprot/Q10757
T2243 3476-3480 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2244 3606-3632 Protein denotes G-protein coupled receptor https://www.uniprot.org/uniprot/Q9QJ51|https://www.uniprot.org/uniprot/Q18LE5
T2246 3855-3858 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2271 3860-3864 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2272 3882-3892 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2309 3924-3934 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2346 3946-3965 Protein denotes des-Arg9 bradykinin https://www.uniprot.org/uniprot/P86628
T2347 3955-3965 Protein denotes bradykinin https://www.uniprot.org/uniprot/A0A088MIT0
T2348 4012-4034 Protein denotes B1 bradykinin receptor https://www.uniprot.org/uniprot/Q9Z1F4|https://www.uniprot.org/uniprot/Q9R250|https://www.uniprot.org/uniprot/Q9BDQ5|https://www.uniprot.org/uniprot/Q95L02|https://www.uniprot.org/uniprot/Q95L01|https://www.uniprot.org/uniprot/Q8N0Y8|https://www.uniprot.org/uniprot/Q8HZP3|https://www.uniprot.org/uniprot/Q8HZP2|https://www.uniprot.org/uniprot/Q8HZP1|https://www.uniprot.org/uniprot/Q8HZN9|https://www.uniprot.org/uniprot/Q61125|https://www.uniprot.org/uniprot/Q546S7|https://www.uniprot.org/uniprot/Q3BCU0|https://www.uniprot.org/uniprot/P97583|https://www.uniprot.org/uniprot/P48748|https://www.uniprot.org/uniprot/P46663|https://www.uniprot.org/uniprot/O35782|https://www.uniprot.org/uniprot/A8K7F5
T2366 4099-4103 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2367 4112-4121 Protein denotes apelin-13 https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08
T2373 4126-4137 Protein denotes neurotensin https://www.uniprot.org/uniprot/Q9TS28|https://www.uniprot.org/uniprot/Q9QV80|https://www.uniprot.org/uniprot/Q9D3P9|https://www.uniprot.org/uniprot/Q3ZCG0|https://www.uniprot.org/uniprot/P81796|https://www.uniprot.org/uniprot/P41536|https://www.uniprot.org/uniprot/P32560|https://www.uniprot.org/uniprot/P31745|https://www.uniprot.org/uniprot/P30990|https://www.uniprot.org/uniprot/P20068|https://www.uniprot.org/uniprot/P13724|https://www.uniprot.org/uniprot/P10673|https://www.uniprot.org/uniprot/P01156
T2386 4139-4157 Protein denotes dynorphin A (1–13) https://www.uniprot.org/uniprot/Q95104|https://www.uniprot.org/uniprot/Q63193|https://www.uniprot.org/uniprot/Q60478|https://www.uniprot.org/uniprot/P06300|https://www.uniprot.org/uniprot/P01214|https://www.uniprot.org/uniprot/P01213|https://www.uniprot.org/uniprot/O35417|https://www.uniprot.org/uniprot/A8K0Q3
T2394 4163-4170 Protein denotes ghrelin https://www.uniprot.org/uniprot/Q9WUZ1|https://www.uniprot.org/uniprot/Q9QYH7|https://www.uniprot.org/uniprot/Q9GKY6|https://www.uniprot.org/uniprot/Q9GKY5|https://www.uniprot.org/uniprot/Q9GKY4|https://www.uniprot.org/uniprot/Q9ET69|https://www.uniprot.org/uniprot/Q9EQX0|https://www.uniprot.org/uniprot/Q9BEF8|https://www.uniprot.org/uniprot/Q9BEF7|https://www.uniprot.org/uniprot/Q9BDJ6|https://www.uniprot.org/uniprot/Q9BDG8|https://www.uniprot.org/uniprot/Q90W22|https://www.uniprot.org/uniprot/Q8JFY4|https://www.uniprot.org/uniprot/Q8AUU1|https://www.uniprot.org/uniprot/Q76IQ4|https://www.uniprot.org/uniprot/Q76HE2|https://www.uniprot.org/uniprot/Q6BEG7|https://www.uniprot.org/uniprot/Q6BEG6|https://www.uniprot.org/uniprot/Q6BEG5|https://www.uniprot.org/uniprot/Q2I0G0|https://www.uniprot.org/uniprot/Q0VH85|https://www.uniprot.org/uniprot/A5X8W4|https://www.uniprot.org/uniprot/A0MLS4
T2417 4213-4219 Protein denotes apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2424 4264-4268 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2425 4390-4394 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2426 4423-4429 Protein denotes apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2433 4518-4522 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2434 4527-4533 Protein denotes Apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2441 4696-4700 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2442 4828-4831 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T74 936-941 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T75 1860-1866 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T76 2207-2217 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T77 2292-2296 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T78 2297-2303 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T79 2542-2547 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T80 3429-3436 http://purl.obolibrary.org/obo/IDO_0000607 denotes product
T81 3690-3695 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T82 3818-3824 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T248 86-91 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T249 96-102 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T250 153-160 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T251 170-176 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T252 719-740 Body_part denotes left ventricular wall http://purl.org/sig/ont/fma/fma9556
