PMC:7556165 / 2164-2572 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7556165","sourcedb":"PMC","sourceid":"7556165","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7556165","text":"locking ACE2 with antibodies, small molecules or peptides, or at neutralizing the virus by competitive binding with exogenously administered ACE2, are currently under investigations. In this review, we will present an overview of the state-of-the-art knowledge on ACE2 biochemistry and pathophysiology, outlining open issues in the context of COVID-19 disease and potential experimental and clinical developm","tracks":[{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T6","span":{"begin":167,"end":181},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A6","pred":"meddra_id","subj":"T6","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"},{"subj":"T6","pred":"source","obj":"LitCovid-sample-MedDRA"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T5","span":{"begin":49,"end":57},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"subj":"T5","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T19","span":{"begin":343,"end":351},"obj":"Species"}],"attributes":[{"id":"A19","pred":"ncbi_taxonomy_id","subj":"T19","obj":"NCBItxid:2697049"},{"subj":"T19","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"63","span":{"begin":8,"end":12},"obj":"Gene"},{"id":"64","span":{"begin":141,"end":145},"obj":"Gene"},{"id":"65","span":{"begin":264,"end":268},"obj":"Gene"},{"id":"87","span":{"begin":343,"end":351},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"pubann:denotes","subj":"63","obj":"Gene:59272"},{"id":"A64","pred":"pubann:denotes","subj":"64","obj":"Gene:59272"},{"id":"A65","pred":"pubann:denotes","subj":"65","obj":"Gene:59272"},{"id":"A87","pred":"pubann:denotes","subj":"87","obj":"MESH:C000657245"},{"subj":"63","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"64","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"65","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"87","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T139","span":{"begin":8,"end":12},"obj":"Protein"},{"id":"T140","span":{"begin":141,"end":145},"obj":"Protein"},{"id":"T141","span":{"begin":264,"end":268},"obj":"Protein"}],"attributes":[{"id":"A139","pred":"uniprot_id","subj":"T139","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A140","pred":"uniprot_id","subj":"T140","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A141","pred":"uniprot_id","subj":"T141","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"subj":"T139","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T140","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T141","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T10","span":{"begin":82,"end":87},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T11","span":{"begin":352,"end":359},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"attributes":[{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T11","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T23","span":{"begin":343,"end":351},"obj":"Disease"}],"attributes":[{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T23","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"63","span":{"begin":8,"end":12},"obj":"Gene"},{"id":"64","span":{"begin":141,"end":145},"obj":"Gene"},{"id":"65","span":{"begin":264,"end":268},"obj":"Gene"},{"id":"87","span":{"begin":343,"end":351},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Gene:59272"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Gene:59272"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Gene:59272"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"MESH:C000657245"},{"subj":"63","pred":"source","obj":"LitCovid-PubTator"},{"subj":"64","pred":"source","obj":"LitCovid-PubTator"},{"subj":"65","pred":"source","obj":"LitCovid-PubTator"},{"subj":"87","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-MedDRA","color":"#93eca1","default":true},{"id":"LitCovid-sample-CHEBI","color":"#ec939e"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#93b8ec"},{"id":"LitCovid-sample-Pubtator","color":"#d2ec93"},{"id":"LitCovid-sample-UniProt","color":"#eb93ec"},{"id":"LitCovid-sample-PD-IDO","color":"#93ecd1"},{"id":"LitCovid-sample-PD-MONDO","color":"#ecb793"},{"id":"LitCovid-PubTator","color":"#9d93ec"}]}]}}