PMC:7546716 / 43797-44110 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T893","span":{"begin":66,"end":77},"obj":"Body_part"},{"id":"T894","span":{"begin":88,"end":93},"obj":"Body_part"},{"id":"T895","span":{"begin":155,"end":159},"obj":"Body_part"},{"id":"T896","span":{"begin":155,"end":157},"obj":"Body_part"},{"id":"T897","span":{"begin":165,"end":167},"obj":"Body_part"},{"id":"T898","span":{"begin":258,"end":263},"obj":"Body_part"}],"attributes":[{"id":"A893","pred":"fma_id","subj":"T893","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A894","pred":"fma_id","subj":"T894","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A895","pred":"fma_id","subj":"T895","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A896","pred":"fma_id","subj":"T896","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A897","pred":"fma_id","subj":"T897","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A898","pred":"fma_id","subj":"T898","obj":"http://purl.org/sig/ont/fma/fma7088"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T52","span":{"begin":258,"end":263},"obj":"Body_part"}],"attributes":[{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T254","span":{"begin":212,"end":224},"obj":"Disease"},{"id":"T255","span":{"begin":258,"end":271},"obj":"Disease"}],"attributes":[{"id":"A254","pred":"mondo_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A255","pred":"mondo_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/MONDO_0005252"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T602","span":{"begin":49,"end":51},"obj":"http://purl.obolibrary.org/obo/PR_000005794"},{"id":"T603","span":{"begin":88,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T604","span":{"begin":141,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T605","span":{"begin":168,"end":170},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T606","span":{"begin":235,"end":236},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T607","span":{"begin":258,"end":263},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T608","span":{"begin":258,"end":263},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T609","span":{"begin":258,"end":263},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T610","span":{"begin":258,"end":263},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T682","span":{"begin":19,"end":29},"obj":"Chemical"},{"id":"T683","span":{"begin":49,"end":51},"obj":"Chemical"},{"id":"T685","span":{"begin":155,"end":157},"obj":"Chemical"},{"id":"T687","span":{"begin":165,"end":167},"obj":"Chemical"}],"attributes":[{"id":"A682","pred":"chebi_id","subj":"T682","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A683","pred":"chebi_id","subj":"T683","obj":"http://purl.obolibrary.org/obo/CHEBI_3380"},{"id":"A684","pred":"chebi_id","subj":"T683","obj":"http://purl.obolibrary.org/obo/CHEBI_73461"},{"id":"A685","pred":"chebi_id","subj":"T685","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A686","pred":"chebi_id","subj":"T685","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A687","pred":"chebi_id","subj":"T687","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A688","pred":"chebi_id","subj":"T687","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T82","span":{"begin":258,"end":271},"obj":"Phenotype"}],"attributes":[{"id":"A82","pred":"hp_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/HP_0001635"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T119","span":{"begin":212,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-sentences","denotations":[{"id":"T187","span":{"begin":0,"end":313},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1723","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"1724","span":{"begin":60,"end":65},"obj":"Gene"},{"id":"1725","span":{"begin":111,"end":120},"obj":"Gene"},{"id":"1726","span":{"begin":155,"end":160},"obj":"Gene"},{"id":"1751","span":{"begin":185,"end":191},"obj":"Species"},{"id":"1801","span":{"begin":202,"end":224},"obj":"Disease"},{"id":"1802","span":{"begin":258,"end":271},"obj":"Disease"}],"attributes":[{"id":"A1723","pred":"tao:has_database_id","subj":"1723","obj":"Gene:216799"},{"id":"A1724","pred":"tao:has_database_id","subj":"1724","obj":"Gene:216799"},{"id":"A1725","pred":"tao:has_database_id","subj":"1725","obj":"Gene:834"},{"id":"A1726","pred":"tao:has_database_id","subj":"1726","obj":"Gene:3552"},{"id":"A1751","pred":"tao:has_database_id","subj":"1751","obj":"Tax:10090"},{"id":"A1801","pred":"tao:has_database_id","subj":"1801","obj":"MESH:D011014"},{"id":"A1802","pred":"tao:has_database_id","subj":"1802","obj":"MESH:D006333"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages"}