T253 936-941 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T254 1878-1883 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T255 1894-1899 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T256 1952-1956 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T257 1993-1997 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T258 2025-2033 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T259 2142-2156 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T260 2198-2206 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T261 2234-2248 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T262 2292-2296 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T263 2519-2547 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T264 2542-2547 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T265 2769-2783 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T266 3606-3615 Body_part denotes G-protein http://purl.org/sig/ont/fma/fma61788
T267 3671-3685 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T268 3690-3703 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T269 3690-3695 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T270 4126-4137 Body_part denotes neurotensin http://purl.org/sig/ont/fma/fma83371
T271 4332-4337 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T61 931-950 Disease denotes high blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T62 2801-2822 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T63 2824-2826 Disease denotes MI http://purl.obolibrary.org/obo/MONDO_0005068
T64 3095-3117 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T65 4332-4345 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T66 4597-4609 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T99 86-91 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T100 96-102 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T101 936-941 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T102 936-941 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T103 1878-1883 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T104 1885-1892 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T105 1894-1899 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T106 2528-2541 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T107 2535-2541 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T108 2774-2783 http://purl.obolibrary.org/obo/MAT_0000497 denotes ventricle
T109 3051-3057 http://purl.obolibrary.org/obo/MAT_0000036 denotes hearts
T110 3690-3703 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessels
T111 3690-3695 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T112 3690-3695 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T113 4332-4337 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T66 379-389 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T67 463-479 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive
T68 1049-1074 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T69 1579-1598 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T70 1579-1589 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T71 1618-1643 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T72 2184-2193 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73 2198-2217 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T74 2292-2303 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T75 2297-2303 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T76 2548-2568 http://purl.obolibrary.org/obo/GO_1990874 denotes (VSMC) proliferation
T77 3256-3281 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T78 3987-4004 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T79 3987-3996 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T16 931-950 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T17 2025-2039 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T18 2801-2822 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 2824-2826 Phenotype denotes MI http://purl.obolibrary.org/obo/HP_0001658
T20 3095-3117 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T21 3818-3824 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 4332-4345 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T23 4597-4609 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T68 379-389 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T69 463-479 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive
