PMC:7546716 / 4956-6466
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T71 | 130-138 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T72 | 167-169 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T73 | 251-253 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T74 | 268-273 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T75 | 429-434 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T76 | 476-481 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T77 | 565-574 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T78 | 608-612 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T79 | 776-781 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T80 | 787-789 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T81 | 804-812 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T82 | 831-836 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T83 | 882-887 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T84 | 923-927 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T85 | 971-973 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T86 | 1028-1033 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T87 | 1041-1043 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T88 | 1109-1114 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T89 | 1191-1199 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T90 | 1247-1252 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T91 | 1292-1294 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T92 | 1351-1353 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T93 | 1365-1367 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T94 | 1411-1415 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T95 | 1416-1420 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T96 | 1428-1433 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T7 | 608-612 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T8 | 923-927 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T49 | 51-59 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T50 | 62-71 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T51 | 76-84 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T52 | 85-94 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T53 | 608-620 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T54 | 928-940 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T55 | 1451-1459 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T56 | 1500-1509 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T54 | 232-235 | http://purl.obolibrary.org/obo/CLO_0051025 | denotes | ST2 |
| T55 | 263-267 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Treg |
| T56 | 268-273 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T57 | 374-379 | http://purl.obolibrary.org/obo/CLO_0053477 | denotes | GATA3 |
| T58 | 424-428 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Treg |
| T59 | 429-434 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T60 | 457-462 | http://purl.obolibrary.org/obo/CLO_0053477 | denotes | GATA3 |
| T61 | 464-469 | http://purl.obolibrary.org/obo/PR_000001350 | denotes | Foxp3 |
| T62 | 471-475 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Treg |
| T63 | 476-481 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T64 | 608-612 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T65 | 608-612 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T66 | 742-745 | http://purl.obolibrary.org/obo/CLO_0051025 | denotes | ST2 |
| T67 | 760-781 | http://purl.obolibrary.org/obo/CL_0001065 | denotes | innate lymphoid cells |
| T68 | 831-836 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T69 | 866-887 | http://purl.obolibrary.org/obo/CL_0001065 | denotes | innate lymphoid cells |
| T70 | 923-927 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T71 | 923-927 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T72 | 1026-1033 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T73 | 1034-1036 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T74 | 1107-1114 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T75 | 1125-1126 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T76 | 1171-1172 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T77 | 1245-1252 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T78 | 1384-1385 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T79 | 1409-1415 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T80 | 1428-1433 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T54 | 167-169 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T56 | 251-253 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T58 | 787-789 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T60 | 971-973 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T62 | 1041-1043 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T64 | 1141-1149 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
| T65 | 1292-1294 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T67 | 1351-1353 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T69 | 1365-1367 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T8 | 85-94 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T9 | 608-620 | Phenotype | denotes | lung disease | http://purl.obolibrary.org/obo/HP_0002088 |
| T10 | 1500-1509 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 330-350 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T11 | 330-343 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T12 | 545-554 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T13 | 928-940 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T14 | 1150-1156 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T20 | 0-435 | Sentence | denotes | In susceptible individuals who develop symptomatic SARS-CoV-2 infection and COVID-19 pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. |
| T21 | 436-1510 | Sentence | denotes | The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might further enhance ST2 expression in innate lymphoid cells, and IL-33 is the key cytokine that drives these cells to differentiate into type 2 innate lymphoid cells (ILC2).17 ILC2 subsequently elicit lung inflammation by releasing large amounts of IL-9, which promotes their own survival and expands γδ T cells.18, 19 IL-9 is known to stimulate proliferation and expansion of Vγ9Vδ2+ T cells that have a predominantly effector memory phenotype and a combined Th1–Th17 cytokine response profile.19 When exposed to TGFβ, γδ T cells can also become an important source of IL-9.20 By acting in both autocrine and paracrine manners, IL-33-induced IL-9 might sustain a proinflammatory ILC2–γδT cell axis in the lungs of patients with COVID-19, thus initiating mild–moderate forms of pneumonia. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 213 | 167-172 | Gene | denotes | IL-33 | Gene:90865 |
| 214 | 232-235 | Gene | denotes | ST2 | Gene:6761 |
| 215 | 251-258 | Gene | denotes | IL-1RL1 | Gene:9173 |
| 216 | 351-372 | Gene | denotes | GATA-binding factor 3 | Gene:2625 |
| 217 | 374-379 | Gene | denotes | GATA3 | Gene:2625 |
| 218 | 457-462 | Gene | denotes | GATA3 | Gene:2625 |
| 219 | 464-469 | Gene | denotes | Foxp3 | Gene:50943 |
| 220 | 624-629 | Gene | denotes | TGFβ2 | Gene:7042 |
| 221 | 742-745 | Gene | denotes | ST2 | Gene:6761 |
| 222 | 787-792 | Gene | denotes | IL-33 | Gene:90865 |
| 223 | 971-975 | Gene | denotes | IL-9 | Gene:3578 |
| 224 | 1041-1045 | Gene | denotes | IL-9 | Gene:3578 |
| 225 | 1236-1240 | Gene | denotes | TGFβ | Gene:7039 |
| 226 | 1292-1296 | Gene | denotes | IL-9 | Gene:3578 |
| 227 | 1351-1356 | Gene | denotes | IL-33 | Gene:90865 |
| 228 | 1365-1369 | Gene | denotes | IL-9 | Gene:3578 |
| 229 | 96-98 | Gene | denotes | eg | Gene:50512 |
| 230 | 694-702 | Species | denotes | patients | Tax:9606 |
| 231 | 1437-1445 | Species | denotes | patients | Tax:9606 |
| 232 | 51-71 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 233 | 76-94 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 234 | 498-530 | Disease | denotes | impaired immunological tolerance | MESH:D018149 |
| 235 | 591-620 | Disease | denotes | autoinflammatory lung disease | MESH:D008171 |
| 236 | 708-716 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 237 | 923-940 | Disease | denotes | lung inflammation | MESH:D011014 |
| 238 | 1451-1459 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 239 | 1500-1509 | Disease | denotes | pneumonia | MESH:D011014 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33073244-28196763-66244519 | 621-623 | 28196763 | denotes | 16 |
| 33073244-32228226-66244520 | 717-719 | 32228226 | denotes | 11 |
| 33073244-31911623-66244521 | 895-897 | 31911623 | denotes | 17 |
| 33073244-26129648-66244522 | 1034-1036 | 26129648 | denotes | 18 |
| 33073244-27543964-66244523 | 1038-1040 | 27543964 | denotes | 19 |
| 33073244-27543964-66244524 | 1217-1219 | 27543964 | denotes | 19 |
| 33073244-27791087-66244525 | 1297-1299 | 27791087 | denotes | 20 |