T70 1049-1074 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T71 1579-1598 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T72 1579-1589 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T73 1618-1643 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T74 2184-2193 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T75 2198-2217 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T76 2292-2303 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T77 2297-2303 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T78 2470-2482 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T79 2548-2568 http://purl.obolibrary.org/obo/GO_1990874 denotes (VSMC) proliferation
T80 3256-3281 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T81 3987-4004 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T82 3987-3996 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T16 931-950 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T17 2025-2039 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T18 2801-2822 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 2824-2826 Phenotype denotes MI http://purl.obolibrary.org/obo/HP_0001658
T20 3095-3117 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T21 3818-3824 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 4332-4345 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T23 4597-4609 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
675 0-4 Gene denotes ACE2 Gene:59272
688 74-78 Gene denotes ACE2 Gene:59272
689 193-197 Gene denotes ACE2 Gene:59272
690 322-326 Gene denotes ACE2 Gene:59272
691 416-420 Gene denotes ACE2 Gene:59272
692 438-441 Gene denotes ACE Gene:1636
693 490-504 Gene denotes angiotensin II Gene:183
694 539-543 Gene denotes ACE2 Gene:70008
695 620-624 Gene denotes ACE2 Gene:70008
696 798-801 Gene denotes ACE Gene:1636
697 904-908 Gene denotes ACE2 Gene:70008
698 607-612 Species denotes mouse Tax:10090
699 587-597 Species denotes transgenic Tax:10090
705 1031-1035 Gene denotes ACE2 Gene:59272
706 1149-1153 Gene denotes ACE2 Gene:59272
707 1263-1266 Gene denotes ACE Gene:1636
708 1488-1492 Gene denotes MasR Gene:116511
709 1402-1406 Gene denotes MasR Gene:116511
718 1574-1578 Gene denotes ACE2 Gene:59272
719 1600-1604 Gene denotes ACE2 Gene:59272
720 1663-1669 Gene denotes ANG II Gene:24179
721 1702-1715 Gene denotes angiotensin I Gene:183
722 1793-1796 Gene denotes ACE Gene:1636
723 1902-1906 Gene denotes ACE2 Gene:59272
724 1946-1951 Gene denotes BKB1R Gene:623
725 1815-1819 Gene denotes MasR Gene:116511
737 2063-2067 Gene denotes ACE2 Gene:59272
738 2420-2424 Gene denotes ACE2 Gene:59272
739 2996-3000 Gene denotes ACE2 Gene:59272
740 2075-2079 Gene denotes MasR Gene:116511
741 3045-3050 Species denotes human Tax:9606
742 3062-3070 Species denotes patients Tax:9606
743 2484-2496 Chemical denotes nitric oxide MESH:D009569
744 2731-2753 Disease denotes myocardial hypertrophy MESH:D006332
745 2801-2822 Disease denotes myocardial infarction MESH:D009203
746 3083-3091 Disease denotes ischemic MESH:D007511
747 3095-3117 Disease denotes dilated cardiomyopathy MESH:D002311
760 3197-3201 Gene denotes ACE2 Gene:59272
761 3251-3255 Gene denotes ACE2 Gene:59272
762 3476-3480 Gene denotes ACE2 Gene:59272
763 3643-3647 Gene denotes MrgD Gene:116512
764 3705-3709 Gene denotes MrgD Gene:116512
765 3285-3298 Chemical denotes Angiotensin A
766 3300-3305 Chemical denotes Ang-A
767 3496-3503 Chemical denotes Ala-Ang
768 3524-3534 Chemical denotes alamandine MESH:C581752
769 3760-3770 Chemical denotes alamandine MESH:C581752
770 3744-3755 Disease denotes cardiopathy MESH:C536187
771 3818-3824 Disease denotes sepsis MESH:D018805
777 3855-3858 Gene denotes ACE Gene:1636
778 3860-3864 Gene denotes ACE2 Gene:59272
779 3882-3892 Gene denotes bradykinin Gene:3827
780 3924-3934 Gene denotes bradykinin Gene:3827
781 4012-4034 Gene denotes B1 bradykinin receptor Gene:623
794 4099-4103 Gene denotes ACE2 Gene:59272
795 4126-4137 Gene denotes neurotensin Gene:4922
796 4213-4219 Gene denotes apelin Gene:8862
797 4264-4268 Gene denotes ACE2 Gene:59272
798 4390-4394 Gene denotes ACE2 Gene:59272
799 4518-4522 Gene denotes ACE2 Gene:59272
800 4527-4533 Gene denotes Apelin Gene:8862
801 4423-4429 Gene denotes apelin Gene:8862
802 4139-4150 Chemical denotes dynorphin A
803 4163-4170 Chemical denotes ghrelin MESH:D054439
804 4332-4345 Disease denotes heart failure MESH:D006333
805 4597-4609 Disease denotes hypertension MESH:D006973
811 4696-4700 Gene denotes ACE2 Gene:59272
812 4828-4831 Gene denotes ACE Gene:1636
813 4918-4922 Gene denotes MrgD Gene:116512
814 4895-4899 Gene denotes MasR Gene:116511
815 4907-4917 Chemical denotes Alamandine MESH:C581752

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T164 0-42 Sentence denotes ACE2, the RAAS System and Cardioprotection
T165 43-307 Sentence denotes After the initial discovery of ACE2 in the heart and kidney, it is now clear that it is widely distributed in tissues (section Tissue Distribution of ACE2), where it exerts many physiological effects and may be involved in pathophysiological events (Turner, 2015).
T166 308-514 Sentence denotes The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II).
T167 515-741 Sentence denotes The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinning of the left ventricular wall.
T168 742-873 Sentence denotes Interestingly, in this knockout model disruption of the ACE pathway could rescue the myocardial phenotype (Crackower et al., 2002).
T169 874-1009 Sentence denotes In another study, a selective ACE2 knockout model showed high blood pressure, worsened by the infusion of Ang-II (Gurley et al., 2006).
T170 1010-1148 Sentence denotes As a matter of fact, ACE2 displays its carboxypeptidase activity converting Ang-II to a heptapeptide, namely Ang1–7 (Turner et al., 2004).
T171 1149-1357 Sentence denotes ACE2 can also convert angiotensin I (Ang-I) to the non apeptide Ang1–9, which is in turn converted into Ang1–7 by ACE, competing with Ang-I and thus further decreasing Ang-II (Arendse et al., 2019; Figure 3).
T172 1358-1563 Sentence denotes Ang1–7 has been demonstrated to bind to the MasR receptor, which was initially regarded as an orphan receptor, since the use of a MasR antagonist caused inhibition of Ang1–7 effects (Alenina et al., 2008).
T173 1564-1797 Sentence denotes FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE.
T174 1798-1901 Sentence denotes ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs).
T175 1902-2040 Sentence denotes ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm.
T176 2041-2392 Sentence denotes In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177 2393-2640 Sentence denotes Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178 2641-2828 Sentence denotes In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179 2829-3163 Sentence denotes In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).
T180 3164-3229 Sentence denotes Additional players contribute to ACE2-mediated cardio-protection.
T181 3230-3424 Sentence denotes Another substrate of ACE2 carboxypeptidase activity is Angiotensin A (Ang-A), identified in 2008, which has a similar, although less potent, vasopressor effect as AngII (Jankowski et al., 2007).
T182 3425-3568 Sentence denotes The product of the enzymatic reaction catalyzed by ACE2 is the peptide Ala-Ang (1–7) also known as alamandine (Lautner et al., 2013; Figure 3).
T183 3569-3704 Sentence denotes Alamandine receptor is a Mas-related G-protein coupled receptor, known as MrgD, which is expressed in cardiomyocytes and blood vessels.
T184 3705-3847 Sentence denotes MrgD knockout animals develop a severe cardiopathy and alamandine showed a cardioprotective effect in a model of sepsis (Santos et al., 2019).
T185 3848-4078 Sentence denotes Unlike ACE, ACE2 is not active on bradykinin, but it can degrade the active bradykinin metabolite des-Arg9 bradykinin (DABK), blocking the signaling pathway of the B1 bradykinin receptor (Vickers et al., 2002; Sodhi et al., 2018).
T186 4079-4186 Sentence denotes Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015).
T187 4187-4389 Sentence denotes Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013).
T188 4390-4654 Sentence denotes ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015).
T189 4655-5009 Sentence denotes On the whole these findings suggest that ACE2 might exert antihypertensive and/or cardioprotective effects by different mechanisms, namely: (i) limiting the availability of ACE substrates, (ii) degrading Ang-II, (iii) activating the Ang1-7/MasR and/or Alamandine/MrgD pathways, (iv) interfering with other substrates, such as DABK and apelins (Figure 3).